☆ 4.4 Article

Prognostic Utility of the SYNTAX Score in Patients With Single Versus Multivessel Disease Undergoing Percutaneous Coronary Intervention (from the Acute Catheterization and Urgent Intervention Triage StrategY [ACUITY] Trial)

AMERICAN JOURNAL OF CARDIOLOGY (2014)

期刊

AMERICAN JOURNAL OF CARDIOLOGY

卷 113, 期 2, 页码 203-210

出版社

EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC

DOI: 10.1016/j.amjcard.2013.08.035

关键词

类别

Cardiac & Cardiovascular Systems

资金

Sanofi/Bristol Myers Squibb (New York, New York)

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

摘要

The SYNergy between percutaneous intervention with TAXus drug-eluting stents and cardiac surgery (SYNTAX) score (SS) is an effective angiographic predictor of clinical outcomes in patients with multivessel coronary artery disease (MVD) undergoing percutaneous coronary intervention. It is not known whether this relation is independent of the number of diseased vessels. The aim of the present study was to assess the relation between the SS and major adverse cardiac events (MACE) in patients with single-vessel disease (SVD) and MVD undergoing percutaneous coronary intervention. In the ACUITY trial, the SS was determined in 2,627 patients undergoing percutaneous coronary intervention. The relation between the SS and the 1-year clinical outcomes was assessed according to SS tertiles: <5 (n = 441), >= 5 but <10 (n = 525), and >= 10 (n = 495) for SVD and <10 (n = 361), >= 10 but <18 (n = 401), and >= 18 (n = 404) for MVD. At 1 year of follow-up, the rate of MACE was 16.8%, 24.7%, and 23.7% for patients with MVD in the first, second and third tertiles, respectively (p = 0.02). The corresponding rates for those with SVD was 13.3%, 15.3%, and 19.1% (p = 0.01). In the patients with MVD, the SS independently predicted 1-year MACE (hazard ratio 1.02, 95% confidence interval 1.01 to 1.03; p = 0.002), myocardial infarction (hazard ratio 1.02, 95% confidence 1.00 to 1.04; p = 0.02), and cardiac death (hazard ratio 1.05, 95% confidence interval 1.02 to 1.09; p = 0.005). In patients with SVD, the SS independently predicted 1-year MACE (hazard ratio 1.03, 95% confidence interval 1.01 to 1.05; p = 0.0009) and myocardial infarction (hazard ratio 1.05, 95% confidence interval 1.02 to 1.07; p = 0.002). In the overall study cohort, the SS was an independent predictor of MACE and death, and MVD (vs SVD) was not. In conclusion, the SS is a useful angiographic predictive tool for patients with SVD and MVD. (C) 2014 Elsevier Inc. All rights reserved.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

主要评分

4.4

评分不足

次要评分

新颖性

重要性

科学严谨性

评价这篇论文

Prognostic impact of white blood cell counts on clinical outcomes in patients with chronic renal insufficiency undergoing percutaneous coronary intervention

Wei Yan, Mengyao Li, Yumeng Lei, Shuaiyong Zhang, Fengfeng Lv, Jiawang Wang, Qian Yang, Na Yu, Ming Chen, Xufen Cao, Liqiu Yan

Summary: This study aimed to investigate whether including white blood cell (WBC) counts in the SYNTAX score (SS) or SS II models could enhance risk stratification in individuals with chronic renal insufficiency (CRI) following percutaneous coronary intervention (PCI). The results showed that higher WBC counts were associated with increased risk of all-cause mortality, cardiac mortality, unplanned revascularization, and major adverse cardiovascular and cerebrovascular events (MACCEs) in CRI patients undergoing PCI. Incorporating ih-WBC counts into the SS or SS II models significantly improved the assessment and prediction of all-cause mortality and cardiac mortality.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2023)