Review
Gastroenterology & Hepatology
Alla Turshudzhyan, David C. Wu, George Y. Wu
Summary: Iron homeostasis is a complex process involving tightly balanced iron uptake and use. HFE gene mutations are the major cause of primary Type 1 hemochromatosis, while non-HFE hemochromatosis involves other genes such as HJV, HAMP, TFR2, and SLC40A1. Non-HFE hemochromatosis is rare but can cause severe iron overload. Diagnosis is made by ruling out HFE mutations and assessing history, physical examination, laboratory values, imaging, and liver biopsy if necessary. Early treatment with phlebotomy is important to prevent irreversible damage and chronic liver disease.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Christine Fischer, Chiara Volani, Timea Komlodi, Markus Seifert, Egon Demetz, Lara Valente de Souza, Kristina Auer, Verena Petzer, Laura von Raffay, Patrizia Moser, Erich Gnaiger, Guenter Weiss
Summary: This study investigates the effects of dietary and genetic iron overload on mitochondrial function, revealing that iron accumulation promotes ROS production and impairs mitochondrial respiratory capacity. Differences in response to iron overload were observed in wildtype and genetic hemochromatosis model mice, suggesting the potential for iron reduction therapy to improve mitochondrial function.
Editorial Material
Hematology
Nermi L. Parrow, Robert E. Fleming
Summary: In this study, the researchers found that the hemochromatosis protein HFE is necessary for the involvement of hepatocellular transferrin receptor 1 (TFR1) in the regulation of iron metabolism and erythropoiesis. This regulation is crucial for maintaining iron balance and normal red blood cell production. The disruption of this regulation contributes to iron-loading anemias and erythropoietin resistance. The identification of the sensors responsible for these processes provides potential targets for therapeutic interventions.
Review
Food Science & Technology
Thaisa Agrizzi Verediano, Nikita Agarwal, Mariana Juste Contin Gomes, Hercia Stampini Duarte Martino, Elad Tako
Summary: A systematic review on the effects of dietary fiber on iron absorption and iron status-related biomarkers found no significant correlations between the consumption of dietary fiber and iron absorption/biomarkers. However, the current evidence may not be substantial enough to invalidate the recommendation of dietary fiber as an agent to improve dietary iron bioavailability. Further clinical trials focusing on populations at high risk for iron deficiency are needed.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Nutrition & Dietetics
Sheran Guo, Gabriella L. L. Shaoni, Wendy A. Stuart-Smith, Alyse J. Davies, Janelle A. Gifford
Summary: This systematic review aims to synthesize the literature on the dietary intakes of masters athletes (MAs) and compare them to younger and older MAs as well as the general population. The review found that energy intake was higher for older MAs compared to the general population, while younger male MAs had higher energy and macronutrient intakes. Micronutrient intake was also found to be higher in MAs compared to the general population. However, it was noted that younger female MAs may restrict or misreport energy intake, requiring further investigation. This study emphasizes the need for comprehensive assessments of dietary intake in masters athletes to evaluate the impact on their health.
Article
Biochemistry & Molecular Biology
Paul Knoop, Dilay Yilmaz, Rossana Paganoni, Peter Steele-Perkins, Andreas Gruber, Banu Akdogan, Hans Zischka, Kerstin Leopold, Maja Vujic Spasic
Summary: Mutations in the HFE/Hfe gene cause Hereditary Hemochromatosis (HH), characterized by iron deposition. HFE acts in hepatocytes and myeloid cells to regulate iron homeostasis. However, HFE actions in liver-resident macrophages seem to be dispensable for cellular, hepatic, and systemic iron regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Emmanuelle Albalat, Thibault Cavey, Patricia Leroyer, Martine Ropert, Vincent Balter, Olivier Loreal
Summary: Hereditary hemochromatosis is a genetic iron overload disease caused by a mutation in the HFE gene. Using Hfe(-/-) mice, this study found that the concentration of iron and stable isotope composition increased in the liver and red blood cells, but not in the spleen. The results suggest that the increase in whole blood isotope composition in hemochromatosis patients is mainly due to the release of heavy isotope-enriched iron from the liver, rather than increased dietary iron absorption.
FRONTIERS IN MEDICINE
(2021)
Review
Nutrition & Dietetics
Rohil S. Bhatnagar, Olga Padilla-Zakour
Summary: Although malnutrition rates have decreased in India over the past decade due to government interventions, anemia prevalence remains high. The high prevalence is not solely attributed to iron deficiency, as staple foods rich in iron are poorly absorbed due to phytates. Iron supplementation is the common intervention, but its effectiveness is limited by low compliance and irregular supplies.
Review
Clinical Neurology
Arman Arab, Elham Karimi, Marta Garaulet, Frank A. J. L. Scheer
Summary: The objective of this systematic review was to examine the association between social jetlag and diet using observational studies. A total of 17 studies with a sample size of 28,905 were included in the review. The findings suggest a negative association between social jetlag and adherence to healthy eating habits, while the results regarding specific food groups and nutrients were mixed and controversial.
SLEEP MEDICINE REVIEWS
(2023)
Article
Medicine, Research & Experimental
Shuolin Cui, Zhi Liu, Tamas Nagy, Elizabeth Oladoyin Agboluaje, May P. Xiong
Summary: Hereditary hemochromatosis (HH) is a genetic iron overload disease that results in excessive cellular iron accumulation due to the inability to regulate dietary iron absorption. This study investigates the use of non-absorbable polymer-deferoxamine (DFO) conjugates as an alternative strategy to reduce iron absorption. The conjugates were synthesized and their properties, transit times in the gut, safety, and efficacy at reducing iron absorption were evaluated. The results showed that nanometer-sized polymer-DFO conjugates were orally non-absorbable, safe, and more effective at reducing dietary iron absorption when taken with non-heme containing food.
MOLECULAR PHARMACEUTICS
(2023)
Review
Nutrition & Dietetics
Kirrilly M. Pursey, Janelle Skinner, Mark Leary, Tracy Burrows
Summary: This review examines the association between addictive eating and nutrients, foods, and dietary patterns. The findings suggest that foods high in fat and refined carbohydrates are commonly associated with addictive eating. Individuals with addictive eating tend to have higher intakes of energy, carbohydrates, and fats compared to those without addictive eating. However, due to the heterogeneity among studies, it is challenging to determine if specific foods or dietary patterns facilitate the addictive process. Further research is needed to explore potential associations. In the meantime, personalized dietary advice targeting foods high in fat and refined carbohydrates could be incorporated into current treatment approaches for addictive eating.
Review
Nutrition & Dietetics
Janika Shah, Zi Yu Cheong, Bingyao Tan, Damon Wong, Xinyu Liu, Jacqueline Chua
Summary: This systematic review comprehensively summarizes the current understanding of the associations between dietary consumption, diabetic retinopathy (DR), and diabetic macular edema (DME). The review found that higher intakes of fruits, vegetables, dietary fibers, fish, a Mediterranean diet, oleic acid, and tea were protective against DR, while high intakes of diet soda, caloric intake, rice, and choline were associated with a higher risk of DR. There was no association between vitamin C, riboflavin, vitamin D, milk, and DR. A single study assessed dietary intake and DME, and found a risk of high sodium intake for DME progression.
Review
Nutrition & Dietetics
Hossein Shahinfar, Ahmad Jayedi, Sakineh Shab-Bidar
Summary: Higher heme iron intake is associated with an increased risk of type 2 diabetes, with a 16% higher risk for each 1 mg/day increment in heme iron intake.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Nutrition & Dietetics
Tessa Delaney, Matthew Mclaughlin, Alix Hall, Sze Lin Yoong, Alison Brown, Kate O'Brien, Julia Dray, Courtney Barnes, Jenna Hollis, Rebecca Wyse, John Wiggers, Rachel Sutherland, Luke Wolfenden
Summary: This review aims to describe the association between DHI engagement and dietary intake. Seven studies were included from a systematic search of 10,653 citations, with mixed evidence regarding the association between usage measures and subjective experiences with dietary intake. Further research on the relationship between DHI engagement and dietary intake is warranted.
Review
Nutrition & Dietetics
Allanah Leed, Emma Sheridan, Brooke Baker, Sara Bamford, Elana Emmanouilidis, Fletcher Stewart, Kristen Ostafe, Mustafa Sarwari, Karen Lim, Miaobing Zheng, Sheikh Mohammed Shariful Islam, Kristy A. Bolton, Carley A. Grimes
Summary: Arterial stiffness, a risk factor for cardiovascular disease, is influenced by diet. However, limited research has been conducted on how dietary factors contribute to arterial stiffness in children. This review analyzed 19 studies and found inconsistent results regarding the association between diet and arterial stiffness. Only two intervention studies showed a protective effect of vitamin D and omega-3 supplementation on arterial stiffness in adolescents. Further longitudinal and intervention studies are needed to confirm these associations.
Article
Hematology
Cornelia Speich, Rita Wegmueller, Gary M. Brittenham, Christophe Zeder, Colin Cercamondi, Daniela Buhl, Andrew M. Prentice, Michael B. Zimmermann, Diego Moretti
Summary: This study presents the first measurements of long-term iron absorption and loss during iron supplementation in African children using a stable isotope of iron (Fe-57). The results showed that both iron absorption and loss significantly increased during the supplementation period, with most of the absorbed iron being lost.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Hematology
Simone Buerkli, Sung-Nan Pei, Shu-Chen Hsiao, Chien-Te Lee, Christophe Zeder, Michael B. Zimmermann, Diego Moretti
Summary: The study shows that the TMPRSS6 rs855791 (2321 C>T) polymorphism affects iron status and oral iron absorption in Taiwanese women, potentially increasing the risk of iron deficiency.
Article
Nutrition & Dietetics
Cornelia Speich, Comlan Evariste S. Mitchikpe, Colin Cercamondi, Christophe Zeder, Gary M. Brittenham, Diego Moretti, Michael B. Zimmermann
Summary: Long-term isotopic dilution measurements of body iron provide a more accurate quantification of basal body iron balance and iron gains during an iron intervention compared to conventional iron indices. The study revealed that Beninese women had lower long-term dietary iron absorption and higher iron losses preintervention compared to Swiss women, but both groups showed similar iron gains during iron supplementation.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Hematology
Colin Cercamondi, Nicole U. Stoffel, Diego Moretti, Thomas Zoller, Dorine W. Swinkels, Christophe Zeder, Francis Mhimibra, Jerry Hella, Lukas Fenner, Michael B. Zimmermann
Summary: Anemia of inflammation is a common feature in tuberculosis patients, with elevated levels of erythroferrone unable to suppress hepcidin. Iron absorption remains negligible during tuberculosis treatment, but improves significantly after completion of treatment, indicating that supplementation should be considered for patients remaining anemic post-treatment.
Article
Nutrition & Dietetics
Cornelia Speich, Gary M. Brittenham, Colin Cercamondi, Christophe Zeder, Thandile Nkosi-Gondwe, Kamija S. Phiri, Diego Moretti, Michael B. Zimmermann
Summary: The study showed that WHO/FAO iron requirements are adequate for healthy iron-sufficient children in rural Malawi, but iron-deficient children require additional bioavailable iron to correct their iron deficit. Iron absorption was not increased in iron-deficient children to correct their iron deficit, likely due to a lack of bioavailable dietary iron.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Rafal Mazgaj, Pawel Lipinski, Mateusz Szudzik, Aneta Jonczy, Zuzanna Kopec, Adrian M. Stankiewicz, Marian Kamyczek, Dorine Swinkels, Beata Zelazowska, Rafal R. Starzynski
Summary: The study found that Sucrosomial iron (SI) emerges as a promising nutritional iron supplement with high potential to correct IDA in piglets. Different iron preparations had varying effectiveness in combating IDA, but none showed signs of iron toxicity, increased hepcidin expression, or alterations in ferroportin protein level. Analysis of piglet gut microbiota indicated individual patterns of bacterial diversity were independent of the type of supplementation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Laura E. Diepeveen, Gaby Stegemann, Erwin T. Wiegerinck, Rian Roelofs, Myrthe Naber, Olivier Loreal, Bart Smeets, Frank Thevenod, Dorine W. Swinkels, Rachel P. L. van Swelm
Summary: Hemolysis can cause acute kidney injury, and the iron regulatory hormone hepcidin plays a protective role during this process. The synthesis of renal hepcidin is induced by iron and hemin through the Nrf2 pathway. Kidney-specific mechanisms of hepcidin regulation exist, highlighting the complexity of iron regulatory mechanisms during AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Mary A. Uyoga, Glory Mzembe, Nicole U. Stoffel, Diego Moretti, Christophe Zeder, Kamija Phiri, Magalie Sabatier, Nicholas P. Hays, Michael B. Zimmermann, Martin N. Mwangi
Summary: Compared to infant cereals based on refined grains, infant cereals containing whole grains and pulses may provide a healthier source of well-absorbed iron. However, the iron absorption from these cereals is still uncertain.
JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Pornpimol Scheuchzer, Michael B. Zimmerman, Christophe Zeder, Antoni Sanchez-Ferrer, Diego Moretti
Summary: This study aimed to assess the effects of different processing temperatures on the starch microstructure, iron solubility, and iron bioavailability of extruded iron-fortified rice. The results showed that warm and hot extrusion altered the starch morphology but did not significantly affect iron solubility or bioavailability. However, the addition of citric acid and trisodium citrate significantly increased iron absorption.
JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Simone Buerkli, Laura Salvioni, Natalie Koller, Christophe Zeder, Maria Jose Teles, Graca Porto, Jana Helena Habermann, Irina Lea Dubach, Florence Vallelian, Beat M. Frey, Diego Moretti, Jeannine Baumgartner, Michael B. Zimmermann
Summary: This study developed a natural polyphenol supplement and evaluated its effect on non-heme iron absorption in patients with HH. The results showed that the supplement can reduce dietary iron absorption and potentially decrease iron accumulation in patients with HH.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Bellam H. Rajashekar Reddy, Prashanth Thankachan, Masoami Hatakayama, Netravati Hiremath, Diego Moretti, Yellodu A. Nanjareddy, Mathi B. Thumilan, Ramapura L. Ravikumar, Shamprasad Phadnis, Beena Bose, Lucy Poveda, Geetha Kalaiah, Michael B. Zimmermann, Kentaro K. Shimizu, Ralph Schlapbach, Anura V. Kurpad, Sheshshayee M. Sreeman
Summary: The study found that a low phytic acid finger millet accession significantly increased iron absorption in Indian women, potentially preventing iron deficiency. Whole genome re-sequencing and analysis of phytic acid transporter gene variations in different accessions identified the advantages of the low phytic acid finger millet variety. This low phytic acid finger millet variety is of great importance in addressing iron deficiency.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Nikolin Hilaj, Michael B. Zimmermann, Valeria Galetti, Christophe Zeder, Roberta Murad Lima, Laila Hammer, Adam Krzystek, Wilfried Andlauer, Diego Moretti
Summary: The addition of Tenebrio molitor to maize porridge does not significantly affect iron absorption. Native T.molitor is high in iron and moderately well absorbed, suggesting it could be a valuable dietary iron source.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Michael Ceulemans, Joline van de Vel, Dorine W. W. Swinkels, Coby M. M. Laarakkers, Jaak Billen, Kristel Van Calsteren, Karel Allegaert
Summary: This observational study aimed to provide the first data on cord blood hepcidin levels in a Belgian cohort and determine variables associated with cord blood hepcidin concentrations. The study found a moderate correlation between cord blood hepcidin and cord blood ferritin and hemoglobin, as well as an association with mode of delivery.
Article
Hematology
Hanna K. von Siebenthal, Diego Moretti, Michael B. Zimmermann, Nicole U. Stoffel
Summary: A study found that taking iron supplements with ascorbic acid in the morning before meals can increase iron absorption. Compared to consuming coffee or breakfast, consuming iron supplements with orange juice can result in a 4-fold increase in iron absorption and provide an additional 20 mg of absorbed iron per dose.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Nutrition & Dietetics
Coralie Signorell, Anura V. Kurpad, Maria Pauline, Swapna Shenvi, Arpita Mukhopadhyay, Janet C. King, Michael B. Zimmermann, Diego Moretti
Summary: This study evaluated the effect of agronomically biofortified whole wheat flour on plasma zinc. The results showed that both agronomically biofortified whole wheat flour and postharvest fortified wheat provided an additional intake of approximately 1.8 to 3.3 mg zinc per day, but had no effect on plasma zinc, zinc deficiency, growth, or DNA strand breaks.
JOURNAL OF NUTRITION
(2023)