Article
Endocrinology & Metabolism
Johannes J. Kovarik, Christopher C. Kaltenecker, Oliver Domenig, Marlies Antlanger, Marko Poglitsch, Chantal Kopecky, Marcus D. Saemann
Summary: In this study, the effects of combined MRA eplerenone and ACEi therapy on key RAAS effectors in CKD patients were examined. The results showed that eplerenone treatment led to global RAAS activation while significantly increasing the alternative RAAS effector Ang-(1-7).
Article
Medicine, General & Internal
Odayme Quesada, Mehmet Yildiz, Timothy D. Henry, Seth Bergstedt, Jenny Chambers, Ananya Shah, Larissa Stanberry, Lucas Volpenhein, Dalia Aziz, Rebekah Lantz, Cassady Palmer, Justin Ugwu, Muhammad J. Ahsan, Ross F. Garberich, Heather S. Rohm, Frank V. Aguirre, Santiago Garcia, Scott W. Sharkey
Summary: This study retrospectively analyzed consecutive STEMI patient cohort data and found that MINOCA patients had a higher risk of mortality compared to obstructive disease patients, while MINOCA mimickers had a similar risk of mortality to obstructive disease patients. Further research is needed to understand the pathophysiological mechanisms involved in this high-risk STEMI population.
Article
Multidisciplinary Sciences
Susanne Rysz, Jonathan Al-Saadi, Anna Sjostrom, Maria Farm, Francesca Campoccia Jalde, Michael Platten, Helen Eriksson, Margareta Klein, Roberto Vargas-Paris, Sven Nyren, Goran Abdula, Russell Ouellette, Tobias Granberg, Malin Jonsson Fagerlund, Johan Lundberg
Summary: Studies suggest that RAAS imbalance worsens the prognosis in COVID-19 patients, and experiments in pigs show that over-activation of ACE2 and RAAS can lead to a disease state similar to COVID-19 in humans. Imbalanced RAAS state in animals can be ameliorated by angiotensin receptor blockers and low-molecular-weight heparin.
NATURE COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Piotr Jedrusik, Bartosz Symonides, Jacek Lewandowski, Zbigniew Gaciong
Summary: Primary aldosteronism (PA) is a potentially curable form of secondary hypertension that requires measuring renin and aldosterone, followed by confirmatory tests. Various antihypertensive drug classes interfere with PA evaluation, with calcium antagonists and alpha-blockers being the least interfering drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Qijun Gao, Fangfang Bie, Yingfu Hu, Yafeng Chen, Bo Yang
Summary: This study analyzed the characteristics of RSTD and its relationship with ST-segment elevation in STEMI patients. The results suggest that RSTD may be attributed to a weakened or absent action potential in the negative electrode of the lead, while the action potential in the positive electrode is not completely offset.
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Dwaipayan Bharadwaj, Gauri Prasad, Andrey Grechko, Margarita A. Sazonova, Alexander N. Orekhov
Summary: Atherosclerosis has a complex pathogenesis involving inflammation, lipid metabolism alterations, and endothelial injury. The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in the inflammatory response regulation, making it a promising target for atherosclerosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Yong Hoon Kim, Ae-Young Her, Myung-Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Summary: In ST-segment elevation myocardial infarction (STEMI) patients after stent implantation, combination therapy with statin and renin-angiotensin system inhibitor (RASI) significantly reduced the occurrence of major adverse cardiac events (MACEs) compared to monotherapy. The combination therapy also showed a lower all-cause death rate compared to statin monotherapy and a decreased repeat revascularization rate compared to RASI monotherapy.
CARDIOLOGY JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Agnieszka Dettlaff-Pokora, Julian Swierczynski
Summary: SARS-CoV-2 impairs the renin-angiotensin-aldosterone system by binding the ACE2 enzyme, leading to an increase in angiotensin 2 and a decrease in angiotensin (1-7), potentially worsening damage to the lungs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Maniraj Jeyaraju, Michael T. McCurdy, Andrea R. Levine, Prasad Devarajan, Michael A. Mazzeffi, Kristin E. Mullins, Michaella Reif, David N. Yim, Christopher Parrino, Allison S. Lankford, Jonathan H. Chow
Summary: In hypotensive patients on vasopressors, the change in plasma renin concentration is a better predictor of in-hospital mortality than the change in lactate concentration. Plasma renin kinetics may be superior to lactate kinetics in predicting mortality in hypotensive, critically ill patients.
CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Eric C. Wong, Christopher B. Fordyce, Graham Wong, Terry Lee, Michele Perry-Arnesen, Martha Mackay, Joel Singer, John A. Cairns, Ricky D. Turgeon
Summary: This study evaluated the real-world utilization of mineralocorticoid receptor antagonists (MRA) for patients with ST-segment-elevation myocardial infarction (STEMI) with left ventricular dysfunction and found that only 1 in 4 eligible patients were prescribed an MRA within 3 months following hospitalization. Additional decision-support tools are needed to improve pharmacotherapy decisions for post-STEMI care.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Fei Qin, Jianling Li, Yong-Fa Dai, Xiao-ge Zhong, Ya-jin Pan
Summary: The study demonstrated that renal denervation reduces levels of RAAS components such as aldosterone and Ang II, leading to lower blood pressure and improved renal function.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Review
Endocrinology & Metabolism
Huai Heng Loh, Norlela Sukor
Summary: This review aims to collate and summarize current research on the association between primary aldosteronism and obstructive sleep apnea, including their relationship, clinical characteristics, implications, treatment outcomes, potential causal links, and mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
M. Ekholm, T. Kahan
Summary: Atherosclerosis is a disease caused by chronic inflammation and endothelial dysfunction, with up-regulated mediators of inflammation in affected individuals. Oxidative stress, imbalance between antioxidants and oxidants, leads to tissue damage. The renin-angiotensin-aldosterone system plays a vital role in vascular disease pathobiology, with angiotensin II causing hypertension and reactive oxygen species production. Blocking this system could potentially reduce inflammatory and thrombotic complications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Matthew Miller, Jessica Quimby, Catherine Langston, Marisa Ames, Valerie J. Parker
Summary: Short-term calcifediol supplementation in this small group of CKD dogs appeared to decrease ACE activity, which may be beneficial for disease progression.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Toxicology
Chenpeng Zhu, Weikuan Gu, Dianjun Sun, Wei Wei
Summary: The renin-angiotensin system (RAS) plays a crucial role in regulating blood pressure. Excess fluoride can increase blood pressure by dysregulating the RAS. The study found that fluoride reduces levels of renin, angiotensin II (Ang II), and angiotensin (1-7) [Ang (1-7)], and disrupts the balance of aldosterone and potassium levels. Excess fluoride also damages the kidneys, myocardium, and aorta, and affects the activation of different components of the RAS, leading to hypertension with low renin levels.
TOXICOLOGY LETTERS
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoxi Yao, Zachi I. Attia, Emma M. Behnken, Melissa S. Hart, Shealeigh A. Inselman, Kayla C. Weber, Fan Li, Nikki H. Stricker, John L. Stricker, Paul A. Friedman, Peter A. Noseworthy
Summary: This study aims to explore whether Apple Watch, used as a long-term monitoring device, is effective in the early diagnosis of atrial fibrillation (AF) and the prevention of cognitive function decline in older adults. By using AI-ECG to screen high-risk patients and record electrocardiograms, the effectiveness of Apple Watch will be evaluated. If successful, this approach could have significant implications on how future clinical practice leverages consumer devices for early diagnosis and disease prevention.
AMERICAN HEART JOURNAL
(2024)