Article
Cardiac & Cardiovascular Systems
T. Jake Samuel, Dalane W. Kitzman, Mark J. Haykowsky, Bharathi Upadhya, Peter Brubaker, M. Benjamin Nelson, W. Gregory Hundley, Michael D. Nelson
Summary: The study revealed that LV circumferential early diastolic strain rate was impaired in older obese patients with HFpEF compared to controls, and there was only modest correlation between LV relaxation and reduced peak (V)over dotO(2). On the other hand, it showed a stronger relationship between elevated LV filling pressures and exercise intolerance in determining future therapeutic priorities.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
James P. Teuber, Kobina Essandoh, Scott L. Hummel, Nageswara R. Madamanchi, Matthew J. Brody
Summary: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases play crucial roles in regulating oxidative stress, redox signaling, and the development of heart failure with preserved ejection fraction (HFpEF). HFpEF is associated with various systemic pathologies and multiple organ dysfunctions. NOX enzymes are involved in diastolic function and several HFpEF-associated comorbidities in animal models.
Article
Cardiac & Cardiovascular Systems
Shahryar M. Chowdhury, Eric M. Graham, Carolyn L. Taylor, Andrew Savage, Kimberly E. McHugh, Stephanie Gaydos, Arni C. Nutting, Michael R. Zile, Andrew M. Atz
Summary: This study aimed to identify high-risk Fontan patients with abnormal diastolic function and preserved ejection fraction and analyze their cardiac mechanics, exercise function, and functional health status.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Letter
Medicine, General & Internal
Elric Zweck, Ralf Westenfeld, Bjorn Redfors, Elmir Omerovic, Robin A. P. Weir, Domenico Gabrielli, Fabrizio Oliva, Giuseppe Zuccala, Scott D. Solomon, Muthiah Vaduganathan, John J. V. McMurray
Summary: Solomon et al. report on the DELIVER trial, which showed that dapagliflozin reduced risks of heart failure-related outcomes in patients with a mildly reduced or preserved left ventricular ejection fraction. These findings are expected to influence guidelines and clinical practice. The trial also confirmed dapagliflozin's efficacy in patients with a left ventricular ejection fraction of 60% or above.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Letter
Medicine, General & Internal
Debdatta Bhattacharyya, Ayan Kar, Saurabh Dhumale, Filippos K. Triposkiadis, Andrew Xanthopoulos, Efstathios K. Iliodromitis, James Amato, Hiddo J. L. Heerspink, Lesley Inker, Tom Greene, Stefan D. Anker, Javed Butler, Milton Packer
Summary: In patients with heart failure and preserved ejection fraction, Empagliflozin reduced the incidence of primary outcome events compared to other drugs, but had higher rates of cardiovascular death, death from any cause, and hospitalization for heart failure compared to spironolactone.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jan-Per Wenzel, Ramona Bei der Kellen, Christina Magnussen, Stefan Blankenberg, Benedikt Schrage, Renate Schnabel, Julius Nikorowitsch
Summary: The study evaluated the prevalence and correlates of left ventricular diastolic dysfunction (DD) in a middle-aged sample of the general population. The results showed that DD without HFpEF (ALVDD) was associated with hypertension and HbA1c, while DD with HFpEF (DDwHFpEF) was associated with factors like female sex, atrial fibrillation, and coronary artery disease.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jerremy Weerts, Sanne G. J. Mourmans, Arantxa Barandiaran Aizpurua, Blanche L. M. Schroen, Christian Knackstedt, Etto Eringa, Alfons J. H. M. Houben, Vanessa P. M. van Empel
Summary: Heart failure with preserved ejection fraction (HFpEF) is a disease with increasing incidence and no effective treatment. Coronary microvascular dysfunction plays a key role in the pathophysiology of HFpEF, possibly due to a low-grade pro-inflammatory state caused by systemic comorbidities. The presence or absence of peripheral microvascular dysfunction in HFpEF may reflect whether it is predominantly a cardiac or a systemic disease.
Article
Clinical Neurology
Stefan Buchner, Michael Wester, Sarah Hobelsberger, Christoph Fisser, Kurt Debl, Andrea Hetzenecker, Okka W. Hamer, Florian Zeman, Lars S. Maier, Michael Arzt
Summary: Sleep-disordered breathing, particularly obstructive sleep apnea, may impair diastolic function in patients with preserved left ventricular ejection fraction after acute myocardial infarction.
Article
Cardiac & Cardiovascular Systems
Sebastian Rosch, Karl-Patrik Kresoja, Christian Besler, Karl Fengler, Anne Rebecca Schoeber, Maximilian von Roeder, Christian Luecke, Matthias Gutberlet, Karin Klingel, Holger Thiele, Karl-Philipp Rommel, Philipp Lurz
Summary: In this study, patients with heart failure with preserved ejection fraction (HFpEF) were stratified based on left ventricular ejection fraction (LVEF), resulting in distinct morphologic and pathophysiologic subphenotypes. Patients with LVEF ranging from 50% to 60% demonstrated reduced contractility, impaired ventriculo-arterial coupling, and higher extracellular volume fraction, while patients with LVEF >60% exhibited a hypercontractile state with excessive left ventricular afterload and diminished preload reserve.
Article
Cardiac & Cardiovascular Systems
Barry A. Borlaug, Kavita Sharma, Sanjiv J. Shah, Jennifer E. Ho
Summary: The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing due to aging, obesity, sedentariness, and cardiometabolic disorders. Despite recent advances in understanding its pathophysiological effects and introduction of new diagnosis approaches, HFpEF remains under-recognized. This is concerning as effective treatments have been identified. This article provides an in-depth examination of the epidemiology, pathophysiology, diagnosis, and treatment of HFpEF. (J Am Coll Cardiol 2023;81:1810-1834) (c) 2023 by the American College of Cardiology Foundation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jin Joo Park, In-Chang Hwang, Si-Hyuck Kang, Jun-Bean Park, Jae-Hyeong Park, Goo-Yeong Cho
Summary: Myocardial strain is a key prognostic factor for patients with apparent HF and preserved EF. Among these patients, those with impaired GLS have higher 5-year all-cause mortality compared to those with normal GLS. Patients with impaired GLS also have a significantly increased risk of all-cause mortality compared to age-matched and sex-matched controls.
Review
Medicine, General & Internal
Agnieszka Kaplon-Cieslicka, Lars H. Lund
Summary: Heart failure with preserved ejection fraction (HFpEF) could soon be the most common type of acute heart failure, but there is still a lack of specific diagnostic criteria and definition. Acute HFpEF may be overdiagnosed in patients presenting with acute dyspnoea.
ANNALS OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yohei Sotomi, Shungo Hikoso, Daisaku Nakatani, Hiroya Mizuno, Katsuki Okada, Tomoharu Dohi, Tetsuhisa Kitamura, Akihiro Sunaga, Hirota Kida, Bolrathanak Oeun, Taiki Sato, Sho Komukai, Shunsuke Tamaki, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Yoshio Yasumura, Takahisa Yamada, Yasushi Sakata
Summary: In patients with HFpEF, female sex is independently associated with a higher prevalence of diastolic dysfunction and worse clinical outcomes compared to male sex. Despite differences in diastolic dysfunction, there was no significant difference in the incidence of clinical endpoints between women and men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Yi-Lin Tsai, Ruey-Hsing Chou, Ya-Wen Lu, Chun-Chin Chang, Chin-Sung Kuo, Po-Hsun Huang, Jaw-Wen Chen, Shing-Jong Lin
Summary: This study found that elevated serum levels of galectin-1 were associated with left ventricular diastolic dysfunction (DD) and the composite endpoint of all-cause mortality and incident HFpEF. High levels of galectin-1 remained significantly associated with DD.
JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dan Tong, Gabriele G. Schiattarella, Nan Jiang, Francisco Altamirano, Pamela A. Szweda, Abdallah Elnwasany, Dong I. Lee, Heesoo Yoo, David A. Kass, Luke I. Szweda, Sergio Lavandero, Eric Verdin, Thomas G. Gillette, Joseph A. Hill
Summary: The study demonstrated through a mouse model that HFpEF is associated with myocardial mitochondrial dysfunction, and NAD(+) supplementation is considered a promising therapeutic approach.
CIRCULATION RESEARCH
(2021)
Correction
Peripheral Vascular Disease
Giuseppe Biondi-Zoccai, Cristian M. Garmendia, Antonio Abbate, Arturo Giordano, Giacomo Frati, Sebastiano Sciarretta, Barbara Antonazzo, Francesco Versaci
CURRENT ATHEROSCLEROSIS REPORTS
(2020)
Review
Peripheral Vascular Disease
Giuseppe Biondi-Zoccai, Cristian M. Garmenda, Antonio Abbate, Arturo Giordano, Giacomo Frati, Sebastiano Sciarretta, Barbara Antonazzo, Francesco Versaci
CURRENT ATHEROSCLEROSIS REPORTS
(2020)
Editorial Material
Peripheral Vascular Disease
Dave L. Dixon, George F. Wohlford, Antonio Abbate
Editorial Material
Cardiac & Cardiovascular Systems
Giuseppe Biondi Zoccai, Antonio Abbate, Giacomo Frati, Mario Gaudino, Enrico Romagnoli, Sebastiano Sciarretta
MINERVA CARDIOANGIOLOGICA
(2020)
Review
Cell Biology
Aldo Bonaventura, Alessandra Vecchie, Antonio Abbate, Fabrizio Montecucco
Review
Cardiac & Cardiovascular Systems
Marouane Boukhris, Ali Hillani, Francesco Moroni, Mohamed Salah Annabi, Faouzi Addad, Marcelo Harada Ribeiro, Samer Mansour, Xiaohui Zhao, Luiz Fernando Ybarra, Antonio Abbate, Luz Maria Vilca, Lorenzo Azzalini
CANADIAN JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Antonio Abbate, Stefano Toldo, Carlo Marchetti, Jordana Kron, Benjamin W. Van Tassell, Charles A. Dinarello
CIRCULATION RESEARCH
(2020)
Article
Endocrinology & Metabolism
Salvatore Carbone, Hayley E. Billingsley, Justin M. Canada, Edoardo Bressi, Brando Rotelli, Dinesh Kadariya, Dave L. Dixon, Roshanak Markley, Cory R. Trankle, Richard Cooke, Krishnasree Rao, Keyur B. Shah, Horacio Medina de Chazal, Juan Guido Chiabrando, Alessandra Vecchie, Megan Dell, Virginia L. Mihalick, Roberta Bogaev, Linda Hart, Benjamin W. Van Tassell, Ross Arena, Francesco S. Celi, Antonio Abbate
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2020)
Article
Cardiac & Cardiovascular Systems
Juan G. Chiabrando, Marco Lombardi, Giovanni M. Vescovo, George F. Wohlford, Rachel A. Koenig, Antonio Abbate, Luis A. Guzman, Daniel H. Berrocal, Giuseppe Biondi-Zoccai
Summary: In this network meta-analysis, DK crush and Mini-crush were associated with fewer events and complications compared to other techniques, including the Provisional approach. However, Culotte and Crush were found to have a higher risk of stent thrombosis compared to the Provisional approach.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cell Biology
Michele Golino, Francesco Moroni, Marco Giuseppe Del Buono, Justin M. M. Canada, Azita H. H. Talasaz, Sebastian Pinel, James Mbualungu, Alessandra Vecchie, Ai-Chen (Jane) Ho, Georgia K. Thomas, Salvatore Carbone, Hayley E. Billingsley, Jeremy Turlington, Roshanak Markley, Cory Trankle, Roberto De Ponti, Benjamin Van Tassell, Antonio Abbate
Summary: Anakinra treatment leads to a transient increase in eosinophils in patients with heart failure, which is associated with injection site reactions and improvement in cardiorespiratory fitness.
Meeting Abstract
Cardiac & Cardiovascular Systems
Allan Klein, S. Allen Luis, Martin M. LeWinter, David Lin, Paul Cremer, Saifullah Nasir, Antonio Abbate, Andrew Ertel, Fang Fang, Anna Beutler, John Paolini
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Jay Park, Aaron Schatz, Jaideep Patel, Zackary Tushak, Antonio Abbate, Hem Bhardwaj, Barbara Lawson, Zachary Gertz
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Jaideep Patel, Anurag Mehta, Mahmoud Al Rifai, Michael Blaha, Khurram Nasir, John W. McEvoy, Ambarish Pandey, Alka Kanaya, Namratha R. Kandula, Salim S. Virani, Antonio Abbate, William G. Hundley, Laurence S. Sperling, Parag Joshi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Zackary Tushak, Jaideep Patel, Aaron Schatz, Rajiv Ashok Kabadi, Taha Al-Jubaishi, Taeshik Park, Antonio Abbate, Phoebe Ashley
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)