期刊
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
卷 27, 期 7, 页码 496-503出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1533317512456067
关键词
Alzheimer's disease; gene-environment interaction; organochlorine pesticides; APOE polymorphism; beta-HCH; dieldrin
资金
- Indian Council of Medical Research (ICMR), New Delhi, India [3/1/2/5/Neuro/2004-NCD-I]
Objectives: The aim was to examine the gene environment (GxE) interaction with reference to APO E genotypes, serum lipids and organochlorine pesticides (OCPs) as one of the factors in the etiology of Alzheimer's disease (AD). Methods: A case control study was used to examine, APOE HhaI polymorphism by polymerase chain reaction (PCR)/PCRrestriction fragment length polymorphism method, serum lipids by autoanalyser and OCPs by gas chromatography (GC). Results: APOE epsilon 4 allele frequency was significantly high (p=0.000, OR=5.73, CI=2.68-12.50) in AD as compared to controls. The serum cholesterol, beta- hexachlorocyclohexane and dieldrin are risk factors for AD independent of the APOE epsilon 4 risk allele, recording an odds ratio of 1.16, 11.38 and 10.45 respectively. Conclusion: GxE interactions exist with APOE e4 allele status that need to be considered for the study design and analysis of such data in future studies of AD.
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