Article
Public, Environmental & Occupational Health
Yangmin Hu, Danyang Li, Lingcheng Xu, Yuping Hu, Yiwen Sang, Gensheng Zhang, Haibin Dai
Summary: Multidrug resistant gram-negative bacteria were the main pathogens of BSI in severe burn patients. Accurate evaluation of risk factors for BSI and the mortality of BSI in severe burn patients may improve early appropriate management.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Critical Care Medicine
Sarah Rehou, Marc G. Jeschke
Summary: This study investigated the relationship between serum creatinine level on admission and outcomes in burn patients. The results showed that high admission creatinine was significantly associated with sepsis, pneumonia, and mortality. Therefore, admission creatinine can be used as an important indicator to identify burn patients at a higher risk of poor outcomes.
Article
Oncology
Daniel N. Willis, Mary Claire McGlynn, Patrick J. Reich, Robert J. Hayashi
Summary: This study evaluated the risk of bloodstream infections (BSI) and death in pediatric oncology patients, finding that BSI is a significant cause of mortality in this population. Younger age, specific diagnoses, ethnicity, and history of hematopoietic stem cell transplant (HSCT) were identified as risk factors for BSI. The mortality rate for patients with BSI was 6.5%. Patients with febrile neutropenia had a lower mortality rate compared to those without. These findings highlight the importance of BSI prevention to reduce the risk of death in pediatric oncology patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Berta Fidalgo, Laura Morata, Celia Cardozo, Ana del Rio, Javier Morales, Mariana Fernandez-Pittol, Jose Antonio Martinez, Josep Mensa, Jordi Vila, Alex Soriano, Climent Casals-Pascual
Summary: Rapid reporting of actionable microbiological results is critical for patient management, and delays in reporting this information to infectious diseases specialists are associated with an increased odds of death.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Pediatrics
Sandra Pong, Robert A. Fowler, Patricia Fontela, Elaine Gilfoyle, James S. Hutchison, Philippe Jouvet, Nicholas Mitsakakis, Srinivas Murthy, Jeffrey M. Pernica, Asgar H. Rishu, Michelle Science, Winnie Seto, Nick Daneman
Summary: This study explored whether delayed adequate antimicrobial treatment for children with bloodstream infections is associated with change in organ dysfunction. The results showed no association between delayed treatment and change in PELOD-2 scores, indicating that PELOD-2 scores are not sensitive to the clinical effects of delayed antimicrobial treatment.
PEDIATRIC RESEARCH
(2023)
Article
Infectious Diseases
Sandra Chamat-Hedemand, Anders Dahl, Lauge Ostergaard, Magnus Arpi, Emil Fosbol, Jonas Boel, Kamal Preet Kaur, Louise Bruun Oestergaard, Trine K. Lauridsen, Gunnar Gislason, Christian Torp-Pedersen, Niels Eske Bruun
Summary: This study aimed to investigate the mortality according to streptococcal species and seasonal variation. Through a study of patients with streptococcal bloodstream infections in the Capital Region of Denmark from 2008 to 2017, it was found that S. pneumoniae was associated with lower 30-day and one-year mortality, while other streptococcal species may be associated with higher mortality. In addition, patients infected with streptococcal species in the autumn and winter had a higher risk of death within 30 days.
Article
Medicine, General & Internal
Wojciech Figiel, Grzegorz Niewinski, Michal Grat, Marek Krawczyk, Jan Stypulkowski, Zbigniew Lewandowski, Maciej Krasnodebski, Waldemar Patkowski, Krzysztof Zieniewicz
Summary: Despite the importance of perioperative hyperoxygenation in preventing postoperative infections, this study found that it should not be used for prophylaxis of infections after liver transplantation due to the lack of efficacy.
Article
Immunology
Jasper Van Heuverswyn, John Karlsson Valik, Suzanne Desiree van der Werff, Pontus Hedberg, Christian Giske, Pontus Naucler
Summary: This cohort study found that delays in appropriate antimicrobial treatment were associated with increased 30-day mortality after 12 hours from blood culture collection, but not at 1, 3, and 6 hours.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Nimet Melis Bilen, Zumrut Sahbudak Bal, Gizem Guner Ozenen, Sema Yildirim Arslan, Gulcihan Ozek, Nihal Ozdemir Karadas, Pinar Yazici, Feriha Cilli, Zafer Kurugol
Summary: This study aimed to evaluate the risk factors for infection and mortality associated with Stenotrophomonas maltophilia bloodstream infections in children and compare them with Pseudomonas aeruginosa bloodstream infections. Results showed that previous Pediatric Intensive Care Unit (PICU) admission, prior glycopeptide and carbapenem use were significantly more common in patients with S. maltophilia BSIs. C-reactive protein (CRP) levels were significantly higher in S. maltophilia BSIs. Prior carbapenem use was identified as a significant risk factor for developing S. maltophilia BSIs.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Infectious Diseases
Tiago da Cunha Ferreira, Ianick Souto Martins
Summary: During the study, infections caused by ESCPM Enterobacterales had high mortality rates, and BSIs caused by MDR-ESCPM were independently associated with 7-day death. The use of piperacillin-tazobactam monotherapy for treating BSI-ESCPM may be associated with mortality and requires further investigation.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Multidisciplinary Sciences
Eleanor Mitchell, Mark Pearce, Anthony Roberts, Julia Newton
Summary: This study analyzed factors associated with in-hospital mortality in patients with GNBSIs caused by Escherichia coli, Klebsiella or Pseudomonas aeruginosa. Results indicated that patients with respiratory, gastrointestinal, or skin infection as primary focus, hospital-onset GNBSIs, dialysis at the time of infection, recent hospital discharge, and vascular device manipulation are at increased risk of in-hospital mortality. The data obtained from enhanced surveillance of GNBSIs in England can predict in-hospital mortality and should be used for identifying high-risk patients who may benefit from closer monitoring.
Article
Nutrition & Dietetics
Shang-Yu Chan, Chih-Po Hsu, Chun-Hsiang Ou Yang, Chia-Cheng Wang, Yu-Tung Wu, Chih-Yuan Fu, Chi-Hsun Hsieh, Chi-Tung Cheng, Wei-Cheng Lin, Jen-Fu Huang, Chien-Hung Liao
Summary: This study examined the impact of low plasma selenium concentration on clinical outcomes in patients with major trauma and found that it did not have a negative effect on mortality, infectious complications, ICU or hospital stay. The meta-analysis of four eligible studies showed no significant association between low serum selenium level and clinical outcomes.
Article
Public, Environmental & Occupational Health
L. Badia-Cebada, J. Penafiel, J. Lopez-Contreras, V Pomar, J. A. Martinez, G. Santana, J. Cuquet, M. M. Montero, C. Hidalgo-Lopez, M. Andres, M. Gimenez, M. D. Quesada, M. Vaque, S. Iftimie, C. Gudiol, R. Perez, A. Coloma, A. Marron, P. Barrufet, M. Marimon, A. Lerida, M. Claros, M. F. Ramirez-Hidalgo, G. Garcia Pardo, M. J. Martinez, E. L. Chamarro, E. Jimenez-Martinez, A. Hornero, E. Limon, M. Lopez, E. Calbo, M. Pujol, O. Gasch
Summary: The mortality associated with CRBSI has decreased in recent years but remains high. Intervention programs should focus on ICUs and medical wards, where the incidence and mortality rates are the highest.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Multidisciplinary Sciences
Koya Nagase, Tsuyoshi Watanabe, Akihiro Nomura, Fumika N. Nagase, Keita Iwasaki, Yoshihiro Nakamura, Hiroki Ikai, Mari Yamamoto, Yukari Murai, Waka Yokoyama-Kokuryo, Naoho Takizawa, Hideaki Shimizu, Yoshiro Fujita
Summary: Severe hyponatremia can be life-threatening and needs rapid correction of serum sodium levels. This study investigated predictive correction methods and found that using the formula derived from the Edelman equation was associated with appropriate correction of serum sodium concentration.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Joe Amoah, Eili Y. Klein, Kathleen Chiotos, Sara E. Cosgrove, Pranita D. Tamma
Summary: According to a multicenter observational study, prioritizing administration of beta-lactam over vancomycin for critically ill patients with suspected bloodstream infections may reduce early mortality, highlighting the significant impact of a simple practice change on improving patient survival.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Surgery
K. Van Den Heede, T. Claerhout, S. Jansen, S. Blontrock, N. Brusselaers, S. Van Slycke
Summary: This long-term follow-up study by a single surgeon in a single center confirms the safety and excellent cure rates of surgery for renal hyperparathyroidism (rHPT), while highlighting the importance of long-term follow-up.
ACTA CHIRURGICA BELGICA
(2023)
Letter
Critical Care Medicine
S. Blot, M. Deschepper
MEDICINA INTENSIVA
(2023)
Review
Nutrition & Dietetics
Lea Ribet, Robin Dessalles, Corinne Lesens, Nele Brusselaers, Mickael Durand-Dubief
Summary: Food fermentation using sourdough, consisting of lactic bacteria and yeasts, is considered natural and beneficial. This study reviewed clinical evidence on the effects of sourdough bread on health and found that there is currently no clear consensus on its benefits compared to other bread types. Factors such as microbial composition, fermentation parameters, and cereal and flour types may influence the nutritional properties of bread. However, specific strains and fermentation conditions showed improvements in glycemic response, satiety, and gastrointestinal comfort. Further standardization is needed to determine the clinical health benefits of sourdough.
ADVANCES IN NUTRITION
(2023)
Article
Biology
Linnea Hases, Lina Stepanauskaite, Madeleine Birgersson, Nele Brusselaers, Ina Schuppe-Koistinen, Amena Archer, Lars Engstrand, Cecilia Williams
Summary: A high-fat diet can cause gut microbiota dysbiosis, chronic intestinal inflammation, and metabolic syndrome. There are sex differences in the microbiota composition, and female mice are less affected. Estrogenic ligands can attenuate high-fat diet-induced dysbiosis and impact the microbial composition, especially in males.
COMMUNICATIONS BIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Lembris L. Njotto, Johanna Simin, Romina Fornes, Ingvild Odsbu, Isabelle Mussche, Steven Callens, Lars Engstrand, Robin Bruyndonckx, Nele Brusselaers
Summary: This study found that maternal and early-life antibiotic use is associated with an increased risk of autism and ADHD in children. The study used a large Swedish nation-wide cohort and discovered that both prenatal and early childhood antibiotic exposure are linked to a higher risk of developing these neurodevelopmental disorders. Rating: 8 out of 10.
Article
Microbiology
Justine W. Debelius, Lars Engstrand, Andreas Matussek, Nele Brusselaers, James T. Morton, Margaretha Stenmarker, Renate S. Olsen
Summary: The gut microbiome has a relationship with survival in colorectal cancer, with single organisms serving as markers of poor prognosis. However, in situ imaging of tumors reveals a polymicrobial tumor-associated community. In this study, a nested case-control approach was used to investigate the role of these polymicrobial communities in survival. The findings suggest that a polymicrobial tumor-specific microbiome is associated with survival in late-stage colorectal cancer patients.
MICROBIOLOGY SPECTRUM
(2023)
Review
Infectious Diseases
Marios Karvouniaris, Maria Panagiota Almyroudi, Mohd Hafiz Abdul-Aziz, Stijn Blot, Elisabeth Paramythiotou, Evdoxia Tsigou, Despoina Koulenti
Summary: Gram-negative bacterial resistance to antimicrobials has been increasing globally in recent decades, posing a daily challenge for hospital practice. Researchers and industry have made efforts to develop novel antimicrobials resilient to bacterial resistance mechanisms. Several new antimicrobials, including cefiderocol, imipenem-cilastatin-relebactam, eravacycline, omadacycline, and plazomicin, have become commercially available in the past five years. Other agents, such as aztreonam-avibactam, cefepime-enmetazobactam, cefepime-taniborbactam, cefepime-zidebactam, sulopenem, tebipenem, and benapenem, are in advanced development and have reached phase 3 clinical trials. This review critically discusses the characteristics, pharmacokinetic/pharmacodynamic properties, and current clinical data of these antimicrobials.
Article
Medicine, General & Internal
Wim Vandenberghe, Jorien De Loor, Katrien Francois, Kristof Vandekerckhove, Ingrid Herck, Johan Vande Walle, Harlinde Peperstraete, Thierry Bove, Daniel De Wolf, Lieve Nuytinck, Jan J. De Waele, Evelyne Meyer, Eric A. J. Hoste
Summary: This study evaluated serum CHI3L1, NGAL, TIMP-2, IGFBP7, and NephroCheck(R) as predictors of acute kidney injury (AKI) after pediatric cardiac surgery. The results showed that these markers could reliably predict the occurrence of AKI within 48 hours and 12 hours, respectively, after adjusting for urine dilution.
Article
Cell Biology
Sanjiv Risal, Congru Li, Qing Luo, Romina Fornes, Haojiang Lu, Gustaw Eriksson, Maria Manti, Claes Ohlsson, Eva Lindgren, Nicolas Crisosto, Manuel Maliqueo, Barbara Echiburu, Sergio Recabarren, Teresa Sir Petermann, Anna Benrick, Nele Brusselaers, Jie Qiao, Qiaolin Deng, Elisabet Stener-Victorin
Summary: The transgenerational effects of PCOS in female progeny are being investigated. This study examines whether sons born to mothers with PCOS transmit reproductive and metabolic phenotypes to their male progeny. The results show that PCOS-sons are more likely to be obese and have dyslipidemia, and a mouse model confirms that these dysfunctions are passed down to multiple generations. The study highlights the potential risk of transmission of reproductive and metabolic dysfunction through the male germline.
CELL REPORTS MEDICINE
(2023)
Article
Infectious Diseases
Frank Mulindwa, Barbara Castelnuovo, Nele Brusselaers, Robert Bollinger, George Yendewa, Willington Amutuhaire, Claudine Mukashaka, Jean-Marc Schwarz
Summary: Dolutegravir (DTG) is recommended as a first and second line antiretroviral therapy due to its favorable side effect profile, but there have been reports of accelerated hyperglycemia in some patients. However, at population level, DTG has been shown to have a lower risk of incident diabetes mellitus compared to other HIV drug classes. In Uganda, there have been similar reports of hyperglycemia during DTG use, leading to a recommendation to withhold DTG in patients with diabetes. However, it remains to be demonstrated whether this recommendation should apply to all patients with incident T2DM.
BMC INFECTIOUS DISEASES
(2023)
Review
Microbiology
Georgios Papathanakos, Ioannis Andrianopoulos, Menelaos Xenikakis, Athanasios Papathanasiou, Despoina Koulenti, Stijn Blot, Vasilios Koulouras
Summary: Sepsis, a life-threatening infection-induced disorder of organ function, is a major cause of mortality worldwide, particularly in intensive care units. With an incomplete understanding of its complex pathophysiology, sepsis exhibits great heterogeneity in clinical expression, patient response to treatment, and outcomes. This heterogeneity poses a significant challenge for improving treatment in critical care. However, artificial intelligence and machine learning techniques offer promise for identifying clinical phenotypes and distinguishing individuals based on various factors such as temperature, hemodynamics, organ dysfunction, fluid status, ICU trajectories, and outcome. Ultimately, this approach may allow for targeted therapeutic interventions and optimal timing in septic patients.
Article
Medicine, Research & Experimental
Wen Zhong, Hanna Danielsson, Nele Brusselaers, Dirk Wackernagel, Ulrika Sjobom, Karin Savman, Ingrid Hansen Pupp, David Ley, Anders K. Nilsson, Linn Fagerberg, Mathias Uhlen, Ann Hellstrom
Summary: This study investigated the changes in blood protein profiles during the first months of life in preterm infants and found that the variations in blood protein expression are mainly associated with the postnatal age of the infants. This provides an increased understanding of the development process after extremely preterm birth.
COMMUNICATIONS MEDICINE
(2023)
Letter
Public, Environmental & Occupational Health
Frank Mulindwa, Jean-Marc Schwarz, Nele Brusselaers, Simon Dujanga, George Yendewa, Barbara Castelnuovo
PAN AFRICAN MEDICAL JOURNAL
(2023)
Article
Surgery
Fien Van den Eynde, Klaas Van den Heede, Nele Brusselaers, Sam Van Slycke
Summary: The need for thyroid surgery is increasing in the elderly population due to aging, increased use of imaging studies, and higher prevalence of thyroid nodules and cancer. This study compared surgical outcomes in different age groups and found that patients aged 75 and older had a higher risk of complications, particularly bleeding, indicating that ambulatory surgery is not advisable for this age group.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
Klaas Van Den Heede, Nele Brusselaers, Esmee Breddels, Sebastien Gaujoux, Camille Buffet, Fabrice Menegaux, Nathalie Chereau
Summary: This study evaluated the prognostic impact of lymph node characteristics on patients with therapeutic neck dissection for clinically N1 classic PTC. The results showed that the number of harvested lymph node, presence of lymph node capsular rupture, and total lymph node ratio were associated with disease persistence or recurrence.
