期刊
AMERICAN JOURNAL OF CHINESE MEDICINE
卷 38, 期 5, 页码 1005-1014出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X10008421
关键词
Psoralea corylifolia; Eucalyptus globules; Bakuchiol; Macrocarpal C; Antifungal; Dermatophyte
资金
- Research Fund for the Control of Infectious Diseases (RFCID) [05050212]
- Food and Health Bureau, Hong Kong SAR, China
Fructus Psoraleae and Folium Eucalypti Globuli have long been used as Chinese medicines to treat various ailments such as asthma, eczema and dermatomycosis. In previous studies, their antifungal activities were demonstrated. The aim of the present study was to isolate active antidermatophytic compounds from their ethanolic extracts by means of bioassay-guided purification. Guided by the inhibitory activities on Trichophyton mentagrophytes, Trichophyton rubrum and Paecilomyces variolii, bakuchiol was isolated from the n-hexane fraction of Fructus Psoraleae whilst macrocarpal C was isolated from the n-hexane fraction of Folium Eucalypti Globuli. Both pure compounds could effectively inhibit the growth of dermatophytes in vitro. This is the first paper to report the isolation and identification of active antidermatophytic compounds from Fructus Psoraleae and Folium Eucalypti Globuli by the bioassay-guided purification.
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