期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 130, 期 2, 页码 224-230出版社
OXFORD UNIV PRESS INC
DOI: 10.1309/8DN7DQRDFB4QNH3N
关键词
GPC3; glypican 3; germ cell tumor; yolk sac tumor; ovary; pediatric
类别
Germ cell tumors (GCTs), rare malignancies that occur in a wide range of locations and display variable histologic patterns, may pose diagnostic challenges. Glypican 3 (GPC3), a membrane-bound heparan sulfate proteoglycan, has been shown to be a novel diagnostic marker in testicular GCT However, GPC3 expression in ovarian and extragonadal GCT has not been reported. We evaluated GPC3 immunoreactivity in GCTs from 63 patients (57 children and 6 adults), including 14 ovarian and 20 extragonadal primary GCTs and 8 metastases along with 21 primary testicular GCTs for comparison. All 33 yolk sac tumors (YSTs) and both choriocarcinomas were immunoreactive for GPC3. In contrast, a minority of immature (4/10) and mature (4/35) teratomas were positive. No positivity was seen in 6 embryonal carcinomas or 5 germinomas. GPC3 is differentially expressed in ovarian and extragonadal GCTs, with. expression predominantly observed in YSTs and choriocarcinoma.
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