Article
Cardiac & Cardiovascular Systems
Giulio G. Stefanini, Carlo Briguori, Davide Cao, Usman Baber, Samantha Sartori, Zhongjie Zhang, George Dangas, Dominick J. Angiolillo, Shamir Mehta, David J. Cohen, Timothy Collier, Dariusz Dudek, Javier Escaned, C. Michael Gibson, Robert Gil, Kurt Huber, Upendra Kaul, Ran Kornowski, Mitchell W. Krucoff, Vijay Kunadian, David J. Moliterno, E. Magnus Ohman, Keith G. Oldroyd, Gennaro Sardella, Samin K. Sharma, Richard Shlofmitz, Giora Weisz, Bernhard Witzenbichler, Stuart Pocock, Roxana Mehran
Summary: In patients with chronic kidney disease undergoing percutaneous coronary intervention, ticagrelor monotherapy was found to reduce the risk of bleeding without a significant increase in ischemic events compared to ticagrelor plus aspirin.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Giulio G. Stefanini, Carlo Briguori, Davide Cao, Usman Baber, Samantha Sartori, Zhongjie Zhang, George Dangas, Dominick J. Angiolillo, Shamir Mehta, David J. Cohen, Timothy Collier, Dariusz Dudek, Javier Escaned, C. Michael Gibson, Robert Gil, Kurt Huber, Upendra Kaul, Ran Kornowski, Mitchell W. Krucoff, Vijay Kunadian, David J. Moliterno, E. Magnus Ohman, Keith G. Oldroyd, Gennaro Sardella, Samin K. Sharma, Richard Shlofmitz, Giora Weisz, Bernhard Witzenbichler, Stuart Pocock, Roxana Mehran
Summary: This study aimed to assess the impact of chronic kidney disease on the safety and efficacy of ticagrelor monotherapy for patients undergoing PCI. The results showed that among CKD patients undergoing PCI, ticagrelor monotherapy reduced the risk of bleeding without a significant increase in ischemic events compared to ticagrelor plus aspirin.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Javier Escaned, Davide Cao, Usman Baber, Johny Nicolas, Samantha Sartori, Zhongjie Zhang, George Dangas, Dominick J. Angiolillo, Carlo Briguori, David J. Cohen, Timothy Collier, Dariusz Dudek, Michael Gibson, Robert Gil, Kurt Huber, Upendra Kaul, Ran Kornowski, Mitchell W. Krucoff, Vijay Kunadian, Shamir Mehta, David J. Moliterno, E. Magnus Ohman, Keith G. Oldroyd, Gennaro Sardella, Samin K. Sharma, Richard Shlofmitz, Giora Weisz, Bernhard Witzenbichler, Stuart Pocock, Roxana Mehran
Summary: The study evaluated the effects of ticagrelor monotherapy in HBR patients after 3 months of DAPT, showing a significant reduction in bleeding risk without increasing the risk of ischemic events. The absolute risk reduction in major bleeding was larger in HBR patients compared to non-HBR patients.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Javier Escaned, Davide Cao, Usman Baber, Johny Nicolas, Samantha Sartori, Zhongjie Zhang, George Dangas, Dominick J. Angiolillo, Carlo Briguori, David J. Cohen, Timothy Collier, Dariusz Dudek, Michael Gibson, Robert Gil, Kurt Huber, Upendra Kaul, Ran Kornowski, Mitchell W. Krucoff, Vijay Kunadian, Shamir Mehta, David J. Moliterno, E. Magnus Ohman, Keith G. Oldroyd, Gennaro Sardella, Samin K. Sharma, Richard Shlofmitz, Giora Weisz, Bernhard Witzenbichler, Stuart Pocock, Roxana Mehran
Summary: This study showed that ticagrelor monotherapy can significantly reduce bleeding in high bleeding risk patients without increasing ischemic events.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Davide Capodanno, Usman Baber, Deepak L. Bhatt, Jean-Philippe Collet, George Dangas, Francesco Franchi, C. Michael Gibson, Hyeon-Cheol Gwon, Adnan Kastrati, Takeshi Kimura, Pedro A. Lemos, Renato D. Lopes, Roxana Mehran, Michelle L. O'Donoghue, Sunil Rao, Fabiana Rollini, Patrick W. Serruys, Philippe G. Steg, Robert F. Storey, Marco Valgimigli, Pascal Vranckx, Hirotoshi Watanabe, Stephan Windecker, Dominick J. Angiolillo
Summary: The evolution of stent design has reduced the risk of stent thrombosis after PCI, potentially shortening the duration of dual antiplatelet therapy. Recent studies suggest that P2Y(12) inhibitor monotherapy after PCI may be safer and more effective than dual antiplatelet therapy.
NATURE REVIEWS CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yikai Zhao, Peng Zhou, Wen Gao, Haoxuan Zhong, Yufei Chen, Wei Chen, Maieryemu Waresi, Kun Xie, Haiming Shi, Hui Gong, Guibin He, Zhaohui Qiu, Xinping Luo, Jian Li
Summary: This study investigated the use of cilostazol combined with P2Y(12) receptor inhibitors as a substitute antiplatelet regimen for aspirin-intolerant patients undergoing percutaneous coronary stent implantation. The results showed that this combination therapy was not inferior to standard therapy based on aspirin and could be considered as a reasonable alternative for these patients.
CLINICAL CARDIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Georg Gelbenegger, Christian Schoergenhofer, Bernd Jilma, Gloria M. Gager, Al Medina Dizdarevic, Mamas A. Mamas, Biljana Parapid, Poonam Velagapudi, Jolanta M. Siller-Matula
Summary: The study indicates that short-term DAPT followed by ticagrelor monotherapy is associated with a more favorable outcome compared to standard DAPT, resulting in reduced all-cause mortality, net adverse clinical events, and major bleeding risk.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
Xuantong Guo, Ruihuan Shen, Siyu Yan, Yanni Su, Lihong Ma
Summary: This study aimed to investigate the prognostic value of the TyG index in predicting repeat revascularization and in-stent restenosis (ISR) in chronic coronary syndrome (CCS) patients undergoing percutaneous coronary intervention (PCI). The results showed that an increased TyG index was associated with elevated risk for long-term PCI complications, including repeat revascularization and ISR. The TyG index could be a potent predictor in evaluating the prognosis of CCS patients undergoing PCI.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Allergy
Sen Hee Tay, Amelia Santosa, Eugene Chen Howe Goh, Chun Xiang Xu, Lik Hang Wu, Mei Bigliardi-Qi, Leroy Sivappiragasam S. O. Pakkiri, Bernett Teck Kwong Lee, Chester Lee Drum, Paul Lorenz Bigliardi
Summary: This study is the first to combine both transcriptomic and metabolomic approaches in patients with NIUA, contributing to a deeper understanding of the pathogenesis of NIUA and potentially paving the way for a molecular diagnosis of NSAID hypersensitivity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yaling Han, Bimmer E. Claessen, Shao-Liang Chen, Qiu Chunguang, Yujie Zhou, Yawei Xu, Lin Hailong, Jiyan Chen, Wu Qiang, Ruiyan Zhang, Suxin Luo, Yongjun Li, Jianhua Zhu, Xianxian Zhao, Xiang Cheng, Jian'an Wang, Xi Su, Jianhong Tao, Yingxian Sun, Geng Wang, Yi Li, Liya Bian, Ridhima Goel, Samantha Sartori, Zhongjie Zhang, Dominick J. Angiolillo, David J. Cohen, C. Michael Gibson, Adnan Kastrati, Mitchell Krucoff, Shamir R. Mehta, E. Magnus Ohman, Philippe Gabriel Steg, Yuqi Liu, George Dangas, Samin Sharma, Usman Baber, Roxana Mehran
Summary: The TWILIGHT trial enrolled 1169 patients from China, showing that ticagrelor monotherapy significantly reduced clinically relevant bleeding without increasing ischemic events compared to ticagrelor plus aspirin in Chinese patients undergoing high-risk percutaneous coronary intervention.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Martino Pepe, Gianluigi Napoli, Eugenio Carulli, Marco Moscarelli, Cinzia Forleo, Palma Luisa Nestola, Giuseppe Biondi-Zoccai, Arturo Giordano, Stefano Favale
Summary: There is a link between autoimmune diseases and in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Patients with insulin-dependent diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune diseases face higher rates of ISR. Endothelial dysfunction appears to be the principal common pathogenic pathway for ISR, influenced by immune system disorders and systemic inflammation.
Article
Multidisciplinary Sciences
Jangho Park, Sangwoo Park, Yong-Giun Kim, Soe Hee Ann, Hyun Woo Park, Jon Suh, Jae-Hyung Roh, Young-Rak Cho, Seungbong Han, Gyung-Min Park
Summary: An analysis of National Health Insurance data in Korea showed that pre-existing depression does not have a significant impact on mortality in patients with established coronary artery disease undergoing PCI. However, younger patients with angina and depression may have a higher risk of all-cause mortality.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Yulanka S. Castro-Dominguez, Yongfei Wang, Karl E. Minges, Robert L. McNamara, John A. Spertus, Gregory J. Dehmer, John C. Messenger, Kimberly Lavin, Cornelia Anderson, Kristina Blankinship, Nestor Mercado, Julie M. Clary, Anwar D. Osborne, Jeptha P. Curtis, Matthew A. Cavender
Summary: This study developed a model for predicting in-hospital mortality risk following PCI, incorporating additional variables. The results suggested that in-hospital mortality following PCI varies based on clinical presentation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jun Gu, Zhao-fang Yin, Zuo-jun Xu, Yu-qi Fan, Chang-qian Wang, Jun-feng Zhang
Summary: This study showed that after PCI, the predominant subtype of HF is HFpEF, and higher BNP levels, lower eGFR levels, and atrial fibrillation are independent risk factors for new-onset HF. Being male and being prescribed with ACEI/ARB medications are negative predictors for new-onset HF. Additionally, long-term ACEI/ARB therapy is associated with reduced risks of developing all three subtypes of HF (HFrEF, HFmrEF, and HFpEF), compared to beta-blocker use.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Seung-Jun Lee, Jae Hong Joo, Sohee Park, Choongki Kim, Dong-Woo Choi, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Chung-Mo Nam, Myeong-Ki Hong
Summary: This observational study evaluated the effects of high-intensity statin monotherapy compared with combination therapy (statin plus ezetimibe) in patients after drug-eluting stent implantation. The results showed that combination therapy was associated with lower occurrence of adverse events and better drug compliance.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)