Article
Food Science & Technology
Xuening Yu, Shijie Dou, Xiaoyang Liu, Fawen Yin, Deyang Li, Pengfei Jiang, Dayong Zhou
Summary: This study developed a new zinc supplement delivery system that showed stability and absorption in gastrointestinal environments. The system had a high zinc ion release rate and slow-release effects, resulting in better zinc absorption.
Article
Food Science & Technology
Santiaga Maria Vivanco-Maroto, Veronica Gallo, Beatriz Miralles, Isidra Recio
Summary: A semi-dynamic gastrointestinal device was used to study the digestion of two different substrates, casein hydrolysate and precursor micellar casein, and their metabolic response in the body. The digestion process showed that casein formed a firm coagulum, while the hydrolysate did not aggregate. The peptide and amino acid composition changed significantly during the gastric and intestinal phases.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Ione de Brito-Ashurst, Marianne Klebach, Eleni Tsompanaki, Sundeep Kaul, Peter van Horssen, Zandrie Hofman
Summary: In this exploratory study, no major differences were found in tolerability and protein absorption markers between the new enteral peptide formula and the standard intact protein formula in ICU patients.
Article
Food Science & Technology
Cuihong Dai, Zihang Cheng, Yanyu Chen, Dongling Qiao, Gaolei Xi, Qiuling Wang, Fan Zhu, Siming Zhao, Binjia Zhang
Summary: Controlling pH during thermal processing can alter the microstructure and digestion features of starch-based food matrices, including protein hydrolysates. Different pH values during thermal processing lead to changes in the structure of binary matrices, affecting the formation of resistant starch.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Agriculture, Dairy & Animal Science
Tim T. Lambers, Jeroen Wissing, Joris Roggekamp
Summary: Milk protein hydrolysates have potential benefits for digestion and digestion-related complications in infants, while intact milk proteins offer functionality beyond their nutritional value. This study examined the in vitro digestion of an experimental infant formula containing both intact milk proteins and a milk protein hydrolysate. The experimental formula showed greater initial protein digestion during simulated gastric digestion compared to the control formula, with a higher proportion of smaller peptides and available amino groups. The addition of the hydrolysate did not affect gastric protein coagulation. Further in vivo studies are needed to determine if these differences in protein digestion and absorption kinetics alter overall protein digestion and affect functional gastrointestinal disorders.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Food Science & Technology
Haowei Zhang, Juan Wu, Yu Cheng
Summary: The production of plant protein has lower carbon emissions than animal protein. This study demonstrated the potential use of potato protein hydrolysate as a substitute for whey protein isolate in gel formation. The investigation showed that increasing the ratio of whey protein to potato protein hydrolysate improved the mechanical properties and digestibility of the composite gels.
Article
Chemistry, Applied
Yuan Cheng, Yurong Liu, Dan Chen, Yang Zhou, Shujuan Yu, Huajian Lin, Christopher Kai Liao, Haili Lin, Peng Xu, Mingdong Huang
Summary: Quercetin has dual effects on protein digestion and absorption, inhibiting protein digestion by inhibiting trypsin in the intestinal fluid and promoting the intestinal absorption of oligopeptides via internalization in intestinal villi cells.
Article
Food Science & Technology
Qiping Zhan, Qian Wang, Qi Liu, Yifang Guo, Fan Gong, Lihua Hao, Hui Wu, Zhou Dong
Summary: This study investigated the changes in antioxidant capacities of protein fractions from Sacha inchi seeds during simulated gastrointestinal digestion, showing that the digestion process increased their antioxidant activity, especially the glutelin fraction. This highlights the potential application of glutelin hydrolysates as natural antioxidant supplements to prevent non-communicable diseases.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Michelle E. G. Weijzen, Rob J. J. van Gassel, Imre W. K. Kouw, Jorn Trommelen, Stefan H. M. Gorissen, Janneau van Kranenburg, Joy P. B. Goessens, Marcel C. G. van de Poll, Lex B. Verdijk, Luc J. C. van Loon
Summary: This study compared protein digestion, amino acid absorption, and muscle protein synthesis response after ingesting intact milk protein or an equivalent amount of free amino acids. The results showed that ingestion of free amino acids led to a faster absorption of amino acids and greater availability in the bloodstream. In conditions where protein digestion and amino acid absorption are compromised, ingestion of free amino acids may be preferred.
JOURNAL OF NUTRITION
(2022)
Article
Food Science & Technology
Yihong Chen, Hazel Rooney, Cathal Dold, Simona Bavaro, John Tobin, Michael J. Callanan, Andre Brodkorb, Peadar G. Lawlor, Linda Giblin
Summary: Membrane filtration can produce infant milk formula that is more similar to breast milk. Compared to traditionally heat-treated formula, membrane-filtered formula has a higher content of native whey protein. In vivo evidence shows that membrane-filtered formula influences protein digestion but has minimal effects on overall growth parameters.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Gommaar D'Hulst, Evi Masschelein, Katrien De Bock
Summary: The ingestion of plant-based and insect proteins induces a lower rise in blood leucine and dampened mTORC1 activation in mouse skeletal muscle compared to whey protein. Matching total leucine content to whey does not rescue the reduced rise in plasma amino acids or the lower increase in mTORC1 activation. Despite lower postprandial amino acid levels, insect protein elicits a similar activation of downstream mTORC1 kinases as plant-based proteins.
Article
Fisheries
Shimaa A. Amer, Afaf N. Abdel Rahman, Mohamed Elhady, Ali Osman, Elsayed M. Younis, Abdel-Wahab A. Abdel-Warith, Amr A. Moustafa, Tarek Khamis, Simon J. Davies, Rowida E. Ibrahim
Summary: This study found that partial replacement of fishmeal (FM) with moringa protein hydrolysate (MPH) in the diet of Nile tilapia can improve growth, digestive enzyme activity, economic efficiency, immune status, and gene expression related to immune function. Increasing levels of MPH replacement showed positive effects on growth parameters, hormone levels, enzyme activity, and immune indices. The resistance to bacterial challenge also increased with FM replacement by MPH. Overall, MPH can be utilized as a replacement for FM up to 60% to enhance the performance and immune status of Nile tilapia.
Article
Biochemistry & Molecular Biology
Zhijie Zhu, Chengyi Sun, Caihong Wang, Liping Mei, Zhaoxian He, Saddam Mustafa, Xianfeng Du, Xu Chen
Summary: This study investigated the effects of soy protein isolate hydrolysate (SPIH) on different starch types and found that SPIH increased the content of resistant starch, reduced water molecule flow in starch, and decreased the catalytic efficiency of amylase. These findings provide new insights into the production of low-glycemic index foods.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Chemistry, Applied
Xin Fan, Huimin Guo, Cong Teng, Xiushi Yang, Peiyou Qin, Aurore Richel, Lizhen Zhang, Christophe Blecker, Guixing Ren
Summary: Research on a mouse model of colorectal cancer found that quinoa protein and its hydrolysate can alleviate clinical symptoms of CRC and increase the content of short chain fatty acids in colon tissues. Furthermore, they can partially alleviate gut microbiota dysbiosis in CRC mice and improve the functional profile of gut microbiota.
Article
Food Science & Technology
Zhijie Zhu, Caihong Wang, Liping Mei, Wenwen Xue, Chengyi Sun, Yiqun Wang, Xianfeng Du
Summary: This study explored the interaction between proteins and corn starch with different amylose contents, and the effects on their physicochemical properties and in vitro digestibility. The results showed that protein hydrolysate inhibited the in vitro digestion of normal corn starch and high amylose corn starch, but promoted the digestion of waxy corn starch. The different distribution of water molecules during gel formation caused significant changes in the microstructure of the three types of corn starch after freeze-drying.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Aaron Hengist, Russell G. Davies, Peter J. Rogers, Jeff M. Brunstrom, Luc J. C. van Loon, Jean-Philippe Walhin, Dylan Thompson, Francoise Koumanov, James A. Betts, Javier T. Gonzalez
Summary: Restricting sugar or total dietary carbohydrate does not modulate physical activity level or energy intake when energy density is controlled for.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Floris K. Hendriks, Jeffrey H. W. Kuijpers, Janneau M. X. van Kranenburg, Joan M. G. Senden, Frank M. Van der Sande, Jeroen P. Kooman, Steven J. R. Meex, Luc J. C. van Loon
Summary: This study recruited 10 ESRD patients for a randomized crossover trial and found that protein ingestion and exercise during hemodialysis did not compromise the removal of uremic toxins.
JOURNAL OF RENAL NUTRITION
(2023)
Article
Sport Sciences
Lisanne H. P. Houben, Maarten Overkamp, Puck Van Kraaij, Jorn Trommelen, Joep G. H. Van Roermund, Peter De Vries, Kevin De Laet, Saskia van der Meer, Ulla R. Mikkelsen, Lex B. Verdijk, Luc J. C. Van Loon, Sandra Beijer, Milou Beelen
Summary: This study aimed to assess the effects of 20 wk resistance exercise training with or without protein supplementation on body composition, muscle mass, muscle strength, physical performance, and aerobic capacity in prostate cancer patients receiving androgen deprivation therapy (ADT). The results showed that resistance exercise training can counteract the adverse effects of ADT on body composition, muscle mass, muscle strength, and aerobic capacity, while protein supplementation did not provide additional benefits.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Endocrinology & Metabolism
Evelyn B. Parr, Imre W. K. Kouw, Michael J. Wheeler, Bridget E. Radford, Rebecca C. Hall, Joan M. Senden, Joy P. B. Goessens, Luc J. C. van Loon, John A. Hawley
Summary: This study aimed to assess the impact of time-restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity. The study found no significant difference in daily MyoPS rates between the TRE group and the control group, but the TRE group had lower total blood glucose levels, greater total body mass reduction, and more lean mass loss. These findings suggest that time-restricted eating may have potential benefits for health management, but further research is needed.
Article
Urology & Nephrology
Maarten Overkamp, Lisanne H. P. Houben, Saskia van der Meer, Joep G. H. van Roermund, Ronald Bos, Arjan P. J. Kokshoorn, Mads S. Larsen, Luc J. C. van Loon, Milou Beelen, Sandra Beijer
Summary: The study aimed to assess the adverse impact of androgen deprivation therapy on body composition, physical performance, cardiometabolic health, and health-related quality-of-life in prostate cancer patients. The findings showed that after 5 months of therapy, patients experienced declines in body fat mass, muscle mass, muscle strength, aerobic capacity, metabolic parameters, habitual physical activity, and health-related quality-of-life, suggesting that androgen deprivation therapy has adverse effects on patients.
SCANDINAVIAN JOURNAL OF UROLOGY
(2023)
Article
Endocrinology & Metabolism
Luuk Hilkens, Marleen Boerboom, Nick van Schijndel, Judith Bons, Luc J. C. van Loon, Jan-Willem van Dijk
Summary: This study examined whether collagen supplementation enhances the effects of high-impact exercise on bone metabolism and whether increasing exercise frequency provides greater benefits. The results showed that 5 minutes of daily high-impact exercise can stimulate bone formation, but collagen supplementation or increased exercise frequency does not further increase bone formation.
Article
Geriatrics & Gerontology
Cas J. Fuchs, Remco Kuipers, Jan A. Rombouts, Kim Brouwers, Vera B. Schrauwen-Hinderling, Joachim E. Wildberger, Lex B. Verdijk, Luc J. C. van Loon
Summary: This study assessed the differences in muscle group volumes between young and older males and found that the most significant differences were observed in the thigh muscle group, with the quadriceps femoris showing the largest difference in muscle volume between young and older men. Overall, young men have larger muscle volumes compared to older men.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Endocrinology & Metabolism
Maarten Overkamp, Lisanne H. P. Houben, Thorben Aussieker, Janneau M. X. van Kranenburg, Philippe J. M. Pinckaers, Ulla R. Mikkelsen, Milou Beelen, Sandra Beijer, Luc J. C. van Loon, Tim Snijders
Summary: ADT reduces skeletal muscle mass in prostate cancer patients, but resistance exercise training can offset this effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Neurosciences
Heather L. Petrick, Rachel M. Handy, Bayley Vachon, Sara M. Frangos, Andrew M. Holwerda, Annemarie P. Gijsen, Joan M. Senden, Luc J. C. van Loon, Graham P. Holloway
Summary: Muscle disuse decreases muscle protein synthesis rates and induces atrophy, while nitrate supplementation can improve mitochondrial function. This study found that nitrate intake could prevent the decline in mitochondrial function caused by muscle disuse, but it was not able to prevent muscle atrophy.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Sport Sciences
Thorben Aussieker, Luuk Hilkens, Andrew m. Holwerda, Cas j. Fuchs, Lisanne h. p. Houben, Joan m. Senden, Jan-willem VAN Dijk, Tim Snijders, Luc j. c. VAN Loon
Summary: This study assessed the impact of whey protein and collagen protein on postexercise protein synthesis rates. The results showed that whey protein increased myofibrillar protein synthesis rates, but had no effect on muscle connective protein synthesis rates. Collagen protein did not further increase muscle connective protein synthesis rates during the early stages of postexercise recovery in recreational athletes.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Sport Sciences
Jorn Trommelen, Glenn A. A. van Lieshout, Pardeep Pabla, Jean Nyakayiru, Floris K. K. Hendriks, Joan M. M. Senden, Joy P. B. Goessens, Janneau M. X. van Kranenburg, Annemie P. P. Gijsen, Lex B. B. Verdijk, Lisette C. P. G. M. de Groot, Luc J. C. van Loon
Summary: Pre-sleep ingestion of casein and whey protein increases overnight muscle protein synthesis rates after exercise.
Article
Nutrition & Dietetics
Devin G. McCarthy, Jack Bone, Matthew Fong, Phillippe J. M. Pinckaers, William Bostad, Douglas L. Richards, Luc J. C. van Loon, Martin J. Gibala
Summary: The effect of acute ketone monoester (KE) supplementation on exercise performance is unclear. This study aimed to investigate the difference in mean power output during a 20-min cycling time trial (TT) after KE ingestion compared to a placebo (PL). Twenty-three trained cyclists completed two trials with either KE or PL ingestion. The results showed that mean TT power output was lower after KE ingestion compared to PL, suggesting impaired performance.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
Article
Endocrinology & Metabolism
Floris K. Hendriks, Michelle E. G. Weijzen, Joy P. B. Goessens, Antoine H. G. Zorenc, Annemie P. Gijsen, Irene Fleur Kramer, Joop P. W. van den Bergh, Martijn Poeze, Taco J. Blokhuis, Luc J. C. van Loon
Summary: Bone protein synthesis is still ongoing in femoral head bone tissue during the early stages following an intracapsular hip fracture in older patients, but trabecular bone protein synthesis rates are lower in the femoral head when compared to the proximal femur.
Article
Nutrition & Dietetics
Luuk Hilkens, Nick van Schijndel, Vera C. R. Weijer, Lieselot Decroix, Judith Bons, Luc J. C. van Loon, Jan-Willem van Dijk
Summary: This study assessed the effect of combined jump training and collagen supplementation on bone mineral density (BMD) in elite road-race cyclists. The results showed that frequent short bouts of jumping exercise combined with collagen supplementation beneficially affects femoral neck BMD in elite road-race cyclists.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
Article
Nutrition & Dietetics
Gabriel Nasri Marzuca-Nassr, Andrea Alegria-Molina, Yuri SanMartin-Calisto, Macarena Artigas-Arias, Nolberto Huard, Jorge Sapunar, Luis A. Salazar, Lex B. Verdijk, Luc J. C. van Loon
Summary: Resistance exercise training can effectively increase muscle mass and function in older adults. This study compared the impact of resistance exercise training on muscle mass and function in older adults aged 65-75 years versus those above 85 years, and found no differences between the two groups.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)