Article
Cardiac & Cardiovascular Systems
Eivind Sorensen, Marius Myrstad, Magnar Gangas Solberg, Erik Oie, Arnljot Tveit, Marit Aaronaes
Summary: The study found that male veteran athletes had significantly larger left atrial volumes compared to non-athletes, while left atrial strain values were lower in individuals with paroxysmal AF, regardless of athletic status. Left atrial strain was a better indicator for identifying participants with AF compared to volumetric measurements.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Henrique M. Lobo, Icaro G. Naves, Silvia Botelho Marcal, Camila Cassia Canzi, Amanda Braun Sabino Rodrigues, Antonio S. Menezes Jr
Summary: According to the 2016 ESC recommendations, moderate regular physical activity is beneficial for preventing atrial fibrillation (AF), while long-lasting vigorous sports engagement may lead to AF. This study synthesized 112 articles on AF and endurance athletes, confirming the negative effects of exercise on cardiac structure and function, as well as the associations between body composition and AF risk.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Sport Sciences
William Newman, Gemma Parry--Williams, Jonathan Wiles, Jamie Edwards, Sabina Hulbert, Konstantina Kipourou, Michael Papadakis, Rajan Sharma, Jamie O'Driscoll
Summary: Athletes have a significantly higher risk of developing AF compared to non-athlete controls, particularly those participating in mixed sports and younger age groups. The mode of exercise and age are crucial factors influencing the risk of AF development.
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)
Article
Medicine, General & Internal
Gregory F. Michaud, William G. Stevenson
Summary: A 63-year-old healthy male with atrial fibrillation presents with symptoms of dyspnea and irregular heartbeat. Physical examination reveals high blood pressure, irregular pulse, and ECG confirms atrial fibrillation. Further evaluation and treatment plan are needed.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Srikanth Perike, Francisco J. Gonzalez-Gonzalez, Issam Abu-Taha, Frederick W. Damen, Laurin M. Hanft, Ken S. Lizama, Anahita Aboonabi, Andrielle E. Capote, Yuriana Aguilar-Sanchez, Benjamin Levin, Zhenbo Han, Arvind Sridhar, Jacob Grand, Jody Martin, Joseph G. Akar, Chad M. Warren, R. John Solaro, Sang-Ging Ong, Dawood Darbar, Kerry S. Mcdonald, Craig J. Goergen, Beata M. Wolska, Dobromir Dobrev, Xander H. T. Wehrens, Mark D. McCauley
Summary: The study revealed that patients with AF have increased expression of PPP1R12C protein, leading to decreased atrial contractility. Overexpression of PPP1R12C in mice increases PP1c targeting to MLC2a, causing MLC2a dephosphorylation, and subsequently increasing AF inducibility.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Ange Maguy, Yuvaraj Mahendran, Jean-Claude Tardif, David Busseuil, Jin Li
Summary: This study explores the association between autoantibodies targeting cardiac ion channels and unexplained AF. They found a common autoantibody response against K(ir)3.4 protein in patients with AF, even before the development of clinically apparent AF. Functional studies and a mouse model of K(ir)3.4 autoimmunity support the causal relationship between K(ir)3.4 autoantibodies and AF.
Article
Medicine, General & Internal
Bianca J. J. M. Brundel, Xun Ai, Mellanie True Hills, Myrthe F. Kuipers, Gregory Y. H. Lip, Natasja M. S. de Groot
Summary: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is increasing in prevalence. Understanding the molecular mechanisms underlying AF is crucial for the development of personalized diagnostic tools and mechanism-based therapies. Co-creation with patients is essential for successful management of AF.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Multidisciplinary Sciences
Maarten Hulsmans, Maximilian J. Schloss, I-Hsiu Lee, Aneesh Bapat, Yoshiko Iwamoto, Claudio Vinegoni, Alexandre Paccalet, Masahiro Yamazoe, Jana Grune, Steffen Pabel, Noor Momin, Hana Seung, Nina Kumowski, Fadi E. Pulous, Daniel Keller, Constanze Bening, Ursula Green, Jochen K. Lennerz, Richard N. Mitchell, Andrew Lewis, Barbara Casadei, Oriol Iborra-Egea, Antoni Bayes-Genis, Samuel Sossalla, Chin Siang Ong, Richard N. Pierson, Jon C. Aster, David Rohde, Gregory R. Wojtkiewicz, Ralph Weissleder, Filip K. Swirski, George Tellides, George Tolis, Serguei Melnitchouk, David J. Milan, Patrick T. Ellinor, Kamila Naxerova, Matthias Nahrendorf
Summary: This study deciphered the role of immune and stromal cells in atrial fibrillation and identified SPP1(+) macrophages as potential targets for immunotherapy in atrial fibrillation.
Article
Cardiac & Cardiovascular Systems
Florian Baptiste, Jerome Kalifa, Cyril Durand, Edouard Gitenay, Michel Bremondy, Anis Ayari, Nicolas Maillot, Antonio Taormina, Aicha Fofana, Guillaume Penaranda, Sabrina Siame, Clement Bars, Julien Seitz
Summary: This study aimed to investigate the prevalence and electrophysiological characteristics of atrial fibrillation (AF) drivers arising from the right atrial appendage (RAA). The results showed that 7% of patients had RAA drivers, which were associated with the termination of AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Guy Rozen, Gilad Margolis, Ibrahim Marai, Ariel Roguin, Eldad Rahamim, David Planer, Edwin Kevin Heist, Offer Amir, Ilgar Tahiroglu, Jeremy Ruskin, Moussa Mansour, Gabby Elbaz-Greener
Summary: The paper reviews the evolution of surgical techniques for left atrial appendage (LAA) exclusion and the use of percutaneous LAA occlusion techniques as alternative stroke prevention methods. The article focuses on recently published randomized data supporting surgical LAA occlusion during cardiac surgery and the emerging trans-catheter techniques for LAA occlusion. The study also highlights the favorable results of Watchman and Amulet devices in reducing stroke risk in atrial fibrillation (AF) patients with contraindications for oral anticoagulation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Hongting Hao, Sen Yan, Xinbo Zhao, Xuejie Han, Ning Fang, Yun Zhang, Chenguang Dai, Wenpeng Li, Hui Yu, Yunlong Gao, Dingyu Wang, Qiang Gao, Yu Duan, Yue Yuan, Yue Li
Summary: Atrial fibrosis plays a critical role in the development of atrial fibrillation. The promotion of atrial fibrosis through inhibition of GPD1L by miR-210-3p in extracellular vesicles is identified. Preventing pathological crosstalk between atrial myocytes and fibroblasts may offer a novel approach to ameliorate atrial fibrosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Julia Krause, Alexander Nickel, Alexandra Madsen, Hamish M. Aitken-Buck, A. M. Stella Stoter, Jessica Schrapers, Francisco Ojeda, Kira Geiger, Melanie Kern, Michael Kohlhaas, Edoardo Bertero, Patrick Hofmockel, Florian Huebner, Ines Assum, Matthias Heinig, Christian Mueller, Arne Hansen, Tobias Krause, Deung-Dae Park, Steffen Just, Dylan Aissi, Daniela Boernigen, Diana Lindner, Nele Friedrich, Khaled Alhussini, Constanze Bening, Renate B. Schnabel, Mahir Karakas, Licia Iacoviello, Veikko Salomaa, Allan Linneberg, Hugh Tunstall-Pedoe, Kari Kuulasmaa, Paulus Kirchhof, Stefan Blankenberg, Torsten Christ, Thomas Eschenhagen, Regis R. Lamberts, Christoph Maack, Justus Stenzig, Tanja Zeller
Summary: Long-chain acyl-carnitines, specifically C18:1AC, have been found to be potential arrhythmogenic metabolites. This metabolite has biphasic effects on cardiac electrophysiology and metabolism, and has the potential to serve as a circulating biomarker for predicting risk of atrial fibrillation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Computer Science, Information Systems
Li Zhu, Viswam Nathan, Jilong Kuang, Jacob Kim, Robert Avram, Jeffrey Olgin, Jun Gao
Summary: Atrial Fibrillation (AF) is a significant cardiac rhythm disorder that can be detected and monitored using wearable sensors. This study developed a highly sensitive and specific AF detection algorithm, and comprehensively validated its performance in a real-world population. The research also demonstrated the robustness and accuracy of the algorithm in daily living scenarios.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Cardiac & Cardiovascular Systems
Sung-Chun Tang, Yen-Bin Liu, Lian-Yu Lin, Hui-Chun Huang, Li-Ting Ho, Ling-Ping Lai, Wen-Jone Chen, Yi-Lwung Ho, Chih-Chieh Yu
Summary: This study aims to clarify the impact of atrial fibrillation burden on cognitive function through detailed electrophysiological recordings and standardized assessments.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Bao-Oanh Nguyen, Vanessa Weberndorfer, Harry J. G. M. Crijns, Bastiaan Geelhoed, Hugo Ten Cate, Henri Spronk, Abraham Kroon, Ruben De With, Meelad Al-Jazairi, Alexander H. Maass, Yuri Blaauw, Robert G. Tieleman, Martin E. W. Hemels, Justin Luermans, Joris de Groot, Cornelis P. Allaart, Arif Elvan, Mirko De Melis, Coert Scheerder, Anton Jan van Zonneveld, Ulrich Schotten, Dominik Linz, Isabelle Van Gelder, Michiel Rienstra
Summary: This study aims to develop a new atrial fibrillation (AF) progression risk prediction model in patients with paroxysmal AF (PAF) to determine the risk and treatment targets for AF progression. The study found that markers for atrial remodeling, sex, mitral valve regurgitation, waist circumference, and biomarkers associated with coagulation, inflammation, cardiomyocyte stretch, and atherosclerosis were all associated with AF progression.
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)