Article
Oncology
Qian Wang, Zhoubo Guo, Zhou Huang, Huiru Sun, Jingyang Zhu, Jinyan Shi, Wencheng Zhang, Desheng Li, Bing Sun
Summary: This study investigated the expression status of ER, PR, and HER2 in breast cancer brain metastases. The results showed that conversion of hormone receptor and HER2 occurred between primary breast tumors, brain metastases, and extra-brain metastases. The conversion rate reached 31% when using a new HER2 categorization.
Article
Multidisciplinary Sciences
Dmitrii Bychkov, Nina Linder, Aleksei Tiulpin, Hakan Kuecuekel, Mikael Lundin, Stig Nordling, Harri Sihto, Jorma Isola, Tiina Lehtimaeki, Pirkko-Liisa Kellokumpu-Lehtinen, Karl von Smitten, Heikki Joensuu, Johan Lundin
Summary: This study utilized deep learning to analyze image data of breast cancer patients, finding that machine learning predicted gene amplification correlated with distant disease-free survival. Patients with higher than median morphology scores had more favorable survival when receiving anti-ERBB2 treatment.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Alexandra Moisand, Mathilde Madery, Thomas Boyer, Charlotte Domblides, Celine Blaye, Nicolas Larmonier
Summary: Breast cancers are a heterogeneous group of diseases with varying responses to current therapies. Hormone receptor-positive breast cancers can benefit from endocrine therapies, but metastatic disease remains a challenge. Immunotherapies have had limited success in breast cancer, only benefiting patients with hormone receptor-negative tumors. Current research focuses on the role of hormone receptor signaling in the sensitivity of breast cancer cells to anti-tumor immune responses and the potential of hormone therapy agents to enhance immune-based interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Katrin Almstedt, Lisa Krauthauser, Franziska Kappenberg, Daniel-Christoph Wagner, Anne-Sophie Heimes, Marco J. J. Battista, Katharina Anic, Slavomir Krajnak, Antje Lebrecht, Roxana Schwab, Walburgis Brenner, Wolfgang Weikel, Joerg Rahnenfuehrer, Jan G. G. Hengstler, Wilfried Roth, Annette Hasenburg, Kathrin Stewen, Marcus Schmidt
Summary: This study investigated the differences in HER2 expression levels between primary tumors and distant metastases in HER2-negative breast cancer patients. The results showed relevant discordance of HER2-low status between primary tumors and their corresponding distant metastases. Significant HER2 discordance rates were observed between different metastatic sites and molecular subtypes. These findings highlight the importance of evaluating potentially therapy-relevant discordance rates between a primary tumor and corresponding distant metastases.
Article
Oncology
Ruoyan Qin, Jie Qian, Mengjun Shan, Guangxin Ruan, Xiaofeng Yang, Yanwen Wang, Lingshuang Liu
Summary: Triple-negative breast cancer is a subtype of breast cancer that lacks estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER2). Treatment of metastatic triple-negative breast cancer mainly relies on chemotherapy, although later-line treatment remains a challenge. Breast cancer is highly heterogeneous, and there is often inconsistency in hormone receptor expression between primary and metastatic lesions.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Anna Thulin, Carola Andersson, Elisabeth Werner Ronnerman, Shahin De Lara, Chaido Chamalidou, Arnd Schoenfeld, Aniko Kovacs, Henrik Fagman, Fredrik Enlund, Barbro K. Linderholm
Summary: This study aimed to investigate mutations in breast cancer brain metastasis, with TP53 and PIK3CA mutations being the most common, and mutations in other genes also identified. Discordant mutation patterns were found in some matched cases, indicating the need to develop methods for assessing mutational status in brain metastasis.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Cell Biology
Mingang Hao, Syn Kok Yeo, Jun-Lin Guan
Summary: Autophagy inhibition can effectively prevent the occurrence of ERBB2-driven breast tumors, with stronger effects than previous studies using other models. Autophagy inhibition disrupts intracellular trafficking of ERBB2 and triggers its release via extracellular vesicles.
Review
Medicine, General & Internal
Cassandra L. Moyer, Powel H. Brown
Summary: Advancements in research have led to a decline in breast cancer mortality over the past thirty years, but the incidence of breast cancer continues to rise. This calls for more effective prevention strategies, including targeted chemo preventive agents. Recent efforts have focused on exploring the role of nuclear receptors in breast cancer development and progression. Drugs targeting nuclear receptors, such as retinoic acid receptor, retinoid X receptor, and vitamin D receptor, have shown potential for preventing both hormone receptor-positive and hormone receptor-negative breast cancer.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
R. Alejandro Marquez-Ortiz, Maria J. Contreras-Zarate, Vesna Tesic, Karen L. F. Alvarez-Eraso, Gina Kwak, Zachary Littrell, James C. Costello, Varsha Sreekanth, D. Ryan Ormond, Sana D. Karam, Peter Kabos, Diana M. Cittelly
Summary: High expression of IL13R alpha 2 in breast cancer brain metastases predicts poor survival, with this target being essential for cancer-cell survival and promoting proliferation while repressing invasion. Targeting IL13R alpha 2 may be a promising therapeutic strategy for brain metastases.
CLINICAL CANCER RESEARCH
(2021)
Article
Surgery
Roi Weiser, Efstathia Polychronopoulou, Yong-fang Kuo, Waqar Haque, Sandra S. Hatch, Douglas S. Tyler, William J. Gradishar, V. Suzanne Klimberg
Summary: In patients aged 50 to 69 with a RS < 11, local treatment alone without long-term endocrine therapy seems to have no impact on overall survival and may improve quality of life. Further prospective studies are needed to investigate this approach.
Article
Medicine, Research & Experimental
Yanli Bi, Xiaoyu Chen, Bajin Wei, Linchen Wang, Longyuan Gong, Haomin Li, Xiufang Xiong, Yongchao Zhao
Summary: DEPTOR interacts with and stabilizes ErbB2, promoting proliferation and survival of ErbB2-positive breast cancer cells. Overexpression of DEPTOR is correlated with poorer patient survival, and the membrane localization of DEPTOR may contribute to the oncogenic characteristics of ErbB2.
Article
Oncology
Amanda L. Nash, Samantha M. Thomas, Jennifer K. Plichta, Oluwadamilola M. Fayanju, E. Shelley Hwang, Rachel A. Greenup, Laura H. Rosenberger
Summary: Background Contralateral axillary nodal metastases (CAM) is classified as stage IV disease, although many centers treat CAM with curative intent. Our study found that patients with CAM treated with multimodality therapy had similar overall survival (OS) to those with locally advanced breast cancer (LABC) and better OS compared to those with distant metastatic disease (M1). Additionally, CAM patients receiving curative treatment may have OS more comparable to LABC patients than M1 patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Jose P. Leone, Bernard F. Cole, Meredith M. Regan, Beat Thurlimann, Alan S. Coates, Manuela Rabaglio, Anita Giobbie-Hurder, Richard D. Gelber, Bent Ejlertsen, Vernon J. Harvey, Patrick Neven, Istvan Lang, Herve Bonnefoi, Andrew Wardley, Aron Goldhirsch, Angelo Di Leo, Marco Colleoni, Ines Vaz-Luis, Nancy U. Lin
Summary: Endocrine therapy resistance is a major cause of distant recurrence in hormone receptor-positive breast cancer. In the BIG 1-98 trial, different adjuvant endocrine therapy regimens did not affect survival after distant recurrence. Age, primary tumor size, nodal and PR status, and DFS were significant factors impacting post-distant recurrence survival.
Article
Oncology
Jennet M. Harvey, Gary M. Clark, C. Kent Osborne, D. Craig Allred
Summary: The purpose of this study was to evaluate the ability of Immunohistochemistry (IHC) compared to the traditional ligand-binding assay (LBA) to predict clinical outcomes in breast cancer. The results showed that IHC was superior to LBA in predicting patient benefits and survival rates.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Andreia S. Margarido, Rebeca Uceda-Castro, Kerstin Hahn, Roebi de Bruijn, Lennart Kester, Ingrid Hofland, Jeroen Lohuis, Danielle Seinstra, Annegien Broeks, Jos Jonkers, Marike L. D. Broekman, Pieter Wesseling, Claire Vennin, Miguel Vizoso, Jacco van Rheenen
Summary: The study demonstrates that breast cancer brain metastasis cells undergo epithelial-to-mesenchymal transition (EMT) when infiltrating the brain parenchyma, and removing these infiltrated tumor cells can improve surgical efficacy, providing new avenues for patient treatment.
Article
Oncology
Chao Wang, Julia Y. Tsang, Ivan K. Poon, Yan Shao, Joshua J. Li, Ka-Ho Shea, Thazin Hlaing, Sio-In Wong, Gary M. Tse
Summary: This study aimed to compare the clinicopathological characteristics and outcomes of uncommon HER2 in situ hybridization patterns in cancer, with typical amplified and non-amplified cases. The findings revealed some similarities among different HER2 categorization groups, supporting the classification approach in the latest guideline.
CLINICAL BREAST CANCER
(2022)
Article
Cell Biology
Joshua J. X. Li, Joanna K. M. Ng, Chaiwat Aphivatanasiri, Ronald C. K. Chan, Ivan K. Poon, Julia Y. Tsang, Gary M. Tse
Summary: This study investigates the predictive value of fine needle aspiration cytology (FNAC), immunohistochemistry (IHC), and clinical parameters in assessing the primary sites of metastatic carcinomas with papillary architecture. The results show that cytological features, IHC, and clinical information are invaluable in determining the primary site.
Article
Oncology
Priscilla Ming Yi Lee, Chi-Hei Kwok, Yee-Kei Tsoi, Cherry Wu, Sze -Hong Law, Koon-Ho Tsang, Yiu-Cheong Yeung, W. C. Chan, Gary M. Tse, Karen Ka -Wan Yuen, Ray Ka Wai Hung, Feng Wang, Lap Ah Tse
Summary: The consumption of cured meat is positively associated with the risk of breast cancer, particularly in Chinese women. Additionally, consuming canned fruit/vegetables at least once a week is also associated with a higher risk of breast cancer, especially in the HER2-positive subtypes.
CANCER PREVENTION RESEARCH
(2022)
Review
Cell Biology
Joshua J. X. Li, Gary M. Tse
Summary: This article reviews the clinicopathological features of ER-positive breast cancers, with a focus on ER-low positive breast cancers. It also provides updates on the assessment, reporting, and interpretation of ER immunohistochemical staining, correlations of ER status with other diagnostic and theragnostic markers, as well as implications for treatment selection and response. Despite advancements in IHC and molecular techniques, ER immunostaining remains a core component in the prognostic and theragnostic assessment of breast cancers.
Article
Pathology
Julia Y. Tsang, Yan Shao, Ivan K. Poon, Yun-Bi Ni, Johnny S. Kwan, Chit Chow, Ka-Ho Shea, Gary M. Tse
Summary: This study characterized genetic alterations in different grades of phyllodes tumors (PTs) and confirmed recurrent alterations observed in previous studies. In addition, the data implicated the roles of cell cycle, epigenetic, and RARA changes in PT recurrence and tumorigenesis.
Review
Medical Laboratory Technology
Yunbi Ni, Gary M. Tse
Summary: This article discusses the morphological and relevant immunohistochemical features of papillary lesions, emphasizes some commonly encountered practical diagnostic issues, and establishes a simple diagnostic algorithm. The relevant molecular characteristics are also discussed.
SEMINARS IN DIAGNOSTIC PATHOLOGY
(2022)
Article
Oncology
Ivan K. Poon, Ronald C. K. Chan, Joseph S. H. Choi, Joanna K. M. Ng, Katsie T. Tang, Yolanda Y. H. Wong, Ka Pang Chan, Wing Ho Yip, Gary M. Tse, Joshua J. X. Li
Summary: This study reviewed matched pleural biopsy and effusion cytology specimens to compare the performance of these two methods. The results suggest that effusion cytology may be better for confirming benignity and diagnosing carcinomatous pleural effusion, while pleural biopsy should be considered for suspected hematolymphoid malignancies and mesothelioma.
Article
Medical Laboratory Technology
Yunbi Ni, Gary M. Tse
Summary: Spindle cell lesions of the breast are a wide range of diseases, from nonneoplastic reactive conditions to high-grade malignant tumors, making diagnosis difficult. This study reviews the classification of breast spindle cell lesions, including clinical features, morphologic characteristics, and the role of immunohistochemistry and molecular tools in assisting differential diagnosis.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Pathology
Joshua J. X. Li, Joanna K. M. Ng, Billy S. W. Lai, Conrad H. C. Lee, Ka-Ho Shea, Julia Y. Y. Tsang, Gary M. M. Tse
Summary: This study reviewed the largest cohort of histologically confirmed aspirates of tubular adenomas and compared them with aspirates of fibroadenomas. The findings further defined the cytological features of tubular adenoma and allowed for differentiation from fibroadenoma.
Article
Oncology
Joshua J. X. Li, Gary M. Tse
CANCER CYTOPATHOLOGY
(2023)
Review
Cell Biology
Julia Y. Tsang, Gary M. Tse
Summary: TNBC is a major challenge in breast cancer management due to its heterogeneity and diversity. Expression profiling has identified at least four predominant subtypes with specific genomic alterations and tumor microenvironment. Recognizing these subtypes can improve prognosis and guide treatment decisions.
Editorial Material
Oncology
Ivan K. K. Poon, Ronald C. K. Chan, Joseph S. H. Choi, Joanna K. M. Ng, Katsie T. T. Tang, Yolanda Y. H. Wong, Ka Pang Chan, Wing Ho Yip, Gary M. M. Tse, Joshua J. X. Li
Article
Pathology
Joshua J. X. Li, Wing Cheung, Joanna K. M. Ng, Gary M. Tse
Summary: The ISRSFC has demonstrated strong diagnostic performance in pericardial fluid cytology. Disease composition and applicable cytological subcategories differ from its peritoneal and pleural counterparts for pericardial effusion. Incorporating immunocytochemistry by an algorithmic approach improves diagnostic accuracy. Cytomorphology is accurate for identifying adenocarcinomas, but further typing necessitates immunocytochemistry.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Cell Biology
Joshua J. X. Li, Gary M. Tse
Summary: This review summarizes the applications of immunocytochemistry-detection of carcinoma cells, confirmation of breast primary, assessment of surrogate immunostains and theragnostic biomarkers, with discussion on potential diagnostic pitfalls, followed by the application of molecular tests and digital cytopathologic techniques for assessing metastatic breast carcinoma in cytology.
Article
Genetics & Heredity
Bin Zhu, Lijin Joo, Tongwu Zhang, Hela Koka, DongHyuk Lee, Jianxin Shi, Priscilla Lee, Difei Wang, Feng Wang, Wing-cheong Chan, Sze Hong Law, Yee-kei Tsoi, Gary M. Tse, Shui Wun Lai, Cherry Wu, Shuyuan Yang, Emily Ying Yang Chan, Samuel Yeung Shan Wong, Mingyi Wang, Lei Song, Kristine Jones, Amy Hutchinson, Belynda Hicks, Ludmila Prokunina-Olsson, Montserrat Garcia-Closas, Stephen Chanock, Lap Ah Tse, Xiaohong R. Yang
Summary: This study analyzed genomic data from Hong Kong breast cancer (HKBC) patients and compared them with European ancestry breast cancer data. The results showed that the genomic features were largely similar between HKBC and European breast cancer. However, there were suggestive differences in some driver genes and mutational signatures, which warrant further investigation in large and diverse Asian populations.
HUMAN GENETICS AND GENOMICS ADVANCES
(2022)
