Article
Biochemistry & Molecular Biology
Francesco Gaudio, Pierluigi Masciopinto, Emilio Bellitti, Pellegrino Musto, Elena Arcuti, Olga Battisti, Gerardo Cazzato, Alessandra Solombrino, Filomena Emanuela Laddaga, Giorgina Specchia, Eugenio Maiorano, Giuseppe Ingravallo
Summary: Large granular lymphocyte leukemia is a rare chronic disease characterized by neutropenia, anemia, and thrombocytopenia. It is often associated with various autoimmune conditions and has an indolent course.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Tao Zhao, Nan Hu, Xiaojuan Yu, Tao Su
Summary: Large granular T lymphocyte leukemia (T-LGLL) is a rare chronic lymphocyte leukemia characterized by clonal proliferation of T cells, which is related to STAT3 gene mutation and abnormal apoptosis pathway. Studies have suggested that exogenous and continuous stimulation, such as virus infection, may be related to the pathogenesis of T-LGLL.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Zachary Braunstein, Eric McLaughlin, Miguel Ruiz, Lai Wei, Naresh Bumma, Don Benson, Srinivas Devarakonda, Maria Chaudhry, Abdullah Khan, Francesca Cottini, Walter Hanel, Robert Baiocchi, Catherine Chung, Daniel Addison, Nina Couette, Alexa Meara, Wael Jarjour, Pierluigi Porcu, Anjali Mishra, John C. Reneau, Ashley E. Rosko, Jonathan E. Brammer
Summary: This study reported a group of patients with combined T-cell malignancies and plasma cell dyscrasias (PCD), including 26 patients. The results showed that there was no significant difference in survival for patients with CTCL or T-LGLL and concomitant PCD, but patients with PTCL and concomitant PCD had worse outcomes. Treatment directed at the T-cell malignancy resulted in the eradication of the PCD clone in some patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Dan Guo, Yuming Wang, Xunyao Wu, Yike Gao, Anqi Wang, Zixin Zhang, Kun Zhao, Xiaoxi Wang, Meiyu Liu, Yaran Zhang, Mei Li, Rui Chen, Jian Sun, Yan Zhang
Summary: Metabolites of tryptophan (Trp) metabolism in the tumor microenvironment play crucial immunosuppressive roles in diffuse large B-cell lymphoma (DLBCL) and natural killer/T-cell lymphoma (NK/TCL). The potential role of Trp metabolism was investigated in DLBCL and NK/TCL patients, and the expression of IDO1, IDO2, TDO2, and IL4I1 was analyzed. However, there was no significant difference in the positivity of these enzymes between PD-L1+ and PD-L1- tissue samples in NK/TCL patients.
Review
Oncology
Weili Xue, Mingzhi Zhang
Summary: NKTCL is a highly invasive subtype of lymphoma with current treatment methods having drawbacks. However, immunotherapy has shown promising results, including targeted antibodies, checkpoint inhibitors, and the role of IL10. Cellular immunotherapy with engineered cytotoxic T lymphocytes also presents potential therapeutic strategies.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Medicine, General & Internal
Laura Strobel, Kilian Vomstein, Christiana Kyvelidou, Susanne Hofer-Tollinger, Katharina Feil, Ruben-Jeremias Kuon, Susanne Ebner, Jakob Troppmair, Bettina Toth
Summary: In this study, we found that compared to sRPL patients, sCtrls had higher numbers of CD56(+) and CD56(dim)CD16(bright) cells. Furthermore, sRPL patients had lower numbers of CD56(dim)CD16(bright)NKG2D(+) and CD56(dim)CD16(bright)NKp46(+) compared to sCtrls.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sheila B. Powers, Nourhan G. Ahmed, Roslin Jose, Marissa Brezgiel, Subhash Aryal, W. Paul Bowman, Porunelloor A. Mathew, Stephen O. Mathew
Summary: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with B-cell ALL being more prevalent and T-cell ALL being more aggressive. The study showed increased expression of LLT1 in B-ALL and T-ALL patients. Surface LLT1 expression was significantly increased in T cells, monocytes, and NK cells of ALL patients. The study also observed increased expression of CS1 and NKp46 on monocytes at the diagnosis of ALL. Post-induction chemotherapy, there was a decrease in LLT1, 2B4, CS1, and NKp46 expression on T cells of ALL patients. The findings suggest that the differential expression of these receptors/ligands may play a role in T-cell- and NK-cell-mediated immune surveillance of pediatric ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Xiao-Peng Tian, Yi Cao, Jun Cai, Yu-Chen Zhang, Qi-Hua Zou, Jin-Ni Wang, Yu Fang, Jia-Hui Wang, Song-Bin Guo, Qing-Qing Cai
Summary: The increasing use of high-throughput screening has greatly advanced our knowledge on the molecular basis of natural killer/T-cell lymphoma (NKTCL) and revolutionized its treatment. Asparaginase-containing regimens have significantly improved survival outcomes in NKTCL patients. Novel treatment strategies, including targeted antibodies, immune checkpoint inhibitors, and chimeric antigen receptor T cells, are currently being developed for NKTCL and show promising potential for future use.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Martina Del Gaizo, Ilaria Sergio, Sara Lazzari, Samantha Cialfi, Maria Pelullo, Isabella Screpanti, Maria Pia Felli
Summary: This article reviews the literature on the regulatory role of miRNAs in the immune response of T-ALL, focusing on their roles in Natural Killer, T, T-regulatory, and Myeloid-derived suppressor cells. A better understanding of this molecular crosstalk may provide the basis for the development of potential immunotherapeutic strategies in the field of leukemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Virology
Jasmina M. Luczo, Sydney L. Ronzulli, Stephen M. Tompkins
Summary: NK cells are part of the innate immunity and function in recognizing and destroying tumorigenic and pathogen-infected cells through activation receptors. The activation receptors on NK cells include NKp46, NKp44, NKp30, NKG2D, and CD16.
Article
Multidisciplinary Sciences
Shouguo Gao, Zhijie Wu, Bradley Arnold, Carrie Diamond, Sai Batchu, Valentina Giudice, Lemlem Alemu, Diego Quinones Raffo, Xingmin Feng, Sachiko Kajigaya, John Barrett, Sawa Ito, Neal S. Young
Summary: T-cell large granular lymphocyte leukemia (T-LGLL) is a lymphoproliferative disease characterized by reduced TCR diversity and deregulation of cell survival genes. After alemtuzumab treatment, apoptosis genes are upregulated, particularly in responders, and TCR diversity is further skewed. Analysis of single cell data provides insights into the clonal expansion and persistence mechanisms in T-LGLL.
NATURE COMMUNICATIONS
(2022)
Article
Hematology
Taekeun Park, Ja Min Byun, Dong-Yeop Shin, Youngil Koh, Junshik Hong, Sung-Soo Yoon, Yoon Hwan Chang, Inho Kim
Summary: Large granular lymphocytic (LGL) leukemia is a rare lymphoproliferative disorder derived from cytotoxic T lymphocytes or natural killer cells. This study investigated the clinical features and treatment outcomes of T-cell LGL leukemia (T-LGLL) patients. The results showed that cyclophosphamide, methotrexate, and cyclosporin A had similar response rates, while splenomegaly, thrombocytopenia, and high LGL number in peripheral blood smear were associated with treatment response. This study provides valuable information for clinical decision-making regarding T-LGLL treatment.
ANNALS OF HEMATOLOGY
(2023)
Review
Oncology
Qin Hu, Yunfei Li, Ying Zhang, Shusen Sun, Hui Wang, Zhiping Jiang, Sheng Deng
Summary: This case report describes a rare case of T-LGLL with a rare gamma delta type and fusion gene NPL-DHX9 rearrangement. The patient was successfully treated with cladribine, indicating that this regimen could be a promising therapeutic strategy for aggressive T-LGLL.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Boheng Li, Qidi Zhou, Qin Wan, Xuan Qiao, Shangying Chen, Jianbiao Zhou, Zhijun Wuxiao, Lei Luo, Siok-Bian Ng, Jieping Li, Wee-Joo Chng
Summary: This study identifies TRIP12 as an E3 ligase that triggers polyubiquitination of EZH2, leading to its stabilization and promoting ENKTL cell migration. The TRIP12-EZH2 axis can be regulated by cytoplasmic HSP60 and targeted by dexamethasone treatment.
CLINICAL EPIGENETICS
(2023)
Article
Medicine, General & Internal
Julio Cruz, Daniela Vargas, Annelisse Goecke, Maria Luisa Molina
Summary: This case describes a male patient with nasal-type extranodal NK/T-cell lymphoma presenting with hoarseness, weight loss, and dyspnea. Immunohistochemistry is crucial for the diagnosis of this condition.
Article
Oncology
Andreas Rosenwald, Susanne Bens, Ranjana Advani, Sharon Barrans, Christiane Copie-Bergman, Mad-Helenie Elsensohn, Yaso Natkunam, Maria Calaminici, Birgitta Sander, Maryse Baia, Alexandra Smith, Daniel Painter, Luu Pham, Shuchun Zhao, Marita Ziepert, Ekaterina S. Jordanova, Thierry J. Molina, Marie Jose Kersten, Eva Kimby, Wolfram Klapper, John Raemaekers, Norbert Schmitz, Fabrice Jardin, Wendy B. C. Stevens, Eva Hoster, Anton Hagenbeek, John G. Gribben, Reiner Siebert, Randy D. Gascoyne, David W. Scott, Philippe Gaulard, Gilles Salles, Catherine Burton, Daphne de Jong, Laurie H. Sehn, Delphine Maucort-Boulch
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Atif Saleem, Yasodha Natkunam
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Anatomy & Morphology
Cristiane R. Ferreira, Vidhya Manohar, Shuchun Zhao, Charles D. Bangs, Athena Cherry, Raymundo Soares Azevedo, Luis A. P. C. Lage, Juliana Pereira, Maria C. N. Zerbini, Dita Gratzinger, Yasodha Natkunam
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2020)
Article
Pathology
Lauren E. B. Lawrence, Atif Saleem, Malaya K. Sahoo, Susanna K. Tan, Benjamin A. Pinsky, Yasodha Natkunam, Christian A. Kunder, Henning Stehr, James L. Zehnder
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2020)
Article
Hematology
Michael S. Binkley, M. Shahzad Rauf, Sarah A. Milgrom, Chelsea C. Pinnix, Richard Tsang, Michael Dickinson, Andrea K. Ng, Kenneth B. Roberts, Sarah Gao, Alex Balogh, Umberto Ricardi, Mario Levis, Carla Casulo, Michael Stolten, Lena Specht, John P. Plastaras, Christopher Wright, Christopher R. Kelsey, Jessica L. Brady, N. George Mikhaeel, Bradford S. Hoppe, Stephanie A. Terezakis, Marco Picardi, Roberta Della Pepa, Youlia Kirova, Saad Akhtar, Irfan Maghfoor, Julie L. Koenig, Christopher Jackson, Erin Song, Shuchi Sehgal, Ranjana H. Advani, Yasodha Natkunam, Louis S. Constine, Hans T. Eich, Andrew Wirth, Richard T. Hoppe
Article
Medical Laboratory Technology
Joshua R. Menke, Michael A. Spinner, Yasodha Natkunam, Roger A. Warnke, Ranjana H. Advani, Dita A. Gratzinger
Summary: NLPHL can present as CD20-negative without prior rituximab therapy, and immunophenotyping is crucial for distinguishing NLPHL from lymphocyte-rich classic Hodgkin lymphoma. CD20-negative NLPHL may exhibit classic and variant histologic patterns and range of clinical behaviors, including potential large cell transformation.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Hematology
Javier Raboso-Gallego, Ana Casado-Garcia, Xiaoyu Jiang, Marta Isidro-Hernandez, Andrew J. Gentles, Shuchun Zhao, Yaso Natkunam, Oscar Blanco, Veronica Dominguez, Belen Pintado, Diego Alonso-Lopez, Javier De las Rivas, Carolina Vicente-Duenas, Izidore S. Lossos, Isidro Sanchez-Garcia
Summary: The study shows that constitutive enforced expression of HGAL leads to DLBCL development, and this protein is mainly present in germinal center B lymphocytes.
Editorial Material
Oncology
Sheren Younes, Yasodha Natkunam
LEUKEMIA & LYMPHOMA
(2021)
Editorial Material
Hematology
Sheren Younes, Yasodha Natkunam
Article
Oncology
Oscar Silva, Vivek Charu, Mark D. Ewalt, Ryan A. Metcalf, Shuchun Zhao, E. Mauricio Castellanos, Elizabeth Orellana, Yasodha Natkunam, Sandra Luna-Fineman
Summary: In Guatemala, children aged 0-6 with cHL have a high EBV expression rate of 97.5%, share similar immune regulatory mechanisms with adult cHL, and show increased CD8+ lymphocytes and tumor-associated macrophages in the tumor microenvironment. Despite high-risk disease in 25 patients, only four died from disease progression, relapse, or infection.
LEUKEMIA & LYMPHOMA
(2021)
Review
Oncology
Sheren Younes, Rebecca B. Rojansky, Joshua R. Menke, Dita Gratzinger, Yasodha Natkunam
Summary: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma with unique biological behavior that requires careful differentiation from other lymphomas and their mimics. Recurrence and progression to different types of lymphomas are possible, highlighting the need for further research to personalize patient care.
Article
Pathology
Fei Fei, Kala Gnanasekaran Kiruthiga, Sheren Younes, Yasodha Natkunam
Summary: This study characterizes the clinicopathologic features of Epstein-Barr virus (EBV)-positive nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) at a single institution. The study found that EBV-positive NLPHL is rare and diagnostically challenging due to atypical immunophenotypic features.
Article
Cell Biology
Yasodha Natkunam, Daphne de Jong, Pedro Farinha, Philippe Gaulard, Wolfram Klapper, Andreas Rosenwald, Birgitta Sander, Reuben Tooze, Ranjana Advani, Catherine Burton, John G. Gribben, Marie-Jose Kersten, Eva Kimby, Georg Lenz, Thierry Molina, Franck Morschhauser, David Scott, Laurie Sehn, Wendy Stevens, Andrew Clear, Maryse Baia, Abdelmalek Habi, Mad-Helenie Elsensohn, Carole Langlois-Jacques, Delphine Maucort-Boulch, Maria Calaminici
Summary: Subclassification of large B cell lymphoma (LBCL) is challenging and conventional morphological parameters are not helpful. The use of fluorescence in-situ hybridisation (FISH) data is essential for accurate classification and prognostication of MYC-rearranged LBCL.
Article
Pathology
Sheren Younes, Shuchun Zhao, Sushma Bharadwaj, Alicia Palomino Mosquera, Diane Libert, Andrew Johnsrud, Robbie G. Majzner, David B. Miklos, Matthew J. Frank, Yasodha Natkunam
Summary: CD58 plays a crucial role in the activation and killing of target cells by T and NK cells. It is downregulated in a significant proportion of B-, T-, and NK-cell lymphomas, and its loss is associated with poor prognostic indicators in DLBCL and ALK and DUSP22 rearrangements in anaplastic large-cell lymphoma. However, it is not directly linked to overall or progression-free survival in any lymphoma subtype. CD58 status serves as an important biomarker for lymphoma patients who may benefit from next-generation T-cell-mediated therapies or other novel approaches to overcome immune escape.
Article
Pathology
Shuchun Zhao, Arturo Molina, Abigail Yu, Jeff Hanson, Harry Cheung, Xiaofan Li, Yasodha Natkunam
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2019)
