Article
Cardiac & Cardiovascular Systems
Quirino Ciampi, Angela Zagatina, Lauro Cortigiani, Karina Wierzbowska-Drabik, Jaroslaw D. Kasprzak, Maciej Haberka, Ana Djordjevic-Dikic, Branko Beleslin, Alla Boshchenko, Tamara Ryabova, Nicola Gaibazzi, Fausto Rigo, Claudio Dodi, Iana Simova, Martina Samardjieva, Andrea Barbieri, Doralisa Morrone, Valentina Lorenzoni, Costantina Prota, Bruno Villari, Francesco Antonini-Canterin, Mauro Pepi, Clara Carpeggiani, Patricia A. Pellikka, Eugenio Picano
Summary: The study aimed to assess the prognostic value of ABCDE-SE in patients with chronic coronary syndromes, showing that it effectively predicts survival in this patient population. Abnormal results were found in different steps of the ABCDE protocol, with annual mortality rates varying based on the score received.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Quirino Ciampi, Angela Zagatina, Lauro Cortigiani, Karina Wierzbowska-Drabik, Jaroslaw D. Kasprzak, Maciej Haberka, Ana Djordjevic-Dikic, Branko Beleslin, Alla Boshchenko, Tamara Ryabova, Nicola Gaibazzi, Fausto Rigo, Claudio Dodi, Iana Simova, Martina Samardjieva, Andrea Barbieri, Doralisa Morrone, Valentina Lorenzoni, Costantina Prota, Bruno Villari, Francesco Antonini-Canterin, Mauro Pepi, Clara Carpeggiani, Patricia A. Pellikka, Eugenio Picano
Summary: The study aimed to evaluate the prognostic value of ABCDE-SE in chronic coronary syndromes patients, showing that ABCDE-SE allows for an effective prediction of survival. The results indicate that the mortality rate increases from 0.4% person-year for a score of 0 to 2.7% person-year for a score of 5.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Theo Pezel, Thierry Unterseeh, Philippe Garot, Thomas Hovasse, Marine Kinnel, Stephane Champagne, Solenn Toupin, Francesca Sanguineti, Jerome Garot
Summary: This study evaluated the prognostic value of vasodilator stress cardiovascular magnetic resonance (CMR) parameters and CMR-based coronary revascularization in predicting major adverse cardiovascular events (MACE) after inconclusive stress testing. Inducible ischemia and late gadolinium enhancement (LGE) were significantly associated with the occurrence of MACE, with the extent of inducible ischemia showing the best improvement in model discrimination. The study suggested no benefit of CMR-related coronary revascularization in reducing MACE.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Medicine, General & Internal
Quirino Ciampi, Iacopo Olivotto, Jesus Peteiro, Maria Grazia D'Alfonso, Fabio Mori, Luigi Tassetti, Alessandra Milazzo, Lorenzo Monserrat, Xusto Fernandez, Attila Palinkas, Eszter Dalma Palinkas, Robert Sepp, Federica Re, Lauro Cortigiani, Milorad Tesic, Ana Djordjevic-Dikic, Branko Beleslin, Mariangela Losi, Grazia Canciello, Sandro Betocchi, Luis Rocha Lopes, Ines Cruz, Carlos Cotrim, Marco A. R. Torres, Clarissa C. A. Bellagamba, Caroline M. Van de Heyning, Albert Varga, Gergely Agoston, Bruno Villari, Valentina Lorenzoni, Clara Carpeggiani, Eugenio Picano
Summary: This study demonstrated that a blunted heart rate reserve (HRR) during exercise stress echocardiography (ESE) independently predicts survival in patients with hypertrophic cardiomyopathy (HCM), even when considering other risk factors such as age and maximal wall thickness.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Doyeon Hwang, Bon-Kwon Koo, Jinlong Zhang, Jiesuck Park, Seokhun Yang, Minsang Kim, Jun Pil Yun, Joo Myung Lee, Chang-Wook Nam, Eun-Seok Shin, Joon-Hyung Doh, Shao-Liang Chen, Tsunekazu Kakuta, Gabor G. Toth, Zsolt Piroth, Nils P. Johnson, Nico H. J. Pijls, Abdul Hakeem, Barry F. Uretsky, Yohei Hokama, Nobuhiro Tanaka, Hong-Seok Lim, Tsuyoshi Ito, Akiko Matsuo, Lorenzo Azzalini, Massoud A. Leesar, Tara Neleman, Nicolas M. van Mieghem, Roberto Diletti, Joost Daemen, Damien Collison, Carlos Collet, Bernard De Bruyne
Summary: The clinical relevance of post-PCI fractional flow reserve (FFR) measurement after drug-eluting stent (DES) implantation was evaluated in this study. The results showed that lower post-PCI FFR was associated with increased risks of target vessel failure (TVF) and cardiac death or target vessel myocardial infarction (TVMI).
Review
Cardiac & Cardiovascular Systems
Charlotte N. G. Lanser, Wessel H. A. van Poecke, Linda E. Scheffers, Linda E. van den Berg, Willem A. Helbing
Summary: This study provides an overview of the cardiac stress response in Fontan patients and examines the use, safety, and clinical value of stress imaging in these patients. The findings reveal that the cardiac stress response in Fontan patients differs from healthy subjects, characterized by lower increases in heart rate, diminished preload, and decreased cardiac output. Stress imaging is deemed safe, but its additional clinical value requires further investigation.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Vidhu Anand, Garvan C. Kane, Christopher G. Scott, Sorin Pislaru, Rosalyn O. Adigun, Robert B. McCully, Patricia A. Pellikka, Cristina Pislaru
Summary: This study aimed to evaluate the prognostic significance of peak exercise cardiac power and power reserve in patients with normal left ventricular ejection fraction. The results showed that both peak stress power/mass and power reserve were independently associated with mortality and heart failure at follow-up.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Vidhu Anand, Garvan C. Kane, Christopher G. Scott, Sorin Pislaru, Rosalyn O. Adigun, Robert B. McCully, Patricia A. Pellikka, Cristina Pislaru
Summary: The assessment of cardiac power and power reserve during exercise stress echocardiography in patients with normal EF provides valuable prognostic information, in addition to stress test findings on inducible myocardial ischaemia and exercise capacity.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Yangjie Xiao, Wenjing Bi, Wei Qiao, Xin Wang, Ying Li, Weidong Ren
Summary: This study systematically reviewed and analyzed ventricular strain as a predictor of adverse outcomes in patients with aortic stenosis undergoing transcatheter aortic valve replacement. The meta-analysis showed that impaired left ventricular and right ventricular longitudinal strain were associated with an increased risk for adverse cardiovascular events, highlighting their prognostic value in risk stratification for these patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sean Tan, Yi Wen Thang, William R. Mulley, Kevan R. Polkinghorne, Satish Ramkumar, Kevin Cheng, Jasmine Chan, John Galligan, Mark Nolan, Adam J. Brown, Stuart Moir, James D. Cameron, Stephen J. Nicholls, Philip M. Mottram, Nitesh Nerlekar
Summary: This study evaluated the prognostic value of exercise capacity on long-term cardiovascular outcomes in kidney transplant candidates. The results showed that achieving predicted METs on pre-transplant exercise stress echocardiography was associated with reduced major adverse cardiovascular events, independent of and similar to subsequent kidney transplantation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Jesus Peteiro, Alberto Bouzas-Mosquera, Cayetana Barbeito-Caamano, Esteban Martin-Alvarez, Borja Souto-Cainzos, Jose M. Vazquez-Rodriguez
Summary: The value of diastolic parameters at exercise in patients with normal or abnormal resting diastolic function referred for exercise echocardiography was assessed. The study found that exercise E/e' was associated with abnormal exercise echocardiography results and predicted patient outcomes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Ana Marques, Ines Cruz, Isabel Joao, Ana Rita Almeida, Paula Fazendas, Daniel Caldeira, Sofia Alegria, Ana Rita Pereira, Alexandra Briosa, Carlos Cotrim, Luis Rocha Lopes, Helder Pereira
Summary: This study confirmed the prognostic value of EE in patients with prior percutaneous coronary intervention, with those having negative EE results at a lower risk for cardiac events. Patients with inconclusive results had a higher risk of cardiac events and require closer follow-up and attention.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Review
Biochemistry & Molecular Biology
Ana Silva, Monica Costa Cerqueira, Beatriz Rosa, Catarina Sobral, Filipa Pinto-Ribeiro, Marta Freitas Costa, Fatima Baltazar, Julieta Afonso
Summary: Cancer produces energy through accelerated glycolysis, resulting in increased lactate production. The lactate is transported to and from cancer cells by monocarboxylate transporters (MCTs). MCT1 acts as both an importer and an extruder of lactate and has been studied extensively in recent years, being generally associated with aggressive cancer. This systematic review aimed to evaluate the prognostic value of MCT1 immunoexpression in various malignancies. The results showed that MCT1 is a poor prognostic indicator and is associated with decreased survival in sixteen types of cancer. However, MCT1 overexpression was also linked to better outcomes in colorectal cancer, pancreatic ductal adenocarcinoma, and non-small cell lung cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Vasileios Anastasiou, Andreas S. S. Papazoglou, Dimitrios V. V. Moysidis, Stylianos Daios, Dimitrios Tsalikakis, George Giannakoulas, Theodoros Karamitsos, Victoria Delgado, Antonios Ziakas, Vasileios Kamperidis
Summary: RV longitudinal strain is a powerful prognosticator in heart failure patients, with worsening strain associated with increased risk of all-cause mortality and the composite outcome.
HEART FAILURE REVIEWS
(2023)
Review
Infectious Diseases
Manuel Urina-Jassir, Maria Alejandra Jaimes-Reyes, Samuel Martinez-Vernaza, Camilo Quiroga-Vergara, Miguel Urina-Triana
Summary: This study provides a systematic review of the clinical, microbiological, and imaging characteristics of patients with infective endocarditis (IE) in Latin America. The results show that IE in Latin America mainly affects male patients, with clinical manifestations including fever, malaise, and heart murmur. Staphylococcus aureus and the viridans group streptococci are the most common isolates.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Satish Ramkumar, Hiroshi Kawakami, Edmond Wong, Mark Nolan, Thomas H. Marwick
Summary: This study compared the cost-effectiveness of two screening strategies for atrial fibrillation and found that imaging-guided screening was more cost-effective with lower costs and better outcomes. The study suggests that targeted screening for specific populations based on clinical and imaging risk parameters is more meaningful for detecting atrial fibrillation.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Edgar M. Hidalgo, Leah Wright, Mats Isaksson, Gavin Lambert, Thomas H. Marwick
Summary: With advances in robotics and telecommunications, robot-assisted teleoperated ultrasound examination can help with medical diagnosis in remote areas, reducing health inequalities. Studies have shown that robots can safely perform ultrasound examinations by following the hand movements of sonographers and researchers. However, real-time transmission of video and ultrasound images requires high bandwidth, and improvements are needed in robot control and interface design.
JACC-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas H. Marwick, Y. Chandrashekhar
JACC-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Neville Tan, Thomas H. Marwick, Nitesh Nerlekar
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Neville Tan, Damini Dey, Thomas H. Marwick, Nitesh Nerlekar
Summary: Coronary computed tomography can quantify coronary inflammation by mapping changes in pericoronary adipose tissue, but there are significant knowledge gaps in its interpretation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan Sen, Quan Huynh, Thomas H. Marwick
Summary: This study found that the use of DICOM structured reporting may lead to misclassifying severe AS as moderate. After validating the data, it was observed that several echocardiographic parameters in DICOM-SR showed significant differences compared to manual validation. This misclassification had an impact on the severity of AS and its association with outcomes. Clinicians' evaluation of AS severity was found to be unable to accurately distinguish between moderate and severe AS.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Medicine, General & Internal
Prasanna Venkataraman, Amanda L. Neil, Geoffrey K. Mitchell, Tony Stanton, Stephen Nicholls, Andrew M. Tonkin, Gerald F. Watts, Thomas H. Marwick
Summary: This study compared the cost-effectiveness of coronary artery calcium (CAC) score-guided statin therapy criteria and American College of Cardiology/American Heart Association (ACC/AHA) guidelines with selection according to Australian guidelines. The findings showed that CAC score-guided selection was cost-effective for people with 5-year ACVDR of at least 5%.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Y. Chandrashekhar, Thomas H. Marwick, Leslee J. Shaw
JACC-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Joshua Wong, Stacey Peters, Thomas H. Marwick
Summary: Heart failure is a heterogeneous disease, and genetic testing provides additional information to imaging in distinguishing phenotypes. Advances in genetic testing have identified harmful variants in specific heart failure phenotypes (dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and hypertrophic cardiomyopathy), with implications for specific treatments. However, the diagnostic yield of genetic testing is modest, and many rare variants have incomplete penetrance and variable expressivity. The heterogeneity of the heart failure phenotype is also influenced by environmental factors and co-morbidities. Future research should focus on the cumulative impact of genetic polymorphisms on the development of heart failure.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Mohammad Shah, Marie-Jeanne Buscot, Jing Tian, Hoang T. Phan, Brooklyn J. Fraser, Thomas H. Marwick, Terence Dwyer, Alison Venn, Seana Gall
Summary: This study analyzed long-term follow-up data from the Australian Schools Health and Fitness Survey and found that childhood risk factors contribute to sex differences in adult carotid artery plaques and intima-media thickness. After adjusting for relevant adult risk factors, the sex differences decreased. The conclusion is that prevention strategies throughout the life course are important for reducing sex differences in cardiovascular diseases.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Paaladinesh Thavendiranathan, Christian Houbois, Thomas H. Marwick, Tiffanie Kei, Sudipta Saha, Kyle Runeckles, Flora Huang, Tamar Shalmon, Kevin E. Thorpe, Rossanna C. Pezo, Anca Prica, Dawn Maze, Husam Abdel-Qadir, Kim A. Connelly, Joyce Chan, Filio Billia, Coleen Power, Kate Hanneman, Bernd J. Wintersperger, Christine Brezden-Masley, Eitan Amir
Summary: This study aimed to assess whether statins can prevent decline in left ventricular ejection fraction in patients treated with anthracyclines. The results showed that primary prevention with atorvastatin did not ameliorate early decline in LVEF, left ventricular remodeling, therapy-related cardiac dysfunction, changes in serum cardiac biomarkers, or myocardial tissue changes in patients at increased risk of CTRCD.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Roberto Enrique Azcui Aparicio, Melinda J. Carrington, Quan Huynh, Jocasta Ball, Thomas H. Marwick
Summary: The study investigated the association between Fuster-BEWAT Score (FBS), Framingham Risk Score (FRS), and Pooled Cohort Equation (PCE) with carotid plaque presence, aiming to develop a stepped screening process for the primary prevention of cardiovascular disease (CVD). The results showed that FBS was able to identify carotid plaque in asymptomatic individuals, suggesting its potential use in initial risk delineation could improve patient selection for further assessment and reduce cost and time.
CARDIOVASCULAR DIGITAL HEALTH JOURNAL
(2023)
Review
Oncology
Yueyang Bao, John Lee, Udit Thakur, Satish Ramkumar, Thomas H. Marwick
Summary: This study compared the atrial fibrillation (AF) detection rate between cancer survivors and the general population and found that the AF risk in cancer survivors was not significantly increased.
Article
Medicine, General & Internal
Quan Huynh, Noah Wexler, Joel Smith, Leah Wright, Felicia Ho, Richard Allwood, Yusuke Sata, Stefano Manca, Erin Howden, Thomas H. Marwick
Summary: This study compared the symptoms and functional impairment of patients with previous COVID-19 infection to uninfected community controls. It found that patients with COVID-19 had lower functional capacity and more depression compared to controls. A pilot group also showed an increase in peak workload after exercise training. The study suggests that an exercise training program might be beneficial for selected patients.
INTERNAL MEDICINE JOURNAL
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Neville Tan, Nitesh Nerlekar, Thomas H. Marwick
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)