Article
Oncology
Sho Yasuta, Motokazu Sugimoto, Masashi Kudo, Shin Kobayashi, Shinichiro Takahashi, Masaru Konishi, Naoto Gotohda
Summary: This study found that decreased skeletal muscle mass in the early postoperative period may be a predictor for recurrence and poor survival in patients undergoing surgery for perihilar cholangiocarcinoma.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Nilian Carla Souza, Carla Maria Avesani, Carla M. Prado, Renata Brum Martucci, Viviane Dias Rodrigues, Nivaldo Barroso de Pinho, Steven B. Heymsfield, Maria Cristina Gonzalez
Summary: The study found that PhA can predict muscle abnormalities and function in cancer patients, and has good diagnostic accuracy for detecting low muscle mass, low muscle mass and radiodensity, low muscle radiodensity and strength, and low muscle mass and strength.
CLINICAL NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Lydia Newton, Ffion Dewi, Angus McNair, Dawn Gane, Jodie Rogers, Harry Dean, Anne Pullyblank
Summary: This study examined patient-reported surgical site infections (SSI) at 30 days following elective colorectal operations over 8 years. The majority of SSIs were reported after discharge, indicating the need for a standardized 30-day surveillance to monitor SSIs accurately.
COLORECTAL DISEASE
(2021)
Article
Oncology
Yang Wang, Yuliuming Wang, Lianjie Ai, Hao Zhang, Guodong Li, Zitong Wang, Xia Jiang, Guoqing Yan, Yunxiao Liu, Chunlin Wang, Huan Xiong, Guiyu Wang, Ming Liu
Summary: This study evaluated the association between body composition and clinical parameters and prognosis in patients with colorectal cancer (CRC) treated by radical resection. The findings suggest that linear skeletal muscle index and muscle attenuation can be used as new independent predictors for CRC patients treated with radical surgery.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jie He, Wei Luo, Yuanyuan Huang, Lingmeng Song, Yang Mei
Summary: This study aimed to evaluate the promise of sarcopenia as a prognostic indicator in individuals with colorectal cancer. Through systematic search and analysis of the literature, it was found that sarcopenia is associated with survival rates and disease-free survival rates in colorectal cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
In Kyu Park, Song Soo Yang, Eric Chung, Eun-Suk Cho, Hye Sun Lee, Su-Jin Shin, Yeong Cheol Im, Eun Jung Park, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang
Summary: In patients with colorectal cancer, the integrated measure of skeletal muscle gauge (SMG) improves prognostic accuracy compared to SMI or SMD alone, with low SMG values associated with worse survival rates.
Article
Biochemistry & Molecular Biology
Zhengye Liu, Thomas Chaillou, Estela Santos Alves, Theresa Mader, Baptiste Jude, Duarte M. S. Ferreira, Heidi Hynynen, Arthur J. Cheng, William O. Jonsson, Gianluigi Pironti, Daniel C. Andersson, Ellinor Kenne, Jorge L. Ruas, Pasi Tavi, Johanna T. Lanner
Summary: The study demonstrates that NDUFA4L2 regulates skeletal muscle mass and force by decreasing mitochondrial activity and production of reactive oxygen species, leading to muscle atrophy. Overexpression of NDUFA4L2 reduces mitochondrial respiration and antioxidant capacity, lowering levels of important intramuscular metabolites, ultimately affecting muscle function.
Review
Veterinary Sciences
Ah Young Kim, Lindsay Hochman Elam, Nicolaas Everhardus Lambrechts, Mo D. Salman, Felix Michael Duerr
Summary: Limb circumference and ultrasound are likely to be the main modalities for serial muscle mass measurement in dogs. The reliability of limb circumference is questionable and several factors need to be controlled to improve its reliability. Ultrasound may provide a reasonable alternative, but further research is needed to evaluate its reliability and identify factors that affect ultrasound measurements.
BMC VETERINARY RESEARCH
(2022)
Article
Nutrition & Dietetics
Jun Young Lim, Young Min Kim, Hye Sun Lee, Jeonghyun Kang
Summary: A machine learning algorithm was developed to predict skeletal muscle gauge in colorectal cancer patients using clinical and inflammatory markers. The algorithm demonstrated superior performance compared to single variables in predicting low skeletal muscle gauge. This model can serve as a screening tool for assessing and intervening in muscle health during treatment.
Article
Public, Environmental & Occupational Health
Dongjin Seo, Han Sang Kim, Joong Bae Ahn, Yu Rang Park
Summary: This study aimed to evaluate the prognostic impact of initial status and trajectories of muscle and BMI on overall survival in colorectal cancer patients. The results indicated that the trajectories of muscle and BMI were related to overall survival, and increasing muscle mass was associated with better survival. Therefore, the changes in muscle and BMI can serve as important indicators for predicting survival in colorectal cancer patients.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Review
Gastroenterology & Hepatology
Robert M. O'Connell, Maeve O'Neill, Micheal G. O. Riordain, Criostoir B. O. Suilleabhain, Adrian W. O'Sullivan
Summary: Obese patients undergoing hepatic resection for colorectal liver metastases do not have worse oncological outcomes, while sarcopenia is associated with poorer long-term survival and increased risk of major postoperative complications.
Article
Nutrition & Dietetics
So-Hyun Jeon, Se-Young Choung
Summary: The study found that oyster hydrolysates TGPN and PNY can inhibit sarcopenia by regulating protein turnover and mitochondrial biogenesis, thus improving muscle strength and mass.
Article
Biochemistry & Molecular Biology
Fan Li, Cong Yin, Zewei Ma, Kelin Yang, Lijuan Sun, Chen Duan, Tao Wang, Abdelaziz Hussein, Lina Wang, Xiaotong Zhu, Ping Gao, Qianyun Xi, Yongliang Zhang, Gang Shu, Songbo Wang, Qingyan Jiang
Summary: The study suggests that PHD3 may affect protein turnover in muscle tissue by mediating the inflammatory NF-kappa B signal pathway, and the increased expression of PHD3 in denervated muscle could be an important regulator in inducing muscle atrophy.
Article
Geriatrics & Gerontology
Lena S. Kiefer, Jana Fabian, Susanne Rospleszcz, Roberto Lorbeer, Jurgen Machann, Mareen S. Kraus, Marc Fischer, Frank Roemer, Wolfgang Rathmann, Christa Meisinger, Margit Heier, Konstantin Nikolaou, Annette Peters, Corinna Storz, Christopher L. Schlett, Fabian Bamberg
Summary: The study compared quantitative assessment of skeletal muscle mass using MRI and BIA, finding strong correlation between the two methods in non-obese subjects but weaker correlation in obese individuals. Abdominal muscle mass was significantly higher in obese subjects compared to non-obese, with MRI-based assessments showing potential as practical imaging biomarkers independent of body weight.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Geriatrics & Gerontology
Martino V. Franchi, Francesca Badiali, Fabio Sarto, Patrick Mueller, Notger G. Mueller, Kathrin Rehfeld, Elena Monti, Debbie Rankin, Stefano Longo, Jon Lund, Anita Hoekelmann, Marco Narici
Summary: This study found that recreational dancing has stronger neuroprotective effects and can increase muscle function in older individuals compared to general fitness exercise training.
Review
Surgery
NIHR Global Hlth Res Unit Global Surg, GlobalSurg Collaborative
Summary: This study aimed to determine if remote wound reviews using telemedicine can be safely upscaled and whether standardized assessment tools are needed. The findings showed that the rate of surgical site infection reported using telemedicine was slightly lower than with in-person review, indicating the need for standardized tools for remote assessment of surgical site infection.
Article
Geriatrics & Gerontology
Matthew S. Brook, Daniel J. Wilkinson, Janelle Tarum, Kyle W. Mitchell, Jonathan L. Lund, Bethan E. Phillips, Nathaniel J. Szewczyk, Fawzi Kadi, Paul L. Greenhaff, Ken Smith, Philip J. Atherton
Summary: Ageing limits the growth capacity of skeletal muscle in response to resistance exercise, but the role of satellite cell function in driving this phenomenon is poorly understood.
Article
Nutrition & Dietetics
E. J. Hardy, C. S. Deane, J. N. Lund, B. E. Phillips
Summary: Despite the implementation of ERAS protocols, major abdominal surgery still leads to significant muscle mass and function loss in the post-operative period. Dietary intake in this period is poorly characterised, with energy and protein intake falling far below the recommended guidelines. Innovative dietary interventions, taking patient dietary preference into account, are needed to address this issue.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Anesthesiology
Brett Doleman, Ole Mathiesen, Alex J. Sutton, Nicola J. Cooper, Jon N. Lund, John P. Williams
Summary: This study used network meta-analysis to identify non-opioid analgesics that may reduce chronic postsurgical pain. Lidocaine, ketamine, and gabapentinoids were found to be potentially effective. However, the low confidence in these findings is due to bias risk and imprecision.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Gastroenterology & Hepatology
Laurie Smith, Alexandra Coxon-Meggy, Michael Shinkwin, Julie Cornish, Alan Watkins, Greg Fegan, Jared Torkington, HART Trial Collaborators
Summary: This study aimed to assess the rates of incisional hernia (IH) at 1 year following abdominal wall closure between junior and senior surgeons in patients undergoing elective colorectal surgery. The results showed that patients closed by trainees had a higher rate of IH (20%) compared to those closed by consultants (12%). Additionally, age, sex, and closure method were identified as risk factors for IH.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
J. E. M. Blackwell, P. J. J. Herrod, B. Doleman, H. R. Boyd-Carson, D. Dolan, L. Wheldon, S. R. Brown, A. Banerjea, S. Moug, J. N. Lund, Michael Wong, POMPOMM Collaborative
Summary: This study investigated the relationship between preoperative radiologically defined lean muscle measures and adverse clinical outcomes in patients undergoing surgery for colorectal cancer. The results showed that measures of lean muscle quality and quantity can be quickly and easily taken from routine preoperative imaging, and they can predict important clinical outcomes.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Anesthesiology
H. Javanmard-Emamghissi, B. Doleman, J. N. Lund, S. Lockwood, S. Hare, L. Pearce, S. Moug, G. M. Tierney
Summary: This study aims to describe the outcomes of patients at extreme risk of death with a NELA-predicted 30-day mortality of >= 50%. The study found that compared to high-risk patients with a predicted mortality of 5-49%, extreme-risk patients were more likely to be admitted electively, had longer hospital stays, higher rates of unplanned return to the operating theatre, and lower 90-day survival rates.
Review
Nutrition & Dietetics
Hala Fatani, Adina Olaru, Rebecca Stevenson, Waad Alharazi, Ayman Jafer, Philip Atherton, Matthew Brook, Gordon Moran
Summary: There is increasing evidence of higher prevalence of sarcopenia in IBD patients due to increased muscle atrophy. This systematic review aimed to estimate the prevalence of sarcopenia in IBD patients, investigate its impact on patients, and assess the effectiveness of nutritional interventions. The review included 35 studies and found that over one third of adult IBD patients have myopenia or pre-sarcopenia, and nearly a fifth have sarcopenia. Myopenic IBD is associated with increased risk of therapy failure, postoperative complications, low bone mineral density (BMD), and potential risk of non-alcoholic fatty liver disease (NAFLD). Personalized nutrition plans may improve muscle mass in IBD patients.
CLINICAL NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Katie L. R. Cross, Steven R. Brown, Jos Kleijnen, James Bunce, Melanie Paul, Sophie Pilkington, Oliver Warren, Oliver Jones, Jon Lund, Henry J. Goss, Michael Stanton, Tatenda Marunda, Artaza Gilani, L. Wee Sing Ngu, Philip Tozer
Summary: This article aims to update the old guidelines on the management of anal fissures and provide recommendations on the most effective treatment for patients with anal fissures using a multidisciplinary, rigorous guideline methodology.
COLORECTAL DISEASE
(2023)
Review
Gastroenterology & Hepatology
J. A. Bunce, J. J. S. Wall, J. N. Lund, G. M. Tierney
Summary: The aim of this scoping review is to describe the current evidence base on risk stratification in emergency abdominal surgery for inflammatory bowel disease (IBD). It is likely that age, the American Society of Anesthesiologists grade, comorbidity, and organ dysfunction play a similar role in risk stratification in IBD patients as in other emergency abdominal surgery cohorts. However, there is variability in the reporting of what is considered an IBD emergency.
COLORECTAL DISEASE
(2023)
Review
Gastroenterology & Hepatology
M. Paul, T. F. Smart, B. Doleman, S. Toft, J. P. Williams, J. N. Lund, B. E. Phillips
Summary: Postoperative aerobic exercise training has beneficial effects on improving aerobic function for patients who have had surgery for intra-abdominal cancer. The exercise can be safely delivered in various formats, including home-based or group/supervised.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Geriatrics & Gerontology
Jessica Cegielski, Joseph J. Bass, Ruth Willott, Adam L. Gordon, Daniel J. Wilkinson, Ken Smith, Philip J. Atherton, Bethan E. Phillips
Summary: This study investigates how different definitions influence the prevalence of sarcopenia in older adults. The results show that the prevalence varies greatly depending on the criteria used, such as muscle mass, gait speed, and handgrip strength.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Letter
Surgery
Hannah Javanmard-Emamghissi, Jonathan N. Lund, Gillian M. Tierney
BRITISH JOURNAL OF SURGERY
(2023)