期刊
AMERICAN JOURNAL OF DERMATOPATHOLOGY
卷 34, 期 6, 页码 565-579出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/DAD.0b013e31821e8744
关键词
cutaneous pathology; matrix metalloproteinases
类别
Matrix metalloproteinases, a group of over 26 zinc-dependent enzymes, share a similar structure to each other and functionally are capable of degrading almost every component of the extracellular matrix. They are essential to normal development during embryogenesis and extracellular matrix remodeling and, given this, understandably enough have been implicated in multiple pathologic processes that encompass the inflammatory and neoplastic spectrum of disease. This review attempts to define roles of matrix metalloproteinases of relevance in normal skin and to elucidate their roles in inflammatory dermatoses and benign and malignant neoplasms.
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