期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 131, 期 3, 页码 393-404出版社
OXFORD UNIV PRESS INC
DOI: 10.1309/AJCPM7DW0XFHDHNY
关键词
Renal neoplasm; Immunohistochemistry; PAX-2; Transcription factor; Kidney-specific cadherin; Renal cell carcinoma marker antigen; RCCM; Nephrogenesis
类别
The diagnosis of renal cell carcinoma (RCC) remains problematic, especially in the context of metastasis or small needle biopsy specimens. The renal cell carcinoma marker (RCCM) and kidney-specific cadherin (KSC) are considered specific markers for RCC but are expressed preferentially in specific subtypes of RCC of lower grades. This study was aimed at evaluating the usefulness of PAX-2 in the diagnosis of renal tumors and comparing it with that of RCCM and KSC. Immunostaining for PAX-2, RCCM, and KSC was performed on consecutive tissue sections of 130 renal tumors. PAX-2 was successfully detected in routine tissue specimens. Although PAX-2 seems to be more sensitive than RCCM and KSC, there is significant staining overlap in relation to histologic subtypes, justifying the use of all 3 markers, which helps detect the vast majority of renal neoplasms. PAX-2 seems to have a significant role in renal neogenesis and may represent a novel therapeutic target.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据