Article
Cardiac & Cardiovascular Systems
Seung Hun Lee, Doosup Shin, Joo Myung Lee, Tim P. van de Hoef, David Hong, Ki Hong Choi, Doyeon Hwang, Coen K. M. Boerhout, Guus A. de Waard, Ji-Hyun Jung, Hernan Mejia-Renteria, Masahiro Hoshino, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Ashkan Eftekhari, Mohamed A. Effat, Tadashi Murai, Koen Marques, Joon-Hyung Doh, Evald H. Christiansen, Rupak Banerjee, Hyun Kuk Kim, Chang-Wook Nam, Giampaolo Niccoli, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Steven A. J. Chamuleau, Niels van Royen, Paul Knaapen, Bon Kwon Koo, Tsunekazu Kakuta, Javier Escaned, Jan J. Piek
Summary: In stable patients with nonobstructive coronary stenoses, a diagnosis of INOCA based only on abnormal NIT did not identify patients with higher risk of long-term cardiovascular events. Incorporating intracoronary physiologic assessment to NIT information in patients with nonobstructive disease allowed identification of patient subgroups with up to 4-fold difference in long-term cardiovascular events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Harmony R. Reynolds, Ariel Diaz, Derek D. Cyr, Leslee J. Shaw, G. B. John Mancini, Jonathon Leipsic, Matthew J. Budoff, James K. Min, Cameron J. Hague, Daniel S. Berman, Bernard R. Chaitman, Michael H. Picard, Sean W. Hayes, Marielle Scherrer-Crosbie, Raymond Y. Kwong, Renato D. Lopes, Roxy Senior, Sudhanshu K. Dwivedi, Todd D. Miller, Benjamin J. W. Chow, Ramesh de Silva, Gregg W. Stone, William E. Boden, Sripal Bangalore, Sean M. O'Brien, Judith S. Hochman, David J. Maron
Summary: This study investigated the prevalence of ischemia with nonobstructive coronary arteries (INOCA) among patients with at least moderate ischemia and the relationship between ischemia severity and non-obstructive atherosclerosis severity. The results showed that the prevalence of INOCA was 13% and there was no significant association between the severity of ischemia and the severity of nonobstructive atherosclerosis. Female sex was identified as an independent predictor of INOCA.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Pharmacology & Pharmacy
Islam Y. Elgendy, Lina Ya'Qoub, Kuan-Han Chen, Carl J. Pepine
Summary: There is increasing interest in open artery syndrome, also known as ischemia with non-obstructive coronary arteries (INOCA). The diagnostic evaluation, including invasive assessment, is key to diagnose and treat this heterogeneous clinical condition. Medical stratification based on the type of INOCA has shown benefit in improving symptoms. The ongoing WARRIOR trial aims to address unanswered questions regarding management of women with INOCA.
Article
Cardiac & Cardiovascular Systems
Eileen M. Handberg, C. Noel Bairey Merz, Rhonda M. Cooper-Dehoff, Janet Wei, Michael Conlon, Margaret C. Lo, William Boden, Susan M. Frayne, Todd Villines, John A. Spertus, William Weintraub, Patrick O'Malley, Bernard Chaitman, Leslee J. Shaw, Matthew Budoff, Andre Rogatko, Carl J. Pepine
Summary: This multi-center prospective randomized trial aims to compare intensive medical therapy with usual care in symptomatic women with INOCA, with the primary outcome being the reduction of MACE occurrence. Secondary outcomes include quality of life, return to work time, healthcare utilization, angina, cardiovascular death, and individual primary outcome components.
AMERICAN HEART JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Monica Locatelli, Daniela Rottoli, Rayan Mahmoud, Mauro Abbate, Daniela Corna, Domenico Cerullo, Susanna Tomasoni, Giuseppe Remuzzi, Carlamaria Zoja, Ariela Benigni, Daniela Macconi
Summary: In BTBR ob/ob mice with type 2 diabetic nephropathy, peritubular capillaries show endothelial cell abnormalities and basement membrane thickening. Remodeling and focal loss of the endothelial glycocalyx were observed in diabetic kidneys, and ACEi treatment preserved the glycocalyx and attenuated the ultrastructural abnormalities of peritubular capillaries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Inge J. van den Hoogen, Umberto Gianni, Malissa J. Wood, Viviany R. Taqueti, Fay Y. Lin, Sharonne N. Hayes, Gudrun M. Feuchtner, Alexander R. van Rosendael, Nanette K. Wenger, Janet Wei, C. Noel Bairey Merz, Carl J. Pepine, Leslee J. Shaw
Summary: Women exhibit less burden of anatomic obstructive coronary atherosclerotic disease compared to men of the same age, but paradoxically have similar or higher cardiovascular mortality rates. This may be due to the higher prevalence of nonexertional cardiac symptoms and nonobstructive coronary atherosclerotic disease in women, leading to under-recognition and undermanagement. Innovative imaging approaches based on sex-specific differences in ischemic heart disease are presented to broaden the understanding of myocardial infarction and ischemia in women.
JACC-CARDIOVASCULAR IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Niya Mileva, Sakura Nagumo, Takuya Mizukami, Jeroen Sonck, Colin Berry, Emanuele Gallinoro, Giovanni Monizzi, Alessandro Candreva, Daniel Munhoz, Dobrin Vassilev, Martin Penicka, Emanuele Barbato, Bernard De Bruyne, Carlos Collet
Summary: This study found that approximately half of patients with nonobstructive coronary artery disease had coronary microvascular disease (CMD) and/or coronary spasm. Female patients had a higher risk of CMD. Greater awareness among physicians is needed for accurate diagnosis and patient-tailored management.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Joon Ho Ahn, Ju Yong Hyun, Myung Ho Jeong, Ju Han Kim, Young Joon Hong, Doo Sun Sim, Min Chul Kim, Hun-Sik Park, Doo-Il Kim, Seung-Ho Hur, Seok Kyu Oh, Youngkeun Ahn
Summary: This study compared the clinical effect of ACEI vs. ARB in MINOCA patients and found that the risk and incidence of MACE were similar between the two treatments, but ACEI significantly reduced the risk of recurrent MI. Further larger scale multi-center randomized clinical trials are needed to clarify the proper use of renin-angiotensin-aldosterone system blocker in these patients.
CARDIOLOGY JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Weiwei Chen, Beibei Du, Kun Liu, Zhixi Yu, Xingtong Wang, Ping Yang
Summary: This case report highlights the association between MINOCA and CAS related to nilotinib in a CML patient, with a good recovery outcome during follow-up. Physicians should be vigilant to adverse vascular events when treating patients with nilotinib.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Rutger G. T. Feenstra, Coen K. M. Boerhout, Janneke Woudstra, Caitlin E. M. Vink, Marianne E. Wittekoek, Guus A. de Waard, Yolande Appelman, Etto C. Eringa, Koen M. J. Marques, Robbert J. de Winter, Marcel A. M. Beijk, Tim P. van de Hoef, Jan J. Piek
Summary: This study evaluated the diagnostic value of additional endothelial function testing in diagnosing vasomotor dysfunction in patients with INOCA. The results showed that endothelial dysfunction was prevalent in the vast majority of patients with INOCA with inducible CAS and/or impaired adenosine-mediated vasodilation.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Biochemistry & Molecular Biology
Fan Deng, Liang-Qing Zhang, Han Wu, Yu Chen, Wen-Qian Yu, Rong-Hui Han, Yuan Han, Xiao-Qi Zhang, Qi-Shun Sun, Ze-Bin Lin, Yu Wang, Yong-Pan Liu, Jing-Yi Chen, Ke-Xuan Liu, Jing-Juan Hu
Summary: This study found that propionate alleviates myocardial ischemia/reperfusion (I/R) injury aggravated by Ang II through the CAV-1/ACE2 axis dependent on GPR41. Propionate inhibits the elevation of Ang II levels, thereby reducing myocardial injury. This research provides a new direction for using diet to regulate intestinal flora for the treatment of myocardial I/R injury.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
J-X Xie, J. Hu, J. Cheng, C. Liu, X. Wei
Summary: This article reviews the role of the ACE2/Ang(1-7)/MasR axis in myocardial ischemia reperfusion injury and highlights its therapeutic potential.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Balaji Tamarappoo, T. Jake Samuel, Omeed Elboudwarej, Louise E. J. Thomson, Haider Aldiwani, Janet Wei, Puja Mehta, Susan Cheng, Behzad Sharif, Ahmed AlBadri, Eileen M. Handberg, John Petersen, Carl J. Pepine, Michael D. Nelson, C. Noel Bairey Merz
Summary: The study reveals that women with coronary microvascular dysfunction (CMD) have higher left ventricular circumferential strain compared to those without CMD, indicating a relationship between circumferential strain and coronary vascular dysfunction.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Acoustics
Ersin Cagri Simsek, Cenk Sari, Murat Kucukokur, Cenk Ekmekci, Ayfer Colak, Oner Ozdogan
Summary: Our results suggest worse endothelial dysfunction in patients with MINOCA compared to those with INOCA, but no significant difference in CT-1 levels between the two groups.
JOURNAL OF CLINICAL ULTRASOUND
(2021)
Article
Cardiac & Cardiovascular Systems
Melanie T. T. Chen, Joseph Chang, Ashley S. Manchanda, Galen Cook-Wiens, Chrisandra L. Shufelt, R. David Anderson, John W. Petersen, Dhaval R. Naik, Louise E. J. Thomson, Daniel S. Berman, Eileen M. Handberg, Carl J. Pepine, C. Noel Bairey Merz, Janet Wei
Summary: This study found a relationship between autoimmune rheumatic diseases (ARDs) and coronary microvascular dysfunction (CMD) in women with signs and symptoms of ischemia and no obstructive arteries (INOCA). Women with a history of ARD had lower functional status and worse myocardial perfusion reserve compared to women without ARD, but there was no significant difference in angina-related health status and invasive coronary function between the two groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Cecil A. Rambarat, Islam Y. Elgendy, Eileen M. Handberg, C. Noel Bairey Merz, Janet Wei, Margo B. Minissian, Michael D. Nelson, Louise E. J. Thomson, Daniel S. Berman, Leslee J. Shaw, Galen Cook-Wiens, Carl J. Pepine
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Geriatrics & Gerontology
Chueh-Lung Hwang, Jisok Lim, Jeung-Ki Yoo, Han-Kyul Kim, Moon-Hyon Hwang, Eileen M. Handberg, John W. Petersen, Brady J. Holmer, Julio A. Leey Casella, Kenneth Cusi, Demetra D. Christou
EXPERIMENTAL GERONTOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
R. David Anderson, John W. Petersen, Puja K. Mehta, Janet Wei, B. Delia Johnson, Eileen M. Handberg, Saibal Kar, Bruce Samuels, Babak Azarbal, Kamlesh Kothawade, Sheryl F. Kelsey, Barry Sharaf, Leslee J. Shaw, George Sopko, C. Noel Bairey Merz, Carl J. Pepin
JOURNAL OF INTERVENTIONAL CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Seong-Mi Park, Janet Wei, Galen Cook-Wiens, Michael D. Nelson, Louise Thomson, Daniel Berman, Eileen Handberg, John Petersen, David Anderson, Carl J. Pepine, C. Noel Bairey Merz
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2019)
Article
Public, Environmental & Occupational Health
Ruxandra I. Sava, Yiqing E. Chen, Steven M. Smith, Yan Gong, Rhonda M. Cooper-DeHoff, Ellen C. Keeley, Carl J. Pepine, Eileen M. Handberg
JOURNAL OF WOMENS HEALTH
(2020)
Article
Cardiac & Cardiovascular Systems
Odayme Quesada, Ahmed AlBadri, Janet Wei, Chrisandra Shufelt, Puja K. Mehta, Jenna Maughan, Nissi Suppogu, Haider Aldiwani, Galen Cook-Wiens, Michael D. Nelson, Behzad Sharif, Eileen M. Handberg, R. David Anderson, John Petersen, Daniel S. Berman, Louise E. J. Thomson, Carl J. Pepine, C. Noel Bairey Merz
AMERICAN HEART JOURNAL
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
R. David Anderson
JACC-CARDIOVASCULAR INTERVENTIONS
(2020)
Article
Cardiac & Cardiovascular Systems
Haider Aldiwani, Melody Zaya, Nissi Suppogu, Odayme Quesada, B. Delia Johnson, Puja K. Mehta, Chrisandra Shufelt, John Petersen, Babak Azarbal, Bruce Samuels, R. David Anderson, Leslee J. Shaw, Saibal Kar, Eileen Handberg, Sheryl F. Kelsey, Carl J. Pepine, C. Noel Bairey Merz
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Review
Medicine, General & Internal
Michael R. Massoomi, R. David Anderson, Mustafa M. Ahmed, Osama Dasa, Philip George, William M. Miles, Juan M. Aranda, Carl J. Pepine
AMERICAN JOURNAL OF MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Thomas J. Povsic, Timothy D. Henry, Jay H. Traverse, R. David Anderson, Geoffrey A. Answini, Benjamin C. Sun, George J. Arnaoutakis, Konstantinos D. Boudoulas, Adam R. Williams, Howard C. Dittrich, Elizabeth A. Tarka, David A. Latter, E. Magnus Ohman, Mark W. Peterson, Dawn Byrnes, Carl J. Pepine, Marcelo F. DiCarli, Ronald G. Crystal, Todd K. Rosengart, Nahush A. Mokadam
Summary: This study evaluated the safety and preliminary efficacy of the novel drug Encoberminogene rezmadenovec in patients with refractory angina. The results showed that epicardial administration of the drug at higher doses improved total exercise duration, myocardial perfusion deficit, and angina class. The highest dose (1x10(11) viral particles) demonstrated good safety and efficacy.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Nissi Suppogu, Janet Wei, Michael D. Nelson, Galen Cook-Wiens, Susan Cheng, Chrisandra L. Shufelt, Louise E. J. Thomson, Balaji Tamarappoo, Daniel S. Berman, Bruce Samuels, Babak Azarbal, R. David Anderson, John W. Petersen, Eileen M. Handberg, Carl J. Pepine, C. Noel Bairey Merz
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Mohamed M. Gad, Ahmed N. Mahmoud, Anas M. Saad, Najdat Bazarbashi, Keerat R. Ahuja, Antonette K. Karrthik, Islam Y. Elgendy, Akram Y. Elgendy, Creighton W. Don, Ravi S. Hira, Michael R. Massoomi, Jacqueline Saw, R. David Anderson, Samir R. Kapadia
JACC-CARDIOVASCULAR INTERVENTIONS
(2020)
Article
Cardiac & Cardiovascular Systems
Seyed Hossein Aalaei-Andabili, Thomas M. Beaver, Anthony A. Bavry, Johnw. Petersen, Ashkan Karimi, Siddharth Wayangankar, George Arnaoutakis, R. David Anderson
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2019)
Article
Cardiac & Cardiovascular Systems
Islam Y. Elgendy, Ahmed N. Mahmoud, Akram Y. Elgendy, Mohammad K. Mojadidi, Ayman Elbadawi, Parham Eshtehardi, Maria Jose Perez-Vizcayno, Siddharth A. Wayangankar, Hani Jneid, R. David Anderson, Fernando Alfonso
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2019)
Article
Cardiac & Cardiovascular Systems
Xiaoxi Yao, Zachi I. Attia, Emma M. Behnken, Melissa S. Hart, Shealeigh A. Inselman, Kayla C. Weber, Fan Li, Nikki H. Stricker, John L. Stricker, Paul A. Friedman, Peter A. Noseworthy
Summary: This study aims to explore whether Apple Watch, used as a long-term monitoring device, is effective in the early diagnosis of atrial fibrillation (AF) and the prevention of cognitive function decline in older adults. By using AI-ECG to screen high-risk patients and record electrocardiograms, the effectiveness of Apple Watch will be evaluated. If successful, this approach could have significant implications on how future clinical practice leverages consumer devices for early diagnosis and disease prevention.
AMERICAN HEART JOURNAL
(2024)