Article
Multidisciplinary Sciences
Selda Tekiner, Gulsen Ceyhun Peker, Mine Ceylan Dogan
Summary: This study evaluated the health beliefs of relatively young individuals in Turkey regarding colorectal cancer screening before the screening age, finding that attitudes towards preventive health measures are mainly associated with age, gender, education level, and marital status.
Editorial Material
Medicine, General & Internal
John M. M. Carethers
Summary: A 56-year-old man with no significant medical history declined screening colonoscopy in the past but now wants a less invasive test due to his father's death from colorectal cancer. What is the next course of action?
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Jie Ping, Yaohua Yang, Wanqing Wen, Sun-Seog Kweon, Koichi Matsuda, Wei-Hua Jia, Aesun Shin, Yu-Tang Gao, Keitaro Matsuo, Jeongseon Kim, Dong-Hyun Kim, Sun Ha Jee, Qiuyin Cai, Zhishan Chen, Ran Tao, Min-Ho Shin, Chizu Tanikawa, Zhi-Zhong Pan, Jae Hwan Oh, Isao Oze, Yoon-Ok Ahn, Keum Ji Jung, Zefang Ren, Xiao-Ou Shu, Jirong Long, Wei Zheng
Summary: PRS constructed using East Asian-specific data showed better performance in predicting colorectal cancer risk compared to PRS constructed using European descendants data. Individuals in the highest 5% risk group had a 2.52-fold elevated risk of colorectal cancer compared to the medium risk group.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Enea Ferlizza, Rossella Solmi, Michela Sgarzi, Luigi Ricciardiello, Mattia Lauriola
Summary: Colorectal cancer (CRC) ranks as the third most common cancer worldwide, emphasizing the significance of early detection. Screening through fecal occult blood tests has shown to reduce CRC incidence and mortality, however, low participation rates and false positives are key challenges. Recent research has focused on new fecal tests, biomarkers, and liquid biopsy methods to enhance accuracy and participation in CRC screening.
Article
Public, Environmental & Occupational Health
Krishna P. Sharma, Amy DeGroff, Annette E. Maxwell, Allison M. Cole, Ngoc Cam Escoffery, Peggy A. Hannon
Summary: Client reminders, provider assessment and feedback, and colorectal cancer screening champions were found to be associated with increased clinic-level colorectal cancer screening rates according to this study. The universal implementation of these strategies can substantially increase colorectal cancer screening rates in the U.S.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Oncology
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
Summary: This study investigated the long-term survival effects of colorectal cancer screening based on screening history and interval time since screening. The results showed that colorectal cancer screening was positively associated with favorable prognosis, especially among individuals screened within 1 year before diagnosis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Aasma Shaukat, Charles J. Kahi, Carol A. Burke, Linda Rabeneck, Bryan G. Sauer, Douglas K. Rex
Summary: This article provides an update on the 2009 American College of Gastroenterology CRC screening guidelines and discusses detailed recommendations for CRC screening in average-risk individuals and those with a family history of CRC, as well as the role of aspirin for chemoprevention, quality indicators for colonoscopy, organized CRC screening approaches, and improving adherence to CRC screening. The optimization of CRC screening is essential to effectively reduce CRC incidence and mortality, which can be achieved through high rates of adherence, quality monitoring, evidence-based guidelines, and the removal of barriers throughout the care spectrum. Developing cost-effective, highly accurate, noninvasive modalities to improve overall adherence to the screening process is also a desirable goal.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Erica K. Barnell, Elizabeth M. Wurtzler, Julie La Rocca, Thomas Fitzgerald, Jessica Petrone, Yansheng Hao, Yiming Kang, Faith L. Holmes, David A. Lieberman
Summary: This study evaluated the sensitivity and specificity of a noninvasive multitarget stool RNA test for colorectal cancer and precancerous lesions. The results showed that the test had a sensitivity of 94% for detecting colorectal cancer and 46% for detecting advanced adenomas, with a specificity of 88%.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Gastroenterology & Hepatology
Marina Hanna, Neelendu Dey, William M. Grady
Summary: Colorectal cancer is a common cancer globally and is a leading cause of cancer-related deaths. Current screening methods for colorectal cancer have limitations and many people are not compliant with screening recommendations. Novel screening tests based on advances in molecular biology, genetics, and epigenetics, as well as sequencing technologies and computational analytic methods, have been developed to improve early detection of colorectal cancer.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Mireia Obon-Santacana, Anna Diez-Villanueva, Maria Henar Alonso, Gemma Ibanez-Sanz, Elisabet Guino, Ana Lopez, Lorena Rodriguez-Alonso, Alfredo Mata, Ana Garcia-Rodriguez, Andres Garcia Palomo, Antonio J. Molina, Montse Garcia, Gemma Binefa, Vicente Martin, Victor Moreno
Summary: Different risk-based colorectal cancer screening strategies, including the use of polygenic risk scores, have been evaluated to enhance effectiveness. This study assessed the utility of polygenic risk scores in a fecal immunochemical test-based screening program and found that while it plays a role along the CRC tumorigenesis pathway, its ability to stratify the general population or act as a second test after a positive FIT result remains uncertain.
Review
Gastroenterology & Hepatology
Aasma Shaukat, Theodore R. Levin
Summary: This Review provides an overview of current CRC screening options worldwide, including colonoscopy and stool-based tests. It also highlights the key features of each modality and describes new screening tests under development.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kohta Toshimitsu, Ai Takano, Masayuki Fujii, Kazuhiro Togasaki, Mami Matano, Sirirat Takahashi, Takanori Kanai, Toshiro Sato
Summary: This study establishes a drug screening platform for patient-derived colorectal cancer organoids and identifies the bromodomain and extra-terminal bromodomain protein inhibitor as a cancer-selective growth suppressor. It also discovers an association between checkpoint with forkhead and ring finger domaines silencing and paclitaxel sensitivity.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Joaquin Cubiella, Maria Lorenzo, Franco Baiocchi, Coral Tejido, Alejandro Conde, Maria Sande-Meijide, Margarita Castro
Summary: Implementing a CRC screening programme can reduce diagnostic delays for symptomatic patients with CRC, but it does not impact the stage of cancer or survival rates.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Medicine, General & Internal
Priyanka Kanth, John M. Inadomi
Summary: Mortality from colorectal cancer can be reduced through screening and early detection; current efforts and tools for screening have been advancing, but overall screening rates in the US are suboptimal.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Review
Gastroenterology & Hepatology
Hermann Brenner, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister
Summary: In the era of widespread uptake of screening colonoscopy, CRC incidence rates decreased by up to 50% in older age groups in the USA, despite adverse trends in CRC risk factors and increasing CRC incidence at younger ages. However, first results from a randomized trial suggest rather modest effects of screening colonoscopy. The apparent discrepancy between real-world and trial evidence can be explained by factors such as limited screening adherence, widespread uptake of colonoscopy outside the screening offers, and the inclusion of prevalent, non-preventable CRC cases in reported numbers of incident cases. Alternative interpretations of screening endoscopy trial results accounting for prevalence bias are in line with trends in countries offering CRC screening, and should encourage more widespread implementation and uptake of effective CRC screening.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Transplantation
Neal Shahidi, Vladimir Marquez Azalgara, Eric Yoshida
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2016)
Review
Gastroenterology & Hepatology
Neal Shahidi, Brian Bressler, Remo Panaccione
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2016)
Article
Gastroenterology & Hepatology
Robert A. Mitchell, Constantin Shuster, Neal Shahidi, Cherry Galorport, Mari L. DeMarco, Gregory Rosenfeld, Robert A. Enns, Brian Bressler
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2016)
Editorial Material
Gastroenterology & Hepatology
Michael F. Byrne, Neal Shahidi, Douglas K. Rex
Editorial Material
Gastroenterology & Hepatology
Neal Shahidi, Mayenaaz Sidhu, Iddo Bar-Yishay, Michael J. Bourke
Editorial Material
Gastroenterology & Hepatology
Neal Shahidi, Mayenaaz Sidhu, Iddo Bar-Yishay, Michael J. Bourke
GASTROINTESTINAL ENDOSCOPY
(2019)
Editorial Material
Gastroenterology & Hepatology
Neal Shahidi, Michael J. Bourke
GASTROINTESTINAL ENDOSCOPY
(2019)
Editorial Material
Gastroenterology & Hepatology
Neal Shahidi, Scott Schoeman, Michael J. Bourke
Letter
Gastroenterology & Hepatology
Neal Shahidi, Michael J. Bourke
Article
Gastroenterology & Hepatology
Neal Shahidi, Mayenaaz Sidhu, Sergei Vosko, W. Arnout van Hattem, Iddo Bar-Yishay, Scott Schoeman, David J. Tate, Bronte Holt, Luke F. Hourigan, Eric Y. T. Lee, Nicholas G. Burgess, Michael J. Bourke
Letter
Gastroenterology & Hepatology
Michael J. Bourke, Neal Shahidi, Steven J. Heitman
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Editorial Material
Gastroenterology & Hepatology
Neal Shahidi, Douglas K. Rex, Tonya Kaltenbach, Amit Rastogi, Sina Hamidi Ghalehjegh, Michael F. Byrne
Letter
Gastroenterology & Hepatology
Neal Shahidi, W. Arnout van Hattem, Michael J. Bourke
GASTROINTESTINAL ENDOSCOPY
(2020)
Editorial Material
Gastroenterology & Hepatology
Neal Shahidi, Mayenaaz Sidhu, W. Arnout van Hattem, Sergei Vosko, Michael J. Bourke
GASTROINTESTINAL ENDOSCOPY
(2020)
Review
Gastroenterology & Hepatology
Neal Shahidi, George Ou, Eric Lam, Robert Enns, Jennifer Telford
ENDOSCOPY INTERNATIONAL OPEN
(2017)