期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 99, 期 2, 页码 392-399出版社
AMER SOC NUTRITION-ASN
DOI: 10.3945/ajcn.113.072066
关键词
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资金
- National Heart, Lung, and Blood Institute [HL071981]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK091718]
- General Clinical Research Center [RR-02635]
- Boston Obesity Nutrition Research Center [DK46200]
- United States Israel Binational Science Foundation [2011036]
- American Heart Association Scientist Development [0730094N]
Background: Circadian rhythm has been shown to be related to glucose metabolism and risk of diabetes, probably through effects on energy balance. Recent genome-wide association studies identified variants in circadian rhythm related genes (CRY2 and MTNRIB) associated with glucose homeostasis. Objective: We tested whether CRY2 and MTNR1B genotypes affected changes in measures of energy expenditure in response to a weight-loss diet intervention in a 2-y randomized clinical trial, the POUNDS (Preventing Overweight Using Novel Dietary Strategies) LOST Trial. Design: The variants CRY2 rs11605924 (n = 721) and MTNR1B rs10830963 (n = 722) were genotyped in overweight or obese adults who were randomly assigned to 1 of 4 weight-loss diets that differed in their proportions of macronutrients. Respiratory quotient (RQ) and resting metabolic rate (RMR) were measured. Results: By 2 y of diet intervention, the A allele of CRY2 rs11605924 was significantly associated with a greater reduction in RQ (P = 0.03) and a greater increase in RMR and RMR/kg (both P = 0.04). The G allele of MTNR1B rs10830963 was significantly associated with a greater increase in RQ (P = 0.01) but was not related to changes in RMR and RMR/kg. In addition, we found significant gene-diet fat interactions for both CRY2 (P-interaction = 0.02) and MTNRIB (P-interaction < 0.001) in relation to 2-y changes in RQ. Conclusions: Our data indicate that variant in the circadian-related genes CRY2 and MTNR1B may affect long-term changes in energy, expenditure, and dietary fat intake may modify the genetic effects.
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