Article
Medicine, General & Internal
Min-Kyung Yeo, Sup Kim, Heon Jong Yoo, Kwang-Sun Suh, Kyung-Hee Kim
Summary: The study compared the performance of four anti-HER2 antibodies in HGSOC specimens with peritoneal dissemination, finding that 39.5% of cases were positive for at least one HER2 antibody. Detection of HER2 gene amplification was limited, but all four antibodies could be potentially used for patient selection for anti-HER2 therapies targeting HGSOC with peritoneal dissemination.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pathology
Anais Malpica
Summary: A lot of new information has been discovered about peritoneal mesothelioma (PeM), including changes in nomenclature, the recognition that it can be associated with tumor predisposition syndromes or germline mutations, and the use of ancillary testing for correct diagnosis. The molecular landscape of PeM is still being studied, with some specific findings in young patients. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy have greatly improved survival rates.
ADVANCES IN ANATOMIC PATHOLOGY
(2023)
Article
Oncology
David M. Gershenson, Lauren P. Cobb, Shannon N. Westin, Yingao Zhang, Amir Jazaeri, Anais Malpica, Charlotte C. Sun
Summary: This study aims to describe a cohort of patients with stage II-IV LGSOC who received contemporary primary treatment and analyze the determinants of relapse and disease-free survival. The findings suggest that factors such as no gross residual disease, normal serum CA 125 at diagnosis, primary peritoneal site, and presence of extensive psammomatous calcifications are associated with improved patient outcomes.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Medicine, General & Internal
Hyun Hee Koh, Eunhyang Park, Hyun-Soo Kim
Summary: Mesonephric-like adenocarcinoma (MLA) arising in the ovary is a rare malignant tumor of the female genital tract. This study investigated the clinicopathological, immunohistochemical, and genetic features of five ovarian MLAs. The findings revealed specific imaging characteristics, histological features, immunophenotypes, and genetic alterations in ovarian MLA, corroborating previous data. These observations emphasize the importance for pathologists to recognize and accurately diagnose this rare but distinct entity.
Article
Pathology
Anais Malpica, Elizabeth D. Euscher, Mario L. Marques-Piubelli, Maria C. Ferrufino-Schmidt, Roberto N. Miranda, Ralph Sams, Richard E. Royal, Kanwal P. S. Raghav, Keith F. Fournier, Preetha Ramalingam
Summary: This study presents the clinicopathologic features of 164 cases of malignant mesothelioma of the peritoneum in women over a 42-year period. The findings include age distribution, symptoms presentation, immunohistochemical results, and treatment approaches. Results show that patients commonly present with abdominal or pelvic pain, and treatments primarily consist of chemotherapy, surgery, and hyperthermic intraperitoneal chemotherapy. Multivariate analysis identifies factors and treatments associated with overall survival rates.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Oncology
Yaniv Berger, Meghana Gadiraju, Ankit Dhiman, Katie Gilliam, Buerkley Opalecky, Heather Chen, Maria Helgeson, Oliver S. S. Eng, Aliya N. N. Husain, Michael W. W. Drazer, Hedy L. L. Kindler, Jane E. E. Churpek, Kiran K. K. Turaga
Summary: This study aimed to investigate the distinct surgical characteristics of peritoneal mesothelioma (PM) patients with germline mutations (GM). The presence of BAP1 GM in surgical PM patients was associated with a higher prevalence of bicavitary disease, lower platelet count, lower mitotic score, and higher peritoneal cancer index (PCI). These findings suggest that germline testing should be considered for PM patients with higher tumor burden and lower platelet count and mitotic score.
Article
Pathology
Anais Malpica, Elizabeth D. Euscher, Mario L. Marques-Piubelli, Roberto N. Miranda, Kanwal P. Raghav, Keith F. Fournier, Preetha Ramalingam
Summary: Localized malignant peritoneal mesothelioma is a rare tumor with limited information available. This study presents the experience with 18 cases seen in a hospital over a period of 43 years. Most patients were Caucasians, and the main symptom was abdominal pain. Microscopic examination revealed typical malignant mesothelioma features in most cases, but some cases had mixed features. Some patients had a history of asbestos exposure, and a family history of tumors was common. The majority of patients underwent surgery, and some also received adjuvant chemotherapy. The mean overall survival was 80.4 months, with a 3-year survival rate of 79% and a 5-year survival rate of 52.6%. Limited sample data suggest that small tumor size, low-grade cytology, and low mitotic index may be associated with a benign behavior.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Pathology
Elizabeth D. Euscher, Mario L. Marques-Piubelli, Preetha Ramalingam, Ignacio Wistuba, Barrett C. Lawson, Michael Frumovitz, Anais Malpica
Summary: This study presents the clinicopathologic, IHC, and MOL features of 33 ExUMLC cases and compares them with other upper gynecologic carcinomas. ExUMLC patients showed a characteristic mixture of architectural patterns and cytologic features, with some cases displaying sarcomatous differentiation. Most patients were diagnosed at an advanced stage, indicating the aggressive behavior of ExUMLC compared to LGEC.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gabriella Serio, Federica Pezzuto, Francesco Fortarezza, Andrea Marzullo, Maria Celeste Delfino, Antonio d'Amati, Daniele Egidio Romano, Sonia Maniglio, Concetta Caporusso, Teresa Lettini, Domenica Cavone, Luigi Vimercati
Summary: There is evidence suggesting that asbestos may play a role in the carcinogenesis of digestive cancers, although the mechanism is still unclear. This study reports four unusual cases of colorectal cancers in patients with long-term asbestos exposure who also developed mesothelioma. The evaluation of certain proteins supports the hypothesis that they are tumor suppressor genes involved in disease progression in both digestive cancers and mesothelioma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Ozlem Ucer, Nevin Kocaman
Summary: Suprabasin and DARS2 markers were found to have potential value in differentiating MM from LAC through immunohistochemistry examination of samples. Suprabasin was only expressed in adenocarcinoma, while DARS2 was expressed in RMH, MM, and adenocarcinoma.
Article
Pathology
David B. Chapel, Michelle S. Hirsch
Summary: Primary peritoneal malignant mesothelioma can have similarities with tubo-ovarian serous neoplasms, but it is distinct in terms of biology and prognosis. Currently, there is no definitive biomarker to distinguish these tumors. SOX6 immunohistochemistry has shown promise in differentiating pleural epithelioid MM from lung adenocarcinoma, but its effectiveness in peritoneal MM needs further evaluation.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Oncology
Dane Cheasley, Marta Llaurado Fernandez, Martin Kobel, Hannah Kim, Amy Dawson, Joshua Hoenisch, Madison Bittner, Derek S. Chiu, Aline Talhouk, C. Blake Gilks, Madawa W. Jayawardana, Kathleen Pishas, Anne-Marie Mes-Masson, Diane Provencher, Abhimanyu Nigam, Neville F. Hacker, Kylie L. Gorringe, Ian G. Campbell, Mark S. Carey
Summary: This study investigates the genomic profiles associated with estrogen receptor (ER) and progesterone receptor (PR) expression patterns in low-grade serous ovarian carcinoma (LGSOC). The results show that PR-low tumors have a higher fraction of the genome altered by copy number changes compared to PR-high tumors. Higher expression of ER and PR is associated with improved overall survival.
NPJ PRECISION ONCOLOGY
(2022)
Article
Medicine, General & Internal
Hyunjin Kim, Kiyong Na, Go Eun Bae, Hyun-Soo Kim
Summary: Research on mesonephric-like adenocarcinoma of the uterine corpus revealed irregularities in immunohistochemical staining, posing challenges for differential diagnosis. Caution should be taken when interpreting immunohistochemical staining results.
Review
Cell Biology
Emily Symes, Melissa Tjota, Brittany Cody, Hedy Kindler, Owen Mitchell, Hunter Witmer, Kiran Turaga, Jeffrey Mueller, Thomas Krausz, Aliya N. Husain, Huihua Li
Summary: This study investigates the morphologic features and results of ancillary testing in peritoneal mesothelioma in situ (MIS). The results show that loss of BAP1 is present in all three cases, and NGS reveals pathogenic alterations in BAP1 as well as mutations in other genes. The study highlights the importance of ancillary studies in the diagnosis of MIS.
Article
Obstetrics & Gynecology
Anais Malpica, Elizabeth D. Euscher, Mario L. Marques-Piubelli, Roberto N. Miranda, Keith F. Fournier, Kanwal P. Raghav, Preetha Ramalingam
Summary: Malignant peritoneal mesothelioma (MPeM) associated with endometriosis is rare, and this study aimed to explore factors contributing to its pathogenesis. Clinicopathologic characteristics of 15 cases of MPeM associated with endometriosis were assessed, revealing a high prevalence of personal/familial history of malignancies in these patients.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2022)
Review
Clinical Neurology
Sayuru Tsuyuguchi, Kazuhiko Sugiyama, Yasuyuki Kinoshita, Manish Kolakshyapati, Takeshi Takayasu, Satoshi Usui, Motoki Takano, Ushio Yonezawa, Akira Taguchi, Vishwa Jeet Amatya, Yukio Takeshima, Kaoru Kurisu, Fumiyuki Yamasaki
WORLD NEUROSURGERY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shumpei Onishi, Chikako Fujioka, Yoko Kaichi, Vishwa Jeet Amatya, Minoru Ishifuro, Yukio Takeshima, Kazuo Awai, Kazuhiko Sugiyama, Kaoru Kurisu, Fumiyuki Yamasaki
EUROPEAN JOURNAL OF RADIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shumpei Onishi, Vishwa Jeet Amatya, Manish Kolakshyapati, Motoki Takano, Ushio Yonezawa, Akira Taguchi, Yoko Kaichi, Yukio Takeshima, Kazuo Awai, Kazuhiko Sugiyama, Kaoru Kurisu, Fumiyuki Yamasaki
EUROPEAN JOURNAL OF RADIOLOGY
(2020)
Article
Oncology
Rui Suzuki, Vishwa Jeet Amatya, Kei Kushitani, Yuichiro Kai, Takahiro Kambara, Yutaro Fujii, Yukio Takeshima
Article
Clinical Neurology
Ushio Yonezawa, Vega Karlowee, Vishwa Jeet Amatya, Takeshi Takayasu, Motoki Takano, Yukio Takeshima, Kazuhiko Sugiyama, Kaoru Kurisu, Fumiyuki Yamasaki
WORLD NEUROSURGERY
(2020)
Article
Pathology
Takahiro Kambara, Vishwa J. Amatya, Kei Kushitani, Rui Suzuki, Yutaro Fujii, Yuichiro Kai, Yoshihiro Miyata, Morihito Okada, Yukio Takeshima
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yusuke Takeishi, Takeshi Takayasu, Manish Kolakshyapati, Ushio Yonezawa, Vishwa Jeet Amatya, Motoki Takano, Akira Taguchi, Yukio Takeshima, Kazuhiko Sugiyama, Kaoru Kurisu, Fumiyuki Yamasaki
EUROPEAN JOURNAL OF RADIOLOGY
(2020)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Shumpei Onishi, Vishwa Jeet Amatya, Manish Kolakshyapati, Motoki Takano, Ushio Yonezawa, Akira Taguchi, Yoko Kaichi, Yukio Takeshima, Kazuo Awai, Kazuhiko Sugiyama, Kaoru Kurisu, Fumiyuki Yamasaki
EUROPEAN JOURNAL OF RADIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Motoki Takano, Yasuyuki Kinoshita, Kazuhiko Sugiyama, Manish Kolakshyapati, Takeshi Takayasu, Ushio Yonezawa, Akira Taguchi, Yuji Akiyama, Vishwa Jeet Amatya, Yukio Takeshima, Kaoru Kurisu, Fumiyuki Yamasaki
Summary: The study demonstrated that relative tumor blood flow (rTBF) obtained by ASL-PWI can be useful in differentiating between germinoma and non-germinomatous germ cell tumor (NGGCT), aiding in deciding the intensity of chemotherapy/radiotherapy.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Yuichiro Kai, Vishwa Jeet Amatya, Kei Kushitani, Takahiro Kambara, Rui Suzuki, Yutaro Fujii, Yasuhiro Tsutani, Yoshihiro Miyata, Morihito Okada, Yukio Takeshima
Summary: The study confirmed the expression of glypican-1 in lung squamous cell carcinoma as a novel positive diagnostic marker, with high sensitivity, specificity, and diagnostic accuracy compared to lung adenocarcinoma. Glypican-1 expression was found in all cases of lung squamous cell carcinoma, but only in a few cases of lung adenocarcinoma, making it a promising additional marker for differentiation between the two types.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Clinical Neurology
Akira Taguchi, Yasuyuki Kinoshita, Vishwa Jeet Amatya, Takeshi Takayasu, Motoki Takano, Ushio Yonezawa, Atsushi Tominaga, Yukio Takeshima, Kazuhiko Sugiyama, Fumiyuki Yamasaki
Summary: This retrospective study analyzed the complications of 100 patients with intraventricular and paraventricular tumors who underwent EB and/or ETV surgery. It was found that some patients developed intratumoral hemorrhage after ETV surgery. Physicians should be aware of the risk of postoperative intratumoral hemorrhage in patients with atypical teratoid/rhabdoid tumors undergoing ETV.
WORLD NEUROSURGERY
(2022)
Article
Medicine, General & Internal
Tomoaki Naka, Yutaka Hatanaka, Yukiko Tabata, Akira Takasawa, Hideo Akiyama, Yasuhiro Hida, Hiromi Okada, Kanako C. Hatanaka, Tomoko Mitsuhashi, Kei Kushitani, Vishwa Jeet Amatya, Yukio Takeshima, Kouki Inai, Kichizo Kaga, Yoshihiro Matsuno
Summary: A reverse translational approach was used to identify two potential MPM marker genes, PHGDH and TRIM29, from limited archival tissues. These markers may be useful for distinguishing between MPMs and PACs in immunohistochemical analysis based on their sensitivity and specificity.
Article
Cell Biology
Ihiro Endo, Vishwa Jeet Amatya, Kei Kushitani, Tetsuya Nakagiri, Kohei Aoe, Yukio Takeshima
Summary: This study identified miR-142-3p as significantly downregulated in mesothelioma cells, and demonstrated that it inhibits cell proliferation, migration, and invasion by targeting ITGAV. These findings suggest that the miR-142-3p/ITGAV axis is involved in tumor progression in malignant mesothelioma.
Meeting Abstract
Oncology
Vishwa J. Amatya, Kei Kushitani, Yukio Takeshima
Review
Clinical Neurology
Shumpei Onishi, Vishwa Jeet Amatya, Vega Karlowee, Yukio Takeshima, Kazuhiko Sugiyama, Kaoru Kurisu, Fumiyuki Yamasaki
PEDIATRIC NEUROSURGERY
(2020)
