Article
Medicine, General & Internal
Che-Yuan Wu, Christa Wang, Refik Saskin, Baiju R. Shah, Moira K. Kapral, Krista L. Lanctot, Nathan Herrmann, Hugo Cogo-Moreira, Bradley J. MacIntosh, Jodi D. Edwards, Walter Swardfager
Summary: This study aimed to investigate the association between metformin initiation and incident dementia in older adults newly diagnosed with diabetes. It found that early metformin initiation did not reduce the risk of dementia in this population.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jung A. Kim, Ji Sung Lee, Eyun Song, Eun Roh, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
Summary: This study examined the relationship between fasting plasma glucose variability and osteoporotic fractures in individuals without diabetes using a nationwide cohort database. The results suggest that FPG variability may be an independent risk factor for osteoporotic fractures in the general population without diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Jung A. Kim, Ji Sung Lee, Eyun Song, Eun Roh, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
Summary: Although previous studies have linked long-term glucose variability to osteoporosis, this study is the first to investigate the relationship between glucose variability and fractures in individuals without diabetes. The results suggest that fasting plasma glucose variability may be an independent risk factor for osteoporotic fractures in the general population without diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Kai Liu, Pengwei Jing, Zehan Liu, Ying Wang, Zhu Han, Youqiang Wang, Zhirui Zheng, Yue Wu, Tong Wang, Yuhui Li, Hongying Zhang, Lichun Wang
Summary: This study found that decreased serum levels of circulating irisin are associated with a high risk of osteoporosis-related hip fractures and osteoporosis.
Article
Oncology
Phillip S. Blanchette, Melody Lam, Britney Le, Lucie Richard, Salimah Z. Shariff, Alexandra M. Ouedraogo, Kathleen Pritchard, Jacques Raphael, Ted Vandenberg, Ricardo Fernandes, Danielle N. Desautels, Kelvin K. W. Chan, Craig C. Earle
Summary: The study did not find a significant difference in the rate of osteoporotic fracture between breast cancer patients treated with aromatase inhibitors and tamoxifen. However, there was a lower risk associated with tamoxifen when considering the total duration of endocrine therapy.
Article
Medicine, General & Internal
Zhuoqing Hu, Kevin Yang, Zhihui Hu, Miaosheng Li, Hao Wei, Zheng Tang, Baitong Chen, Chengbiao Su, De Cai, Jinrong Xu
Summary: The study found an association between hypertension and bone metabolism markers in osteoporotic patients, with lower levels of OC and 25-OHD in hypertensive individuals. This may contribute to reduced bone turnover and could be a mechanism for hypertension-related osteoporosis.
Review
Biochemistry & Molecular Biology
Hui Cai, Huimei Zhang, Weiting He, Heng Zhang
Summary: Postmenopausal osteoporosis, known as the "invisible killer," is a degenerative disease. Estrogen is crucial for maintaining bone mineral content in women. Iron accumulation, with serum ferritin levels higher than normal but less than 1000 μg/L, has been found to occur simultaneously with osteoporosis after menopause. Recent studies have shown that iron accumulation plays a vital role in postmenopausal osteoporosis and is significantly correlated with fragility fractures.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Review
Rheumatology
Mihail A. Boyanov, Anna-Maria Borissova, Tzvetanka P. Petranova, Plamen R. Popivanov, Rumen M. Stoilov, Reneta T. Petkova
Summary: In real-world clinical practice, the duration of osteoporosis treatment is often suboptimal, lasting less than 3-4 years regardless of fracture risk. Factors beyond medical considerations, such as limitations imposed by the Health Insurance Fund, play a significant role. Health authorities should take note of this issue.
RHEUMATOLOGY AND THERAPY
(2021)
Article
Medicine, Research & Experimental
Panpan Li, Bei Xu, Jiadai Xu, Yawen Wang, Yang Yang, Wenjing Wang, Aiziguli Maihemaiti, Jing Li, Tianhong Xu, Liang Ren, Tianwei Lan, Chi Zhou, Pu Wang, Peng Liu
Summary: Patients with newly diagnosed multiple myeloma (NDMM), especially those treated with immunomodulatory drugs (IMiDs), have a high risk of thrombosis. However, large cohorts studying NDMM patients in Asia are lacking. In this retrospective study, the clinical information of 931 NDMM patients in Zhongshan Hospital Fudan University was analyzed. The incidence of thrombotic events (TEs) was higher in patients treated with IMiDs, but TEs did not affect progression-free survival (PFS) or overall survival (OS) in MM patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, General & Internal
In Sun Ryou, Jooyoung Chang, Joung Sik Son, Ahryoung Ko, Seulggie Choi, Kyuwoong Kim, Sung Min Kim, Sang Min Park
Summary: Early initiation of statin treatment in newly diagnosed hypercholesterolaemia patients is associated with lower risk of CVD, while discontinuation of statin treatment increases the risk of CVD.
Letter
Medicine, General & Internal
Jungwei Fan, Molly Moore Jeffery, W. Michael Hooten, Nilay D. Shah, Rozalina G. McCoy
Summary: This cohort study examined the trends in pain medication initiation rates and types prescribed among patients newly diagnosed with diabetic peripheral neuropathy from 2014 to 2018.
Article
Medicine, Research & Experimental
Qing Wu, Jongyun Jung
Summary: This study introduces a novel genome-wide polygenic score (GPS) to quantify inherited susceptibility to osteoporosis and osteoporotic fracture, providing new opportunities for clinical prevention and risk assessment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ke Lu, Qin Shi, Ya-qin Gong, Chong Li
Summary: The study aims to elucidate the independent correlation between vitamin D content and zoledronate (ZOL)-triggered acute-phase response (APR) fever risk in osteoporotic (OP) patients, and to examine the potential threshold for optimal vitamin D concentrations that prevent the occurrence of ZOL-induced fever.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Orthopedics
Jie Cheng, Songli Ju, Zihan Zhang
Summary: For young patients with fragility fractures, especially in young women, more attention should be paid to glucocorticoid excess caused by Cushing's syndrome, due to a higher rate of misdiagnosis and different treatment strategies.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Endocrinology & Metabolism
Jacopo Antonino Vitale, Veronica Sansoni, Martina Faraldi, Carmelo Messina, Chiara Verdelli, Giovanni Lombardi, Sabrina Corbetta
Summary: The study investigated the relationship between osteocalcin (OC) and body composition, risk of fall, and bone-muscle crosstalk in osteoporotic postmenopausal women. Results showed that serum cOC levels correlated with skeletal muscle mass and function, acting as a mediator in the bone-muscle crosstalk. Circulating levels of cOC and uOC may be differentially regulated in fractured and unfractured osteoporotic women, indicating potential differences in bone metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2021)