Article
Radiology, Nuclear Medicine & Medical Imaging
Zhen-Chong Yang, Ying-Ying Hu, Li-Ting Liu, Shan-Shan Guo, Chao-Chao Du, Yu-Jing Liang, Qiu-Yan Chen, Hai-Qiang Mai
Summary: By evaluating the post-PCT Deauville scores and EBV DNA levels of mNPC patients, it can be determined which patients would benefit from receiving DRT along with their existing PCT. According to the RPA analysis, patients in the low- and mid-risk groups had better survival rates when treated with PCT+DRT, while patients in the high-risk group did not experience the same benefits.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Jiyi Hu, Qingting Huang, Jing Gao, Weixu Hu, Jing Yang, Xiyin Guan, Xianxin Qiu, Wenna Zhang, Lin Kong, Jiade J. Lu
Summary: The study demonstrated that the combination of IMRT with CIRT boost therapy provides excellent disease control and favorable toxicity profile for patients with non-metastatic nasopharyngeal carcinoma. The results suggest that this mixed treatment strategy is safe and well-tolerated, with promising outcomes in terms of disease control.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Mei Lin, Xiao-Long Zhang, Xiong Zou, Rui You, Qi Yang, Xiong Zou, Kai Yu, You-Ping Liu, Ru-Hai Zou, Yi-Jun Hua, Pei-Yu Huang, Jin Wang, Qi Zhao, Xiao-Bing Jiang, Jun Tang, Yang-Kui Gu, Tao Yu, Gui-Ping He, Yu-Long Xie, Zhi-Qiang Wang, Ting Liu, Si-Yuan Chen, Zhi-Xiang Zuo, Ming-Yuan Chen
Summary: By sequencing samples from 26 nasopharyngeal carcinoma patients, it was found that NPC has a higher neoantigen load compared to other cancers. Neoantigen depletion was more severe in metastatic sites, with the reduction occurring during metastasis.
Article
Medicine, General & Internal
Shuo-Han Zheng, Song-Ran Liu, Hai-Bo Wang, Ying-Hong Wei, He Li, Guan-Nan Wang, Zi-Lu Huang, Shi-Rong Ding, Chen Chen, Ya-Lan Tao, Xiao-Hui Li, Christophe Glorieux, Peng Huang, Yang-Feng Wu, Yun-Fei Xia
Summary: The study suggests that the use of PFLL in the treatment of mNPC is associated with similar overall survival but prolonged subsequent-line, treatment-free survival compared to standard regimens. PFLL also shows a better survival to toxicity ratio compared to other regimens, indicating potentially less severe toxic effects. Therefore, PFLL may be a promising option for first-line treatment of mNPC.
Article
Dermatology
Ko-Chun Fang, Chih-Hung Lee, Hui-Ching Chuang, Tai-Lin Huang, Chih-Yen Chien, Wen-Ling Tsai, Fu-Min Fang
Summary: An observational study investigated the prognostic factors and treatment outcomes of acute radiation dermatitis (ARD) among nasopharyngeal carcinoma patients treated with proton beam therapy. The results showed habitual smoking and advanced nodal status as independent predictors of grade 2 and 3 ARD. Topical corticosteroid, silver sulfadiazine, and non-adhering silicone dressing were effective treatments for ARD induced by PBT.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Otorhinolaryngology
Zhen-Chong Yang, Mei-Juan Luo, Xue-Song Sun, Li-Ting Liu, Qiu-Yan Chen, Hai-Qiang Mai, Shan-Shan Guo
Summary: This study evaluated the suitability of radiation therapy and liver local therapy for patients with lmNPC. The results showed that radiation therapy may be beneficial for lmNPC patients regardless of the tumor response after chemotherapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Medicine, Research & Experimental
Renba Liang
Summary: This review provides a comprehensive summary of the clinical data of targeted therapy and immunotherapy for recurrent and/or metastatic nasopharyngeal carcinoma (RM-NPC), exploring the potential of these treatment options as viable alternatives.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Otorhinolaryngology
Hanchuan Xu, Lihu Lu, Tianzhu Lu, Yun Xu, Jingfeng Zong, Chaobin Huang, Fengjie Lin, Yahan Zheng, Cheng Lin, Senan Lin, Sufang Qiu, Jianji Pan, Shaojun Lin, Qiaojuan Guo
Summary: Additional locoregional radiation therapy (LRRT) can significantly improve overall survival (OS) in de novo metastatic nasopharyngeal carcinoma patients, especially those with oligometastatic diseases. However, the survival benefit is not observed in patients with polymetastatic disease, suggesting the need for intensive systemic treatment such as immunotherapy and adequate palliative chemotherapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Zhen-Chong Yang, Ting Liu, Yan-Zhou Chen, Chun-Yan Guo, Li-Ting Liu, Sai-Lan Liu, Qiu-Yan Chen, Hai-Qiang Mai, Shan-Shan Guo
Summary: Compared with PCT + DRT, first-line immunochemotherapy is associated with improved progression free survival and overall survival in patients with mNPC. However, the efficacy of first-line immunochemotherapy is not significant in patients with unfavorable tumor response and metastasis involving specific organs or multiple sites.
Article
Medicine, General & Internal
Yu Fang, Ning Su, Qihua Zou, Yi Cao, Yi Xia, Linquan Tang, Xiaopeng Tian, Panpan Liu, Qingqing Cai
Summary: The study found that anlotinib monotherapy showed promising anti-tumor activities and disease control for RM-NPC patients, with a tolerable toxicity profile.
Article
Oncology
Corey Smith, Margaret McGrath, Michelle A. Neller, Katherine K. Matthews, Pauline Crooks, Laetitia Le Texier, Benedict Panizza, Sandro Porceddu, Rajiv Khanna
Summary: This study presented a novel case report of a patient with metastatic nasopharyngeal carcinoma who was successfully treated with a combination of EBV-specific ACT and PD-1 blockade therapy, resulting in complete resolution of metastatic disease for 22 months. Follow-up immunological analysis showed significant restructuring of the global T-cell repertoire coincident with the clinical response, providing an important platform for further translating these findings to a larger cohort of NPC patients.
NPJ PRECISION ONCOLOGY
(2021)
Article
Otorhinolaryngology
Khodayar Goshtasbi, Brandon M. Lehrich, Jack L. Birkenbeuel, Arash Abiri, Jeremy P. Harris, Edward C. Kuan
Summary: The study investigated the treatment and outcome of nasopharyngeal carcinoma (NPC), revealing that survival is influenced by various clinical and sociodemographic factors. Optimal overall survival was found with chemoradiotherapy (CRT) or radiotherapy (RT) for different stages of NPC, with additional benefits seen in surgery plus CRT for certain patients. Patients of Asian/Pacific Islander race had better survival outcomes, while nonendemic histology cases were not well characterized.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Oncology
Y-J. Hu, T. -Z. Lu, H. Zhang, M. Fang, B. -J. Chen, Q. -J. Guo, S. -J. Lin, P. Feng, Y. Wang, T. -C. Jiang, X. -C. Gong, J. -J. Pan, J. -G. Li, Y. -F. Xia
Summary: Palliative chemotherapy combined with anti-PD-1 mAbs followed by LRRT improved the progression-free survival (PFS) in patients with de novo metastatic nasopharyngeal carcinoma (dmNPC), especially for patients with early Epstein-Barr virus DNA (EBV DNA) clearance.
Article
Oncology
Ying Lu, Zhou Jiang, Huan Lin, Hui Yang, Xishan Chen, Haixin Huang
Summary: This study found that S1-MT significantly improved the progression-free survival and overall survival of metastatic nasopharyngeal carcinoma patients. The status of EBV-DNA and SAA were closely associated with the effectiveness of S1-MT.
Article
Oncology
Chwee Ming Lim, Anthony Liou, Michelle Poon, Liang Piu Koh, Lip Kun Tan, Kwok Seng Loh, Bengt Fredrik Petersson, Eric Ting, Dario Campana, Boon Cher Goh, Noriko Shimasaki
Summary: The study demonstrated that combining cetuximab with autologous expanded NK cells in patients with recurrent and/or metastatic NPC is safe and showed promising clinical responses, with some patients achieving durable stable disease.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Soehartati A. Gondhowiardjo, Handoko, Ivan Tham, Angela Giselvania, Ramesh S. Bilimagga, Steven Octavianus, Masahiro Hiraoka, Vito Filbert Jayalie, Tomoaki Tamaki, Miriam Calaguas, Takashi Nakano
Summary: The delivery of high-quality cancer treatment in Asia, especially in terms of radiation therapy, faces challenges such as shortage of treatment centres and outdated technology. The Federation of Asian Organizations for Radiation Oncology (FARO) was established to address these issues through regional collaboration, aiming to improve treatment quality collectively. This organization has already achieved some early successes in fact-finding and educational activities, and looks towards future possibilities for strategic proposals that could benefit the radiation therapy community and patients in Asia.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guang Ma, Bingxin Gu, Jiyi Hu, Lin Kong, Jiangang Zhang, Zili Li, Yangbo Xue, Jiade Lu, Junning Cao, Jingyi Cheng, Yingjian Zhang, Shaoli Song, Zhongyi Yang
Summary: The study examined the value of pretreatment F-18-FDG uptake heterogeneity in predicting the prognosis of locally recurrent nasopharyngeal carcinoma (LRNPC) patients treated with carbon ion radiotherapy (CIRT). Results showed that F-18-FDG uptake heterogeneity, particularly with a HI>=0.81, was significantly associated with poorer LRFS and PFS outcomes, indicating its potential as an independent predictor for LRNPC patients undergoing CIRT.
ANNALS OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Wanzun Lin, Xianxin Qiu, Pian Sun, Yuling Ye, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: While successful clinical trials of immunotherapy have shown promising strategies for many cancers, its application in glioma has lagged behind compared to other cancers. This study focused on the molecular alterations affecting therapeutic response in lower-grade glioma (LGG) and characterized the immunological phenotypes with different molecular subtypes to improve our understanding and application of immunotherapies in LGG. The research collected data from 1,052 patients, stratified them into three genetic subgroups, and discovered distinct immunological tumor microenvironments associated with IDH mutations and 1p/19q codeletions in LGG, ultimately leading to the construction of an immune-related prognostic signature that predicts overall survival time in LGG.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Review
Cell Biology
Vivek Kumar, Mohit Vashishta, Lin Kong, Xiaodong Wu, Jiade J. Lu, Chandan Guha, B. S. Dwarakanath
Summary: Resistance to therapy is a major challenge in cancer management, with cancer cells rewiring their cellular processes to resist the deleterious effects of various therapeutic approaches. Understanding the role of developmental pathways in cancer and their contribution to resistance can lead to insights for developing novel therapeutic approaches. Recognizing the importance of molecular networks in overcoming drug resistance can provide a rational basis for improving cancer treatment with safer and more effective combined therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jian Chen, Jingfang Mao, Ningyi Ma, Kai-Liang Wu, Jiade Lu, Guo-Liang Jiang
Summary: The study evaluated the effects and toxicities of carbon ion radiotherapy in the management of tracheobronchial adenoid cystic carcinoma. Among 18 eligible patients, the 2-year overall survival, local control, and progression-free survival rates were 100%, 100%, and 61.4%, respectively, with an overall response rate of 88.2%. Only one patient experienced severe tracheal stenosis after CIRT, which was relieved after stent implantation.
Article
Immunology
Wanzun Lin, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: The study found that high expression of VMP1 in glioma patients is associated with faster disease progression and poorer prognosis. Depletion of VMP1 by CRISPR-Cas9 gene editing significantly inhibits cell proliferation, increases cell death, and induces cell cycle arrest. Knockout of VMP1 blocks autophagic flux and sensitizes glioma cells to radiotherapy and chemotherapy.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Oncology
Jiyi Hu, Qingting Huang, Jing Gao, Weixu Hu, Jing Yang, Xiyin Guan, Xianxin Qiu, Wenna Zhang, Lin Kong, Jiade J. Lu
Summary: The study demonstrated that the combination of IMRT with CIRT boost therapy provides excellent disease control and favorable toxicity profile for patients with non-metastatic nasopharyngeal carcinoma. The results suggest that this mixed treatment strategy is safe and well-tolerated, with promising outcomes in terms of disease control.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shubing Jia, Jian Chen, Ningyi Ma, Jingfang Zhao, Jingfang Mao, Guoliang Jiang, Jiade Lu, Kailiang Wu
Summary: This study demonstrates the dosimetric benefits of adaptive carbon ion radiotherapy (CIRT) for locally advanced non-small cell lung cancer (LANSCLC) and compares the differences between patients with and without adaptive plans. The results show that adaptive plans can ensure target coverage and reduce spinal cord dose. Patients with adaptive plans have larger tumor volumes and greater volume changes. iGTV volume changes and iGTV center movements are the main factors influencing adaptive planning.
Article
Oncology
Fangzhu Wan, Haojiong Zhang, Jiyi Hu, Li Chen, Shikai Geng, Lin Kong, Jiade J. Lu
Summary: This study identified miR-125a as highly expressed in normal nasopharyngeal epithelial tissue compared to nasopharyngeal carcinoma. It demonstrated that miR-125a inhibits the migration and vasculogenic mimicry (VM) formation in nasopharyngeal carcinoma cells, targeting TAZ. Additionally, artificial engineering of mesenchymal stem cells (MSCs) allowed the generation of miR-125a-overexpressing exosomes which attenuated VM formation and migration in nasopharyngeal carcinoma, providing a potential therapeutic approach.
FRONTIERS IN ONCOLOGY
(2022)
Article
Ophthalmology
Jingli Guo, Xianxin Qiu, Wenyi Tang, Gezhi Xu, Michael F. Moyers, Wei Ren, Ying Xing, Jin Gao, Jiayao Sun, Jiade Lu, Lin Kong, Wei Liu
Summary: The study demonstrates that PBI combined with IVC may help promote regression and closure of polyps in PCV, reduce central macular thickness, and improve BCVA with good safety profile after 12 months. Hence, PBI may be a useful adjuvant therapy for patients with refractory or recurrent PCV.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Oncology
Dong Yang, Weiwei Wang, Jiyi Hu, Weixu Hu, Xiyu Zhang, Xiaodong Wu, Jiade J. Lu, Lin Kong
Summary: This study investigated the feasibility of lattice radiotherapy (LRT) using proton or carbon-ion beams in the treatment of sinonasal malignancies. The results showed that proton and carbon-ion LRT plans can better protect critical organs compared to photon LRT plans, despite minimal differences in PVDR.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Robert L. Foote, Hirohiko Tsujii, Reiko Imai, Hiroshi Tsuji, Eugen B. Hug, Tatsuaki Kanai, Jiade J. Lu, Juergen Debus, Rita Engenhart-Cabillic, Anita Mahajan
Summary: As of December 31, 2020, there were 12 facilities in Asia and Europe providing carbon ion radiotherapy (CIRT) for cancer patients, with a total of 37,548 patients treated worldwide. The absence of CIRT facilities in the U.S. limits access to this treatment for American cancer patients and prevents their inclusion in phase III clinical trials, which are essential for FDA approval and insurance coverage. Overcoming this barrier would require establishing a limited number of CIRT facilities in the U.S.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Wanzun Lin, Jing Gao, Haojiong Zhang, Li Chen, Xianxin Qiu, Qingting Huang, Jiyi Hu, Lin Kong, Jiade J. Lu
Summary: This study classified lower-grade glioma (LGG) into inflammation-, low, -mid, and -high subtypes based on the inflammatory response, which have distinct clinicopathologic features, prognosis, and tumor microenvironment. An inflammation-related prognostic model was also established with strong predictive power for prognosis assessment.
INFLAMMATION AND REGENERATION
(2022)
Review
Oncology
Anna Lee, Sarin Kitpanit, Marina Chilov, Johannes A. Langendijk, Jiade Lu, Nancy Y. Lee
Summary: This study systematically reviewed the literature on proton therapy in nasopharyngeal cancer patients, finding that proton therapy can maintain good treatment outcomes while reducing toxic dose to normal tissues. Compared with intensity-modulated radiation therapy, proton therapy showed lower rates of feeding tube and mucositis, indicating an improved toxicity profile in NPC patients.
INTERNATIONAL JOURNAL OF PARTICLE THERAPY
(2021)
Article
Oncology
Cihang Bao, Yun Sun, Bilikere Dwarakanath, Yuanli Dong, Yangle Huang, Xiaodong Wu, Chandan Guha, Lin Kong, Jiade J. Lu
Summary: This study revealed that carbon ion could induce necroptosis in nasopharyngeal carcinoma cells, especially in photon-resistant cells, and the mechanisms involve the regulation of BCL-x.