Article
Infectious Diseases
Angela Yen Moore, Kara Hurley, Stephen Andrew Moore
Summary: This study aimed to analyze the efficacy of using sarecycline in Hispanics with moderate-to-severe acne. The results showed a significant reduction in facial inflammatory lesion counts in Hispanic patients with acne treated with oral sarecycline for 12 weeks. Therefore, oral sarecycline shows promising results as a safe and effective treatment for acne in Hispanics.
Editorial Material
Medicine, General & Internal
Aminath Shiwaza Moosa, Joanne Hui Min Quah, Choon How How
Summary: Roy, an 18-year-old polytechnic student, visited the clinic for an uncomplicated upper respiratory tract infection and requested a medical certificate to rest at home. His medical records showed frequent visits for minor ailments, and he expressed concern about the pimples on his face due to an upcoming graduation ball in a few months.
SINGAPORE MEDICAL JOURNAL
(2021)
Article
Dermatology
Hye Sung Han, Jae Wan Park, Sun Hye Shin, Kwang Ho Yoo, Young Sung Sohn, Beom Joon Kim
Summary: This study evaluated the safety and efficacy of a topical gel, DA-5520, for the treatment of different types of acne scars. The results showed that DA-5520, when combined with laser resurfacing or used alone, improved acne scars clinically, without any associated adverse reactions.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Nutrition & Dietetics
Mi-Ju Kim, Kun-Pyo Kim, Eunhye Choi, June-Hyuck Yim, Chunpil Choi, Hyun-Sun Yun, Hee-Yoon Ahn, Ji-Young Oh, Yunhi Cho
Summary: Dietary supplementation of Lactobacillus plantarum CJLP55 showed beneficial effects on acne lesion count, sebum triglycerides, hydration, and the composition of urine bacterial extracellular vesicle phylum in patients with acne vulgaris.
Article
Infectious Diseases
Angela Yen Moore, Kara Hurley, Stephen Andrew Moore, Luke Moore, Ilana Zago
Summary: Truncal acne, often overlooked due to focus on facial acne, can have a significant psychosocial impact. The Acne Symptom and Impact Scale (ASIS) is a reliable tool for assessing signs and impacts of acne vulgaris. A pilot study involving 10 patients with moderate-to-severe truncal acne vulgaris showed that treatment with oral sarecycline reduced the psychosocial burden based on ASIS-C patient-reported outcome measures.
Article
Dermatology
James Del Rosso, Jeffrey Sugarman, Lawrence Green, Theodore Lain, Ofra Levy-Hacham, Rinat Mizrahi, Linda Stein Gold
Summary: This study demonstrated the efficacy and safety of encapsulated benzoyl peroxide/tretinoin (E-BPO/T) cream in the treatment of acne, overcoming the limitations of chemical instability and potential irritation associated with these medications.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Critical Care Medicine
Fumitaka Yanase, Sofia Spano, Akinori Maeda, Anis Chaba, Thummaporn Naorungroj, Connie Pei Chen Ow, Yugeesh R. Lankadeva, Clive N. May, Ashenafi H. Betrie, Darius J. R. Lane, Glenn M. Eastwood, Mark P. Plummer, Rinaldo Bellomo
Summary: In patients with septic shock, mega-dose NaAscorbate did not significantly increase cumulative 24-h urine output. However, it induced a significantly greater increase in urine output and a greater reduction in vasopressor dose and SOFA score over time. One episode of hypernatremia and one of hemolysis were observed in the NaAscorbate group. These findings support further cautious investigation of this novel intervention.
Article
Medicine, General & Internal
Hongyu Zhong, Xiang Li, Wanqi Zhang, Xiaoxiao Shen, Yuangang Lu, Hongli Li
Summary: This study utilized ultrasound and soft mask as a purely physical treatment to improve acne, demonstrating significant reduction in papules, hyperpigmented lesions, improved skin roughness and local blood circulation in the treatment group. The new non-drug combined therapy provides potential benefits for patients seeking topical treatments with mild side effects and low antibiotic resistance rates, especially for those with moderate acne.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Aurelio Trofe, Milena Raffi, David Muehsam, Andrea Meoni, Francesco Campa, Stefania Toselli, Alessandro Piras
Summary: PEMF enhances muscle oxygenation by increasing deoxyhemoglobin levels, accelerating oxygen kinetic transitions, but does not affect total oxygenation index and pulmonary oxygen kinetics, implying its effects may be limited to the local level.
APPLIED SCIENCES-BASEL
(2021)
Article
Dermatology
Chanudda Washrawirul, Thanaporn Puaratana-arunkon, Yuda Chongpison, Nopadon Noppakun, Pravit Asawanonda, Chanat Kumtornrut
Summary: The study confirmed the effectiveness and safety of topical oxymetazoline hydrochloride (OxH) 0.05% solution for post-acne erythema (PAE), showing reduction in PAE lesion counts, improved clinical response rate, and higher patient satisfaction.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Lawrence F. Eichenfield, Janet C. DuBois, Michael H. Gold, Christopher J. Nardo, Zoe D. Draelos
Summary: This study evaluated the safety, tolerability, and efficacy of DMT310 in treating moderate-to-severe acne. The results showed that DMT310 once-weekly topical treatment significantly reduced both inflammatory and noninflammatory lesions and had higher treatment success rates compared to the placebo group.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Engineering, Biomedical
Elaheh Lotfi, Roxana Kaveh, Nazanin Zeinali Nezhad, Behzad Iranmanesh, Seyed Ali Hosseini, Najmeh Ahramiyanpour
Summary: Acne vulgaris is a common condition, especially among teenagers, and can cause psychosocial problems due to post-acne scarring. This study explored the efficacy and safety of endo-radiofrequency subcision in treating acne scars. The trial involved 30 patients, and outcomes were measured using various assessment tools. Results showed significant improvement in acne scars and high satisfaction rates among treated patients, with minimal and transient side effects. Overall, endo-radiofrequency subcision proved to be a safe and effective treatment for acne scars.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Dermatology
Emine Unal, Ayse Serap Karadag, Aysun Sikar Akturk, Nazli Dizen Namdar, Kiymet Handan Kelekci, Berna Aksoy, Emin Ozlu, Leyla Baykal, Goksun Karaman, Hayriye Saricaoglu, Ilkin Zindanci, Ilknur Balta, Cagri Turan, Burce Can Kuru
Summary: This study found that acne vulgaris does not cause systemic comorbidities, but the incidence of nonmigraine headache was higher in adolescents with acne, while metabolic diseases were less common in postadolescent acne patients compared to the control group.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Azadeh Dorostkar, Mehdi Ghahartars, Mohammadreza Namazi, Nafiseh Todarbary, Maryam Hadibarhaghtalab, Maryam Rezaee
Summary: The study showed that topical sodium hypochlorite solution (0.005%) can be effective in treating mild to moderate acne lesions by reducing the number of papules and pustules. The clinical efficacy of this treatment was evaluated among different genders and hormonal statuses.
DERMATOLOGY PRACTICAL & CONCEPTUAL
(2021)
Article
Dermatology
Azmy A. Abdellatif, Mohamed S. Hasan, Ahmed M. Fahmy, Osama E. Mahmoud, Mohamed L. Elsaie
Summary: This case-controlled study found a possible association between acne vulgaris and enthesitis, with significant correlations identified through clinical examination and ultrasound at multiple sites. The severity of acne may impact ultrasound findings at tendon sites, indicating acne as a systemic disease triggering potential comorbidities.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Review
Food Science & Technology
Luigi Barrea, Matteo Megna, Sara Cacciapuoti, Evelyn Frias-Toral, Gabriella Fabbrocini, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: Psoriasis is a chronic immune-mediated skin disease influenced by genetic and lifestyle factors. Nutrition and obesity are significant contributors to its pathogenesis and severity. Certain diets with anti-inflammatory properties, such as the very-low-calorie ketogenic diet (VLCKD), may improve clinical severity by reducing weight and systemic inflammation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Dermatology
Matteo Megna, Eleonora Cinelli, Lucia Gallo, Elisa Camela, Angelo Ruggiero, Gabriella Fabbrocini
Summary: Efficacy and safety of risankizumab were confirmed in the treatment of psoriasis, with significant improvements observed in both PASI and BSA, even in a challenging population of patients with multiple treatment failures.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Letter
Dermatology
Alessia Villani, Gabriella Fabbrocini, Massimiliano Scalvenzi
DERMATOLOGIC THERAPY
(2022)
Letter
Dermatology
Lucia Genco, Teresa Battista, Matteo Noto, Mario De Lucia, Eleonora Cinelli, Massimiliano Scalvenzi, Gabriella Fabbrocini, Matteo Megna
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Delia Colombo, Luca Bianchi, Gabriella Fabbrocini, Salvatore Corrao, Annamaria Offidani, Luca Stingeni, Antonio Costanzo, Giovanni Pellacani, Ketty Peris, Federico Bardazzi, Giuseppe Argenziano, Silvana Ruffolo, Paolo Dapavo, Carlo Carrera, Maria Concetta Fargnoli, Aurora Parodi, Marco Romanelli, Piergiorgio Malagoli, Marina Talamonti, Matteo Megna, Massimo Raspanti, Matteo Paolinelli, Katharina Hansel, Alessandra Narcisi, Andrea Conti, Clara De Simone, Marco Adriano Chessa, Alina De Rosa, Eugenio Provenzano, Michela Ortoncelli, Chiara Moltrasio, Rosaria Fidanza, Martina Burlando, Annalisa Tonini, Francesca Maria Gaiani, Lucia Simoni, Alessandra Ori, Martina Fiocchi, Emanuela Zagni
Summary: The study aimed to provide real-world evidence of the effectiveness of biologics in Italian patients with moderate-severe psoriasis. Results showed that biologics were effective and well tolerated in psoriasis patients, with a high percentage of patients achieving PASI 75 at 16-52 weeks of treatment and a high sustained response rate after 1 year.
DERMATOLOGIC THERAPY
(2022)
Letter
Dermatology
Maddalena Napolitano, Mariateresa Nocerino, Vincenzo Picone, Fabrizio Martora, Gabriella Fabbrocini, Stefano Dastoli, Cataldo Patruno
DERMATOLOGIC THERAPY
(2022)
Letter
Dermatology
Fabrizio Martora, Gabriella Fabbrocini, Claudio Marasca
DERMATOLOGIC THERAPY
(2022)
Editorial Material
Pharmacology & Pharmacy
Maddalena Napolitano, Luca Potestio, Mario De Lucia, Mariateresa Nocerino, Gabriella Fabbrocini, Cataldo Patruno
Summary: Alitretinoin can be considered as a valid therapeutic option for patients with Chronic Hand Eczema who do not respond to conventional treatments. Clinical trials and real-life experiences have shown that it effectively improves both objective and subjective clinical symptoms, leading to a significant enhancement in patients' Quality of Life. Prior caution should be exercised in patients with certain chronic diseases or women of childbearing age when prescribing alitretinoin.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Letter
Virology
Fabrizio Martora, Vincenzo Picone, Luigi Fornaro, Gabriella Fabbrocini, Claudio Marasca
JOURNAL OF MEDICAL VIROLOGY
(2022)
Letter
Dermatology
Alessia Villani, Gabriella Fabbrocini, Claudia Costa, Massimiliano Scalvenzi
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Z. Apalla, V Nikolaou, D. Fattore, G. Fabbrocini, A. Freites-Martinez, P. Sollena, M. Lacouture, L. Kraehenbuehl, A. Stratigos, K. Peris, E. Lazaridou, B. Richert, E. Vigarios, J. Riganti, B. Baroudjian, A. Filoni, R. Dodiuk-Gad, C. Lebbe, V Sibaud
Summary: The introduction of ICIs revolutionized oncologic therapy but also brought the risk of irAEs, with dermatologic irAEs being common. The EADV task force provided treatment recommendations for skin toxicities, focusing on balancing symptom relief with ongoing oncologic treatment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Letter
Dermatology
Alessia Villani, Maria Carmela Annunziata, Matteo Megna, Massimiliano Scalvenzi, Gabriella Fabbrocini
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marcella Nunziato, Anna Balato, Anna Ruocco, Valeria D'Argenio, Roberta Di Caprio, Nicola Balato, Fabio Ayala, Francesco Salvatore
Summary: Psoriasis is a chronic skin disorder with an immune basis, characterized by red, flaky patches that often release silvery scales. The study aimed to determine if there are genetic alterations that can explain the onset of the disease by using next-generation sequencing technologies and a multigene panel. Variants associated with psoriasis were found in the TRAF3IP2 gene, and a missense variant was found in the NAT9 gene. The use of multigene panels can help identify new susceptibility genes and allow for early diagnoses in affected families.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Giuseppe Broggi, Maria Failla, Andrea Russo, Antonio Longo, Andrea Palicelli, Magda Zanelli, Claudia Lombardo, Carla Loreto, Francesco Merolla, Rosa Maria Di Crescenzo, Gennaro Ilardi, Silvia Varricchio, Stefania Staibano, Rosario Caltabiano
Summary: PRAME is a tumor antigen that can distinguish between benign nevi and malignant melanomas, and is also expressed in non-melanocytic tumors. This study found that PRAME expression is correlated with higher metastatic risk and lower metastasis-free survival in primary uveal melanoma. It suggests that PRAME can be included in immunohistochemical panels to predict metastatic risk and stratify patient outcomes.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Oncology
Giuseppe Argenziano, Maria Concetta Fargnoli, Fabrizio Fantini, Massimo Gattoni, Giulio Gualdi, Francesco Pastore, Giovanni Pellacani, Pietro Quaglino, Paola Queirolo, Teresa Troiani
Summary: Cutaneous squamous cell carcinoma (CSCC) is a common skin malignancy with poor prognosis in advanced cases. A multi-disciplinary advisory group has proposed absolute and relative criteria for the use of cemiplimab in treating advanced CSCC.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)