Article
Nutrition & Dietetics
Camilla Olofsson, Monica Eriksson, Ann-Christin Bragfors Helin, Bjorn Anderstam, Nicola Orsini, Peter Stenvinkel, Neda Rajamand Ekberg
Summary: Inflammation plays a key role in the development of diabetic complications. The acute effects of fructose loading on metabolic and inflammatory markers in patients with type 2 diabetes and healthy subjects were investigated, highlighting a potential role for MCP-1 in linking postprandial state and diabetes complications. Further mechanistic studies on a larger population of T2D patients are needed for confirmation of these results.
Review
Pharmacology & Pharmacy
Jialin Zhou, Wenjing Xu, Jitao Wang, Zhe Fan
Summary: Acute appendicitis is the most common surgical emergency in children, but it is sometimes misdiagnosed or missed. Accurately distinguishing between simple appendicitis and complex appendicitis is crucial for choosing appropriate treatment. Finding a safe, cheap, rapid, extensive, and accurate diagnostic marker for appendicitis is highly important for emergency general surgeons.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Respiratory System
Julia Beimdiek, Sabina Janciauskiene, Sabine Wrenger, Sonja Volland, Adriana Rozy, Jan Fuge, Beata Olejnicka, Isabell Pink, Thomas Illig, Alexander Popov, Joanna Chorostowska, Falk F. R. Buettner, Tobias Welte
Summary: The changes in specific plasma protein levels and N-glycosylation in COVID-19 patients highlight the complexity of the inflammatory process and warrant further investigation.
RESPIRATORY RESEARCH
(2022)
Article
Food Science & Technology
Tianqi Zhang, Siqi Huang, Min Wang, Na Yang, Huaijun Zhu
Summary: This pilot study used untargeted and targeted proteomics to explore the expression characteristics of plasma proteins in PQ poisoned patients and identified differentially expressed proteins between survivors and non-survivors. The findings highlighted the value of label-free and mass spectrometry-based proteomics in screening prognostic biomarkers of PQ poisoning and studying the mechanism of PQ toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Medicine, General & Internal
Dimitrios Moris, Erik Karl Paulson, Theodore N. Pappas
Summary: Acute appendicitis is a common abdominal surgical emergency with an annual incidence of 96.5 to 100 cases per 100,000 adults worldwide. While laparoscopic appendectomy is the most common treatment, antibiotics may be used instead of surgery for selected patients with uncomplicated acute appendicitis.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yon-Cheong Wong, Li-Jen Wang, Cheng-Hsien Wu, Yi-Chia Chang, Huan-Wu Chen, Being-Chuan Lin, Yu-Pao Hsu
Summary: The MRI appendicitis scale is a significant independent predictor of acute appendicitis in pregnant women. The addition of diffusion-weighted imaging (DWI) to MRI examinations can improve the diagnosis of acute appendicitis in this population.
EUROPEAN RADIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Magbool Alelyani, Ibrahim Hadadi, Nasser Shubayr, Yazeed Alashban, Mohammed Alqahtani, Mohamed Adam, Hajar Almater, Sultan Alamri
Summary: The study showed a low level of diagnostic accuracy in using ultrasound to diagnose acute appendicitis cases in Saudi Arabia, with no significant association found between the years of experience of sonographers and the diagnosis. Only a small number of patients were accurately diagnosed through ultrasound, and years of experience did not impact ultrasound diagnostic accuracy.
APPLIED SCIENCES-BASEL
(2021)
Article
Gastroenterology & Hepatology
J. de Jonge, J. C. G. Scheijmans, C. C. van Rossem, A. A. W. van Geloven, M. A. Boermeester, W. A. Bemelman
Summary: In patients with confirmed acute appendicitis, approximately 2 out of 100 patients have both normal white blood cell count and C-reactive protein levels, with very rare cases found in patients with complicated appendicitis. This suggests that normal inflammatory markers can sometimes be present in acute appendicitis cases.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Review
Medicine, General & Internal
Nigel D'Souza, Georgina Hicks, Richard Beable, Antony Higginson, Bo Rud
Summary: MRI appears to be highly accurate in confirming and excluding acute appendicitis in adults, children, and pregnant women regardless of protocol. The methodological quality of the included studies was generally low due to incomplete and low standards of follow-up, so summary estimates of sensitivity and specificity may be biased. We could not assess the impact and direction of potential bias given the very low number of high-quality studies. Studies comparing MRI protocols were few, and although we found no influence of MRI protocol variables on the summary estimates of accuracy, our results do not rule out that some MRI protocols are more accurate than others.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Gastroenterology & Hepatology
Zhemin Shen, Peilong Sun, Miao Jiang, Zili Zhen, Jingtian Liu, Mu Ye, Weida Huang
Summary: This study aimed to evaluate the feasibility and safety of endoscopic retrograde appendicitis therapy (ERAT) in the treatment of acute uncomplicated appendicitis. The results showed that ERAT can serve as an alternative and efficient method to treat acute uncomplicated appendicitis.
BMC GASTROENTEROLOGY
(2022)
Article
Pediatrics
Jiaming Lan, Hai Zhu, Qingshuang Liu, Chunbao Guo
Summary: This study aimed to explore the impact of inflammatory markers in the blood combined with symptom duration on the diagnosis and prediction of severity of acute appendicitis. The results showed that the combination of WBCC, CRP, and NE% values is highly sensitive for diagnosing acute appendicitis, but when predicting complicated acute appendicitis, consideration of the time of symptom onset is necessary.
FRONTIERS IN PEDIATRICS
(2021)
Article
Hematology
Alper Adir, Andrei Braester, Perelstein Natalia, Dally Najib, Luiza Akria, Celia Suriu, Barhoum Masad, Waksman Igor
Summary: This study aimed to evaluate the role of preoperative inflammatory markers in the clinical diagnosis of acute appendicitis. The results showed that neutrophil to lymphocyte ratio (NLR) and monocyte to lymphocyte ratio (MLR) can assist in the diagnosis of acute appendicitis.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Article
Obstetrics & Gynecology
Pinar Erdogan, Aliriza Erdogan
Summary: This study aimed to evaluate and compare platelet-related parameters and white cell-based parameters in pregnant women with appendicitis. The results suggest that mean platelet volume might be an independent predictor of acute appendicitis in pregnant women, providing useful guidance for clinicians dealing with these patients and potentially reducing negative laparotomy rates. Further large-scale studies are needed to validate these findings.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Surgery
Daniel Dante Yeh, Ahmed Eid, Katelyn A. Young, Jeffrey Wild, Haytham M. A. Kaafarani, Mohamed Ray-Zack, Tala Kana'an, Ryan Lawless, Alexis L. Cralley, Marie Crandall
Summary: In the United States, the majority of patients with appendicitis receive CT imaging, undergo laparoscopic appendectomy, and stay in the hospital for 1 day. One in five patients initially treated with antibiotics required appendectomy within 30 days. Delay to appendectomy in the hospital is not a risk factor for complicated appendicitis.
Article
Multidisciplinary Sciences
Gulsum Feyza Turkes, Abdulkadir Unsal, Hakan Bulus
Summary: This study aims to investigate the effectiveness of immature granulocyte (IG) level in determining the complication of acute appendicitis. The results showed that acute complicated appendicitis patients had higher levels of WBC, PNL, monocyte, IG count, and IG% compared to acute simple appendicitis patients, and IG had a higher negative predictive value for Acute Appendicitis.
Article
Pediatrics
Kelly M. A. Dreuning, Rinse W. Barendsen, A. S. Paul van Trotsenburg, Jos W. R. Twisk, Christien Sleeboom, L. W. Ernest van Heurn, Joep P. M. Derikx
JOURNAL OF PEDIATRIC SURGERY
(2020)
Article
Pediatrics
Dominique Catherine Olthof, Sophie Reemst, Christian Sleeboom, C. F. Kuijper, Joost van Schuppen, J. P. M. Derikx, R. R. Gorter
Summary: The study demonstrates that the diagnostic accuracy of ultrasound for detecting underlying congenital abnormalities requiring surgery for umbilical discharge in pediatric population is limited, even with experienced pediatric radiologists. The sensitivity of ultrasound is 71.1% and specificity is 72.2%, indicating room for improvement in diagnostic capabilities for this condition.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Letter
Pediatrics
Kelly M. A. Dreuning, A. S. Paul van Trotsenburg, L. W. Ernest van Heurn, Joep P. M. Derikx
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Sofia el Manouni el Hassani, Hendrik J. Niemarkt, Joep P. M. Derikx, Daniel J. C. Berkhout, Andrea E. Ballon, Margot de Graaf, Willem P. de Boode, Veerle Cossey, Christian V. Hulzebos, Anton H. van Kaam, Boris W. Kramer, Richard A. van Lingen, Daniel C. Vijlbrief, Mirjam M. van Weissenbruch, Marc A. Benninga, Nanne K. H. de Boer, Tim G. J. de Meij
Summary: Lower gestational age, early clinical onset, and no maternal corticosteroids administration are predictors for surgical NEC. Low serum bicarbonate in the 3 days prior clinical onset and patent ductus arteriosus for which ibuprofen was administered predict surgical NEC.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Pediatrics
Laurens D. Eeftinck Schattenkerk, Gijsbert D. Musters, David J. Nijssen, Wouter J. de Jonge, Ralph de Vries, L. W. Ernest van Heurn, Joep P. M. Derikx
Summary: This study aggregated the incidence of different surgical site infections in infants who underwent surgery for abdominal birth defects, finding that complications like wound infection, wound dehiscence, and anastomotic leakage varied among different birth defects.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Review
Endocrinology & Metabolism
Annabel S. Zaat, Joep P. M. Derikx, Nitash Zwaveling-Soonawala, A. S. Paul van Trotsenburg, Christiaan F. Mooij
Summary: A systematic review shows that thyroidectomy is a safe treatment option for pediatric GD patients. Only a minority of patients may experience transient and benign morbidities, with hypocalcemia being the most common transient postoperative morbidity. Permanent postoperative morbidities are relatively rare.
EUROPEAN THYROID JOURNAL
(2021)
Review
Pediatrics
Francesco Morini, Kelly M. A. Dreuning, Maarten J. H. Janssen Lok, Tomas Wester, Joep P. M. Derikx, Florian Friedmacher, Hiromu Miyake, Haitao Zhu, Luca Pio, Martin Lacher, Stefania Sgro, Augusto Zani, Simon Eaton, L. W. Ernest van Heurn, Agostino Pierro
Summary: This study evaluated the evidence on pediatric inguinal hernia repair and compiled recommendations on six topics including surgical approach, timing, and anesthesia technique. Results suggest that laparoscopic repair may be beneficial for children with bilateral hernia, while preterm infants may benefit from regional anesthesia and delayed surgery. Evidence for other topics was less conclusive.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Pediatrics
Froukje A. Feenstra, Sara J. Kuik, Joep P. M. Derikx, M. Rebecca Heiner-Fokkema, Elisabeth M. W. Kooi, Arend F. Bos, Jan B. F. Hulscher
Summary: The study found that plasma citrulline levels gradually decreased in the first 48 hours after the onset of necrotizing enterocolitis (NEC), indicating ongoing intestinal injury. In survivors, measuring citrulline levels in the first 24 hours after NEC onset may provide an indication of intestinal recovery rate.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Laurens D. Eeftinck Schattenkerk, Gijsbert D. Musters, S. E. Le Coultre, Wouter J. de Jonge, L. W. Ernest van Heurn, Joep Pm Derikx
Summary: This study identified the incidence of incisional hernia following abdominal surgery in infants to be 5.2%. High risk diseases included necrotizing enterocolitis, gastroschisis, and omphalocele. Risk factors for incisional hernia included wound infection, preterm birth, and history of stoma.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Review
Pediatrics
Sanne Maat, Kelly Dreuning, Stefi Nordkamp, Wim van Gemert, Jos Twisk, Ruben Visschers, Ernst van Heurn, Joep Derikx
Summary: This systematic review compared different laparoscopic techniques for repairing pediatric inguinal hernias and found that single-port extra-corporeal closure had a lower recurrence rate and shorter operative time compared to intra-corporeal purse-string suture closing technique. Other outcome measures were inconclusive due to substantial heterogeneity.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Danielle Roorda, Jaap Oosterlaan, Ernest van Heurn, Joep P. M. Derikx
Summary: This study found a relatively low incidence of HAEC in patients with Hirschsprung disease, with preoperative and postoperative rates of 8% and 21% respectively. The median HAEC free interval after surgery was 226 days, with a decline in incidence over follow-up. No specific patient or clinical characteristics were associated with the risk of postoperative HAEC.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Review
Nutrition & Dietetics
Ilse H. de Lange, Charlotte van Gorp, Laurens D. Eeftinck Schattenkerk, Wim G. van Gemert, Joep P. M. Derikx, Tim G. A. M. Wolfs
Summary: This article summarizes the pathogenesis of necrotizing enterocolitis (NEC), highlighting the immaturity of the intestinal immune system in preterm infants and abnormal microbial colonization as key factors. Enteral feeding is considered an important factor influencing NEC pathogenesis, with bioactive components in breast milk being effective in preventing NEC.
Article
Pediatrics
Danielle Roorda, Jaap Oosterlaan, Ernest van Heurn, Joep Derikx
Summary: This retrospective study evaluated the effectiveness of BT injections in treating obstructive defecation problems in patients with Hirschsprung disease. The findings showed that BT injections can effectively improve symptoms with mild adverse effects.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Kelly M. A. Dreuning, Joep P. M. Derikx, Johan E. van Limbergen, Frea Kruisinga, Ilan J. N. Koppen
Summary: The infant with chylous ascites was unexpectedly found during surgery for bilateral inguinal hernia repair. With treatment and monitoring, the condition was controlled and the symptoms disappeared, allowing the child to successfully transition to regular feeding.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2021)
Article
Pediatrics
Fenne A. I. M. van den Bunder, Jan Hein Allema, Marc A. Benninga, Ivo de Blaauw, Tim van de Brug, Marcel den Dulk, Jan B. F. Hulscher, Claudia M. G. Keyzer-Dekker, Marieke J. Witvliet, Ernest L. W. van Heurn, Joep P. M. Derikx
Summary: The study found that the average incidence of IHPS in the Netherlands is 1.28 per 1,000 livebirths, with no changing trend or seasonal variation in incidence observed.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2021)
Letter
Emergency Medicine
Zhao-Yu Hsieh, Chen-Xiong Hsu
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Laura E. Walker, Jessica A. Stanich, Fernanda Bellolio
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
E. Tekin
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amanda S. Dupont, Patrick S. Walsh
Summary: Recent research indicates that children who unintentionally ingest cannabis often undergo extensive additional testing, such as head imaging or lumbar puncture. However, the yield of these tests is limited. While head imaging and lumbar puncture are frequently performed, diagnoses such as skull fracture, intracranial hemorrhage, intracranial neoplasm, meningitis, or intracranial abscess are rare. Additionally, discharge diagnoses related to other drugs are infrequent. The most common co-diagnoses are cocaine and opioids. Therefore, prompt consideration of cannabis ingestion and quick identification through testing may result in more effective neuroimaging outcomes.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
Mio Nagata, Shunsuke Kudo, Motoyasu Nakamura
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Andy Hung-Yi Lee, Katherine Dickerson Mayes, Regan Marsh, Christina Toledo-Cornell, Eric Goralnick, Michael Wilson, Leon D. Sanchez, Alice Bukhman, Damarcus Baymon, Dana Im, Paul C. Chen
Summary: This study assessed the disparities in transferring patients from an academic medical center emergency department to a community hospital general medical service, revealing healthcare disparities among different patient populations.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Annabelle Croskey, William Trautman, David Barton, Mary Kathleen Ratay, Joshua Shulman
Summary: This case report describes a successful management of ocular palytoxin exposure in a young male, highlighting the importance of prompt recognition and treatment of ocular PTX toxicity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Matthew K. Kolbeck, Rachel F. Schult, Nicholas Nacca
Summary: This article presents four cases of adolescents who experienced seizures after acute fluoxetine overdose. Although seizures are an uncommon complication after fluoxetine overdose, they occurred in some patients at doses lower than those reported in the literature.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Daven Patel, John Bailitz, Simone Ymson, Jonas Neichin, Gary D. Peksa, Michael Gottlieb
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amichai Gutgold, Shaden Salameh, Jeries Nashashibi, Yonatan Gershinsky
Summary: This study aimed to test the prognosis of patients with a pH lower than 6.9 on emergency department admission. The findings showed that a small but significant portion of these patients survived at least 24 hours and until hospital discharge.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Na-Yeon Emily Song, Ki Hong Kim, Ki Jeong Hong
Summary: This study aimed to evaluate the effect of the duration of no-flow (NF) interval on the vaso-pressor effect of initial epinephrine administration in a porcine model of cardiac arrest. The results showed that a shorter NF interval can enhance the vasopressor effect of epinephrine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Kenneth A. Scheppke, Paul E. Pepe, Jonathan Jui, Remle P. Crowe, Eric K. Scheppke, Nancy G. Klimas, Aileen M. Marty
Summary: This study reported cases of rapid and complete remission of severe long COVID after receiving monoclonal antibody treatment. The findings suggest that monoclonal antibody infusions may be effective in treating severe debilitation caused by long COVID.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Suhrith Bhattaram, Varsha S. Shinde
Summary: Nerve blocks have emerged as promising options for targeted pain relief in the Emergency Department, providing effective analgesia without compromising motor function. The successful use of ultrasound-guided genicular nerve blocks (GNBs) in this case series demonstrates their potential as an alternative to traditional nerve blocks and opioid-based pain control strategies in the ED.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Rick Kye Gan, Jude Chukwuebuka Ogbodo, Yong Zheng Wee, Ann Zee Gan, Pedro Arcos Gonzalez
Summary: The aim of this study was to evaluate and compare the performance of ChatGPT, Google Bard, and medical students in performing START triage during mass casualty situations. The results showed that Google Bard had significantly higher accuracy compared to ChatGPT, while there was no significant difference between Google Bard and medical students.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Nancy Clemens, Paria M. Wilson, Matthew J. Lipshaw, Holly Depinet, Yin Zhang, Michelle Eckerle
Summary: This study compared clinical features and outcomes between pediatric sepsis patients with blood cultures positive versus negative for bacterial pathogens. The results showed that children with blood culture positive sepsis had higher rates of organ dysfunction, a larger base deficit, and higher procalcitonin levels.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)