Article
Medicine, General & Internal
Seon-Ah Cha
Summary: This study investigated the association between heart rate-corrected QT interval and heart rate variability in patients with type 2 diabetes mellitus. The results showed that prolonged QTc interval was associated with older age, female gender, hypertension, higher hemoglobin A1c level, and decreased values for various heart rate variability parameters, except the LF/HF ratio, in patients with T2DM.
Article
Medicine, General & Internal
Francesco Luzza, Rosalba De Sarro, Roberto Licordari, Pasquale Crea, Pietro Pugliatti, Giuseppe Certo, Lorenzo Pistelli, Francesca Campanella, Maria Claudia Lo Nigro, Matteo Casale, Michele Correale, Giuseppe Dattilo
Summary: QT interval varies with heart rate and needs to be corrected. Atrial fibrillation (AF) is associated with elevated heart rate and beat-to-beat variation. The study aims to find the best correlation between QTc in AF and restored sinus rhythm (SR) and determine the best correction formula and method for determining QTc in AF. The results show that Bazzett's formula is the least accurate in estimating QTc during AF.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Psychiatry
Hiroaki Okayasu, Takahiro Shinozaki, Yumiko Takano, Norio Sugawara, Kumiko Fujii, Norio Yasui-Furukori, Yuji Ozeki, Kazutaka Shimoda
Summary: This study evaluated the risk of sudden cardiac death in schizophrenia patients treated with antipsychotics by assessing deceleration capacity (DC) and examining the association between DC and the corrected QT interval (QTc). The results showed that assessing DC could facilitate monitoring and identification of increased risk of cardiac mortality in schizophrenia patients taking antipsychotics.
GENERAL HOSPITAL PSYCHIATRY
(2023)
Article
Food Science & Technology
Yu-Syuan Luo, Zunwei Chen, Alexander D. Blanchette, Yi-Hui Zhou, Fred A. Wright, Erin S. Baker, Weihsueh A. Chiu, Ivan Rusyn
Summary: This study characterized the chemical profiles and effects of energy drinks and their ingredients on human induced pluripotent stem cell-derived cardiomyocytes, identifying potential active ingredients contributing to adverse effects. The analysis revealed that some ingredients in energy drinks, such as theophylline, adenine, and azelate, may be responsible for QT prolongation in cardiomyocytes. Additionally, adverse effects on cardiomyocytes were observed, including increased beat rate and QT prolongation, particularly at lower concentrations.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Physiology
Wesam Mulla, Michael Murninkas, Or Levi, Yoram Etzion
Summary: This review summarizes recent experimental findings on the correction of QT interval in small mammals and highlights the potential errors in data interpretation that may arise from using existing QTc formulas.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Tomohiro Ueyama, Ayaka Yoshino, Harunobu Nakamura, Yoshimitsu Okita
Summary: This work proposes a model that incorporates QT-interval variability (QTV) by extending the synthetic electrocardiogram (ECG) model including heart rate variability (HRV). The model consists of modified coupled ordinary differential equations and an equation to incorporate QTV by shifting the position of the T-wave. RR and QT tachograms with multiple Gaussian distribution peaks are used to generate an ECG signal. This proposed model has significant implications for understanding the neurophysiological mechanisms underlying the relationship between QTV, HRV, and autonomic activity, and it can address issues in measuring the QT interval.
IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Benjamin Neumann, A. Suzanne Vink, Ben J. M. Hermans, Krystien V. V. Lieve, Didem Comert, Britt-Maria Beckmann, Sally-Ann B. Clur, Nico A. Blom, Tammo Delhaas, Arthur A. M. Wilde, Stefan Kaeaeb, Pieter G. Postema, Moritz F. Sinner
Summary: Pairwise comparisons between automatic and manual measurements of QT intervals and QTc revealed significant discrepancies, especially in patients with aberrant QTc values. Novel automatic algorithms may be able to improve the agreement between these measurements.
Article
Medicine, General & Internal
Geoffrey A. Rubin, Amar D. Desai, Zilan Chai, Aijin Wang, Qixuan Chen, Amy S. Wang, Cameron Kemal, Haajra Baksh, Angelo Biviano, Jose M. Dizon, Hirad Yarmohammadi, Frederick Ehlert, Deepak Saluja, David A. Rubin, John P. Morrow, Uma Mahesh R. Avula, Jeremy P. Berman, Alexander Kushnir, Mark P. Abrams, Jessica A. Hennessey, Pierre Elias, Timothy J. Poterucha, Nir Uriel, Christine J. Kubin, Elijah LaSota, Jason Zucker, Magdalena E. Sobieszczyk, Allan Schwartz, Hasan Garan, Marc P. Waase, Elaine Y. Wan
Summary: In this study, COVID-19 infection was independently associated with significant mean QTc prolongation compared to patients without COVID-19, regardless of other clinical factors. More patients with COVID-19 had QTc of 500 milliseconds or greater compared to those without COVID-19.
Article
Physiology
Beatrice De Maria, Daniela Lucini, Mariana de Oliveira Gois, Aparecida Maria Catai, Francesca Perego, Mara Malacarne, Massimo Pagani, Alberto Porta, Laura Adelaide Dalla Vecchia
Summary: QT interval variability analysis can provide pathophysiological and prognostic information in cardiac and non-cardiac diseases, complementary to heart period variability analysis. Long-term moderate exercise can reduce cardiovascular risk and improve cardiac control complexity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Environmental Sciences
Rahul Gondalia, Antoine Baldassari, Katelyn M. Holliday, Anne E. Justice, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Stephanie M. Engel, David Sheps, Kristina M. Jordahl, Parveen Bhatti, Steve Horvath, Themistocles L. Assimes, Ellen W. Demerath, Weihua Guan, Myriam Fornage, Jan Bressler, Kari E. North, Karen N. Conneely, Yun Li, Lifang Hou, Andrea A. Baccarelli, Eric A. Whitsel
Summary: The study found that sub-chronic exposures to coarser particulates may not have appreciable effects on cardiac autonomic function or ventricular repolarization among racially/ethnically and environmentally diverse U.S. populations. Mediation by DNA methylation was also not evident in this study. Further research in better-powered studies is needed to explore the effects of shorter duration exposures to finer particulates on non-electrocardiographic outcomes among relatively susceptible populations.
ENVIRONMENTAL RESEARCH
(2021)
Article
Medicine, General & Internal
Maja Tschumper, Lukas Weber, Hans Rickli, Sebastian Seidl, Roman Brenner, Marc Buser, Niklas F. Ehl, Franziska Jager-Rhomberg, Peter Ammann, Micha T. Maeder
Summary: In patients with severe aortic stenosis, prolonged corrected QT interval (QTc) is a marker of advanced disease stage associated with adverse hemodynamic profile and increased long-term mortality after aortic valve replacement.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Physiology
Lisa A. Gottlieb, Karin Larsen, Ganesh Halade, Martin E. Young, Morten B. Thomsen
Summary: Mice with cardiomyocyte-specific disruption of the molecular clock genes have lower heart rate and prolonged ventricular repolarization. The QT interval shows diurnal and circadian rhythms independent of heart rate, with increased arrhythmia vulnerability when the cardiac clock is disrupted.
Article
Engineering, Biomedical
Deshan Ma, Li Li, Wenbin Shi, Mengwei Li, Jian Zhang, Yong Fan, Yu Kang, Xiu Zhang, Pengming Yu, Qing Zhang, Zhengbo Zhang, Chien-Hung Yeh
Summary: Autonomic nervous system dysfunction is a significant characteristic of congestive heart failure patients. This study introduced HRV and MMCA-derived parameters to quantify ANS function in CHF patients and compared their clinical efficacy. The results showed that most parameters improved after treatment in SRHF patients, while only a few showed significant differences in ARHF patients. PNS function and ANS balance were recovered in all CHF patients after treatment. These metrics can be used for prognosis and therapeutic efficacy monitoring.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2024)
Article
Clinical Neurology
Anne T. Berg, Keith Coffman, Deborah Gaebler-Spira
Summary: The study revealed a correlation between functional impairments and autonomic symptoms in young people with DEEs, with these symptoms also contributing to parental stress. This correlation poses challenges for caregivers of children with DEEs.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Clinical Neurology
Hiroaki Okayasu, Takahiro Shinozaki, Yumiko Takano, Norio Sugawara, Kumiko Fujii, Norio Yasui-Furukori, Yuji Ozeki, Kazutaka Shimoda
Summary: This study reevaluated the risk of sudden cardiac death due to antipsychotic drug use by measuring improved ECG markers. Results indicated inconsistent correlations between different ECG markers and medications, highlighting the inadequacy of relying solely on QTc for predicting sudden cardiac death risk.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Review
Pharmacology & Pharmacy
Christine Garnett, Peter L. Bonate, Qianyu Dang, Georg Ferber, Dalong Huang, Jiang Liu, Devan Mehrotra, Steve Riley, Philip Sager, Christoffer Tornoe, Yaning Wang
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
(2018)
Article
Pharmacology & Pharmacy
Georg Ferber, Yaning Sun, Borje Darpo, Christine Garnett, Jiang Liu
JOURNAL OF CLINICAL PHARMACOLOGY
(2018)
Article
Public, Environmental & Occupational Health
Marek Malik, Christine Garnett, Katerina Hnatkova, Jose Vicente, Lars Johannesen, Norman Stockbridge
Article
Public, Environmental & Occupational Health
Marek Malik, Christine Garnett, Katerina Hnatkova, Jose Vicente, Lars Johannesen, Norman Stockbridge
Article
Pharmacology & Pharmacy
Jose Vicente, Robbert Zusterzeel, Lars Johannesen, Roberto Ochoa-Jimenez, Jay W. Mason, Carlos Sanabria, Sarah Kemp, Philip T. Sager, Vikram Patel, Murali K. Matta, Jiang Liu, Jeffry Florian, Christine Garnett, Norman Stockbridge, David G. Strauss
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2019)
Correction
Public, Environmental & Occupational Health
Marek Malik, Christine Garnett, Katerina Hnatkova, Jose Vicente, Lars Johannesen, Norman Stockbridge
Correction
Public, Environmental & Occupational Health
Marek Malik, Christine Garnett, Katerina Hnatkova, Jose Vicente, Lars Johannesen, Norman Stockbridge
Editorial Material
Cardiac & Cardiovascular Systems
Cecile Ollivier, Haihao Sun, Wayne Amchin, Maurice Beghetti, Rolf M. F. Berger, Stefanie Breitenstein, Christine Garnett, Ninna Gullberg, Patrik Hassel, Dunbar Ivy, Steven M. Kawut, Agnes Klein, Catherine Lesage, Marek Migdal, Barbara Nije, Michal Odermarsky, James Strait, Pieter A. de Graeff, Norman Stockbridge
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Physiology
Katerina Hnatkova, Jose Vicente, Lars Johannesen, Christine Garnett, Norman Stockbridge, Marek Malik
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Physiology
Katerina Hnatkova, Jose Vicente, Lars Johannesen, Christine Garnett, David G. Strauss, Norman Stockbridge, Marek Malik
FRONTIERS IN PHYSIOLOGY
(2019)
Review
Pharmacology & Pharmacy
Christine Garnett, Lars Johannesen, Tzu-Yun McDowell
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Multidisciplinary Sciences
Katerina Hnatkova, Jose Vicente, Lars Johannesen, Christine Garnett, David G. Strauss, Norman Stockbridge, Marek Malik
SCIENTIFIC REPORTS
(2019)
Review
Pharmacology & Pharmacy
Zhihua Li, Christine Garnett, David G. Strauss
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Lars Johannesen, Christine Garnett, Man Luo, Shari Targum, Jens Stampe Sorensen, Nitin Mehrotra
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2018)
Review
Pharmacology & Pharmacy
Jose Vicente, Robbert Zusterzeel, Lars Johannesen, Jay Mason, Philip Sager, Vikram Patel, Murali K. Matta, Zhihua Li, Jiang Liu, Christine Garnett, Norman Stockbridge, Issam Zineh, David G. Strauss
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2018)
Article
Cardiac & Cardiovascular Systems
Xiaoxi Yao, Zachi I. Attia, Emma M. Behnken, Melissa S. Hart, Shealeigh A. Inselman, Kayla C. Weber, Fan Li, Nikki H. Stricker, John L. Stricker, Paul A. Friedman, Peter A. Noseworthy
Summary: This study aims to explore whether Apple Watch, used as a long-term monitoring device, is effective in the early diagnosis of atrial fibrillation (AF) and the prevention of cognitive function decline in older adults. By using AI-ECG to screen high-risk patients and record electrocardiograms, the effectiveness of Apple Watch will be evaluated. If successful, this approach could have significant implications on how future clinical practice leverages consumer devices for early diagnosis and disease prevention.
AMERICAN HEART JOURNAL
(2024)