Article
Pharmacology & Pharmacy
Shafi Ullah, Asif Nawaz, Arshad Farid, Muhammad Shahid Latif, Muhammad Fareed, Shakira Ghazanfar, Charis M. Galanakis, Abdulhakeem S. Alamri, Majid Alhomrani, Syed Mohammed Basheeruddin Asdaq
Summary: The study aimed to embed folate-modified chitosan 5FU nanoparticles into calcium alginate beads for colon-targeted delivery. The results showed that the swelling, erosion, and water uptake properties of FA-CS-5FU-NP-Bf beads were significantly higher than those of FA-CS-5FU-NP-Bo beads at simulated intestinal pH.
Article
Nutrition & Dietetics
Emanuela Pannia, Rola Hammoud, Rebecca Simonian, Erland Arning, Paula Ashcraft, Brandi Wasek, Teodoro Bottiglieri, Zdenka Pausova, Ruslan Kubant, G. Harvey Anderson
Summary: The study showed that there are differences in the programming effects on maternal phenotype between MTHF and FA, and potential adverse effects of either form when given at higher doses.
Article
Multidisciplinary Sciences
Kelsey M. Cochrane, Rajavel Elango, Angela M. Devlin, Jennifer A. Hutcheon, Crystal D. Karakochuk
Summary: Folic acid supplementation during pregnancy can lead to an increase in unmetabolized folic acid (UMFA) in breast milk. In contrast, using natural (6S)-5-methyltetrahydrofolic acid [(6S)-5-MTHF] as a supplement may prevent the accumulation of UMFA in breast milk. This study found that folic acid supplementation significantly increased the concentration of UMFA in breast milk compared to (6S)-5-MTHF supplementation.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Applied
Matthew C. Davis, Stephen Fallis, Craig R. Tobias
Summary: The manufacture and use of explosives in the past have resulted in environmental contamination. It is now important to understand the environmental fate and transport of new and improved energetic materials before they cause damage to ecosystems. To conduct these studies, synthesis of new insensitive energetic materials (IEM) DNAN and NTO with isotopic labels was necessary.
JOURNAL OF ENERGETIC MATERIALS
(2023)
Article
Nutrition & Dietetics
Kelsey M. Cochrane, Rajavel Elango, Angela M. Devlin, Chantal Mayer, Jennifer A. Hutcheon, Crystal D. Karakochuk
Summary: This study investigated the effect of (6S)-5-methyltetrahydrofolic acid ((6S)-5-MTHF) and folic acid on blood folate status during pregnancy. The results showed that supplementation with (6S)-5-MTHF may reduce plasma unmetabolised folic acid (UMFA) by approximately 50% compared to folic acid supplementation, but the biological relevance of this finding remains unclear.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Kehinde M. Taiwo, Owen B. Becette, Guanghui Zong, Bin Chen, Peter Y. Zavalij, Theodore Kwaku Dayie
Summary: Solution NMR using the magnetically active fluorine-19 (F-19) isotope is advantageous for studying RNA structure and conformational changes, but synthesizing fluorinated RNA building blocks poses challenges. The study presents a scalable and reliable method to produce labeled nucleotides for incorporation into biologically active RNAs.
MONATSHEFTE FUR CHEMIE
(2021)
Article
Nutrition & Dietetics
Sara Shama, Sharon Unger, Yves Pouliot, Alain Doyen, Shyam Suwal, Paul Pencharz, Michael A. Pitino, Melanie Sergius, Susanne Aufreiter, Debbie Stone, Deborah L. O'Connor
Summary: The study demonstrated that using human milk-based protein concentrate supported normal growth in weanling rats. Rats fed the concentrate had higher cecum weights compared to the control group.
JOURNAL OF NUTRITION
(2021)
Article
Medicine, General & Internal
Cindy-Lee Dennis, Flavia Marini, Jennifer Abbass Dick, Stephanie Atkinson, Jon Barrett, Rhonda Bell, Anick Berard, Howard Berger, Hillary K. Brown, Evelyn Constantin, Deborah Da Costa, Andrea Feller, Astrid Guttmann, Magdalena Janus, K. S. Joseph, Peter Juni, Sarah Kimmins, Nicole Letourneau, Patricia Li, Stephen Lye, Jonathon L. Maguire, Stephen G. Matthews, David Millar, Dragana Misita, Kellie Murphy, Anne Monique Nuyt, Deborah L. O'Connor, Rulan Savita Parekh, Andrew Paterson, Martine Puts, Joel Ray, Paul Roumeliotis, Stephen Scherer, Daniel Sellen, Sonia Semenic, Prakesh S. Shah, Graeme N. Smith, Robyn Stremler, Peter Szatmari, Deanna Telnner, Kevin Thorpe, Mark S. Tremblay, Simone Vigod, Mark Walker, Catherine Birken
Summary: The study aims to evaluate a telephone intervention and e-health resources tailored for pregnant women and their partners to optimize growth and development among children, with the primary goal of reducing child overweight and obesity. Secondary objectives include improving child growth trajectories, cardiometabolic risk factors, health behaviors, and school readiness at age 5.
Article
Pediatrics
Curtis J. D'Hollander, Charles D. G. Keown-Stoneman, Catherine S. Birken, Deborah L. O'Connor, Jonathon L. Maguire
Summary: Early introduction of infant cereal at 4 months compared with 6 months was associated with higher BMI z score, increased obesity risk, similar height-for-age z score, and less favorable eating behavior. Therefore, recommendations for introducing solid food around 6 months of age are supported.
JOURNAL OF PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Alison Mildon, Jane Francis, Stacia Stewart, Bronwyn Underhill, Yi Man Ng, Christina Rousseau, Erica Di Ruggiero, Cindy-Lee Dennis, Deborah L. O'Connor, Daniel W. Sellen
Summary: While 70% of participants continued breastfeeding for 6 months, only 18% practiced exclusive breastfeeding for the full duration. The early use of formula was common in the first three months, and the introduction of solids and non-formula fluids at 5 to 6 months further compromised exclusive breastfeeding rates. Transitions between different categories of breastmilk feeding intensity were common, with 35% making two or more transitions. High levels of breastmilk provision were observed despite low rates of exclusive breastfeeding for 6 months, highlighting the need for nuanced reporting and intervention designs in future studies.
MATERNAL AND CHILD NUTRITION
(2022)
Review
Pediatrics
Megan R. Beggs, Nicole Bando, Sharon Unger, Deborah L. O'Connor
Summary: Infants born preterm or with low birth weight are at higher risk for health complications and neurodevelopmental issues. Nutritional strategies, particularly through fortification of human milk, may improve short-term growth outcomes, but there is still a lack of evidence on long-term neurodevelopmental benefits. Further research is needed to determine the most effective fortification practices and their impact on clinical outcomes.
Editorial Material
Nutrition & Dietetics
Deborah L. O'Connor
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Kathryn Walton, Meghan McGee, Julie Sato, Nicole Law, Kathryn E. Hopperton, Nicole Bando, Alex Kiss, Sharon L. Unger, Deborah L. O'Connora
Summary: This study compared the dietary patterns and body composition of very low birth weight (VLBW) children with poor social-emotional functioning to those with typical functioning. The results showed that poor social-emotional functioning was positively associated with higher fruit juice intake and energy intake. Children with poor social-emotional functioning were more likely to have a limited food repertoire but less likely to exceed dietary fat recommendations. Overall diet quality and body composition did not differ between the two groups. Diet counselling is important to improve the nutrition of VLBW children and mitigate chronic disease risk.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Public, Environmental & Occupational Health
Mirriam Tyebally Fang, Efstratios Chatzixiros, Laurence Grummer-Strawn, Cyril Engmann, Kiersten Israel-Ballard, Kimberly Mansen, Deborah O'Connor, Sharon Unger, Marisa Herson, Gillian Weaver, Nikola Biller-Andorno
Summary: The establishment and progress of human milk banks are hindered by the lack of unified quality, safety, and ethical standards, as well as insufficient evidence-based guidance. Further research is recommended to fill knowledge gaps, while optimal support for mothers to provide their own breastmilk and establish breastfeeding early is highlighted as necessary.
BULLETIN OF THE WORLD HEALTH ORGANIZATION
(2021)
Article
Food Science & Technology
Michael A. Pitino, Sharon Unger, Alexander Gill, Allison J. McGeer, Alain Doyen, Yves Pouliot, Richard P. Bazinet, Akash Kothari, Tony Mazzulli, Debbie Stone, Deborah L. O'Connor
Summary: This study demonstrates that HPP is effective in inactivating representative enveloped and nonenveloped viruses in human milk, reducing bacterial load, with no adverse effect on macronutrient and energy composition. Therefore, HPP shows great promise in replacing HoP in human milk banking facilities.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Article
Nutrition & Dietetics
Amber J. Mullen, Deborah L. O'Connor, Anthony J. Hanley, Giovanni Piedimonte, Maeve Wallace, Sylvia H. Ley
Summary: The study aimed to identify metabolic and obstetric risk factors for delayed onset of lactogenesis II. Results showed that delayed onset of lactogenesis II was associated with prolonged time to first breast contact postpartum.
Review
Nutrition & Dietetics
Kathryn Walton, Allison Daniel, Quenby Mahood, Simone Vaz, Nicole Law, Sharon L. Unger, Deborah L. O'Connor
Summary: This article presents a systematic review and meta-analysis on feeding difficulties and eating behaviors among preterm children. The findings suggest that preterm children are more likely to experience oromotor eating difficulties and challenging eating behaviors compared to term-born peers. Additionally, the article highlights the importance of studying the effects of caregiver-child interactions on subsequent diet in order to prevent obesity and diet-related chronic diseases.
ADVANCES IN NUTRITION
(2022)
Article
Chemistry, Applied
Melanie Sergius-Ronot, Michael A. Pitino, Shyam Suwal, Sara Shama, Sharon Unger, Deborah L. O'Connor, Yves Pouliot, Alain Doyen
Summary: This study found that heat treatments had a greater impact on human milk protein concentrate than high hydrostatic pressure treatments, with heat treatment mainly causing aggregation of lactoferrin and alpha-lactalbumin. High hydrostatic pressure treatment had minimal impact on protein structure, indicating its potential as a pasteurization method for HMPC.
Article
Pediatrics
Arin C. Deveci, Charles D. G. Keown-Stoneman, Jonathon L. Maguire, Deborah L. O'Connor, Laura N. Anderson, Cindy-Lee Dennis, Catherine S. Birken
Summary: This study found an association between maternal preconception BMI and child growth rates and mean zBMI in children aged 0-10 years. The strongest association was observed from 0 to 4 months of age.
Editorial Material
Nutrition & Dietetics
Deborah L. O'Connor
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Alison Mildon, Jane Francis, Stacia Stewart, Bronwyn Underhill, Yi Man Ng, Christina Rousseau, Valerie Tarasuk, Erica Di Ruggiero, Cindy-Lee Dennis, Deborah L. O'Connor, Daniel W. Sellen
Summary: This study aimed to assess the prevalence, severity, and predictors of household food insecurity among vulnerable women accessing the Canada Prenatal Nutrition Program (CPNP), as well as the associations between household food insecurity and breastfeeding practices up to 6 months. The results showed that household food insecurity was highly prevalent among this cohort, affecting almost half of the participants. However, there was no significant association between food insecurity and continued or exclusive breastfeeding.
PUBLIC HEALTH NUTRITION
(2023)