Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Article
Nutrition & Dietetics
Rui Liu, Mengyao Zhang, Li Xu, Jingjin Liu, Pingan Yang, Min Li, Jie Qin
Summary: The study showed that fAGEs levels increased with the duration of diabetes in patients with T2DM, and were significantly correlated with HbA1c. The continuous increase of fAGEs might lead to elevated levels of HbA1c, UACR, and CIMT in patients with T2DM.
FRONTIERS IN NUTRITION
(2022)
Review
Endocrinology & Metabolism
Andrea Garza-Campos, Jose Roberto Prieto-Correa, Jose Alfredo Dominguez-Rosales, Zamira Helena Hernandez-Nazara
Summary: Obesity and type 2 diabetes mellitus (T2DM) are chronic diseases that have a high incidence globally. They have shared pathological mechanisms that can lead to the development of cancer. The review focuses on the role of the receptor for advanced glycation end products (RAGE) in obesity, T2DM, and cancer, aiming to understand the intracellular signaling mechanisms involved in cancer initiation and to develop diagnostic and therapeutic strategies to reduce the morbidity and mortality associated with these diseases.
WORLD JOURNAL OF DIABETES
(2023)
Article
Endocrinology & Metabolism
Tian Jiang, Yi Zhang, Fang Dai, Chao Liu, Honglin Hu, Qiu Zhang
Summary: This study aimed to explore the role of non-invasive detection of advanced glycation end products (AGEs) in the early screening of diabetes mellitus (DM) in the Chinese community and investigate the moderating effect of body mass index (BMI) and metabolic indexes. The results indicate that in Chinese participants with high AGE accumulation, priority should be given to the quality of metabolic-related indicators such as BMI, TG, and TC to effectively reduce fasting blood glucose levels.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Review
Nutrition & Dietetics
Jeongmin Lee, Jae-Seung Yun, Seung-Hyun Ko
Summary: Diabetes is a chronic disease with a high health burden primarily caused by mortality or morbidity from vascular complications. Prolonged hyperglycemia leads to abnormal metabolism and the formation of advanced glycation end products (AGEs). The interaction between AGEs and their receptors promotes oxidative stress and inflammation through multiple pathways.
Article
Peripheral Vascular Disease
Reem T. Atawia, Robert K. Batori, Coleton R. Jordan, Simone Kennard, Galina Antonova, Thiago Bruder-Nascimento, Vinay Mehta, Muhammad I. Saeed, Vijay S. Patel, Tohru Fukai, Masuko Ushio-Fukai, Yuqing Huo, David J. R. Fulton, Eric J. Belin de Chantemele
Summary: Type 1 diabetes (T1D) is a major cause of endothelial dysfunction, and glycolysis in cellular bioenergetics has been identified as a new regulator of vascular function. This study found that glycolysis regulates vascular tone and excess glycolysis is a novel mechanism of endothelial dysfunction in T1D.
Article
Oncology
Ya-Jui Lin, Chiung-Yin Huang, Ya-Ching Shen, Kuo-Chen Wei, Chi-Cheng Chuang, Peng-Wei Hsu, Yin-Cheng Huang, Tsong-Long Hwang, Pin-Yuan Chen
Summary: The manzamine derivative PCTC exhibits cytotoxic and anti-proliferative effects on glioma cells by promoting apoptosis and cell cycle arrest. It shows synergistic anti-tumor effects when used in combination with temozolomide. Safety, efficacy, and survival benefits are also demonstrated in an animal model.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Immunology
Hui Wang, Kangli Cao, Siyu Liu, Yuanhong Xu, Ling Tang
Summary: The study found that the frequency and absolute number of NK cells in patients with type 2 diabetes mellitus were significantly lower than in healthy individuals. The expression of surface receptors and cytokine production in NK cells were affected in patients, and correlated with high blood glucose levels.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Nagesha Guthalu Kondegowda, Joanna Filipowska, Jeong-su Do, Nancy Leon-Rivera, Rosemary Li, Rollie Hampton, Selassie Ogyaadu, Camilla Levister, Josef M. Penninger, Helena Reijonen, Carol J. Levy, Rupangi C. Vasavada
Summary: Inhibition of the RANKL/RANK pathway promotes beta cell regeneration and survival, offering potential therapeutic benefits for type 1 diabetes. Osteoprotegerin and denosumab provide protection against cytokine-induced beta cell death, and have shown promising results in reversing recent-onset type 1 diabetes in mice and reducing inflammation.
Article
Multidisciplinary Sciences
Atsuhiro Kitaura, Takashi Nishinaka, Shinichi Hamasaki, Omer Faruk Hatipoglu, Hidenori Wake, Masahiro Nishibori, Shuji Mori, Shinichi Nakao, Hideo Takahashi
Summary: Hyperglycaemia promotes infections and glucose toxicity through the formation of advanced glycation end-products. Internalisation of endotoxin impacts immune responses in cells. Toxic AGE (AGE-3) plays a role in the pathogenesis of diabetic complications.
Article
Food Science & Technology
Hee-Weon Lee, Min Ji Gu, Jee-Young Lee, Seungju Lee, Yoonsook Kim, Sang Keun Ha
Summary: The study found that MOLD significantly increases RAGE expression in mouse mesangial cells, leading to ROS production and mitochondrial dysfunction. MOLD activates PI3KB and NF-kappa B signaling pathways, triggering inflammatory responses.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dai Miyazaki, Michiko Kandori-Inoue, Yumiko Shimizu, Fumie Ohtani, Ikuyo Chono, Yoshitsugu Inoue, Satoru Yamagami
Summary: Senescence, sterile inflammation, and infection can lead to dysfunction of corneal endothelial cells, requiring corneal transplantation. Corneal endothelial cells respond to HSV-1 infection by activating interferon responses, with RAGE playing a key role as a sensor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Yimin Dai, Shuang Zhou, Lin Qiao, Zhao Peng, Jiuliang Zhao, Dong Xu, Chanyuan Wu, Mengtao Li, Xiaofeng Zeng, Qian Wang
Summary: Diabetes mellitus affects pulmonary function and can lead to related complications. Non-apoptotic programmed cell deaths have been found to be associated with diabetic pulmonary dysfunction. The AGE-RAGE axis plays an important role in the traditional pathogenesis of diabetes lung disease as well as non-apoptotic cell death.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hee-Weon Lee, Min Ji Gu, Yoonsook Kim, Jee-Young Lee, Seungju Lee, In-Wook Choi, Sang Keun Ha
Summary: This study evaluated the impact of glyoxal-lysine dimer (GOLD) on oxidative damage and inflammatory response in SV40 MES 13 mesangial cells. GOLD increased RAGE expression, reactive oxygen species production, and regulated NRF2 and GLO1 expression. Additionally, GOLD induced mitochondrial deterioration and inflammation through oxidative stress, and regulated MAPK and proinflammatory cytokines release. Inhibition of RAGE using RAGE siRNA suppressed the oxidative stress and inflammatory responses triggered by GOLD, highlighting the importance of the interaction between GOLD and RAGE in mesangial cell function.
Article
Endocrinology & Metabolism
Yi Chen, Wei Li, Xiaolin Nong, Chen Liang, Jiaquan Li, Wei Lu, Bingge Wang, Zhong Yuan, Shiying Yang
Summary: The study showed that artesunate treatment could protect against diabetes-related cardiovascular complications in rats by inhibiting the expression of proteins in the RAGE/NF-κB signaling pathway and downstream inflammatory factors. High concentrations of artesunate had a hypoglycemic effect, while a low concentration of artesunate prevented cardiovascular complications.
BMC ENDOCRINE DISORDERS
(2021)
Review
Medicine, General & Internal
Guanya Zhu, Qi Wang, Shuliang Lu, Yiwen Niu
MEDICAL PRINCIPLES AND PRACTICE
(2017)
Article
Endocrinology & Metabolism
Qi Wang, Guanya Zhu, Xiaozan Cao, Jiaoyun Dong, Fei Song, Yiwen Niu
JOURNAL OF DIABETES RESEARCH
(2017)
Article
Cell Biology
Mingyuan Miao, Yiwen Niu, Ting Xie, Bo Yuan, Chun Qing, Shuliang Lu
WOUND REPAIR AND REGENERATION
(2012)
Article
Endocrinology & Metabolism
Qi Wang, Xiaozan Cao, Guanya Zhu, Ting Xie, Kui Ge, Yiwen Niu
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2020)