期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 140, 期 4, 页码 544-549出版社
OXFORD UNIV PRESS INC
DOI: 10.1309/AJCPM2Z4NGIIPBGE
关键词
Mesothelioma; CD90; Immunohistochemistry; Lung carcinoma
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Ministry of Health, Labor and Welfare of Japan
- Nichias Corporation
- Grants-in-Aid for Scientific Research [24591185, 23591136] Funding Source: KAKEN
Objectives: To pathologically distinguish mesothelioma from lung carcinoma, particularly adenocarcinoma. Methods: We conducted immunohistochemical analyses on clinical specimens, including 26 cases of mesothelioma, 28 cases of lung adenocarcinoma, and 33 cases of lung squamous cell carcinoma. Results: We found that CD90 expression was useful in making a differential diagnosis between epithelioid mesothelioma and lung adenocarcinoma, whereas sarcomatoid mesothelioma and lung carcinoma specimens, irrespective of the histologic types, were negative in general. The sensitivity and specificity of CD90 expression in epithelioid mesothelioma and lung adenocarcinoma were comparable to those of well-established markers used for the differential diagnosis. Conclusions: These data collectively indicate that CD90 is a novel diagnostic marker that contributes to a diagnosis of epithelioid mesothelioma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据