Article
Chemistry, Analytical
Thomas G. Kontou, Charli Sargent, Gregory D. Roach
Summary: This laboratory-based study examined the effect of sleep restriction on glucose regulation during nighttime sleep. The results showed that sleep restriction did not cause elevated glucose levels during sleep, but further research is needed to determine if increased insulin is required to maintain normal blood glucose levels.
Article
Clinical Neurology
Michelle E. Stepan, Erik M. Altmann, Kimberly M. Fenn
Summary: Short naps may not mitigate the effects of sleep deprivation on cognitive processing, longer naps may be necessary. However, in participants who took naps, more time spent in slow-wave sleep was associated with reduced performance deficits.
Article
Clinical Neurology
Simon J. Schreiner, Esther Werth, Leonie Ballmer, Philipp O. Valko, Kai M. Schubert, Lukas L. Imbach, Christian R. Baumann, Angelina Maric, Heide Baumann-Vogel
Summary: This study found that excessive daytime sleepiness (EDS) in Parkinson disease (PD) is associated with nocturnal sleep disturbance, as indicated by reduced overnight slow-wave activity (SWA) decline and reduced spindle frequency activity.
Article
Veterinary Sciences
Caroline M. M. Loos, Kristine L. Urschel, Eric S. Vanzant, Erin L. Oberhaus, Adam D. Bohannan, James L. Klotz, Kyle R. McLeod
Summary: The study examined the effects of the synthetic ergot alkaloid bromocriptine on glucose and lipid metabolism in insulin dysregulated and non-insulin dysregulated mares. The results showed that bromocriptine treatment reduced insulin sensitivity in all horses and had an impact on their metabolism.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Clinical Neurology
Michelle E. Stepan, Erik M. Altmann, Kimberly M. Fenn
Summary: Studies on the impact of brief naps on cognitive processing found that longer nap times may be necessary to mitigate impairments caused by sleep deprivation, but spending more time in slow-wave sleep was associated with improved memory consolidation in participants who napped.
Review
Clinical Neurology
Jennifer M. Johnson, Simon J. Durrant, Graham R. Law, Joao Santiago, Eleanor M. Scott, Ffion Curtis
Summary: Poor glycaemic control in diabetes is associated with sleep quality and specific sleep stages, but the exact relationship remains unclear. This systematic review found that disruption of slow-wave sleep (SWS) is associated with increased insulin resistance, while fasting or post-prandial glucose or insulin levels are not significantly affected. Further research is needed to explore mechanisms and potential interventions for optimizing sleep stage disruption and enhancement.
Article
Physiology
Robin K. Yuan, Kirsi-Marja Zitting, Jeanne F. Duffy, Nina Vujovic, Wei Wang, Stuart F. Quan, Elizabeth B. Klerman, Frank A. J. L. Scheer, Orfeu M. Buxton, Jonathan S. Williams, Charles A. Czeisler
Summary: Insufficient sleep and circadian disruption can affect metabolism, with research showing that sleep restriction may impact metabolism through concurrent circadian disruption. When circadian disruption is minimized, the adverse effects of insufficient sleep on glycemic control may be attenuated.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Bin Wang, Haojie Zhang, Ying Sun, Xiao Tan, Jihui Zhang, Ningjian Wang, Yingli Lu
Summary: This study aimed to investigate whether the association between sleep patterns and cardiovascular disease (CVD) risk differs according to glucose tolerance status. The findings showed a significant interaction between sleep score and glucose tolerance status on CVD outcomes. The risk of CVD associated with a poor sleep pattern was exacerbated among individuals with glucose intolerance.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Neurosciences
Aileen Seidler, Katy Sarah Weihrich, Frederik Bes, Jan de Zeeuw, Dieter Kunz
Summary: This study investigated the seasonal variation in objective sleep measures in a cohort of patients living in an urban environment. The results showed longer sleep duration and shorter REM-sleep latency during winter. The findings suggest that there is a seasonal variation in sleep architecture even in individuals with sleep disturbances living in an urban environment.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Seyyed Mostafa Arabi, Leila Sadat Bahrami, Narges Milkarizi, Mohsen Nematy, Vladislav Kalmykov, Amirhossein Sahebkar
Summary: This study analyzed eight randomized controlled trials and found that walnut consumption can reduce serum triglyceride levels in individuals with metabolic syndrome, but it has no significant effect on other cardiometabolic indices. Further well-designed and large-scale studies are needed to further explore the beneficial effects of walnut consumption on cardiometabolic profile.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Clinical Neurology
Andras Bikov, Sebastien Bailly, Dries Testelmans, Francesco Fanfulla, Athanasia Pataka, Izolde Bouloukaki, Holger Hein, Zoran K. Dogas, Ozen Basoglu, Richard Staats, Gianfranco Parati, Carolina Lombardi, Ludger Grote, Stefan Mihaicuta, ESADA Study Grp
Summary: Periodic limb movements during sleep may be an additional risk factor for cardiovascular disease in patients with obstructive sleep apnea, as it is associated with dyslipidemia. This study aimed to determine the impact of periodic limb movements during sleep on serum lipid levels in obstructive sleep apnea patients.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Cell Biology
Seyed Amirhossein Tabatabaei Dakhili, Kunyan Yang, Cassandra A. A. Locatelli, Christina T. Saed, Amanda A. Greenwell, Jordan S. F. Chan, Jadin J. Chahade, Jared Scharff, Shahad Al-Imarah, Farah Eaton, Peter A. Crawford, Keshav Gopal, Erin E. Mulvihill, John R. Ussher
Summary: Acute elevations in circulating ketones improve glucose tolerance in obesity, independent of muscle ketone oxidation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Health Care Sciences & Services
Andrea Foppiani, Fabiana Ciciriello, Arianna Bisogno, Silvia Bricchi, Carla Colombo, Federico Alghisi, Vincenzina Lucidi, Maria Ausilia Catena, Mariacristina Lucanto, Andrea Mari, Giorgio Bedogni, Alberto Battezzati
Summary: This study aimed to describe the distribution and provide reference quartiles of OGTT-related variables in the Italian cystic fibrosis population. The results showed the deterioration of glucose tolerance and insulin secretion with age according to sex and pancreatic insufficiency, highlighting a deviation from linearity for patients 35 years of age.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Zoology
Ziyue Qin, Ali Mujtaba Shah, Qing Zhu, Yan Wang, Diyan Li, Gang Shu, Yaofu Tian, Xiaoling Zhao
Summary: This study aimed to evaluate the genotypic effect on glucose homeostasis in chickens, and assessed the blood glucose concentration in fast-growing and slow-growing broilers through OGTT and IST tests. The results showed that the growth speed significantly affected the oral glucose tolerance and hypoglycemic response to insulin in chickens.
PAKISTAN JOURNAL OF ZOOLOGY
(2022)
Article
Multidisciplinary Sciences
Bandish Kapadia, Soma Behera, Sireesh T. Kumar, Tapan Shah, Rebecca Kristina Edwin, Phanithi Prakash Babu, Partha Chakrabarti, Kishore V. L. Parsa, Parimal Misra
Summary: This study found that PIMT expression was upregulated in the livers of short-term fasted and obese mice. Modulating PIMT directly affected gluconeogenic gene expression and hepatic glucose output. Further investigations revealed that PKA regulated PIMT through phosphorylation and enhanced translation of TGS1 mRNA, thus promoting gluconeogenesis.
Article
Cardiac & Cardiovascular Systems
Mathieu Berger, Vincent Pichot, Geoffroy Solelhac, Pedro Marques-Vidal, Jose Haba-Rubio, Peter Vollenweider, Gerard Waeber, Martin Preisig, Jean-Claude Barthelemy, Frederic Roche, Raphael Heinzer
Summary: This study aimed to evaluate the association between nocturnal HRV and cardiovascular disease incidence. The results showed that novel HRV parameters such as AC, DC, and HRF during the night were better predictors of CVD events than traditional HRV parameters.
Article
Medicine, General & Internal
Virginie Bayon, Mathieu Berger, Geoffroy Solelhac, Jose Haba-Rubio, Pedro Marques-Vidal, Marie-Pierre Strippoli, Martin Preisig, Damien Leger, Raphael Heinzer
Summary: There is an association between work schedules and metabolic syndrome and its components. Men who work permanent night shifts have a higher risk of metabolic syndrome, while women who work night shifts have a higher risk of elevated triglyceride levels.
Article
Nutrition & Dietetics
Pedro Marques-Vidal, Romain Schaller, Peter Vollenweider, Gerard Waeber, Idris Guessous, Jose Haba-Rubio, Raphaeel Heinzer
Summary: This study examined the association between sleep duration and dietary intake. The results showed little to no association between objectively measured sleep duration and dietary intake in a Swiss general adult population. However, there may be differences in the intake of certain nutrients.
CLINICAL NUTRITION ESPEN
(2022)
Article
Clinical Neurology
Jari K. Gool, Zhongxing Zhang, Martijn S. S. L. Oei, Stephanie Mathias, Yves Dauvilliers, Geert Mayer, Giuseppe Plazzi, Rafael del Rio-Villegas, Joan Santamaria Cano, Karel Sonka, Markku Partinen, Sebastiaan Overeem, Rosa Peraita-Adrados, Raphael Heinzer, Antonio Martins da Silva, Birgit Hoegl, Aleksandra Wierzbicka, Anna Heidbreder, Eva Feketeova, Mauro Manconi, Jitka Buskova, Francesca Canellas, Claudio L. Bassetti, Lucie Barateau, Fabio Pizza, Markus H. Schmidt, Rolf Fronczek, Ramin Khatami, Gert Jan Lammers
Summary: In this study, data-driven algorithms were used to identify distinct patient subgroups within the population of central disorders of hypersomnolence. The results challenge the inclusion of sleep-onset REM periods in diagnostic criteria for individuals without cataplexy and provide new variables for more reliable diagnostic categories that better represent different patient phenotypes.
Article
Clinical Neurology
Jacob L. Edelson, Logan D. Schneider, David Amar, Andreas Brink-Kjaer, Katie L. Cederberg, Zoltan Kutalik, Erika W. Hagen, Paul E. Peppard, Priscila Farias Tempaku, Sergio Tufik, Daniel S. Evans, Katie Stone, Greg Tranah, Brian Cade, Susan Redline, Jose Haba-Rubio, Raphael Heinzer, Pedro Marques-Vidal, Peter Vollenweider, Juliane Winkelmann, James Zou, Emmanuel Mignot
Summary: A genome-wide association study discovered two genetic loci that were significantly associated with periodic limb movements in sleep. These movements were found to be genetically correlated with restless leg syndrome, insomnia, and risk of stroke, but not with iron deficiency. Causal effect of restless leg syndrome on periodic limb movements in sleep was identified through analysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rudy Rizzo, Martyna Dziadosz, Sreenath P. Kyathanahally, Amirmohammad Shamaei, Roland Kreis
Summary: The purpose of this work is to optimize quantification in MR spectroscopy by exploring deep learning architectures, spectroscopic input types, and learning designs. Simulated pathological spectra are used to train and test 24 different deep learning architectures, and active learning through altered data distributions is used to improve performance. It is found that a combination of 1D frequency-domain and 2D time-frequency domain spectrograms as input in heterogeneous networks performs the best.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Respiratory System
Georgia Mitropoulou, Raphael Heinzer, Jean-Paul Janssens, Christophe von Garnier, Maura Prella
Summary: This study reported the real-life experience of adult patients using MI-E devices at home and identified factors associated with its use. Regular home use of MI-E was associated with increased symptom burden and overall satisfaction with the device, and it was not influenced by baseline cough peak flow, bulbar impairment, or non-invasive ventilation use.
Letter
Critical Care Medicine
Geoffroy Solelhac, Manuel Sanchez-de-la-Torre, Margaux Blanchard, Ferran Barbe, Frederic Gagnadoux, Raphael Heinzer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martyna Dziadosz, Rudy Rizzo, Sreenath P. Kyathanahally, Roland Kreis
Summary: This article investigates the application of machine learning and deep learning in improving the signal-to-noise ratio (SNR) of magnetic resonance spectroscopy (MRS) measurements. The results show that although the denoising techniques have visually appealing effects, they have biases in quantitative evaluations.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Clinical Neurology
Dario Pfyffer, Sandra Zimmermann, Kadir Simsek, Roland Kreis, Patrick Freund, Maryam Seif
Summary: There were no significant differences in memory performance, metabolic concentrations, and hippocampal volume between SCI patients and healthy controls, suggesting that chronic SCI may not have a significant and clinically relevant impact on hippocampal function, metabolism, and macrostructure.
FRONTIERS IN NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Aboubakari Nambiema, Quentin Lisan, Julien Vaucher, Marie-Cecile Perier, Pierre Boutouyrie, Nicolas Danchin, Frederique Thomas, Catherine Guibout, Geoffroy Solelhac, Raphael Heinzer, Xavier Jouven, Pedro Marques-Vidal, Jean-Philippe Empana
Summary: The study found that higher healthy sleep scores and improvement over time were associated with a lower risk of coronary heart disease and stroke in the community.
EUROPEAN HEART JOURNAL
(2023)
Article
Biophysics
Rudy Rizzo, Roland Kreis
Summary: The study aimed to develop a new single-voxel MR spectroscopy acquisition scheme for simultaneous determination of metabolite-specific concentrations and transverse relaxation times within realistic clinical scan times. The novel scheme, called multi-echo single-shot (MESS), acquired partly truncated multi-TE data as an echo train in a single acquisition and used a 2D multiparametric model fitting approach to estimate concentration and T-2 for major brain metabolites. Compared with traditional multi-echo multi-shot methods, MESS provided valid estimates with improvements ranging from 5% to 30% for T(2)s and from 10% to 50% for concentrations. However, the reproducibility of MESS may be hampered by unsuppressed water signals.
NMR IN BIOMEDICINE
(2023)
Article
Clinical Neurology
Raphaela Muri, Stephanie Maissen-Abgottspon, Murray Bruce Reed, Roland Kreis, Maike Hoefemann, Piotr Radojewski, Katarzyna Pospieszny, Michel Hochuli, Roland Wiest, Rupert Lanzenberger, Roman Trepp, Regula Everts
Summary: Despite increasing knowledge about the effects of phenylketonuria on brain structure and function, it is uncertain whether white matter microstructure is affected and if it is linked to patients' metabolic control or cognitive performance. This study quantitatively assessed white matter characteristics in adults with phenylketonuria and their relationship to brain and blood phenylalanine levels, historical metabolic control, and cognitive performance.
BRAIN COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Clemence Ligneul, Chloe Najac, Andre Doring, Christian Beaulieu, Francesca Branzoli, William T. Clarke, Cristina Cudalbu, Guglielmo Genovese, Saad Jbabdi, Ileana Jelescu, Dimitrios Karampinos, Roland Kreis, Henrik Lundell, Malgorzata Marjanska, Harald E. Moeller, Jessie Mosso, Eloise Mougel, Stefan Posse, Stefan Ruschke, Kadir Simsek, Filip Szczepankiewicz, Assaf Tal, Chantal Tax, Georg Oeltzschner, Marco Palombo, Itamar Ronen, Julien Valette
Summary: Brain cell structure and function reflect neurodevelopment, plasticity, and aging, and can help identify pathological processes. Noninvasively unraveling cellular structural features is important in brain research. Diffusion-weighted MRS remains a challenging technique in data acquisition, analysis, quantification, modeling, and interpretation.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Clinical Neurology
Eric Albrecht, Pedro Pereira, Virginie Bayon, Mathieu Berger, Julien Wegrzyn, Alexander Antoniadis, Raphael Heinzer
Summary: There was no significant difference in the severity of sleep apnea between oral oxycodone and tramadol on the first postoperative night after hip arthroplasty.
NATURE AND SCIENCE OF SLEEP
(2022)