Article
Oncology
Maaret Eskelinen, Jannica Meklin, Kari Syrjanen, Matti Eskelinen
Summary: The aim of the study was to compare the accuracy of common clinical findings, laboratory tests and diagnostic score in diagnosis of clinically confirmed acute appendicitis in children. The study showed that the diagnostic score was superior in diagnosing acute appendicitis in children compared to clinical history/symptoms and signs/lab tests.
ANTICANCER RESEARCH
(2021)
Article
Emergency Medicine
Eric J. Schmieler
Summary: This case describes a unique post-operative infection that is significant to emergency medicine. Pyometra is rarely seen in pediatric patients, so it is important for emergency physicians to have knowledge of this disease and its management.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Pediatrics
Syed Maaz Salahuddin, Omair Ayaz, Mehtab Jaffer, Rubaba Naeem, Shiyam Sundar Tikmani, Asad I. Mian
Summary: The study found that Pediatric Appendicitis Score (PAS) has good diagnostic accuracy in predicting acute appendicitis in children presenting to the Emergency Department.
Review
Medicine, General & Internal
Nellai Krishnan, Sachit Anand, Niklas Pakkasjarvi, Minu Bajpai, Anjan Kumar Dhua, Devendra Kumar Yadav
Summary: Although mean platelet volume (MPV) has been suggested as a biomarker for acute appendicitis (AA) in adults, its utility in pediatric AA remains unclear. A systematic review and meta-analysis of relevant studies found no significant difference in MPV levels between AA and healthy controls or AA and non-AA cases in children.
Article
Pediatrics
Christos Kaselas, Maria Florou, Charikleia Demiri, Maria Tsopozidi, Kleanthis Anastasiadis, Ioannis Spyridakis
Summary: This study aimed to examine whether the classification systems for acute appendicitis could be applied in the emergency department as an indicator for surgical consultation, in order to reduce unnecessary paediatric surgery admission. The results showed that these scoring systems provided acceptable prediction of patients with and without appendicitis, and may be useful in the emergency department as assistive diagnostic tools to reduce paediatric surgery consultations, admissions, and treatment costs.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Review
Medicine, Research & Experimental
Sarah V. L. Hodge, Beata Mickiewicz, Matthew Lau, Craig N. Jenne, Graham C. Thompson
Summary: Reliable and efficient diagnosis of pediatric appendicitis is crucial for clinical management and patient outcomes, but an optimal diagnostic strategy has not yet been determined. The introduction of precision medicine techniques has improved the diagnostic sensitivity and specificity of appendicitis, suggesting the potential integration of precision medicine into clinical practice through point-of-care technologies in the future.
BIOMARKERS IN MEDICINE
(2021)
Article
Pediatrics
Ruchira Nandan, Amat Us Samie, Samir Kant Acharya, Prabudh Goel, Vishesh Jain, Anjan Kumar Dhua, Maroof Ahmad Khan, Devendra Kumar Yadav
Summary: This study aimed to prospectively assess the performance of the pediatric appendicitis score (PAS) in diagnosing acute appendicitis in children with lower abdominal pain and its correlation with ultrasound findings. The results showed that PAS has high efficacy in diagnosing acute appendicitis. The clinical outcome was more favorable with the use of PAS. Ultrasonography should be used judiciously and in combination with clinical judgment.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Medicine, General & Internal
Apoorv Singh, Zenon Pogorelic, Aniket Agrawal, Carlos Martin Llorente Munoz, Deepika Kainth, Ajay Verma, Bibekanand Jindal, Sandeep Agarwala, Sachit Anand
Summary: This study evaluated the role of serum ischemia-modified albumin (IMA) in diagnosing and prognosticating acute appendicitis. The results showed that IMA levels were significantly elevated in patients with acute appendicitis and higher in patients with complicated appendicitis compared to non-complicated appendicitis. However, the methodological quality of the available studies was limited, indicating a need for further well-designed and adequately powered studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Tal Taraboulos Klein, Elkana Kohn, Baruch Klin, Tomer Ziv-Baran, Eran Kozer, Matityahu Berkovitch, Ibrahim Abu Kishk
Summary: The study found that serum sTREM-1 is not an efficient biomarker for acute appendicitis, while leukocytes, neutrophils, and CRP are significantly elevated in cases of appendicitis. Therefore, routine diagnostic tests along with proper patient history and physical examination remain the most effective methods for diagnosing acute appendicitis.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Xiaoya Guo, Hengli Yang, Jinghua Li, Lingchao Zeng, Chunhui Wang, Ruijing Yang, Yilin Yang
Summary: This study aims to explore the application value of high-frequency ultrasonography in endoscopic retrograde appendicitis therapy (ERAT) for pediatric acute appendicitis. The retrospective analysis found that the success rate of endoscopic treatment under the guidance of high-frequency ultrasonography was 96.32%, indicating that this method is safe and effective in treating pediatric acute appendicitis.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Immunology
Isis Ricano-Ponce, Toon Peeters, Vasiliki Matzaraki, Bert Houben, Ruth Achten, Peter Cools, Mihai G. Netea, Inge C. Gyssens, Vinod Kumar
Summary: Genetic variation may be associated with the risk of acute appendicitis, and there may be a shared genetic mechanism between CRP and acute appendicitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pediatrics
Rebecca N. Cherry, Samra S. Blanchard, Ashish Chogle, Neha R. Santucci, Khyati Mehta, Alexandra C. Russell
Summary: Chronic abdominal pain is a common problem in children, affecting approximately 20% of children worldwide. The pathophysiology involves multiple factors. Treatment approaches include dietary, pharmacologic, and complementary medicine interventions, as well as psychosocial support.
Review
Pediatrics
Stevie Puckett-Perez, Brittany Gresl
Summary: The purpose of this review is to discuss up-to-date psychological treatment strategies for functional abdominal pain disorders (FAPDs) and provide practical implications for primary care providers. Recent findings suggest that positive diagnosis, pain education, and access to multidisciplinary care improve outcomes for FAPD patients. Cognitive behavioral therapy (CBT) and hypnosis have the strongest evidence in psychological treatments, but other nonpharmacological approaches also show promise.
CURRENT OPINION IN PEDIATRICS
(2022)
Article
Surgery
Susan Zheng, Kerry Christy, Kristy Herzak, Nadia Kobal, Megan Novak, Julia Young, Eiichi Miyasaka
Summary: This study aimed to evaluate the predictive value of postoperative labs in intra-abdominal abscess (IAA) development in pediatric patients with perforated appendicitis. The results showed extensive heterogeneity and overlap in postoperative lab values between patients with and without IAA. Clinical signs were more indicative of abscess formation than postoperative lab results. Although patients with IAA had higher postoperative WBC counts and smaller decreases in WBC count, no specific cutoff value for any examined lab value predicted abscess formation. Therefore, postoperative labs have limited clinical utility in evaluating IAA development in children with perforated appendicitis.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Claus Kjaer Pedersen, Carsten Stengaard, Morten Thingemann Botker, Hanne Maare Sondergaard, Karen Kaae Dodt, Christian Juhl Terkelsen
Summary: The AROMI trial aimed to evaluate if an accelerated dual-marker rule-out strategy using prehospital copeptin and in-hospital high-sensitivity troponin T could safely reduce length of stay in patients discharged after early rule-out of AMI. The results showed that this strategy reduced mean length of stay by 0.9 hours and was non-inferior in terms of 30-day major adverse cardiac events compared to the standard rule-out strategy.
EUROPEAN HEART JOURNAL
(2023)
Letter
Emergency Medicine
Zhao-Yu Hsieh, Chen-Xiong Hsu
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Laura E. Walker, Jessica A. Stanich, Fernanda Bellolio
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
E. Tekin
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amanda S. Dupont, Patrick S. Walsh
Summary: Recent research indicates that children who unintentionally ingest cannabis often undergo extensive additional testing, such as head imaging or lumbar puncture. However, the yield of these tests is limited. While head imaging and lumbar puncture are frequently performed, diagnoses such as skull fracture, intracranial hemorrhage, intracranial neoplasm, meningitis, or intracranial abscess are rare. Additionally, discharge diagnoses related to other drugs are infrequent. The most common co-diagnoses are cocaine and opioids. Therefore, prompt consideration of cannabis ingestion and quick identification through testing may result in more effective neuroimaging outcomes.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
Mio Nagata, Shunsuke Kudo, Motoyasu Nakamura
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Andy Hung-Yi Lee, Katherine Dickerson Mayes, Regan Marsh, Christina Toledo-Cornell, Eric Goralnick, Michael Wilson, Leon D. Sanchez, Alice Bukhman, Damarcus Baymon, Dana Im, Paul C. Chen
Summary: This study assessed the disparities in transferring patients from an academic medical center emergency department to a community hospital general medical service, revealing healthcare disparities among different patient populations.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Annabelle Croskey, William Trautman, David Barton, Mary Kathleen Ratay, Joshua Shulman
Summary: This case report describes a successful management of ocular palytoxin exposure in a young male, highlighting the importance of prompt recognition and treatment of ocular PTX toxicity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Matthew K. Kolbeck, Rachel F. Schult, Nicholas Nacca
Summary: This article presents four cases of adolescents who experienced seizures after acute fluoxetine overdose. Although seizures are an uncommon complication after fluoxetine overdose, they occurred in some patients at doses lower than those reported in the literature.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Daven Patel, John Bailitz, Simone Ymson, Jonas Neichin, Gary D. Peksa, Michael Gottlieb
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amichai Gutgold, Shaden Salameh, Jeries Nashashibi, Yonatan Gershinsky
Summary: This study aimed to test the prognosis of patients with a pH lower than 6.9 on emergency department admission. The findings showed that a small but significant portion of these patients survived at least 24 hours and until hospital discharge.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Na-Yeon Emily Song, Ki Hong Kim, Ki Jeong Hong
Summary: This study aimed to evaluate the effect of the duration of no-flow (NF) interval on the vaso-pressor effect of initial epinephrine administration in a porcine model of cardiac arrest. The results showed that a shorter NF interval can enhance the vasopressor effect of epinephrine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Kenneth A. Scheppke, Paul E. Pepe, Jonathan Jui, Remle P. Crowe, Eric K. Scheppke, Nancy G. Klimas, Aileen M. Marty
Summary: This study reported cases of rapid and complete remission of severe long COVID after receiving monoclonal antibody treatment. The findings suggest that monoclonal antibody infusions may be effective in treating severe debilitation caused by long COVID.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Suhrith Bhattaram, Varsha S. Shinde
Summary: Nerve blocks have emerged as promising options for targeted pain relief in the Emergency Department, providing effective analgesia without compromising motor function. The successful use of ultrasound-guided genicular nerve blocks (GNBs) in this case series demonstrates their potential as an alternative to traditional nerve blocks and opioid-based pain control strategies in the ED.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Rick Kye Gan, Jude Chukwuebuka Ogbodo, Yong Zheng Wee, Ann Zee Gan, Pedro Arcos Gonzalez
Summary: The aim of this study was to evaluate and compare the performance of ChatGPT, Google Bard, and medical students in performing START triage during mass casualty situations. The results showed that Google Bard had significantly higher accuracy compared to ChatGPT, while there was no significant difference between Google Bard and medical students.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Nancy Clemens, Paria M. Wilson, Matthew J. Lipshaw, Holly Depinet, Yin Zhang, Michelle Eckerle
Summary: This study compared clinical features and outcomes between pediatric sepsis patients with blood cultures positive versus negative for bacterial pathogens. The results showed that children with blood culture positive sepsis had higher rates of organ dysfunction, a larger base deficit, and higher procalcitonin levels.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)