Article
Cardiac & Cardiovascular Systems
Zach Rozenbaum, Yoav Granot, Ben Sadeh, Ofer Havakuk, Joshua H. Arnold, Jason Shimiaie, Michael Ghermezi, Orly Barak, Yanai Ben Gal, Yacov Shacham, Gad Keren, Yan Topilsky, Michal Laufer-Perl
Summary: In this study, the differences in peak VO2 between male and female patients with heart failure (HF) were compared using combined stress echocardiography (SE) and cardiopulmonary exercise testing (CPET). The results showed that female patients with HF had lower exercise capacity compared to male patients. For females diagnosed with HFpEF, this was due to poorer left ventricular compliance and attenuated peripheral oxygen extraction, while for females diagnosed with HFmrEF/HFrEF, this was due to attenuated increase in peak stroke volume and cardiac output. This study provides important information for understanding the differences in exercise physiology in HF patients, which may improve patient selection for targeted therapeutics.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biology
Pedro Garcia Bras, Antonio Valentim Goncalves, Joao Ferreira Reis, Rita Ilhao Moreira, Tiago Pereira-da-Silva, Pedro Rio, Ana Teresa Timoteo, Sofia Silva, Rui M. Soares, Rui Cruz Ferreira
Summary: This study aimed to assess the predictive value of heart transplantation thresholds in heart failure (HF) patients. Results showed that peak VO2, VE/VCO2 slope, and percent of predicted peak VO2 were independent discriminators of the composite endpoint particularly in women. Sex-specific thresholds may improve patient selection for heart transplantation.
Review
Medicine, General & Internal
Arianne Clare Agdamag, Erik H. H. Van Iterson, W. H. Wilson Tang, J. Emanuel Finet
Summary: Heart failure is a complex syndrome with diverse presentations and severity. Current prognostic markers, such as left ventricular ejection fraction, have limitations in accurately predicting outcomes and guiding management decisions. Metabolic exercise testing, which evaluates multisystem responses and aerobic capacity during exercise, provides a more comprehensive and reliable assessment, especially in heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Javier Roibal Pravio, Eduardo Barge Caballero, Cayetana Barbeito Caamano, Maria Jesus Paniagua Martin, Gonzalo Barge Caballero, David Couto Mallon, Patricia Pardo Martinez, Zulaika Grille Cancela, Paula Blanco Canosa, Jose Manuel Garcia Pinilla, Jose Manuel Vazquez Rodriguez, Maria Generosa Crespo Leiro
Summary: Maximum oxygen uptake (VO2max) is an important parameter in assessing the functional capacity of heart failure (HF) patients. Clinical factors such as NYHA class, age, body mass index, hemoglobin levels, and right ventricular function significantly influence exercise capacity in HF patients. The severity of HF and age, body composition, and hemoglobin levels can impact maximal oxygen uptake in HF patients.
Article
Cardiac & Cardiovascular Systems
Pallav Deka, Bunny J. Pozehl, Dola Pathak, Mark Williams, Joseph F. Norman, Windy W. Alonso, Tiny Jaarsma
Summary: The study aimed to evaluate the predictive validity of equations from different authors in predicting peak VO2 in heart failure patients. It was found that the equation provided by Cahalin et al. had the best predictive validity for peak VO2 in patients with HF, and caution should be exercised when using equations to predict individual maximal oxygen uptake.
Article
Medicine, General & Internal
Wei-Ming Huang, Chiao-Nan Chen, Yung-Hsin Chen, Ju-Hsin Yen, Tzu-Ying Tseng, Hao-Min Cheng, Wen-Chung Yu, Chen-Huan Chen, Shih-Hsien Sung
Summary: This study investigated the feasibility and safety of using a stepwise protocol for CPX-ESE in patients with heart failure (HF). The results showed that the stepwise protocol was feasible and provided an adequate stress load for these patients, and it was also safe and well-tolerated.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Andre Zimerman, Anderson D. da Silveira, Marina S. Borges, Pedro H. B. Engster, Thomas U. Schaan, Gabriel C. de Souza, Isabela P. M. A. de Souza, Luiz Eduardo F. Ritt, Ricardo Stein, Otavio Berwanger, Muthiah Vaduganathan, Luis Eduardo Rohde
Summary: In this multicentre study, CPET parameters were compared between HF patients classified as NYHA class I and II, revealing a substantial overlap in objective physiological measures and prognosis. NYHA classification may not be a good discriminator of cardiopulmonary capacity in patients with mild HF.
Article
Biochemistry & Molecular Biology
Pedro Garcia Bras, Antonio Valentim Goncalves, Joao Ferreira Reis, Rita Ilhao Moreira, Tiago Pereira-da-Silva, Pedro Rio, Ana Teresa Timoteo, Sofia Silva, Rui M. Soares, Rui Cruz Ferreira, Vinay Kumar, Surendra Kumar Shukla
Summary: This study aimed to evaluate the prognostic power of current listing criteria for heart transplantation in heart failure patients. Follow-up of heart failure patients who underwent cardiopulmonary exercise testing between 2009-2014 and 2015-2018 found that the current criteria showed lower overall prognostic effectiveness in a contemporary heart failure population. Novel parameters may be needed to improve risk stratification.
Review
Cardiac & Cardiovascular Systems
Giulia Crisci, Mariarosaria De Luca, Roberta D'Assante, Brigida Ranieri, Anna D'Agostino, Valeria Valente, Federica Giardino, Valentina Capone, Salvatore Chianese, Salvatore Rega, Rosangela Cocchia, Muhammad Zubair Israr, Radek Debiek, Liam M. Heaney, Andrea Salzano
Summary: Heart failure with preserved ejection fraction (HFpEF) is a common phenotype of heart failure in patients aged > 65 years. Exercise intolerance is the cardinal symptom of HFpEF. Exercise training programs can improve the cardiorespiratory performance of HFpEF patients, but have limited effects on diastolic or systolic functions.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Environmental Sciences
Reza Mazaheri, Mohammad Sadeghian, Mahshid Nazarieh, David Niederseer, Christian Schmied
Summary: The study found that peak VO2 is higher on treadmill than on cycle ergometer in severe HFrEF patients. Additionally, VE/VCO2 slope is not modality dependent and not related to patients' effort during CPET.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Cardiac & Cardiovascular Systems
Elisabetta Salvioni, Alice Bonomi, Damiano Magri, Marco Merlo, Beatrice Pezzuto, Mattia Chiesa, Massimo Mapelli, Nikita Baracchini, Gianfranco Sinagra, Massimo Piepoli, Piergiuseppe Agostoni
Summary: Cardiopulmonary exercise tests (CPET) are crucial for evaluating the functional capacity of chronic heart failure (HF) patients. The MECKI score, developed by a group of Italian centers skilled in HF management and CPET analysis, has been extensively validated and shown to be effective in risk stratification for HF. The MECKI score research group has grown over time and is now investigating other areas such as cardiomyopathy.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Helen Triantafyllidi, Dionyssia Birmpa, Dimitrios Benas, Paraskevi Trivilou, Anastasia Fambri, Efstathios K. Iliodromitis
Summary: CPET is a comprehensive technique for evaluating cardiopulmonary diseases, and it is important for Clinical Cardiologists to understand its utility and indications. With evolving clinical applications of CPET, doctors need to learn how to use and interpret CPET results effectively for accurate diagnosis and treatment of patients.
Review
Hospitality, Leisure, Sport & Tourism
Yasmin Ezzatvar, Mikel Izquierdo, Julio Nunez, Joaquin Calatayud, Robinson Ramirez-Velez, Antonio Garcia-Hermoso
Summary: Cardiorespiratory fitness is inversely associated with mortality in patients with established cardiovascular disease, with each 1-MET increment significantly reducing all-cause mortality risk. Among coronary artery disease patients, high cardiorespiratory fitness is linked to a lower risk of all-cause mortality.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Nicola Riccardo Pugliese, Nicolo De Biase, Luna Gargani, Matteo Mazzola, Lorenzo Conte, Iacopo Fabiani, Andrea Natali, Frank L. Dini, Paolo Frumento, Javier Rosada, Stefano Taddei, Barry A. Borlaug, Stefano Masi
Summary: Risk stratification based on a multi-parametric evaluation, including biomarkers, cardiopulmonary exercise testing-exercise stress echocardiography, and lung ultrasound, can effectively predict adverse events in HFpEF patients and individuals at risk for developing HF, offering a more personalized treatment approach.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Masahiro Koen, Yoshiaki Kubota, Miwa Tokita, Kazuyo Kato, Hiroshi Takahashi, Koichi Akutsu, Kuniya Asai, Hitoshi Takano
Summary: This retrospective observational study examined the relationship between maximum walking speed (MWS) and peak oxygen uptake (peak VO2) and anaerobic threshold (AT) in heart failure patients. The study found that MWS was positively correlated with percent-predicted peak VO2 and percent-predicted AT. Furthermore, MWS was identified as a significant factor in predicting peak VO2 and AT in heart failure patients.
Article
Cardiac & Cardiovascular Systems
Robert J. Mentz, Vera Bittner, Phillip J. Schulte, Jerome L. Fleg, Ileana L. Pina, Steven J. Keteyian, Gordon Moe, Anil Nigam, Ann M. Swank, Anekwe E. Onwuanyi, Meredith Fitz-Gerald, Andrew Kao, Stephen J. Ellis, William E. Kraus, David J. Whellan, Christopher M. O'Connor
AMERICAN HEART JOURNAL
(2013)
Article
Cardiac & Cardiovascular Systems
Robert J. Mentz, Phillip J. Schulte, Jerome L. Fleg, Mona Fiuzat, William E. Kraus, Ileana L. Pina, Steven J. Keteyian, Dalane W. Kitzman, David J. Whellan, Stephen J. Ellis, Christopher M. O'Connor
AMERICAN HEART JOURNAL
(2013)
Article
Medicine, Research & Experimental
Jason D. Allen, Jennifer L. Robbins, Mitch D. VanBruggen, Daniel P. Credeur, Neil M. Johannsen, Conrad P. Earnest, Carl F. Pieper, Johanna L. Johnson, Timothy S. Church, Eric Ravussin, William E. Kraus, Michael A. Welsch
CONTEMPORARY CLINICAL TRIALS
(2013)
Article
Medicine, Research & Experimental
James A. Blumenthal, Patrick J. Smith, Kathleen Welsh-Bohmer, Michael A. Babyak, Jeffrey Browndyke, Pao-Hwa Lin, P. Murali Doraiswamy, James Burke, William Kraus, Alan Hinderliter, Andrew Sherwood
CONTEMPORARY CLINICAL TRIALS
(2013)
Article
Cardiac & Cardiovascular Systems
Daniela Dobre, Faiez Zannad, Steven J. Keteyian, Susanna R. Stevens, Patrick Rossignol, Dalane W. Kitzman, Joel Landzberg, Jonathan Howlett, William E. Kraus, Stephen J. Ellis
EUROPEAN HEART JOURNAL
(2013)
Article
Cardiac & Cardiovascular Systems
Mona Fiuzat, Megan L. Neely, Aijing Z. Starr, William E. Kraus, G. Michael Felker, Mark Donahue, Kirkwood Adams, Ileana L. Pina, David Whellan, Christopher M. O'Connor
EUROPEAN JOURNAL OF HEART FAILURE
(2013)
Article
Genetics & Heredity
Cavin Ward-Caviness, Carol Haynes, Colette Blach, Elaine Dowdy, Simon G. Gregory, Svati H. Shah, Benjamin D. Horne, William E. Kraus, Elizabeth R. Hauser
Article
Oncology
Allison Ottenbacher, Richard Sloane, Denise C. Snyder, William Kraus, Lisa Sprod, Wendy Demark-Wahnefried
INTEGRATIVE CANCER THERAPIES
(2013)
Letter
Cardiac & Cardiovascular Systems
Alain Cohen-Solal, Steven J. Keteyian, John R. Horton, Stephen J. Ellis, William E. Kraus, Ryan D. Kilpatrick
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2013)
Review
Cardiac & Cardiovascular Systems
Connie W. Bales, William E. Kraus
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2013)
Article
Cardiac & Cardiovascular Systems
Deepak Voora, Derek Cyr, Joseph Lucas, Jen-Tsan Chi, Jennifer Dungan, Timothy A. McCaffrey, Richard Katz, L. Kristin Newby, William E. Kraus, Richard C. Becker, Thomas L. Ortel, Geoffrey S. Ginsburg
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2013)
Article
Geriatrics & Gerontology
Maragatha N. Kuchibhatla, Gerda G. Fillenbaum, William E. Kraus, Harvey Jay Cohen, Dan G. Blazer
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2013)
Article
Endocrinology & Metabolism
Baodong Sun, Keri Fredrickson, Stephanie Austin, Adviye A. Tolun, Beth L. Thurberg, William E. Kraus, Deeksha Bali, Yuan-Tsong Chen, Priya S. Kishnani
MOLECULAR GENETICS AND METABOLISM
(2013)
Article
Multidisciplinary Sciences
Daniel Nolan, William E. Kraus, Elizabeth Hauser, Yi-Ju Li, Dana K. Thompson, Jessica Johnson, Hsiang-Cheng Chen, Sarah Nelson, Carol Haynes, Simon G. Gregory, Virginia B. Kraus, Svati H. Shah
Article
Cardiac & Cardiovascular Systems
Jonathan P. Piccini, Anne S. Hellkamp, David J. Whellan, Stephen J. Ellis, Steven J. Keteyian, William E. Kraus, Adrian F. Hernandez, James P. Daubert, Ileana L. Piña, Christopher M. O'Connor
JACC-HEART FAILURE
(2013)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)