Article
Oncology
Chih-Jung Chen, Jen-Fan Hang, Yun-An Chen, Shu-Jiuan Lin, Hung-Ming Chiu, Chih-Yi Hsu, Chiung-Ru Lai, Chi-Shun Yang
Summary: TRPS1 is a sensitive and specific marker for metastatic breast cancer in serous effusion cell-block specimens. It shows superior sensitivity and specificity compared with GATA3, especially in the TNBC setting and for excluding urothelial carcinoma.
CANCER CYTOPATHOLOGY
(2023)
Article
Cell Biology
Ramesh Elango, Sameera Rashid, Radhakrishnan Vishnubalaji, Reem Al-Sarraf, Mohammed Akhtar, Khalid Ouararhni, Julie Decock, Omar M. E. Albagha, Nehad M. M. Alajez
Summary: By performing transcriptomic profiling on breast cancer patients from Qatar, we identified differential gene and miRNA expression patterns based on molecular subtypes, tumor grade, patients' age, and ethnicity. We uncovered miRNA-mRNA regulatory networks and potential therapeutic targets, and validated mRNA and miRNA-based signatures predictive of relapse free survival.
CELL DEATH & DISEASE
(2023)
Article
Pathology
Henning Plage, Henrik Samtleben, Sebastian Hofbauer, Kira Kornienko, Sarah Weinberger, Paul Giacomo Bruch, Sefer Elezkurtaj, Florian Rossner, Simon Schallenberg, Martina Kluth, Maximilian Lennartz, Niclas C. Blessin, Andreas H. Marx, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Steffen Hallmann, Stefan Koch, Nico Adamini, Sarah Minner, Ronald Simon, Guido Sauter, Tobias Klatte, Thorsten Schlomm, David Horst, Henrik Zecha
Summary: The expression of GATA3 protein in urothelial bladder cancer is not significantly correlated with pathological parameters and patient prognosis, but it is common in noninvasive urothelial carcinoma.
Article
Pathology
Francisco Javier Queipo, Gorka Muniz Unamunzaga, Begona Fuertes Negro, Sandra Gracia Fuertes, Marina alvarez Cortes, Elena Carceller Tejedor, Carmen Maria Bernal Manas, Arceli Bono Arino, Gottfrid Sjodahl, Carmen Beorlegui
Summary: The aim of this study was to develop an immunohistochemical algorithm for subtyping muscle-invasive bladder cancer (MIBC) based on morphology and the expression of three common antibodies. The algorithm was applied to 113 MIBC cases, resulting in classification into different subtypes. Overall, this algorithm provides a feasible and cost-effective approach for MIBC subtyping, although further validation studies are needed.
Article
Oncology
Donghao Shang, Yuting Liu, Xiuhong Xu, Zhenghao Chen, Daye Wang
Summary: The study found that both CellDetect and FISH have superior sensitivity in diagnosing UC compared to traditional urine cytology, with no significant difference in specificity. CellDetect shows varying sensitivity in different types and grades of UC, making it suitable for monitoring UC recurrence and screening undetectable cases.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Daeseon Yoo, Kyueng-Whan Min, Jung-Soo Pyo, Nae Yu Kim
Summary: This study evaluated the diagnostic and prognostic roles of GATA-binding protein 3 (GATA3) immunohistochemistry in urothelial carcinoma (UC) through a meta-analysis. The results showed that GATA3 expression significantly correlated with low-stage and better prognosis in UC, while also exhibiting high variability across histological subtypes.
MEDICINA-LITHUANIA
(2023)
Article
Pathology
Nada Shaker, Saba Shafi, Bryce Parkinson, Wei Chen, Anil V. Parwani, Qingqing Ding, Zaibo Li
Summary: Wnt9b has been identified as a highly sensitive and specific marker for breast carcinomas, especially in TNBCs. The study further investigated the utility of Wnt9b in breast carcinoma, including metaplastic carcinomas.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Ewe Seng Ch'ng
Summary: This study uses TCGA gene expression data to verify expressions of lineage markers in bladder urothelial carcinomas and prostate adenocarcinomas. The study shows that a combination of four lineage markers can achieve close to 100% accuracy in distinguishing between these two types of carcinomas.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Michelle Hong, George He, Siting Goh, Alvin Wei Xiang Low, Kae Jack Tay, Tony Kiat Hon Lim, Joe Yeong, Li Yan Khor, Tong Seng Lim
Summary: Urothelial carcinoma (UC) is the most common malignancy of the urinary system, with 70-75% being non-muscle invasive bladder cancer subtype requiring lifelong monitoring. The current diagnostic methods for UC, cytology and cystoscopy, are invasive, costly, and associated with comorbidities. Therefore, there is significant interest in developing highly specific and sensitive urinary biomarkers for early non-invasive UC detection. Advances in single-cell technologies may offer new opportunities for UC biomarker discovery and precision diagnostics.
Article
Pathology
Sruthi Babu, Nam W. Kim, Maoxin Wu, Ina Chan, Luisa F. Escobar-Hoyos, Kenneth R. Shroyer
Summary: The study demonstrates that K17 ICC is highly sensitive and specific for the diagnosis of UC in urine specimens, effective for initial screening and detection of recurrence across all grades of UC.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Oncology
Thomas van Doeveren, Jose A. Nakauma-Gonzalez, Andrew S. Mason, Geert J. L. H. van Leenders, Tahlita C. M. Zuiverloon, Ellen C. Zwarthoff, Isabelle C. Meijssen, Angelique C. van der Made, Antoine G. van Der Heijden, Kees Hendricksen, Bas W. G. van Rhijn, Charlotte S. Voskuilen, Job van Riet, Winand N. M. Dinjens, Hendrikus J. Dubbink, Harmen J. G. van de Werken, Joost L. Boormans
Summary: By sequencing genes in 15 UTUC patients treated by RNU, it was found that the majority of patients had a clonal relationship between UTUC and subsequent UCB, supporting the idea that UCBs following UTUC surgery are primarily clonally derived recurrences.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Editorial Material
Oncology
Derek B. Allison
Summary: The study suggests that the variant morphologic findings of P-CIS are subtle and often do not meet the criteria for high-grade urothelial carcinoma according to the Paris System.
CANCER CYTOPATHOLOGY
(2021)
Article
Oncology
Masayuki Tsuneki, Makoto Abe, Fahdi Kanavati
Summary: This study investigated the use of deep learning techniques for classifying urine liquid-based cytology specimens into neoplastic and non-neoplastic categories. The best performing model achieved good classification accuracy, highlighting the potential of using deep learning models in routine clinical practices for urothelial carcinoma screening. As conventional screening methods are limited in terms of human resources, integrating deep learning methods can automate and speed up the diagnosis process for a large number of specimens without delay. The study utilized transfer learning, fully supervised, and weakly supervised learning approaches to train deep learning models, and achieved a high area under the curve for diagnosis, demonstrating the promising potential use of the models for aiding urine cytodiagnostic processes.
Article
Urology & Nephrology
Stefan Pycha, Emanuela Trenti, Christine Mian, Christine Schwienbacher, Esther Hanspeter, Margherita Palermo, Armin Pycha, Hansjorg Danuser, Carolina D'Elia
Summary: The study evaluated the performance of Xpert(R)-BC-Detection and Bladder-Epicheck(R)-test in the detection of upper urinary tract tumors (UTUC) and compared them with cytology and Urovysion(R)-FISH test. The results showed that Bladder-Epicheck(R) and Urovysion(R)-FISH, combined with cytology, could be helpful ancillary methods for the diagnosis of UTUC while Xpert(R)-BC-Detection had limited usefulness due to its low specificity.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Immunology
Ryota Sakai, Minako Ito, Kyoko Komai, Mana Iizuka-Koga, Kazuhiko Matsuo, Takashi Nakayama, Osamu Yoshie, Koichi Amano, Hiroshi Nishimasu, Osamu Nureki, Masato Kubo, Akihiko Yoshimura
Summary: Tregs accumulation in the kidney is crucial for disease control, with GATA3 playing an important role in recruiting Tregs to the kidney. The experimental data suggest that PPAR gamma agonist enhances the accumulation of GATA3(+) Tregs in the kidney.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)