Article
Nutrition & Dietetics
Christina Raftopoulou, George Paltoglou, Evangelia Charmandari
Summary: This review summarizes the impact of childhood obesity on telomere length, revealing a negative association. Lifestyle interventions in children may lead to increased telomere length peripherally, suggesting a potential mechanistic relation worth further investigation.
Article
Endocrinology & Metabolism
Chenxue Bai, Zixiong Shen, Binxu Qiu, Songling Zhang
Summary: The study found that a genetically predicted longer LTL increases the risk of endometriosis, but endometriosis has no causal impact on LTL. The results strengthen the causal link between LTL and endometriosis, suggesting that LTL may serve as a potential biomarker for endometriosis, offering new possibilities for prevention and treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daniela Scarabino, Liana Veneziano, Alessia Fiore, Suran Nethisinghe, Elide Mantuano, Hector Garcia-Moreno, Gianmarco Bellucci, Nita Solanky, Maria Morello, Ginevra Zanni, Rosa Maria Corbo, Paola Giunti
Summary: SCA1, SCA2, and SCA3 have different effects on leukocyte telomere length (LTL), with SCA1 and SCA3 patients showing significant reduction in LTL and SCA2 patients showing significant increase in LTL. The relationship between LTL and age varies among the subtypes, with SCA1 patients having a significant negative relationship between LTL and age. The number of CAG repeats does not affect LTL in these SCAs. These findings suggest that LTL could serve as a potential biomarker for differentiating between SCAs and HD, but further research is needed for validation in larger cohorts and longitudinal studies.
Review
Food Science & Technology
Mahdieh Abbasalizad-Farhangi
Summary: This meta-analysis evaluated the association between central obesity and leukocyte telomere length in adults. The results showed a negative association between higher leukocyte telomere length and waist circumference, while the association with waist to hip ratio was not significant.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Environmental Sciences
Ram K. Chandyo, Catherine Schwinger, Ingrid Kvestad, Manjeswori Ulak, Suman Ranjitkar, Merina Shrestha, Linda Vy Nguyen, Diana Corona-Perez, Immaculata DeVivo, Laxman Shrestha, Tor A. Strand
Summary: This study aims to investigate the association between household biomass fuel exposure in infancy and leukocyte telomere length (LTL) in children. The results showed that children living in households using biomass fuel had significantly shorter LTL. These findings highlight the importance of reducing biomass fuel exposure in resource-poor settings.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daniela Scarabino, Liana Veneziano, Elide Mantuano, Ivan Arisi, Alessia Fiore, Marina Frontali, Rosa Maria Corbo
Summary: Identification of potential biomarkers, such as leukocyte telomere length (LTL), is crucial for monitoring disease progression in neurodegenerative disorders like Huntington's disease. The study found that LTL reduction independently of CAG number could accurately discriminate pre-HD subjects from controls and even pre-HD from manifest HD, providing robust prognostic value in pre-HD individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
George Paltoglou, Christina Raftopoulou, Nicolas C. Nicolaides, Sofia M. Genitsaridi, Sofia I. Karampatsou, Marina Papadopoulou, Penio Kassari, Evangelia Charmandari
Summary: The study demonstrated a significant increase in LTL after a one-year lifestyle intervention program among 508 children and adolescents aged 10-11, as well as notable improvements in their metabolic profile.
Article
Health Care Sciences & Services
LaShaunta M. Glover, Crystal W. Cene, Alexander Reiner, Samson Gebreab, David R. Williams, Kari E. North, Mario Sims
Summary: The study found that discrimination and coping with discrimination have different effects on LTL in individuals of different genders and levels of depressive symptoms. In some cases, actively coping with lifetime discrimination may help maintain longer LTL.
Article
Geriatrics & Gerontology
Sara Pudas, Maria Josefsson, Annelie Nordin Adolfsson, Mattias Landfors, Karolina Kauppi, Line Marie Veng-Taasti, Magnus Hultdin, Rolf Adolfsson, Sofie Degerman
Summary: Shorter baseline LTL is associated with subsequent memory decline, but intra-individual changes in LTL may not be as informative of cognitive outcomes in aging. Long-term longitudinal evaluation of outcomes in biomarker research is essential.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Environmental Sciences
Teresa Durham, Jia Guo, Whitney Cowell, Kylie W. Riley, Shuang Wang, Deliang Tang, Frederica Perera, Julie B. Herbstman
Summary: This study analyzed the association between prenatal PM2.5 exposure and relative leukocyte telomere length (TL) in mothers and newborns. The results showed a negative relationship between prenatal PM2.5 exposure and TL in both mothers and newborns, particularly in the second trimester.
Article
Medicine, General & Internal
Meric Coskun, Alev Eroglu Altinova, Afruz Babayeva, Aydin Tuncer Sel, Dilek Yapar, Mine Karaca, Mehmet Muhittin Yalcin, Mujde Akturk, Fusun Balos Toruner, Mehmet Ayhan Karakoc, Ilhan Yetkin
Summary: The study aimed to investigate the relationship between leukocyte telomere length (LTL) and serum neuregulin-4 levels and their association with disease activity, co-morbidities, and body fat distribution in female acromegaly patients. The results showed that there was no significant difference in LTL between acromegaly and control groups, but neuregulin-4 levels were significantly higher in acromegaly patients. There were no differences in LTL, T/S ratio, and neuregulin-4 levels between active and controlled acromegaly groups. Neuregulin-4 was positively correlated with fasting glucose, triglyceride, and lean body mass in the acromegaly group, and there was a negative correlation between LTL and neuregulin-4 in the control group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Genetics & Heredity
Mohammad Saeed Kahrizi, Indrajit Patra, Abduladheem Turki Jalil, Harun Achmad, Samira Alesaeidi, Moaed E. Al-Gazally, Sogol Alesaeidi
Summary: Obesity is associated with shorter leukocyte telomere length (LTL) among children and adolescents. However, the relationship between obesity and LTL varies across studies and may be influenced by factors such as geographical location, quality scores, participant weight, and baseline LTL.
FRONTIERS IN GENETICS
(2022)
Article
Andrology
Masoumeh Amirzadegan, Niloofar Sadeghi, Marziyeh Tavalaee, Mohammad Hossein Nasr-Esfahani
Summary: The study found that men with oligozoospermia had shorter telomere length, significantly increased sperm DNA damage and protamine deficiency, indicating poor sperm quality. Low sperm concentration may be a sign of issues during meiotic division in the spermatogenesis process.
Article
Pediatrics
Joshua Garfein, Kerry S. J. Flannagan, Mercedes Mora-Plazas, Henry Oliveros, Constanza Marin, Eduardo Villamor
Summary: This study found that longer LTL among girls in middle childhood is associated with smaller increases in waist circumference, an indicator of abdominal adiposity.
Article
Immunology
Donglei Wei, Yage Jiang, Jianwen Cheng, Hui Wang, Ke Sha, Jinmin Zhao
Summary: This study systematically assessed the causal relationship between leukocyte telomere length (LTL) and ankylosing spondylitis (AS) and rheumatoid arthritis (RA) using Mendelian randomization. The results suggested that longer LTL might be associated with an increased risk of developing AS.
FRONTIERS IN IMMUNOLOGY
(2023)
