Review
Food Science & Technology
Seyedeh-Masomeh Derakhshandeh-Rishehri, Saeed Ghobadi, Masoumeh Akhlaghi, Shiva Faghih
Summary: Calcium supplement intake is associated with a significant reduction in low density lipoprotein cholesterol level, especially in individuals without dyslipidemia, higher calcium intakes, and longer period of consumption.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Medicine, General & Internal
Jeffrey E. Jones, Kevin S. Tang, Ailin Barseghian, Nathan D. Wong
Summary: Discussions on the exact targets for LDL-C reduction have become more aggressive, especially for high-risk patients with ASCVD. Statin therapy has been proven effective, and recent trials have shown the impact of non-statin therapies as well.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Harold Superko, Brenda Garrett
Summary: Despite statin use and LDL-C reduction, residual cardiovascular disease event risk remains. Abnormal lipoprotein size and density distribution, known as lipoprotein heterogeneity, contributes to this residual risk. Recent clinical trial evidence reinforces the importance of LDL heterogeneity measurement and its impact on CHD risk prediction and outcomes.
Review
Cell Biology
Andreina Arias, Alonso Quiroz, Nicolas Santander, Eugenia Morselli, Dolores Busso
Summary: Cholesterol plays a crucial role in maintaining the proper functioning of animal cells. Abnormal metabolism of high-density lipoproteins (HDL) may affect female fertility. HDL in follicular fluid (FF) can uptake excess unesterified cholesterol (UC) from cumulus cells, and the accumulation of UC may impair the developmental capacity of the egg. Cholesterol accumulation can affect cell viability and the activity of membrane proteins, potentially through the activation of calcium channels and dysregulation of cell death/survival signaling pathways. Evaluating cholesterol and lipid levels is important for the diagnosis and treatment of infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Nutrition & Dietetics
Janet C. Tou, Enza Gucciardi, Ian Young
Summary: The systematic review and meta-analysis evaluated the effect of lean fish and fish-derived proteins on serum/plasma lipid and lipoprotein levels, concluding that lean fish intake can lower triacylglycerol levels. However, it showed no significant differences in total cholesterol or lipoprotein levels. Further well-designed, longer, and larger RCTs, particularly crossover RCTs, are needed to provide more insight into the impact of lean fish and fish proteins on lipid profiles.
Article
Biochemistry & Molecular Biology
Na Yang, Miao Wang, Jing Liu, Jun Liu, Yongchen Hao, Dong Zhao
Summary: One-fifth of patients hospitalized for acute coronary syndrome have elevated remnant cholesterol concentrations, even among those who reach target levels of LDL-C or/and non-HDL-C. This highlights the need to consider remnant cholesterol as a target for secondary prevention of ASCVD.
Article
Nutrition & Dietetics
Chien-Yu Lin, Sandy Huey-Jen Hsu, Ching-Way Chen, Chikang Wang, Fung-Chang Sung, Ta-Chen Su
Summary: Exposure to lead and cadmium is associated with abnormal lipid profiles and increased carotid intima-media thickness (CIMT), potentially mediated by lipoprotein levels.
Article
Public, Environmental & Occupational Health
Ann Von Holle, Kari E. North, Sheila Gahagan, Estela Blanco, Raquel Burrows, Betsy Lozoff, Annie Green Howard, Anne E. Justice, Mariaelisa Graff, Saroja Voruganti
Summary: This study investigated the association between infant growth before 6 months and lipid levels in adolescents. They found that faster length growth was associated with higher levels of high-density lipoprotein cholesterol, while slower weight-for-length growth was associated with higher levels of low-density lipoprotein cholesterol.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Environmental Sciences
Soon Hoe Ho, Stacy Xin Hui Soh, Min Xian Wang, Janet Ong, Annabel Seah, Yvonne Wong, Zhanxiong Fang, Shuzhen Sim, Jue Tao Lim
Summary: This systematic review examines the associations between perfluoroalkyl substances (PFAS) and lipid concentrations in human populations. The results suggest that PFAS exposure is associated with higher levels of LDL, HDL, and TC, while the association with TG tends to be negative. Additionally, the study indicates a positive relationship between PFAS concentrations and cholesterol-related health outcomes. Further research is needed to investigate the effects of less-studied PFAS on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Calvin Yeang, Joseph L. Witztum, Sotirios Tsimikas
Summary: A novel method has been developed to quantify Lp(a)-C, improving the accuracy of LDLC by subtracting for Lp(a)-C. This method provides insights into the relationship between Lp(a) mass/cholesterol and may be used to more accurately report LDL-C levels and reassess its role in clinical medicine.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Environmental Sciences
Hao Zhao, Wei Gui, Xin Tan, Ying Chen, Yao Ning, Xin Wang
Summary: This study investigated the relationship between neonicotinoid insecticides (NNIs) and their metabolites in urine with serum lipid profiles in adults. The results showed a significant positive correlation between N-desmethyl-acetamiprid and total cholesterol (TC) levels, especially in participants aged over 46 years. Body mass index (BMI) also modified the association between N-desmethyl-acetamiprid and LDL-C and Apo-B levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
R. Scott Wright, Kausik K. Ray, Frederick J. Raal, David G. Kallend, Mark Jaros, Wolfgang Koenig, Lawrence A. Leiter, Ulf Landmesser, Gregory G. Schwartz, Andrew Friedman, Peter L. J. Wijngaard, Lorena Garcia Conde, John J. P. Kastelein
Summary: Inclisiran, a double-stranded small interfering RNA, was shown to effectively lower LDL-C levels in adults with heterozygous familial hypercholesterolemia, ASCVD, or ASCVD risk equivalents, with a good safety profile in a patient-level pooled analysis from three phase 3 studies.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan Kong, Yong-Jia Yi, Xiao-Qing Liu, Pan Yu, Lin-Guo Zhao, Dong-Dong Li
Summary: In this study, a series of berberine analogs were synthesized and evaluated for their lipid-lowering activities. Compound 1m was found to exhibit potent cholesterol inhibitory activity and had significant effects on LDLC and HDLC levels. The results suggest that 1m has the potential to be a new lipid-lowering agent.
BIOORGANIC CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Bahare Salehi, Cristina Quispe, Javad Sharifi-Rad, Natalia Cruz-Martins, Manisha Nigam, Abhay Prakash Mishra, Dmitryi Alexeevich Konovalov, Valeriya Orobinskaya, Ibrahim M. Abu-Reidah, Wissam Zam, Farukh Sharopov, Tommaso Venneri, Raffaele Capasso, Wirginia Kukula-Koch, Anna Wawruszak, Wojciech Koch
Summary: Phytosterols are plant-originated steroids with significant pharmacological effects, but their bioavailability is influenced by various factors and more research is needed to fully understand their therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Rahul Aggarwal, Deepak L. Bhatt, Fatima Rodriguez, Robert W. Yeh, Rishi K. Wadhera
Summary: Lipid concentrations improved among US adults over the past decade, while rates of lipid control did not significantly change among adults receiving statin therapy. There were improvements in lipid control among certain racial and ethnic groups, but disparities remained between genders and races.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)