Article
Infectious Diseases
Piyanuch Thongsamer, Kamolwish Laoprasopwattana
Summary: This study aimed to determine whether a procalcitonin (PCT) level > 0.5 ng/mL can differentiate between bacterial and viral infections. The results showed that among children with high-risk features, a PCT level > 0.5 ng/mL had the highest sensitivity and negative predictive value for predicting bacterial infection. Therefore, antibiotics can be withheld in febrile children with high-risk features and a PCT level < 0.5 ng/mL.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2022)
Article
Pediatrics
Jennifer Dunnick, Maia Taft, Robert T. Tisherman, Andrew J. Nowalk, Robert W. Hickey, Paria M. Wilson
Summary: The study found that bacteremia in children aged 2-36 months is rare, with a slightly higher relative risk for unvaccinated or undervaccinated children. However, the association between vaccination status and bacteremia from S pneumoniae or Hib was inconclusive.
JOURNAL OF PEDIATRICS
(2021)
Review
Emergency Medicine
Leah Finkel, Camila Ospina-Jimenez, Michael Byers, Wesley Eilbert
Summary: Fever is a common complaint in children brought to the emergency department, with most febrile children under 3 years old having a clinically apparent source of infection. However, approximately 20% of these children cannot have a source identified through history and physical examination alone. The diagnostic approach to fever without source (FWS) in children under 3 years old has dramatically changed in the past 30 years due to the widespread use of vaccines.
PEDIATRIC EMERGENCY CARE
(2021)
Article
Pediatrics
Anne-Sophie Romain, Romain Guedj, Anais Chosidow, Nicolas Mediamolle, Aurelie Schnuriger, Sophie Vimont, Charlene Ferrandiz, Nicolas Robin, Marie-Helene Odievre, Emmanuel Grimprel, Mathie Lorrot
Summary: This study investigated the performance of procalcitonin (PCT) assay between 12 and 36 hours after onset of fever (PCT H12-H36) in predicting invasive bacterial infection (IBI) in febrile neonates. The results showed that PCT H12-H36 had high sensitivity and specificity in identifying IBI and could potentially help in stopping early antibiotic treatment in febrile neonates.
FRONTIERS IN PEDIATRICS
(2022)
Review
Clinical Neurology
Amy Y. Tsou, Sudha Kilaru Kessler, Mingche Wu, Nicholas S. Abend, Shavonne L. Massey, Jonathan R. Treadwell
Summary: This article summarizes the findings of surgical treatments for early life epilepsy in children aged 1-36 months. It is found that some infants achieve seizure freedom after surgery, and over 50% of infants achieve favorable outcomes. However, more prospective studies are needed due to limited evidence.
Review
Clinical Neurology
Jonathan R. Treadwell, Sudha Kilaru Kessler, Mingche Wu, Nicholas S. Abend, Shavonne L. Massey, Amy Y. Tsou
Summary: Summary in English: Early life epilepsies lack evidence-based management guidelines, other than those for infantile spasms. This systematic review examined the effectiveness and harms of pharmacologic and dietary treatments for epilepsy in children aged 1-36 months. The findings suggest that levetiracetam may lead to seizure freedom in some infants, while the ketogenic diet may also achieve seizure freedom and reduce seizure frequency to a greater extent than the modified Atkins diet.
Article
Multidisciplinary Sciences
Rabab Batool, Sonia Qureshi, Zoya Haq, Mohammad Tahir Yousafzai, Rehana A. Salam, Rafey Ali, Tahira Sadaf, Miqdad Ali, Farah Naz Qamar
Summary: The objective of this study was to estimate the coverage rate of typhoid conjugate vaccine (TCV) among children aged 6 months to 15 years in Lyari Town Karachi, Pakistan. A cross-sectional survey was conducted using the World Health Organization (WHO) recommended rapid assessment technique. The results showed that the overall vaccine coverage of TCV in Lyari Town was 80%, with lower coverage in younger children.
Article
Public, Environmental & Occupational Health
Nginache Nampota-Nkomba, Osward M. Nyirenda, Lameck Khonde, Victoria Mapemba, Maurice Mbewe, John M. Ndaferankhande, Harrison Msuku, Clemens Masesa, Theresa Misiri, Felistas Mwakiseghile, Priyanka D. Patel, Pratiksha Patel, Ifayet Johnson-Mayo, Marcela F. Pasetti, Robert S. Heyderman, J. Kathleen Tracy, Shrimati Datta, Yuanyuan Liang, Kathleen M. Neuzil, Melita A. Gordon, Matthew B. Laurens
Summary: This study assessed the immunogenicity and safety of typhoid conjugate vaccine (TCV) in Malawi. The results confirmed the immunogenicity and safety of TCV in children aged 9 months to 12 years.
LANCET GLOBAL HEALTH
(2022)
Review
Pediatrics
Sanne Graaf, Maya Wietske Keuning, Dasja Pajkrt, Frans Berend Plotz
Summary: This comparative review examines the consistencies and differences in FWS guidelines for the management of children with fever without a source. Ten guidelines from five high-income countries were included, with variations in age ranges and recommendations for diagnostic testing and antibiotic treatment. The findings can assist in harmonizing guideline development and future research for the management of children with FWS.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Diana Sunardi, Saptawati Bardosono, Ray W. Basrowi, Erika Wasito, Yvan Vandenplas
Summary: The study found that the prevalence of anemia among children aged 6-36 months in poor urban areas of Jakarta, Indonesia was 29.4%. Anemia was significantly associated with two dietary determinants as risk factors: cow's milk formula consumption and zinc intake.
Article
Pediatrics
Lilia Bliznashka, Nandita Perumal, Aisha Yousafzai, Christopher Sudfeld
Summary: This study found that there is an association between child diet and receiving more stimulation activities, but independently of stimulation, socioeconomic status, and other factors, child diet seems to be a significant determinant only for literacy-numeracy development among children aged 36-59 months.
ARCHIVES OF DISEASE IN CHILDHOOD
(2021)
Article
Pediatrics
Lilia Bliznashka, Nandita Perumal, Aisha Yousafzai, Christopher Sudfeld
Summary: There are associations between diet, stimulation, and development among children aged 36-59 months in low-income and middle-income countries. Children with higher dietary diversity, meeting the minimum dietary diversity criteria, and consuming animal source foods had more stimulation activities. However, child diet appeared to primarily influence literacy-numeracy development among these children.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Multidisciplinary Sciences
Robin Henriksson, Daniel Huber, Thomas Mooe
Summary: The study found that a nurse-led, telephone-based intervention including medical titration was superior to usual care in improving blood pressure and LDL-C values in patients 36 months after acute coronary syndrome. The intervention group had significantly lower systolic BP, diastolic BP, and LDL-C levels, with a higher proportion of patients meeting treatment targets compared to the control group after 36 months.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Lifen Zhang, Fan Gao, Gang Zeng, Haitao Yang, Taotao Zhu, Shuangmin Yang, Xing Meng, Qunying Mao, Xiaoqiang Liu
Summary: The study demonstrated good safety and immunogenicity of the Sinovac EV71 vaccine in children aged 36-71 months, showing superior results compared to the control group.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Psychology, Multidisciplinary
Ana Duarte, Silvana Martins, Luis Lopes, Maria Jose Silva, Claudia Augusto, Rute Santos, Rafaela Rosario
Summary: This study demonstrates that sleep duration is directly associated with socio-emotional development in toddlers, while sleep quality is not significantly related. Body weight does not explain the associations between sleep and socio-emotional development.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Pediatrics
Ran D. Goldman, Sophie McGregor, Shashidhar R. Marneni, Tomohiro Katsuta, Mark A. Griffiths, Jeanine E. Hall, Michelle Seiler, Eileen J. Klein, Cristina Parra Cotanda, Renana Gelernter, Julia Hoeffe, Adrienne L. Davis, Gianluca Gualco, Ahmed Mater, Sergio Manzano, Graham C. Thompson, Sara Ahmed, Samina Ali, Julie C. Brown
Summary: The study found that changes in risk perception due to COVID-19 and previous vaccination history can influence caregivers' decisions regarding influenza vaccination for their children. Additionally, children with up-to-date vaccination status and caregivers with a history of receiving influenza vaccine are more likely to plan to vaccinate against influenza next year.
JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Jocelyn Gravel, Sergio Manzano, Marie-Lyne Nault, Emilie Vallieres, Fabien Rallu, Christian Renaud
Summary: The study found no association between oropharyngeal carriage of Kingella kingae and transient synovitis of the hip in preschool children. However, there was a higher carriage rate of Kingella kingae in children with osteoarticular infections.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Ran D. Goldman, Georg Staubli, Cristina Parra Cotanda, Julie C. Brown, Julia Hoeffe, Michelle Seiler, Renana Gelernter, Jeanine E. Hall, Mark A. Griffiths, Adrienne L. Davis, Sergio Manzano, Ahmed Mater, Sara Ahmed, David Sheridan, Matt Hansen, Samina Ali, Graham C. Thompson, Naoki Shimizu, Eileen J. Klein
Summary: The study found that only one fifth of families surveyed would consider enrolling their child in a vaccine trial. Parental interest, history of vaccinating their child, and the child's age were factors associated with parents allowing their child to participate in a COVID vaccine trial.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Medicine, Research & Experimental
Frederic Ehrler, Cyril Sahyoun, Sergio Manzano, Oliver Sanchez, Alain Gervaix, Christian Lovis, Delphine S. Courvoisier, Laurence Lacroix, Johan N. Siebert
Summary: This study aims to investigate the impact of the mHealth tool InterFACE on enhancing situational awareness and effective team communication during in-hospital pediatric resuscitation. The results of this clinical trial, which is registered on ClinicalTrials.gov, may play a crucial role in improving care for children receiving in-hospital CPR in the age of advancing communication technology.
Article
Public, Environmental & Occupational Health
Michelle Seiler, Georg Staubli, Julia Hoeffe, Gianluca Gualco, Sergio Manzano, Ran D. Goldman
Summary: During the early stages of the pandemic, parents in the South of Switzerland were more exposed to COVID-19 positive cases compared to those in the North, and were also more concerned about themselves and their children contracting the virus. Additionally, a significantly higher proportion of children in the South were reported to wear facemasks compared to the North.
Article
Emergency Medicine
Adrienne L. Davis, Alia Sunderji, Shashidhar R. Marneni, Michelle Seiler, Jeanine E. Hall, Cristina Parra Cotanda, Eileen J. Klein, Julie C. Brown, Renana Gelernter, Mark A. Griffiths, Julia Hoeffe, Gianluca Gualco, Ahmed Mater, Sergio Manzano, Graham C. Thompson, Sara Ahmed, Samina Ali, Ran D. Goldman
Summary: The study found that nearly one in five caregivers delayed seeking emergency department care for their sick or injured child due to fear of contracting COVID-19 in the hospital during the COVID-19 pandemic. Factors such as being a mother, younger caregiver, caring for a child with chronic illness, and concerns about lost work during the pandemic were independently associated with delaying emergency department presentation.
CANADIAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Health Care Sciences & Services
Matthieu Lacour, Laurie Bloudeau, Christophe Combescure, Kevin Haddad, Florence Hugon, Laurent Suppan, Frederique Rodieux, Christian Lovis, Alain Gervaix, Frederic Ehrler, Sergio Manzano, Johan N. Siebert
Summary: This study aimed to evaluate the effectiveness of an evidence-based mobile app compared to conventional methods in reducing acute stress in paramedics during pediatric out-of-hospital cardiac arrest scenarios. The results showed a 30.1% lower relative change in stress response in participants who used the app, indicating that dedicated mobile apps can reduce acute perceived stress during the preparation of emergency drugs in the prehospital setting.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Medicine, General & Internal
Johan N. Siebert, Laurie Bloudeau, Christophe Combescure, Kevin Haddad, Florence Hugon, Laurent Suppan, Frederique Rodieux, Christian Lovis, Alain Gervaix, Frederic Ehrler, Sergio Manzano
Summary: Medication errors are a leading cause of injury worldwide. This study evaluated the efficacy of a mobile app in reducing medication errors during pediatric out-of-hospital cardiac arrest scenarios. The app significantly decreased medication errors and time to drug delivery, highlighting its potential to improve medication safety in emergency medicine.
Article
Multidisciplinary Sciences
Eva Aeschimann, Oliver Sanchez, Jacques Birraux, Barbara E. Wildhaber, Sergio Manzano
Summary: Complete urinary tract ultrasonography does not appear to be useful during a first episode of orchidpididymitis in boys without genitourinary malformations. Urinalysis is sufficient to investigate a first episode of orchidpididymitis, and antibiotics should be reserved for patients with positive urinalysis.
Article
Immunology
Shannon H. Baumer-Mouradian, Rebecca J. Hart, Jeffrey N. Bone, Michelle Seiler, Prasra Olson, Kristina Keitel, Sergio Manzano, Gianluca Gualco, Danna Krupik, Stephanie Schroter, Rachel M. Weigert, SunHee Chung, Graham C. Thompson, Nina Muhammad, Pareen Shah, Nathalie O. Gaucher, Maren M. Lunoe, Megan Evers, Cosette Pharisa Rochat, Courtney E. Nelson, Moran Shefler Gal, Adrianna Doucas, Ran D. Goldman
Summary: This study investigated caregiver attitudes toward mandating COVID-19 vaccines for schools/daycares. The findings showed that 37% of caregivers were opposed to any school vaccine mandate. The acceptance varied depending on the level of education, with the lowest acceptance rate observed for daycare settings and the highest for college. About 26% of caregivers reported a high likelihood of removing their child from school if the vaccine became mandatory. The safety of their child was caregivers' greatest concern regarding vaccine mandates.
Article
Immunology
R. D. Goldman, R. J. Hart, J. N. Bonec, M. Seiler, P. G. Olson, K. Keitel, S. Manzano, G. Gualco, D. Krupik, S. Schroter, R. M. Weigert, S. Chung, G. C. Thompsonm, N. Muhammad, P. Shah, N. O. Gaucher, M. Hou, J. Griffiths, M. M. Lunoes, M. Evers, C. Pharisa Rochatu, C. E. Nelsonv, M. Gal, S. H. Baumer-Mouradian
Summary: This study investigated vaccine hesitancy in pediatric emergency departments during the COVID-19 pandemic and found that hesitancy increased over time. Caregivers who were fully vaccinated, had higher education, and were worried about their child contracting COVID-19 were more likely to plan to vaccinate.
Article
Chemistry, Medicinal
Frederique Rodieux, Flavia Storelli, Francois Curtin, Sergio Manzano, Alain Gervaix, Klara M. Posfay-Barbe, Jules Desmeules, Youssef Daali, Caroline F. Samer
Summary: The study aimed to evaluate pupillometry as a phenotyping method for assessing CYP2D6 activity in children treated with tramadol. The results showed that tramadol affected pupillary parameters in children, but a correlation between pupillometry measurements and CYP2D6 activity could not be identified.
Meeting Abstract
Medicine, General & Internal
A. Piletta-Zanin, A. Scherl, T. Harr, H. Nigolian, S. Manzano, S. Grosgurin, Tonson A. la Tour, G. Braendle, H. Soechbach, J. C. Caubet, J. P. Pahud, D. Ortelli, P. EEdder, P. Eigenmann
SWISS MEDICAL WEEKLY
(2022)
Article
Health Care Sciences & Services
Johan N. Siebert, Laetitia Gosetto, Manon Sauvage, Laurie Bloudeau, Laurent Suppan, Frederique Rodieux, Kevin Haddad, Florence Hugon, Alain Gervaix, Christian Lovis, Christophe Combescure, Sergio Manzano, Frederic Ehrler
Summary: This study evaluated the usability and acceptance of an evidence-based mobile app among pediatric emergency nurses and advanced paramedics. The results showed that the app was easy to use and highly accepted by frontline emergency caregivers.
JMIR HUMAN FACTORS
(2022)
Article
Medicine, General & Internal
Michelle Seiler, Ran D. Goldman, Georg Staubli, Julia Hoeffe, Gianluca Gualco, Sergio Manzano
Summary: The study aimed to assess parents' intentions towards influenza vaccination for themselves and their children in Switzerland during the COVID-19 pandemic. Results showed that there was an increase in parents' intention to vaccinate their children against influenza, especially in regions heavily impacted by COVID-19. Regional differences were found in parents' intent to vaccinate their children against influenza for the coming season, but not for a hypothetical COVID-19 vaccination.
SWISS MEDICAL WEEKLY
(2021)
Letter
Emergency Medicine
Zhao-Yu Hsieh, Chen-Xiong Hsu
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Laura E. Walker, Jessica A. Stanich, Fernanda Bellolio
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
E. Tekin
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amanda S. Dupont, Patrick S. Walsh
Summary: Recent research indicates that children who unintentionally ingest cannabis often undergo extensive additional testing, such as head imaging or lumbar puncture. However, the yield of these tests is limited. While head imaging and lumbar puncture are frequently performed, diagnoses such as skull fracture, intracranial hemorrhage, intracranial neoplasm, meningitis, or intracranial abscess are rare. Additionally, discharge diagnoses related to other drugs are infrequent. The most common co-diagnoses are cocaine and opioids. Therefore, prompt consideration of cannabis ingestion and quick identification through testing may result in more effective neuroimaging outcomes.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
Mio Nagata, Shunsuke Kudo, Motoyasu Nakamura
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Andy Hung-Yi Lee, Katherine Dickerson Mayes, Regan Marsh, Christina Toledo-Cornell, Eric Goralnick, Michael Wilson, Leon D. Sanchez, Alice Bukhman, Damarcus Baymon, Dana Im, Paul C. Chen
Summary: This study assessed the disparities in transferring patients from an academic medical center emergency department to a community hospital general medical service, revealing healthcare disparities among different patient populations.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Annabelle Croskey, William Trautman, David Barton, Mary Kathleen Ratay, Joshua Shulman
Summary: This case report describes a successful management of ocular palytoxin exposure in a young male, highlighting the importance of prompt recognition and treatment of ocular PTX toxicity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Matthew K. Kolbeck, Rachel F. Schult, Nicholas Nacca
Summary: This article presents four cases of adolescents who experienced seizures after acute fluoxetine overdose. Although seizures are an uncommon complication after fluoxetine overdose, they occurred in some patients at doses lower than those reported in the literature.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Daven Patel, John Bailitz, Simone Ymson, Jonas Neichin, Gary D. Peksa, Michael Gottlieb
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amichai Gutgold, Shaden Salameh, Jeries Nashashibi, Yonatan Gershinsky
Summary: This study aimed to test the prognosis of patients with a pH lower than 6.9 on emergency department admission. The findings showed that a small but significant portion of these patients survived at least 24 hours and until hospital discharge.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Na-Yeon Emily Song, Ki Hong Kim, Ki Jeong Hong
Summary: This study aimed to evaluate the effect of the duration of no-flow (NF) interval on the vaso-pressor effect of initial epinephrine administration in a porcine model of cardiac arrest. The results showed that a shorter NF interval can enhance the vasopressor effect of epinephrine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Kenneth A. Scheppke, Paul E. Pepe, Jonathan Jui, Remle P. Crowe, Eric K. Scheppke, Nancy G. Klimas, Aileen M. Marty
Summary: This study reported cases of rapid and complete remission of severe long COVID after receiving monoclonal antibody treatment. The findings suggest that monoclonal antibody infusions may be effective in treating severe debilitation caused by long COVID.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Suhrith Bhattaram, Varsha S. Shinde
Summary: Nerve blocks have emerged as promising options for targeted pain relief in the Emergency Department, providing effective analgesia without compromising motor function. The successful use of ultrasound-guided genicular nerve blocks (GNBs) in this case series demonstrates their potential as an alternative to traditional nerve blocks and opioid-based pain control strategies in the ED.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Rick Kye Gan, Jude Chukwuebuka Ogbodo, Yong Zheng Wee, Ann Zee Gan, Pedro Arcos Gonzalez
Summary: The aim of this study was to evaluate and compare the performance of ChatGPT, Google Bard, and medical students in performing START triage during mass casualty situations. The results showed that Google Bard had significantly higher accuracy compared to ChatGPT, while there was no significant difference between Google Bard and medical students.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Nancy Clemens, Paria M. Wilson, Matthew J. Lipshaw, Holly Depinet, Yin Zhang, Michelle Eckerle
Summary: This study compared clinical features and outcomes between pediatric sepsis patients with blood cultures positive versus negative for bacterial pathogens. The results showed that children with blood culture positive sepsis had higher rates of organ dysfunction, a larger base deficit, and higher procalcitonin levels.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)