Article
Biochemistry & Molecular Biology
Yong-guo Zhang, Yinglin Xia, Jun Sun
Summary: The study presents a simple and sensitive qPCR method to detect reduction of intestinal VDR using fecal samples. This method was validated in several experimental models and correlated with the protein level of VDR, indicating its potential for detecting the expression level of intestinal VDR in various diseases.
Article
Chemistry, Multidisciplinary
Ning-ning Zhao, Xiaorui Tian, Fei Ma, Chun-yang Zhang
Summary: We have developed a new fluorescent biosensor for detecting flap endonuclease 1 (FEN1) based on CRISPR/Cas12-enhanced single-molecule counting. This biosensor is simple, selective, and sensitive, with a detection limit of 2.325 x 10(-5) U. It can be used for inhibitor screening, kinetic parameter analysis, and quantifying cellular FEN1 with single-cell sensitivity.
CHEMICAL COMMUNICATIONS
(2023)
Review
Immunology
Gaidaa M. Dogheim, Mohamed T. Amralla, Rehab H. Werida
Summary: Inflammation plays a crucial role in the development of heart failure, and neopterin, an inflammatory biomarker, can be used for diagnosing HF, determining disease severity, and monitoring disease progression.
INFLAMMOPHARMACOLOGY
(2022)
Article
Dermatology
Hesham N. Khalid, Eman M. Abd El Gayed, Asmaa M. A. Elrsool, Heba A. S. Bazid
Summary: The study found a significant increase in urinary ORM protein A levels in psoriasis patients, which is correlated to disease severity. u-ORM/u-CREAT can serve as a new inflammatory biomarker for psoriasis.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Oncology
Qifeng Wang, Lin Peng, Yongtao Han, Tao Li, Wei Dai, Yi Wang, Lei Wu, Yang Wei, Tianpeng Xie, Qiang Fang, Qiang Li, Jinyi Lang, Bangrong Cao
Summary: Low preoperative serum sodium is associated with poor outcome in esophageal carcinoma patients, and may predict survival benefit of adjuvant therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Barbara Morawin, Anna Tylutka, Filip Bielewicz, Agnieszka Zembron-Lacny
Summary: This study aimed to investigate the relationship between inflammation and sarcopenia and evaluate the impact of lifestyle on inflammatory markers. The results showed significantly higher levels of C-reactive protein and inflammatory markers (IL-1β, cfDNA, and bilirubin) in the sarcopenia group compared to the no sarcopenia group. Gait speed was negatively correlated with cfDNA and IL-1β. Furthermore, the study revealed a link between inflammation and fitness level in older adults, suggesting that lifestyle exercise is a key therapeutic strategy for sarcopenia prevention.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Gurhan Guney, Mine Islimye Taskin, Antonio Simone Lagana, Ezgi Tolu, Figen Aslan, Adnan Adil Hismiogullari, Cihan Kaya
Summary: This study aimed to investigate serum NGAL levels and endometrioma tissue expression in women with endometriosis. The results showed that NGAL levels and immunohistochemical staining were significantly higher in the endometrioma group compared to the control group, and they were correlated with C-reactive protein and CA-125 levels. NGAL may be considered as a potential noninvasive biomarker of endometriosis.
Article
Biochemical Research Methods
Mai Pham, Quynh Pham, Ung Nguyen, Lanh Nguyen, Hoa Nguyen, Thang Vu, Ba Nguyen, Jakob Stenman, Ho Tho
Summary: The EGFR L858R missense mutation is more sensitive to EGFR tyrosine kinase inhibitor therapy, but there is still a significant non-response rate. A new one-step real-time RT-PCR assay based on RNA has been developed to detect the EGFR L858R mutation at the mRNA level. Compared to the DNA-based assay, this RNA-based assay can detect the EGFR L858R mutation in more FFPE samples and also shows a wide range of mRNA levels in tumor tissues. The circulating mRNA of the EGFR L858R mutation can be detected in the plasma of NSCLC patients.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Cell Biology
Alireza Bakhshi, Mohammad Khani, Saeed Alipour Parsa, Isa Khaheshi, Mohammad Hassan Namazi, Arash Mazouri, Peyman Bidram, Morteza Safi, Hossein Vakili, Vahid Eslami, Habib Saadat, Laleh Heidari, Nasim Sohrabifar
Summary: The expression levels of miR-17-3p, miR-101-3p, miR-335-3p, miR-296-3p, and NLRP3 were evaluated in STEMI, NSTEMI, and control groups. NLRP3 was upregulated in both STEMI and NSTEMI patients, while miR-17-3p, miR-101-3p, and miR-296-3p were downregulated. MiR-17-3p showed the highest diagnostic power in distinguishing STEMI patients from controls.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Walter J. Paulus, Michael R. Zile
Summary: According to the comorbidity-inflammation paradigm, comorbidities, especially metabolic ones, are believed to drive the development and severity of heart failure with preserved ejection fraction. Recent evidence includes myocardial infiltration, inducible nitric oxide synthase expression, patient phenogroups, and direct connections between comorbidities, inflammatory biomarkers, and abnormal myocardial structure/function.
CIRCULATION RESEARCH
(2021)
Article
Nutrition & Dietetics
Julian Hackler, Raban Arved Heller, Qian Sun, Marco Schwarzer, Joachim Diegmann, Manuel Bachmann, Arash Moghaddam, Lutz Schomburg
Summary: The study suggests that serum levels of copper and selenium in COVID-19 patients are related to survival rates, with higher concentrations of copper and ceruloplasmin associated with higher chances of survival. Additionally, copper and selenium levels in serum showed a positive correlation in contrast to expectations, indicating their importance in predicting survival and influencing disease course.
Article
Nutrition & Dietetics
Salvatore Sciacca, Arturo Lo Giudice, Maria Giovanna Asmundo, Sebastiano Cimino, Ali A. Alshatwi, Giuseppe Morgia, Matteo Ferro, Giorgio Ivan Russo
Summary: This study assessed the relationship between the level of food processing and prostate cancer severity. It found that individuals who consumed more unprocessed/minimally processed foods were less likely to have greater prostate cancer severity, while a borderline association was found between higher consumption of ultra-processed foods and greater prostate cancer severity. However, these associations were not significant after adjusting for potential confounding factors.
Article
Medicine, General & Internal
Hailong Liu, Xi Chen, Zhicong Wang, Yuehong Liu, Mozhen Liu
Summary: The study aimed to explore the association between the systemic inflammation response index (SIRI) and the risk of lower extremity deep venous thrombosis (LEDVT). The results showed that a high SIRI was significantly associated with an increased risk of LEDVT in hospitalized patients, and this association had a non-linear distribution with an inflection point. The potential clinical use of SIRI as a readily available biomarker deserves further exploration.
ANNALS OF MEDICINE
(2023)
Article
Clinical Neurology
Denis S. Smirnov, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Joel Simren, Juan Lantero-Rodriguez, Thomas K. Karikari, Annie Hiniker, Robert A. Rissman, David P. Salmon, Douglas Galasko
Summary: Plasma biomarkers show promise in identifying the pathological features of Alzheimer's Disease. P-tau181 and P-tau231 are diagnostic biomarkers related to AD neuropathological change and can predict future cognitive decline. NfL can predict cognitive decline and is increased in non-AD cases. Plasma A beta 42/40 is a relatively weak predictor of amyloid pathology and may require different assay methods for improvement.
ACTA NEUROPATHOLOGICA
(2022)
Article
Clinical Neurology
Christa Meisinger, Dennis Freuer, Timo Schmitz, Michael Ertl, Philipp Zickler, Markus Naumann, Jakob Linseisen
Summary: This cross-sectional study aimed to evaluate potential associations between the etiologic subtypes of ischemic stroke and blood-based proteins. The study found that stromal-cell-derived-factor 1 alpha (SDF-1a) showed significantly higher serum levels in cardioembolic stroke compared with large vessel atherosclerotic stroke, while interleukin-6 (IL-6) and macrophage migration inhibitory factor (MIF) levels were significantly lower in the small vessel stroke subtype compared to the large vessel stroke subtype.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shani Shenhar-Tsarfaty, Sharon Toker, Itzhak Shapira, Ori Rogowski, Shlomo Berliner, Yaacov Ritov, Hermona Soreq
MOLECULAR MEDICINE
(2016)
Article
Psychology, Clinical
Galit Armon, Samuel Melamed, Sharon Toker, Shlomo Berliner, Itzhak Shapira
Article
Cardiac & Cardiovascular Systems
Hezzy Shmueli, Ori Rogowski, Sharon Toker, Shmuel Melamed, Eran Leshem-Rubinow, Eyal Ben-Assa, Itzhak Shapira, Shlomo Berliner, Arie Steinvil
JOURNAL OF CARDIOVASCULAR MEDICINE
(2014)
Article
Multidisciplinary Sciences
Shani Shenhar-Tsarfaty, Nadav Yayon, Nir Waiskopf, Itzhak Shapira, Sharon Toker, David Zaltser, Shlomo Berliner, Ya'acov Ritov, Hermona Soreq
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Psychology, Clinical
Renzo Bianchi, Jay Verkuilen, Sharon Toker, Irvin Sam Schonfeld, Markus Gerber, Elmar Braehler, Kurt Kroenke
Summary: In this study, the researchers examined the dimensionality, scalability, and monotonicity properties of the PHQ-9 as well as the scale's total-score reliability. They found that the PHQ-9 can be used as a reliable and valid unidimensional measure of depressive symptoms. The study provides robust evidence for researchers and practitioners to use the PHQ-9 in assessing depression.
PSYCHOLOGICAL ASSESSMENT
(2022)
Article
Psychology, Applied
Ofer I. I. Atad, Sharon Toker
Summary: Based on Hobfoll's conservation of resources theory, this study aimed to investigate the impact of subjective workload at baseline on the development of new-onset metabolic syndrome (MetS) during follow-up. The study also examined whether increased job burnout mediates this association, and whether the level of engagement in leisure-time physical activity (PA) attenuates the effect of workload on MetS. The findings showed that subjective workload at baseline was linked to the risk of new-onset MetS, but this association was moderated by PA. The results suggest that engaging in PA while being overloaded not only protects employees from adverse outcomes but actually reverses the cardiovascular risk.
INTERNATIONAL JOURNAL OF STRESS MANAGEMENT
(2023)
Article
Psychology, Applied
Keren Turgeman-Lupo, Sharon Toker, Nili Ben-Avi, Shani Shenhar-Tsarfaty
EUROPEAN JOURNAL OF WORK AND ORGANIZATIONAL PSYCHOLOGY
(2020)
Article
Psychology, Social
Nili Ben-Avi, Sharon Toker, Daniel Heller
JOURNAL OF EXPERIMENTAL SOCIAL PSYCHOLOGY
(2018)
Article
Business
Annekatrin Hoppe, Sharon Toker, Vivian Schachler, Matthias Ziegler
JOURNAL OF ORGANIZATIONAL BEHAVIOR
(2017)
Article
Psychology, Applied
Michal Biron, Renee De Reuver, Sharon Toker
EUROPEAN JOURNAL OF WORK AND ORGANIZATIONAL PSYCHOLOGY
(2016)
Article
Psychology, Applied
Sharon Toker, Catherine A. Heaney, Danit Ein-Gar
EUROPEAN JOURNAL OF WORK AND ORGANIZATIONAL PSYCHOLOGY
(2015)
Article
Psychology, Applied
Yuval Kalish, Gil Luria, Sharon Toker, Mina Westman
JOURNAL OF APPLIED PSYCHOLOGY
(2015)
Article
Medicine, General & Internal
Eran Leshem-Rubinow, Shani Shenhar-Tsarfaty, Assi Milwidsky, Sharon Toker, Itzhak Shapira, Shlomo Berliner, Yael Benyamini, Samuel Melamed, Ori Rogowski
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2015)
Article
Business
Sharon Toker, Gregory A. Laurence, Yitzhak Fried
JOURNAL OF ORGANIZATIONAL BEHAVIOR
(2015)
Meeting Abstract
Cardiac & Cardiovascular Systems
Y. Fried, G. I. Laurence, A. Shirom, S. Melamed, S. Toker, S. Berliner, I. Shapira
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)