Review
Medicine, General & Internal
Claudio Tana, Cesare Mantini, Iginio Donatiello, Luciano Mucci, Marco Tana, Fabrizio Ricci, Francesco Cipollone, Maria Adele Giamberardino
Summary: Cardiac sarcoidosis is a potentially harmful manifestation of systemic sarcoidosis, often associated with a poor prognosis, especially in African American patients. The diagnosis is often complicated by non-specific clinical manifestations, but imaging and biopsies are essential for accurate diagnosis and management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Rabea Asleh, Alexandros Briasoulis, Ilias Doulamis, Hilmi Alnsasra, Aspasia Tzani, Paulino Alvarez, Toshiki Kuno, Polydoros Kampaktsis, Sudhir Kushwaha
Summary: The study found that patients with sarcoid cardiomyopathy had similar short-term and long-term outcomes after heart transplantation compared to patients with non-ischaemic cardiomyopathy.
Article
Cell Biology
Juan A. Perez-Bermejo, Serah Kang, Sarah J. Rockwood, Camille R. Simoneau, David A. Joy, Ana C. Silva, Gokul N. Ramadoss, Will R. Flanigan, Parinaz Fozouni, Huihui Li, Pei-Yi Chen, Ken Nakamura, Jeffrey D. Whitman, Paul J. Hanson, Bruce M. McManus, Melanie Ott, Bruce R. Conklin, Todd C. McDevitt
Summary: This study found that heart cells of COVID-19 patients exposed to SARS-CoV-2 may suffer significant damage such as myofibrillar fragmentation and nuclear disruption, providing insights for potential therapeutic discovery.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Engineering, Biomedical
Tyler J. Schmidt, Andrew N. Rosenbaum, Nikhil Kolluri, John M. Stulak, Richard C. Daly, John A. Schirger, Mohamed Y. Elwazir, Suraj Kapa, Leslie T. Cooper, Lori A. Blauwet
Summary: A retrospective study identified 232 consecutive patients meeting cardiac sarcoidosis (CS) criteria, with 10 diagnosed by evaluation of the apical core or explanted heart. Clinical characteristics and outcomes for these patients were comparable to those with known CS before LVAD implant/transplant.
Article
Multidisciplinary Sciences
Yu Tan, Robert C. Coyle, Ryan W. Barrs, Sophia E. Silver, Mei Li, Dylan J. Richards, Yiliang Lin, Yuanwen Jiang, Hongjun Wang, Donald R. Menick, Kristine Deleon-Pennell, Bozhi Tian, Ying Mei
Summary: Human cardiac organoids engineered with electrically conductive silicon nanowires significantly enhance therapeutic efficacy for treating infarcted hearts by promoting contractile development and cardiac functional recovery.
Review
Medicine, General & Internal
Irina R. R. Strambu
Summary: Sarcoidosis is a disease of unknown origin that can affect multiple organs. Cardiac sarcoidosis is particularly challenging due to its potential for serious cardiac complications and difficulty in diagnosis. This manuscript reviews the current understanding and guidelines for diagnosing and treating cardiac sarcoidosis, highlighting a case study of a young adult with no known risk factors or prior diagnosis of sarcoidosis presenting with disabling cardiac symptoms.
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Takeru Nabeta, Takeshi Kitai, Yoshihisa Naruse, Tatsunori Taniguchi, Kenji Yoshioka, Hidekazu Tanaka, Takahiro Okumura, Shuntaro Sato, Yuichi Baba, Keisuke Kida, Yodo Tamaki, Shingo Matsumoto, Yuya Matsue
Summary: This study evaluated the prognosis and prognostic factors of patients with cardiac sarcoidosis (CS) and found that although mortality is relatively low, adverse events are common, mainly due to fatal ventricular arrhythmia events. Patients with low left ventricular ejection fraction, high brain natriuretic peptide levels, a history of ventricular tachycardia/fibrillation, and requiring radiofrequency ablation for ventricular tachycardia are at high risk.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Natalie S. Rosen, Noelle Pavlovic, Chloe Duvall, Alison L. Wand, Jan M. Griffin, David R. Okada, Jonathan Chrispin, Harikrishna Tandri, Stephen C. Mathai, Barney Stern, Carlos A. Pardo, Edward K. Kasper, Michelle Sharp, Edward S. Chen, Nisha A. Gilotra
Summary: This study compares the clinical characteristics and outcomes of patients with cardiac sarcoidosis (CS) as their first recognized organ manifestation and those with a prior history of sarcoidosis. The results show that patients with de novo CS have more advanced cardiac presentation, worse outcomes, and increased risk of adverse cardiac events compared to patients with prior extracardiac sarcoidosis (ECS).
RESPIRATORY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
William C. Roberts, Lena Hasson, Murad H. Hassan
Summary: This article describes two clinically diagnosed giant cell myocarditis patients who had short clinical courses before undergoing life-saving heart transplantation. The examination of their hearts revealed multiple widespread yellow lesions in the ventricular walls. The short clinical courses and color differences of myocardial lesions distinguish giant cell myocarditis from cardiac sarcoidosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sho Kazui, Sakae Takenaka, Toshiyuki Nagai, Yoshiya Kato, Hirokazu Komoriyama, Yuta Kobayashi, Akinori Takahashi, Kiwamu Kamiya, Takuma Sato, Atsushi Tada, Yutaro Yasui, Michikazu Nakai, Takahiro Sato, Ichizo Tsujino, Satoshi Konno, Toshihisa Anzai
Summary: This study found that the longitudinal trajectory of cardiac troponin levels in patients with cardiac sarcoidosis after prednisolone treatment was associated with adverse cardiac events, suggesting that longitudinal measurement of cardiac troponin levels would be useful for the early identification of high-risk patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jing Liu, Pan Ma, Lulu Lai, Ana Villanueva, Andrew Koenig, Gregory R. Bean, Dawn E. Bowles, Carolyn Glass, Michael Watson, Kory J. Lavine, Chieh-Yu Lin
Summary: This study utilized spatial transcriptomics and single-nucleus RNA sequencing to analyze the cellular and transcriptional landscape of cardiac sarcoidosis, and compared it with other inflammatory heart diseases. The results identified diverse populations of immune cells with distinct molecular signatures in cardiac sarcoidosis, providing new insights into the pathology of this condition.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Per Eldhagen, Emanuele Bobbio, Pernilla Darlington, Johan Grunewald, Anders Eklund, Christian L. Polte, Niklas Bergh, Entela Bollano, Peder Sorensson, Susanna Kullberg
Summary: This study included 87 Swedish patients with cardiac sarcoidosis (CS) and found that patients who presented with CS as their first manifestation were younger, had more severe cardiac symptoms, and may be at risk of missed or delayed diagnosis.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cell & Tissue Engineering
Lynn Yap, Li Yen Chong, Clarissa Tan, Swarnaseetha Adusumalli, Millie Seow, Jing Guo, Zuhua Cai, Sze Jie Loo, Eric Lim, Ru San Tan, Elina Grishina, Poh Loong Soong, Narayan Lath, Lei Ye, Enrico Petretto, Karl Tryggvason
Summary: Stem cell-derived committed cardiac progenitors (CCPs) showed potential in regenerative cardiology, as observed in a study where pluripotent stem cells were differentiated into CCPs and transplanted into infarcted pig hearts, resulting in significant improvement in heart function and reduction in infarction size.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Richard C. Daly, Andrew N. Rosenbaum, Joseph A. Dearani, Alfredo L. Clavell, Naveen L. Pereira, Barry A. Boilson, Robert P. Frantz, Atta Behfar, Shannon M. Dunlay, Richard J. Rodeheffer, John A. Schirger, Timucin Taner, Manish J. Gandhi, Julie K. Heimbach, Charles B. Rosen, Brooks S. Edwards, Sudhir S. Kushwaha
Summary: This study demonstrates the successful transplantation using a heart-after-liver transplantation protocol, which provides profound immunologic protection and prevents adverse immunological outcomes in highly sensitized patients requiring combined heart-liver transplantation. The results show near-elimination of donor specific antibodies and minimal rejection episodes, leading to favorable long-term patient and graft outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Suzan Hatipoglu, Syed K. M. Gardezi, Alessia Azzu, John Baksi, Francisco Alpendurada, Cemil Izgi, Raj Khattar, Vasileios Kouranos, Athol Umfrey Wells, Rakesh Sharma, Kshama Wechalekar, Dudley J. Pennell, Raad Mohiaddin
Summary: This study aimed to describe advanced imaging patterns suggestive of cardiac sarcoidosis (CS) in patients presenting with cardiac arrest or life-threatening arrhythmias. The study found that FDG-PET had lower sensitivity compared to CMR oedema imaging in detecting myocardial inflammation in CS patients. Therefore, CMR imaging can be used to detect the possibility of cardiac scarring in CS patients.
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)