Article
Computer Science, Artificial Intelligence
Animesh Ray
Summary: Machine learning is revolutionizing biology by enabling the analysis of massive biological datasets and solving biological problems. It is distinct from classical statistical methods and has the potential to transform medicine, public health, and agricultural technology while providing valuable gene-based guidance for complex environmental management.
WILEY INTERDISCIPLINARY REVIEWS-DATA MINING AND KNOWLEDGE DISCOVERY
(2022)
Editorial Material
Medicine, General & Internal
Suzanne Koven, Jessica E. Haberer, Deborah Gomez Kwolek
Summary: Residents who want to get pregnant often have few options to adjust their schedules without interrupting their careers. This situation highlights the need for both structural and cultural changes.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medical Laboratory Technology
Brenda Mai, Nfn Aakash, Jacob Huddin, Brian Castillo, Amer Wahed
Summary: A new comprehensive AP/CP residency syllabus has been proposed to reduce the burden of residents to complete multiple fellowships and allow them earlier entrance into the workforce.
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2021)
Article
Health Care Sciences & Services
Valentyn Fournier, Thomas Prebet, Alexandra Dormal, Maite Brunel, Robin Cremer, Loris Schiaratura
Summary: This study found that students unfamiliar with the medical field tended to view personalized medicine more positively compared to targeted therapies, while familiar students showed no significant difference in their perceptions. Only students familiar with the medical field defined personalized medicine and targeted therapies with technical aspects such as genetics or immunology. Further research is needed to explore other factors influencing the definitions of personalized medicine and targeted therapies and their potential impact in clinical settings.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mubashir Hassan, Faryal Mehwish Awan, Anam Naz, Enrique J. deAndres-Galiana, Oscar Alvarez, Ana Cernea, Lucas Fernandez-Brillet, Juan Luis Fernandez-Martinez, Andrzej Kloczkowski
Summary: Big data has great potential in healthcare for personalized medicine and health care. The large volumes of biomedical and clinical data present opportunities and challenges for analysis and interpretation, and the development of new algorithms has enabled personalized precision medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Irati Romero-Garmendia, Koldo Garcia-Etxebarria
Summary: Colorectal cancer is a highly diagnosed cancer and the second leading cause of cancer-related death. Studying biomarkers for its diagnosis, prognosis, and treatment is essential for improving and personalizing colorectal cancer prevention and clinical management. Omic techniques provide an opportunity to better understand CRC and make personalized medicine possible, but also present challenges.
Review
Pathology
Levon Katsakhyan, Christopher Preciado, Zubair W. Baloch
Summary: This study conducted a systematic review of pathology graduate medical education, focusing on novel educational curricula. It found that there has been an increase in curricular endeavors addressing educational needs that are not commonly taught in traditional residency training. The study highlighted the diversity in teaching methods, implementation, and originating institutions. The lack of meaningful evaluated outcomes and available curricular materials may limit the wider use of such curricula and should be considered by future pathology educators.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Emergency Medicine
Monica K. Wattana, Demis N. Lipe, Christopher J. Coyne, Sarah Shafer, Patricia Brock, Kumar Alagappan
Summary: This study proposes a focused oncologic emergency medicine curriculum to address the gaps in knowledge among emergency medicine residents. The curriculum consists of 10 hours of didactic instruction, aiming to enhance EM residents' understanding and management skills of cancer complications. The suggested curriculum topics are designed to be flexible and integrated into existing emergency education programs.
JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Sara Green, Annamaria Carusi, Klaus Hoeyer
Summary: Politically authorized reports emphasize the urgent need for finer-grained disease categories and faster taxonomic revision in personalized and precision medicine. However, developing a data-driven taxonomy is not as simple as it seems. Analysis of the Danish National Genome Center initiatives reveals challenges in implementing integrated data infrastructure in centralized and digitalized healthcare systems. The study discusses the epistemic and organizational implications of a genomics-based disease taxonomy, highlighting tensions between variation and standardization in medicine and concerns about regulatory shifts in evidence standards.
SOCIAL SCIENCE & MEDICINE
(2022)
Review
Health Care Sciences & Services
Wanda Lattanzi, Cristian Ripoli, Viviana Greco, Marta Barba, Federica Iavarone, Angelo Minucci, Andrea Urbani, Claudio Grassi, Ornella Parolini
Summary: The rapid development in research areas has advanced personalized medicine by improving our understanding of genomic functions, patient phenotypes, and diseases, as well as enabling the design of innovative biological treatments tailored to individual patients. Meanwhile, diverse biotechnological advancements have uncovered disease mechanisms and prompted the development of personalized regenerative medicine strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Pharmacology & Pharmacy
M. S. Sarvan, Lakshmi Prasanthi Nori
Summary: This article provides a framework for understanding personalized and precision medicine, emphasizing tailored patient identification, diagnosis, and treatment. Investigating predictive variables for diseases within communities and customization of healthcare will lead to more individualized care for patients.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Biology
Juliana P. L. Goncalves, Christine Bollwein, Kristina Schwamborn
Summary: Novel profiling methodologies are revolutionizing the field of diagnostics and therapeutics, enabling more precise and personalized healthcare. Mass spectrometry imaging and other techniques provide molecular level information directly from tissues, aiding in understanding aberrant cellular behavior and disease characterization.
Article
Biochemistry & Molecular Biology
Taylor M. Weiskittel, Choong Y. Ung, Cristina Correia, Cheng Zhang, Hu Li
Summary: Despite the limited understanding of individual disease etiology and therapeutics, a novel computational pipeline has been proposed to collect potent disease gene cooperative pathways for individualized disease etiology and therapies. The importance of mutated genes in specific patients and the synthetic penetrance of these genes across patients can be elucidated through individualized disease modules. This study reveals the fluctuation of importance for notorious cancer drivers in breast cancers and the high disease module importance of rarely mutated genes in specific individuals. Furthermore, customized singular and combinatorial target therapies can be devised through individualized module disruption, emphasizing the need for precision therapeutics pipelines. This analysis demonstrates the power of individualized disease modules for precision medicine, offering deep novel insights on the activity of diseased genes in individuals.
Review
Chemistry, Analytical
Zhonghua Sun, Cleo Wee
Summary: 3D printing technology has shown great potential in medical applications, particularly in the diagnosis and surgical planning of cardiovascular diseases.
Review
Biochemistry & Molecular Biology
Ethan Hau Yin Lam, Fengqing Yu, Sabrina Zhu, Zongjie Wang
Summary: In the past decade, personalized medicine has made significant progress in addressing patient-specific disease complexities and developing individualized treatment strategies. The emergence of 3D bioprinting has provided novel opportunities for personalized medicine, although current bioprinted constructs have limitations in achieving anatomically realistic organs with mature biological functions. This review discusses the principles and realizations of bioprinting, focusing on techniques such as extrusion printing and digital light processing (DLP). It also explores the applications of bioprinted constructs in regenerative medicine and drug discovery. Despite the challenges, bioprinting shows promise as an empowering technology to overcome critical obstacles in personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
