Article
Nutrition & Dietetics
Jun-Hyuk Lee, Yu-Jin Kwon, Hye Sun Lee, Jee Hye Han, Boyoung Joung, Sung Jin Kim
Summary: This study confirms an inverse dose-dependent association between serum 25-hydroxyvitamin D levels and elevated intraocular pressure (EIOP) in a large sample of 15,338 individuals. Each unit increase in serum 25-hydroxyvitamin D is associated with a 3% decrease in the odds of having EIOP. Compared to individuals deficient in 25-hydroxyvitamin D, those with insufficiency and sufficiency have a 28% and 49% lower odds of EIOP, respectively. Therefore, clinical assessment of intraocular pressure may be helpful in the treatment and prevention of glaucoma in patients with insufficient 25-hydroxyvitamin D.
Article
Nutrition & Dietetics
Berenice Rivera-Paredez, Alberto Hidalgo-Bravo, Guadalupe Leon-Reyes, Leith S. Leon-Maldonado, Arnoldo Aquino-Galvez, Manuel Castillejos-Lopez, Edgar Denova-Gutierrez, Yvonne N. Flores, Jorge Salmeron, Rafael Velazquez-Cruz
Summary: This study evaluated the association between 25(OH)D (total, free, and bioavailable) with adiposity and metabolic traits. The findings suggest that free and bioavailable 25(OH)D do not offer additional advantages over total 25(OH)D regarding its association with adiposity and several metabolic traits in Mexican adults.
Article
Biochemistry & Molecular Biology
Shufei Zeng, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: There is a strong positive linear correlation between free 25(OH)D (f25(OH)D) and total 25(OH)D, making them useful for assessing vitamin D levels. The recommended threshold level for f25(OH)D is 8.499 pg/mL, corresponding to a target concentration of at least 30 ng/mL for t25(OH)D. The upper limit for vitamin D is still unclear, with most experts favoring a upper limit of 100 ng/mL for t25(OH)D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Nutrition & Dietetics
Guowei Li, Likang Li, Jonathan D. Adachi, Ruoting Wang, Zebing Ye, Xintong Liu, Lehana Thabane, Gregory Y. H. Lip
Summary: This study found a quasi J-shaped relationship between serum circulating 25-hydroxyvitamin D (25(OH)D) level and risk of recurrent stroke in patients with a stroke history. The lowest risk of recurrent stroke was observed at a 25(OH)D level of approximately 60 nmol/L, which was associated with a 48% reduction in risk compared to a level of 10 nmol/L.
Article
Biochemistry & Molecular Biology
Frank Z. Stanczyk, Intira Sriprasert, Rachel Danis, Raj Pandian, Harpreet Matharu, Nicole Bender, Melissa Natavio
Summary: This study compared the effects of two combined oral contraceptive formulations on 25(OH)D levels and VDBP levels, revealing different impacts. LNG may have a suppressive effect on VDBP. Further research is needed to understand the influence of hormonal contraceptive formulations on vitamin D status and women's health.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hsin-Ya Tang, Wang-Sheng Ko, Yuan-Horng Yan, Su-Chen Yu, Ya-ling Chiou
Summary: Shift nurses in Taiwan often experience 25(OH)D deficiency, sleep disturbances, depression, and fatigue. However, no significant correlation was found between 25(OH)D levels and mental health.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Naoko Tsugawa, Mayu Nishino, Akiko Kuwabara, Honami Ogasawara, Maya Kamao, Shunjiro Kobayashi, Junichi Yamamura, Satoshi Higurashi
Summary: The study found that the low vitamin D status in recent lactating mothers may have decreased the concentrations of vitamin D and 25OHD in breast milk, compared to the 1980s. This has important implications for improving the vitamin D status of lactating mothers and infants.
Article
Rheumatology
Bin Cai, Mengmeng Zhou, Qingqing Xiao, Hejian Zou, Xiaoxia Zhu
Summary: This study examined the relationship between serum 25-hydroxyvitamin D and all-cause, cause-specific mortality in patients with RA. It found a nonlinear, L-shaped association, with lower serum 25-hydroxyvitamin D levels being associated with increased risk of all-cause mortality.
Article
Endocrinology & Metabolism
Rebecca J. Moon, Laura D. F. Cooke, Stefania D'Angelo, Elizabeth M. Curtis, Philip Titcombe, Justin H. Davies, Keith M. Godfrey, Jane K. Cleal, Rohan M. Lewis, Cyrus Cooper, Nicholas C. Harvey
Summary: There is an association between specific single nucleotide polymorphisms (SNPs) in genes related to vitamin D metabolism pathway and cord blood 25(OH)D in both mothers and offspring, indicating a potential role of genetic factors in this relationship.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Sonja Soininen, Aino-Maija Eloranta, Ursula Schwab, Timo A. Lakka
Summary: The purpose of this study was to investigate the intake and sources of vitamin D, as well as the determinants of serum 25-hydroxyvitamin D (S-25(OH)D) in Finnish adolescents. The results showed that most adolescents had vitamin D intake at the recommended level, although a quarter did not meet the recommended intake and almost a third had low levels of S-25(OH)D. The main determinants of S-25(OH)D were vitamin D intake from supplements, consumption of milk products, consumption of meat products, travels to sunny countries, and average daylight time.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Shaojing Yu, Lulu Song, Qing Wei, Yongman Lv, Zhengce Wan
Summary: The study revealed that higher serum 25(OH)D concentrations were associated with a dose-response decreased risk of MetS among Chinese adults, especially in men and those with renal impairment or liver dysfunction.
CLINICAL NUTRITION
(2021)
Article
Biotechnology & Applied Microbiology
Jinhua Gong, Lina He, Qinyuan Zou, Yangyang Zhao, Bangzhou Zhang, Rongmu Xia, Baolong Chen, Man Cao, Wenxiu Gong, Lin Lin, Xiujuan Lin, Guowei Wang, Muyun Guo, Jianquan He, Chuanxing Xiao, Jian Chen
Summary: This study reveals the association between serum 25-hydroxyvitamin D levels and the gut microbiota and metabolites in postmenopausal women. The low 25(OH)D group showed higher diversity in the gut microbiota, while the high 25(OH)D group exhibited specific enrichments of certain bacterial genera. Additionally, the metabolic profiles differed between the two groups.
MICROBIAL CELL FACTORIES
(2022)
Article
Endocrinology & Metabolism
Yingdong Han, Yun Zhang, Xuejun Zeng
Summary: This study used a two-sample bidirectional Mendelian Randomization analysis to investigate the causal association between serum uric acid and 25-hydroxyvitamin D and to determine the direction of the association. The results suggested a causal association of genetically predicted uric acid on 25-hydroxyvitamin D, while no causal relationship was found for 25-hydroxyvitamin D on serum uric acid.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemical Research Methods
Stephen A. Wise, Johanna E. Camara, Carolyn Q. Burdette, Grace Hahm, Federica Nalin, Adam J. Kuszak, Joyce Merkel, Ramon A. Durazo-Arvizu, Emma L. Williams, Christian Popp, Christian Beckert, Jan Schultess, Glen Van Slooten, Carole Tourneur, Camille Pease, Ravi Kaul, Alfredo Villarreal, Marcelo Cidade Batista, Heather Pham, Alex Bennett, Eugene Jansen, Dilshad Ahmed Khan, Mark Kilbane, Patrick J. Twomey, James Freeman, Neil Parker, Sohail Mushtaq, Christine Simpson, Pierre Lukas, Etienne Cavalier, Christopher T. Sempos
Summary: The study conducted by VDSP evaluated the performance of ligand binding assays for measuring serum total 25-hydroxyvitamin D, finding that only half of the assays met the established criteria. Multiple regression analysis showed that most assays underestimated certain vitamin D metabolites, with some assays potentially having cross-reactivity issues.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)