Article
Cardiac & Cardiovascular Systems
Takashi Kataoka, Ken Harada, Akihito Tanaka, Tomohiro Onishi, Shun Matsunaga, Hiroshi Funakubo, Kazuhiro Harada, Tomoyuki Nagao, Norihiro Shinoda, Nobuyuki Marui, Kiyoshi Niwa, Hiroshi Tashiro, Yusuke Hitora, Kenji Furusawa, Hideki Ishii, Tetsuya Amano, Toyoaki Murohara
Summary: The study found that Epicardial adipose tissue (EAT) volume is significantly associated with coronary artery spasm, while total abdominal adipose tissue (AAT) may not have a significant impact.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natalia V. Naryzhnaya, Olga A. Koshelskaya, Irina V. Kologrivova, Olga A. Kharitonova, Vladimir V. Evtushenko, Alla A. Boshchenko
Summary: The study compared the morphological characteristics of epicardial adipose tissue (EAT) adipocytes and their sensitivity to insulin with coronary artery disease (CAD) severity, finding a relationship between the size and degree of hypertrophy of epicardial adipocytes and CAD severity. Insulin resistance of adipocytes may mediate this relationship.
Review
Cardiac & Cardiovascular Systems
Marco Guglielmo, Andrew Lin, Damini Dey, Andrea Baggiano, Laura Fusini, Giuseppe Muscogiuri, Gianluca Pontone
Summary: EAT and PCAT are not inert fat tissues, they secrete adipokines that have significant effects on cardiovascular health; PCAT inflammation is associated with CAD and cardiovascular events, and CCT has become a key technology for assessing EAT and PCAT.
Article
Health Care Sciences & Services
Olga V. Gruzdeva, Yulia A. Dyleva, Ekaterina V. Belik, Maxim Y. Sinitsky, Aleksandr N. Stasev, Aleksandr N. Kokov, Natalia K. Brel, Evgenia O. Krivkina, Evgenia E. Bychkova, Roman S. Tarasov, Olga L. Barbarash
Summary: This study assessed the expression and secretion of adipocytokine genes in the adipose tissue of patients with coronary artery disease (CAD) and patients with aortic or mitral valve replacement. The results showed that epicardial fat depots in CAD patients exhibited more pronounced changes and increased pro-inflammatory activity compared to the group with heart defects.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zdenek Matloch, Milos Mraz, Barbora Judita Kasperova, Helena Kratochvilova, Petr Svoboda, Iveta Pleyerova, Katerina Reznickova, Sarah Norman, Daniel Hlavacek, Jakub Mahrik, Peter Ivak, Zdenka Lacinova, Ivan Netuka, Martin Haluzik
Summary: In this study, changes in serum CTRP3 and its gene expression in patients with CAD and T2DM undergoing cardiac surgery were examined. The results showed that decreased EAT mRNA levels of CTRP3 may contribute to higher risk of atherosclerosis in patients with CAD and T2DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Iokfai Cheang, Xu Zhu, Xin Yue, Yuan Tang, Yujie Gao, Xinyi Lu, Shi Shi, Shengen Liao, Wenming Yao, Yanli Zhou, Haifeng Zhang, Yinsu Zhu, Yi Xu, Xinli Li
Summary: The purpose of this study was to investigate the prognostic values of ventricle epicardial fat volume (EFV) in patients with chronic heart failure (CHF) using cardiac magnetic resonance. A total of 516 CHF patients were recruited, and 136 (26.4%) of them experienced major adverse cardiovascular events (MACE) within a median follow-up of 24 months. The study found that EFV was significantly associated with MACE and showed promising predictive ability for MACE at different time points.
Article
Radiology, Nuclear Medicine & Medical Imaging
Runlei Ma, Marly van Assen, Grigory Sidorenkov, Daan Ties, Gert Jan Pelgrim, Arthur Stillman, Carlo de Cecco, Pim van der Harst, Rozemarijn Vliegenthart
Summary: In both CAD and non-CAD patients, EAT density, but not EAT volume, showed significant associations with PCAT(MA). Men had higher PCAT(MA) and EAT volume independently of disease status, but similar or slightly lower EAT density compared to women. Personalized interpretation and thresholding may be needed due to differences in trends and relations of PCAT(MA) and EAT by sex.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenjun Fan, Yueqiao Si, Enhong Xing, Zengbin Feng, Zhenjiang Ding, Yixiang Liu, Chen Wei, Yanan Tian, Ying Zhang, Jingyi Liu, Lixian Sun
Summary: This study investigates the expression of novel adipocytokines and inflammatory cells infiltration in epicardial adipose tissue (EAT) and subcutaneous adipose tissue (SAT) between 27 coronary artery disease (CAD) and 21 non-CAD (NCAD) patients. The results showed dysregulation of novel adipocytokines and inflammatory cells infiltration in EAT, which could be important pathophysiological mechanisms and novelly promising medicating targets of CAD.
Article
Cardiac & Cardiovascular Systems
Xiangbo Jin, Beibei Gao, Jiamin Zheng, Xueer Wu, Ning Zhang, Lijun Zhu, Xinyu Zhu, Jianchang Xie, Zhen Wang, Guoxin Tong, Jinyu Huang
Summary: This study found that epicardial adipose tissue (EAT) volume is significantly associated with the presence and severity of cardiovascular disease in Chinese patients, independent of traditional risk factors and coronary artery calcium. When combined with obstructive coronary artery disease, EAT volume significantly improves the diagnostic performance for cardiovascular disease, suggesting that EAT could be a reliable noninvasive indicator of hemodynamically significant CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Emmanuel Cosson, Minh Tuan Nguyen, Imen Rezgani, Narimane Berkane, Sara Pinto, Helene Bihan, Sopio Tatulashvili, Malak Taher, Meriem Sal, Michael Soussan, Pierre-Yves Brillet, Paul Valensi
Summary: Epicardial adipose tissue (EAT) is considered a novel diagnostic marker for cardiometabolic disease. This study found that EAT volume is positively correlated with age, body mass index, and triglyceridemia, but negatively correlated with HbA1c, HDL- and LDL-cholesterol levels in asymptomatic people living with diabetes. While EAT may play a role in coronary atherosclerosis and coronary circulation in patients with diabetes, it is not a better marker for discriminating the risk of asymptomatic myocardial ischemia than classic clinical data.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Infectious Diseases
Thomas Heseltine, Elen Hughes, Jean Mattew, Scott Murray, Sandra Ortega-Martorell, Ivan Olier, Damini Dey, Gregory Y. H. Lip, Saye Khoo
Summary: This study compared the association of cardiovascular disease (CVD) with epicardial adipose tissue (EAT) in HIV-positive and HIV-negative patients. The results showed that, after adjustment, EAT volume was significantly associated with coronary calcification in the HIV-positive group, but not in the HIV-negative group, suggesting differences in the mechanistic drivers of atherosclerosis between these two groups.
JOURNAL OF INFECTION
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander R. van Rosendael, Jeff M. Smit, Mohammed El'Mahdiui, Philippe J. van Rosendael, Melissa Leung, Victoria Delgado, Jeroen J. Bax
Summary: This study evaluated the association between left atrial epicardial fat and left atrial volume in patients with different types of atrial fibrillation (AF). The results showed that left atrial epicardial fat was larger in patients with paroxysmal AF, while larger left atrial volumes were associated with persistent/permanent AF.
Article
Cardiac & Cardiovascular Systems
Yu Sun, Xiao-Gang Li, Kai Xu, Jie Hou, Hong-Rui You, Rong-Rong Zhang, Miao Qi, Li-Bo Zhang, Li-Sheng Xu, Stephen E. Greenwald, Ben-Qiang Yang
Summary: This study aims to evaluate the relationship between epicardial fat volume (EFV) level and coronary atherosclerosis severity in patients with stable three-vessel coronary artery disease (CAD). The study found that patients with three-vessel CAD had significantly higher EFV levels compared to normal controls. Moreover, there was an inverse relationship between EFV level and the severity of coronary atherosclerosis in these patients. This relationship may be influenced by body mass index.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yarong Yu, Xiaoying Ding, Lihua Yu, Ziting Lan, Yufan Wang, Jiayin Zhang
Summary: This study investigates the predictive value of peri-coronary adipose tissue (PCAT) attenuation for microvascular complications in diabetic patients without significant stenosis and develops a prediction model for early risk stratification.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Noura N. Ballasy, Anshul S. Jadli, Pariya Edalat, Sean Kang, Ali Fatehi Hassanabad, Karina P. Gomes, Paul W. M. Fedak, Vaibhav B. Patel
Summary: The study found that epicardial adipose tissue (EAT) treated with high glucose, high palmitate, and lipopolysaccharide released a large amount of proinflammatory cytokines, which may lead to EAT inflammation in patients with type 2 diabetes, causing coronary artery endothelial cell dysfunction.
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)