Article
Cardiac & Cardiovascular Systems
Paloma Jorda, Laurens P. Bosman, Alessio Gasperetti, Andrea Mazzanti, Jean-Baptiste Gourraud, Brianna Davies, Tanja Charlotte Frederiksen, Zoraida Moreno Weidmann, Andrea Di Marco, Jason D. Roberts, Ciorsti MacIntyre, Colette Seifer, Antoine Deliniere, Wael Alqarawi, Deni Kukavica, Damien Minois, Alessandro Trancuccio, Marine Arnaud, Mattia Targetti, Annamaria Martino, Giada Oliviero, Daniel C. Pipilas, Corrado Carbucicchio, Paolo Compagnucci, Antonio Dello Russo, Iacopo Olivotto, Leonardo Calo, Steven A. Lubitz, Michael J. Cutler, Philippe Chevalier, Elena Arbelo, Silvia Giuliana Priori, Jeffrey S. Healey, Hugh Calkins, Michela Casella, Henrik Kjaerulf Jensen, Claudio Tondo, Rafik Tadros, Cynthia A. James, Andrew D. Krahn, Julia Cadrin-Tourigny
Summary: This study validated a 5-year risk prediction model for ARVC patients, demonstrating its superior performance in guiding ICD implantation decisions compared to other published guidelines and consensus statements. The findings support the use of this model for shared decision making in the primary prevention of SCD in ARVC patients.
EUROPEAN HEART JOURNAL
(2022)
Review
Medicine, General & Internal
Riccardo Bariani, Ilaria Rigato, Marco Cason, Maria Bueno Marinas, Rudy Celeghin, Kalliopi Pilichou, Barbara Bauce
Summary: Arrhythmogenic left ventricular cardiomyopathy (ALVC) is a variant of arrhythmogenic cardiomyopathy characterized by left ventricular involvement. Multiple disease-genes have been identified in ALVC, with DSP and FLNC being the most common ones. ALVC patients often exhibit ECG abnormalities, severe ventricular arrhythmias, and heart failure symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Julia Cadrin-Tourigny, Laurens P. Bosman, Anna Nozza, Weijia Wang, Rafik Tadros, Aditya Bhonsale, Mimount Bourfiss, Annik Fortier, Oyvind H. Lie, Ardan M. Saguner, Anneli Svensson, Antoine Andorin, Crystal Tichnell, Brittney Murray, Katja Zeppenfeld, Maarten P. van den Berg, Folkert W. Asselbergs, Arthur A. M. Wilde, Andrew D. Krahn, Mario Talajic, Lena Rivard, Stephen Chelko, Stefan L. Zimmerman, Ihab R. Kamel, Jane E. Crosson, Daniel P. Judge, Sing-Chien Yap, Jeroen F. van der Heijden, Harikrishna Tandri, Jan D. H. Jongbloed, Marie-Claude Guertin, J. Peter van Tintelen, Pyotr G. Platonov, Firat Duru, Kristina H. Haugaa, Paul Khairy, Richard N. W. Hauer, Hugh Calkins, Anneline S. J. M. te Riele, Cynthia A. James
Summary: We developed a prediction model for incident VA/SCD in ARVC patients using readily available clinical parameters, which accurately distinguished patients with and without events and showed superior clinical benefit compared to current ICD placement algorithms.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Natalia Sangiorgi Olivetti, Luciana Sacilotto, Fanny Wulkan, Gabrielle D'Arezzo Pessente, Mariana Lombardi Peres de Carvalho, Danilo Moleta, Denise Tessariol Hachul, Pedro Veronese, Carina Hardy, Cristiano Pisani, Tan Chen Wu, Marcelo Luiz Campos Vieira, Lucas Arraes de Franca, Matheus de Souza Freitas, Carlos Eduardo Rochitte, Savia Christina Bueno, Vitor Bastos Lovisi, Jose Eduardo Krieger, Mauricio Scanavacca, Alexandre da Costa Pereira, Francisco da Costa Darrieux
Summary: This study analyzed the clinical features, genetic findings, natural history, and risk factors for life-threatening arrhythmic events (LTAEs) and HF-death/HTx in 111 patients with ARVC. Reduced right ventricle ejection fraction, HF symptoms, epsilon wave, and low QRS voltage were predictors for HF-death/HTx. Prior syncope, T wave inversion, low QRS voltage, younger age, and prior ventricular arrhythmia/fibrillation were predictors for LTAEs. In patients without ventricular arrhythmia before diagnosis, low QRS voltage was independently associated with HF-death/HTx.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marit Kristine Smedsrud, Monica Chivulescu, Marianne Inngjerdingen Forsa, Isotta Castrini, Eivind Westrum Aabel, Christine Rootwelt-Norberg, Martin Proven Bogsrud, Thor Edvardsen, Nina Eide Hasselberg, Andreas Fruh, Kristina Hermann Haugaa
Summary: The study aimed to investigate the incidence of severe cardiac events in paediatric arrhythmogenic right ventricular cardiomyopathy (ARVC) patients and the ARVC penetrance in paediatric relatives. The results showed a high incidence of severe cardiac events in paediatric ARVC cohort, with half occurring in children aged 12 or below. Additionally, the ARVC penetrance in genotype positive paediatric relatives was 18%.
EUROPEAN HEART JOURNAL
(2022)
Article
Emergency Medicine
Leen Alblaihed, Christine Kositz, William J. Brady, Tareq Al -Salamah, Amal Mattu
Summary: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic disorder of the myocardium that can cause ventricular arrhythmia and sudden cardiac death. Early recognition of the disease by emergency clinicians is crucial to prevent subsequent death, as it is a significant cause of arrhythmic death among young people and athletes. This publication reviews the pathophysiology, classification, clinical presentations, and appropriate approach to diagnosis and management of ARVC.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Medicine, General & Internal
Riccardo Bariani, Maria Bueno Marinas, Ilaria Rigato, Paola Veronese, Rudy Celeghin, Alberto Cipriani, Marco Cason, Valeria Pergola, Giulia Mattesi, Petra Deola, Alessandro Zorzi, Giuseppe Limongelli, Sabino Iliceto, Domenico Corrado, Cristina Basso, Kalliopi Pilichou, Barbara Bauce
Summary: This study analyzed a series of childbearing women affected by arrhythmogenic left ventricular cardiomyopathy (ALVC) and found that pregnancy had no significant influence on disease progression and degree of electrical instability in ALVC patients without previous episodes of heart failure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Alex Horby Christensen, Pyotr G. Platonov, Anneli Svensson, Henrik K. Jensen, Christine Rootwelt-Norberg, Pia Dahlberg, Trine Madsen, Tanja Charlotte Frederiksen, Tiina Helio, Kristina H. Haugaa, Henning Bundgaard, Jesper H. Svendsen
Summary: This study describes the complications associated with implantable cardioverter-defibrillators (ICD) treatment in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). The results show that during long-term follow-up, approximately 41% of patients experienced potentially life-saving ICD therapy, while 27% had complications requiring surgery, mainly lead-related complications.
Article
Medicine, General & Internal
Nadine Molitor, Firat Duru
Summary: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease characterized by fibro-fatty replacement of the right ventricle, which can lead to ventricular tachyarrhythmias and sudden cardiac death. Diagnosis is challenging due to its variable expressivity, incomplete penetrance, and lack of specific diagnostic criteria. Other cardiac diseases may mimic the clinical phenotypes of ARVC, leading to misdiagnosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Anneline S. J. M. te Riele, Cynthia A. James, Hugh Calkins, Adalena Tsatsopoulou
Summary: ARVC is an inherited cardiomyopathy characterized by fibrofatty infiltration of predominantly the right ventricular myocardium, with affected patients typically presenting as young adults at high risk of sudden cardiac death and heart failure. Diagnosis is made by combining multiple sources of information as prescribed by the Task Force Criteria, and some patients carry genetic variants associated with the cardiac desmosome.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, Research & Experimental
Yan Liang, Robert C. Lyon, Jason Pellman, William H. Bradford, Stephan Lange, Julius Bogomolovas, Nancy D. Dalton, Yusu Gu, Marcus Bobar, Mong-Hong Lee, Tomoo Iwakuma, Vishal Nigam, Angeliki Asimaki, Melvin Scheinman, Kirk L. Peterson, Farah Sheikh
Summary: A recently discovered COP9 desmosomal resident protein complex, consisting of subunit 6 of the COP9 signalosome (CSN6), was found to enzymatically restrict neddylation and target desmosomal proteome degradation, ultimately playing a crucial role in preventing diseases such as ARVD/C.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Paul J. Scheel, Brittney Murray, Crystal Tichnell, Cynthia A. James, Harikrishna Tandri, Hugh Calkins, Stephen P. Chelko, Nisha A. Gilotra
Summary: Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) may initially present as myocarditis, exhibiting characteristics such as female gender, left ventricular involvement, and DSP gene variants.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jie Ren, Konstantinos Tsilafakis, Liang Chen, Konstantinos Lekkos, Ioanna Kostavasili, Aimilia Varela, Dennis Cokkinos, Constantinos H. Davos, Xiaogang Sun, Jiangping Song, Manolis Mavroidis
Summary: The study found activation of the complement system in the myocardium of ARVC patients, with autoantibodies against myocardial proteins possibly contributing to this mechanism. Crosstalk between the complement and coagulation systems exacerbated myocardial injury in ARVC mice, which was reduced by using the thrombin inhibitor lepirudin. Patients showed significantly elevated plasma levels of sC5b9 and thrombin, which were correlated with all-cause mortality.
Article
Cardiac & Cardiovascular Systems
Sara Hosseini, Ladina Erhart, Shehab Anwer, Pascal S. Heiniger, Neria E. Winkler, Tolga Cimen, Nazar Kuzo, Refael Hess, Deniz Akdis, Sarah Costa, Alessio Gasperetti, Corinna Brunckhorst, Firat Duru, Ardan M. Saguner, Felix C. Tanner
Summary: The study shows that tissue Doppler imaging (TDI) provides information on the ARVC phenotype, is associated with adverse events in ARVC patients, and can differentiate between patients with and without adverse events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Weijia Wang, Alessio Gasperetti, Samuel F. Sears, Crystal Tichnell, Brittney Murray, Harikrishna Tandri, Cynthia A. James, Hugh Calkins
Summary: This study compared clinical and quality-of-life outcomes between subcutaneous and transvenous ICDs in patients with ARVC. No significant difference was observed in the rate of appropriate ICD shocks, but the subcutaneous group had more inappropriate shocks and fewer complications. The subcutaneous ICD was associated with more body image concerns and range of motion issues.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yingfei Xue, Alexander P. Kossar, Alexey Abramov, Antonio Frasca, Mingze Sun, Mariya Zyablitskaya, David Paik, David Kalfa, Mila Della Barbera, Gaetano Thiene, Satoshi Kozaki, Takayuki Kawashima, Joseph H. Gorman III, Robert C. Gorman, Matthew J. Gillespie, Chrystalle Katte Carreon, Stephen P. Sanders, Robert J. Levy, Giovanni Ferrari
Summary: This study investigates the mechanisms of structural valve degeneration in young patients and juvenile animals with bioprosthetic heart valves, and presents models for studying this phenomenon.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Giovanni Peretto, Marco Merlo, Piero Gentile, Aldostefano Porcari, Anna Palmisano, Davide Vignale, Paola Sormani, Stefania Rizzo, Monica De Gaspari, Cristina Basso, Paolo Della Bella, Simone Sala, Enrico Ammirati, Gianfranco Sinagra, Antonio Esposito, Patrizia Pedrotti
Summary: This study evaluated the diagnostic sensitivity of cardiac magnetic resonance imaging based on Lake Louise criteria in patients with acute myocarditis. The results showed that using updated Lake Louise criteria increased the sensitivity of the diagnosis. It was also found that septal abnormalities were more common in patients with complicated acute myocarditis.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Pathology
Michael Allen Beck De Lotto, Giovanni Magno, Gaetano Thiene, Fabio Zampieri, Alberto Zanatta
Summary: A recent study conducted with modern medical instruments and methods on the skull of Santorio Santorio, founder of the University of Padua, revealed interesting pathological phenomena, including lobular formation and depressions in the skull, tooth loss, and temporomandibular joint osteoarthritis. This study is of great significance in uncovering the history of the University of Padua.
Article
Pathology
Katarzyna Michaud, Christina Jacobsen, Cristina Basso, Jytte Banner, Britt M. Blokker, Hans H. de Boer, Fabrice Dedouit, Chris O'Donnell, Carla Giordano, Virginie Magnin, Silke Grabherr, S. Kim Suvarna, Krzysztof Wozniak, Sarah Parsons, Allard C. van der Wal
Summary: Postmortem imaging (PMI) is an increasingly used alternative to conventional autopsies, particularly in sudden cardiac deaths (SCD). However, PMI has limitations when compared to clinical imaging, which impacts the diagnosis of myocardial injuries, coronary occlusion, and other SCD-related cardiac lesions. Emerging minimally invasive techniques in PMI show promising results and require further investigation. The field of postmortem imaging is rapidly developing and will require detailed knowledge of both radiology and pathology for the diagnosis of sudden death due to cardiovascular diseases.
Review
Pathology
Joseph J. J. Maleszewski, Cristina Basso, Allen Burke, Mathieu Castonguay, Charles Leduc, Fabio Tavora, Mary Sheppard, Rakesh Suri, Meagan Judge, Wendy A. A. Cooper
Summary: The International Collaboration on Cancer Reporting (ICCR) was established to develop internationally standardized datasets for pathologists' reporting of cancer, aiming to improve cancer patient outcomes worldwide and advance international benchmarking in cancer management. The ICCR datasets are aligned with the revisions of the WHO Classification of Tumours and are regularly updated. The dataset for neoplasms of the heart, pericardium, and great vessels has been revised to align with the 2021 WHO Blue Book series.
Article
Cardiac & Cardiovascular Systems
Gregory A. Fishbein, Ornella Leone, Cristina Basso, John T. Fallon, Karin Klingel, Carmela Tan
Summary: Histological examination of endomyocardial biopsy or myocardium at autopsy is crucial for diagnosing myocarditis. However, there is significant variability among pathologists in their routine practices and diagnostic criteria, leading to a lack of consensus. This article reviews two manuscripts highlighting the importance of standardizing histopathological diagnostic criteria for myocarditis.
CARDIOVASCULAR PATHOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Karen L. Kelly, Peter T. Lin, Cristina Basso, Melanie Bois, L. Maximilian Buja, Stephen D. Cohle, Giulia d'Amati, Emily Duncanson, John T. Fallon, Dennis Firchau, Gregory Fishbein, Carla Giordano, Charles Leduc, Silvio H. Litovsky, Shannon Mackey-Bojack, Joseph J. Maleszewski, Katarzyna Michaud, Robert F. Padera, Stavroula A. Papadodima, Sarah Parsons, Stanley J. Radio, Stefania Rizzo, Susan J. Roe, Maria Romero, Mary N. Sheppard, James R. Stone, Carmela D. Tan, Gaetano Thiene, Allard C. van der Wal, John P. Veinot
Summary: Sudden cardiac death is an unexpected death caused by a cardiac condition, accounting for approximately 15-20% of all deaths. It commonly occurs in older adults with acquired heart disease but can also happen in young individuals due to genetic transmission. Investigation of these deaths is crucial due to the potential impact on other family members and the lack of consistent guidelines for cardiac examination in these cases.
CARDIOVASCULAR PATHOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniela Marrone, Cristina Basso, Gaetano Thiene
EUROPEAN HEART JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Seyed Soheil Saeedi Saravi, Nicole R. Bonetti, Ana Vukolic, Daria Vdovenko, Pratintip Lee, Luca Liberale, Cristina Basso, Stefania Rizzo, Alexander Akhmedov, Thomas F. Luscher, Giovanni G. Camici, Jurg H. Beer
Summary: This study investigated the preventive effects of long-term dietary alpha linolenic acid (ALA) on left ventricular diastolic dysfunction and vascular aging in aged mice. The results showed that long-term dietary ALA supplementation could alleviate age-related left ventricular diastolic dysfunction, impaired vasorelaxation, cardiac fibrosis, inflammation, and arterial stiffening, accompanied by reductions in fibrosis biomarkers expression. This study provides evidence for the efficacy of ALA in preventing age-related heart failure and vascular dysfunction.
VASCULAR PHARMACOLOGY
(2023)
Review
Pathology
Mary N. Sheppard, Allard C. van der Wal, Jytte Banner, Giulia d'Amati, Monica De Gaspari, Rosa De Gouveia, Cira Di Gioia, Carla Giordano, Maiken Kudahl Larsen, Matthew J. Lynch, Joaquin Lucena, Pilar Molina, Sarah Parsons, M. Paz Suarez-Mier, Stefania Rizzo, Simon Kim Suvarna, Wouter P. te Rijdt, Gaetano Thiene, Aryan Vink, Joseph Westaby, Katarzyna Michaud, Cristina Basso
Summary: This article discusses the etiology, clinical manifestations, and diagnostic methods of cardiomyopathy. In cases of cardiac hypertrophy and/or dilatation/scarring with normal coronary arteries, the possibility of inherited cardiomyopathy should be considered and a histological examination is essential. In order to further investigate the disease, tissue-based and/or fluid-based genetic testing may be required. The article emphasizes the important role of pathologists in the diagnosis of cardiomyopathy.
Article
Cardiac & Cardiovascular Systems
Monica De Gaspari, Giulio Sinigiani, Laura De Michieli, Mila Della Barbera, Stefania Rizzo, Gaetano Thiene, Sabino Iliceto, Martina Perazzolo Marra, Donato Mele, Cristina Basso, Alberto Cipriani
Summary: The study investigates the correlation between myocardial longitudinal strain abnormalities and amyloid burden in cardiac amyloidosis (CA) patients. It finds that the typical RELAPS pattern on echocardiography is not always directly related to the base-to-apex gradient of amyloid burden on histopathology, suggesting complex interactions among amyloid infiltration, myocardial structure, and adaptation.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Manuel De Lazzari, Alberto Cipriani, Annagrazia Cecere, Alice Niero, Monica De Gaspari, Benedetta Giorgi, Giorgio De Conti, Raffaella Motta, Stefania Rizzo, Francesco Tona, Luisa Cacciavillani, Giuseppe Tarantini, Gino Gerosa, Cristina Basso, Sabino Iliceto, Martina Perazzolo Marra
Summary: This study evaluated the feasibility of cardiac magnetic resonance (CMR) and the role of myocardial strain in the diagnostic work-up of patients with acute myocardial infarction (AMI) and suspected cardiac rupture (CR). CMR was found to be a safe and effective tool to diagnose CR and visualize tissue abnormalities associated with CR. Strain analysis parameters may provide insights into the pathophysiology of CR and help identify patients with sub-acute CR.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniela Marrone, Cristina Basso, Gaetano Thiene
CARDIOVASCULAR PATHOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Elena Arbelo, Alexandros Protonotarios, Juan R. Gimeno, Eloisa Arbustini, Roberto Barriales-Villa, Cristina Basso, Connie R. Bezzina, Elena Biagini, Nico A. Blom, Rudolf A. de Boer, Tim De Winter, Perry M. Elliott, Marcus Flather, Pablo Garcia-Pavia, Kristina H. Haugaa, Jodie Ingles, Ruxandra Oana Jurcut, Sabine Klaassen, Giuseppe Limongelli, Bart Loeys, Jens Mogensen, Iacopo Olivotto, Antonis Pantazis, Sanjay Sharma, J. Peter Van Tintelen, James S. Ware, Juan Pablo Kaski
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)