Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Ivana Djuricic, Philip C. Calder
Summary: Oxidative stress and inflammation are important contributors to chronic non-communicable diseases. Different types of fatty acids have varying effects on chronic diseases, with moderate intake of Ω-6 fatty acids lowering the risk of cardiovascular diseases and Ω-3 fatty acids helping to reduce inflammation levels.
Article
Chemistry, Multidisciplinary
Xin Qian, Stephan Klatt, Katrin Bennewitz, David Philipp Wohlfart, Bowen Lou, Ye Meng, Michael Buettner, Gernot Poschet, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Ingrid Fleming, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll
Summary: This study identifies the enzyme Aldh9a1b as a key player in the detoxification of tt-DDE and elucidates its role in insulin resistance and impaired glucose metabolism. The study also reveals that vascular changes induced by aldh9a1b knockout or tt-DDE treatment can be rescued by insulin receptor sensitizers.
Article
Nutrition & Dietetics
Farzad Mohammadi, Nicolas Bertrand, Iwona Rudkowska
Summary: The objective of this study is to evaluate the taste preference of trans fatty acids (TFA) and its effects on mice. The results showed that mice preferred consuming TFA, but their preference varied depending on the specific type of TFA. In conclusion, this study demonstrates the potential for TFA substitution in diet.
Review
Medicine, General & Internal
Brian A. Bergmark, Njambi Mathenge, Piera A. Merlini, Marilyn B. Lawrence-Wright, Robert P. Giugliano
Summary: Although progress has been made in diagnosing and treating acute coronary syndromes, cardiovascular disease remains a leading cause of death globally. High-sensitivity troponin assays have allowed for rapid diagnosis in suspected cases. Dual antiplatelet therapy and additional preventive measures are recommended. The diagnosis and management of acute coronary syndromes continue to evolve, especially in response to the COVID-19 pandemic.
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Jia Luo, Honghan Ge, Jing Sun, Kangyu Hao, Wenqin Yao, Dongfeng Zhang
Summary: Our study suggests that ω-6 fatty acid consumption and the ω-6:ω-3 ratio are positively associated with the risk of sleep disorders, while the negative relationship between ω-3 fatty acids and sleep disorders may only be present in men. Additionally, consumption of ω-3 and ω-6 fatty acids is linked to a reduced risk of non-normal sleep duration.
Article
Geriatrics & Gerontology
Guangxiang Huang, Gang Ren
Summary: This study evaluated the interaction effect between blood cadmium and omega-6 fatty acids intake on low cognitive performance in Americans, and found that low-level omega-6 fatty acids intake may amplify the adverse effects of high-level blood cadmium on cognitive performance.
Article
Biochemistry & Molecular Biology
Ornella Selmin, Andreas J. Papoutsis, Sabine Hazan, Christopher Smith, Nick Greenfield, Micah G. Donovan, Spencer N. Wren, Thomas C. Doetschman, Justin M. Snider, Ashley J. Snider, Sherry H-H Chow, Donato F. Romagnolo
Summary: This study compared the effects of a typical Western diet and a soybean oil-rich n-6HFD on gut inflammation and microbiome using a mouse model. The results showed that n-6HFD induced colonic inflammation and altered gut bacterial composition, promoting the growth of proinflammatory bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Anna Wyrostek, Katarzyna Czyz, Ewa Sokola-Wysoczanska, Bozena Patkowska-Sokola, Wieslaw Bielas
Summary: This study examined the effect of supplementation with ethyl esters of linseed oil on the fatty acid profile in blood serum, erythrocyte membranes, and hair sebum of healthy beagle dogs. The results showed that the supplementation decreased the content of saturated fatty acids and increased the level of beneficial unsaturated fatty acids, especially those from the omega-3 family.
Review
Medicine, General & Internal
Marijana Tadic, Carla Sala, Guido Grassi, Giuseppe Mancia, Stefano Taddei, Wolfgang Rottbauer, Cesare Cuspidi
Summary: Omega-3 fatty acids show promise in reducing cardiovascular risk in patients with high triglycerides, especially in secondary prevention. Apart from triglyceride reduction, omega-3 fatty acids may have other cardiovascular benefits that warrant further investigation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Qi Sun, Ning Gao, Weiliang Xia
Summary: This study found a negative correlation between omega-3 and omega-6 levels and the risk of cholelithiasis. Individuals with low serum omega-3/6 levels should be aware of the risk of cholelithiasis.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Elisabetta Del Duca, Anna Sansone, Mayla Sgrulletti, Federica Di Nolfo, Loredana Chini, Carla Ferreri, Viviana Moschese
Summary: Peanut allergy is a lifelong and potentially life-threatening disease that affects families and communities. A preliminary study explored the fatty-acid-based membrane lipidome profile of patients with angioedema and/or anaphylaxis after peanut ingestion. The study found significant differences in the levels of omega-6 and omega-3 fatty acids between allergic patients and healthy individuals, as well as a correlation between specific immunoglobulin E (IgE) levels and certain fatty acids. The results of this study suggest the need for larger screenings and further research to understand the molecular mechanisms and develop effective treatments for chronic allergic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Review
Biochemistry & Molecular Biology
Geir Bjorklund, Maryam Dadar, Monica Daniela Dosa, Salvatore Chirumbolo, Joeri J. Pen
Summary: Various nutrients with antioxidant properties are being investigated for their potential impact on diseases like cancer, including their effects on prostaglandins. The omega6/omega-3 PUFA ratio is being studied for its antioxidative effects in countering pathophysiological mechanisms. This research focuses specifically on the bone microenvironment and its implications for health, particularly in the context of malignant bone metastasis.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Cardiac & Cardiovascular Systems
Theresa M. Coles, L. Lin, Kevin Weinfurt, Bryce B. Reeve, John A. Spertus, Robert J. Mentz, Ileana L. Pin, Fraser d. Bocell, Michelle e. Tarver, Debra m. Henke, Anindita Saha, Brittany Caldwell, Silver Spring
Summary: Women diagnosed with heart failure report worse quality of life than men on PRO measures. The assumption that women and men interpret quality of life questions the same way is crucial for valid comparison and combining outcomes by subgroups in heart failure. This issue not only affects clinical trials, but also has important implications for addressing health inequities. The validity of PRO measures is key to interpreting differences in heart failure outcomes.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Health Care Sciences & Services
Theresa M. Coles, Nicole Lucas, Molly McFatrich, Debra Henke, Jennifer L. Ridgeway, Emma M. Behnken, Kevin Weinfurt, Bryce B. Reeve, Amy Corneli, Shannon M. Dunlay, John A. Spertus, Li Lin, Ileana L. Pina, Fraser D. Bocell, Michelle E. Tarver, Heidi Dohse, Anindita Saha, Brittany Caldwell
Summary: The purpose of this study is to evaluate potential gender-based differences in interpreting the KCCQ-23 and explore aspects of HRQOL not captured by the questionnaire. The findings indicate that there were no significant differences in interpreting the questionnaire between men and women, but some modifications may improve interpretation for a wide range of patients.
QUALITY OF LIFE RESEARCH
(2023)
Letter
Cardiac & Cardiovascular Systems
Casey E. Cavanagh, Lindsey Rosman, Philip Chui, Karl Minges, Nihar R. Desai, Sarah Goodlin, Savitri Fedson, John A. Spertus, Ty J. Gluckman, Yang Song, Luke Zheng, Alexander Turchin, Gheorghe Doros, Jane J. Lee, Matthew M. Burg
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander T. Sandhu, Jimmy Zheng, Neil M. Kalwani, Anshal Gupta, Jamie Calma, Megan Skye, Roy Lan, Brian Yu, John A. Spertus, Paul A. Heidenreich
Summary: This study examined whether collecting patient-reported health status improves the accuracy of clinician assessments in heart failure clinic. The results showed that using the Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) improved clinicians' accuracy of health status assessment and patients felt that their clinicians better understood their symptoms.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Megan Lee, Matthew D. Pichert, Andy T. Tran, Awais Farooq, Jan M. Heyligers, Jean-Paul P. M. de Vries, John A. Spertus, Raul J. Guzman, Merrill Thomas, Carlos I. Mena-Hurtado, Kim G. Smolderen
Summary: This study investigates whether patients with peripheral artery disease (PAD) are being screened for abdominal aortic aneurysms (AAA). The results show that approximately 68% of patients were screened for AAA, with about 6.1% having AAA. While there were no significant differences in AAA screening rates between different countries, there was a large variation between different healthcare institutions, highlighting the need for more efforts in guideline implementation and evidence-building for high-risk populations, including patients with PAD.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Dan D. Nguyen, Kensey L. Gosch, Rayan El-Zein, Paul S. Chan, William L. Lombardi, Dimitri Karmpaliotis, John A. Spertus, R. Michael Wyman, William J. Nicholson, Jeffrey W. Moses, J. Aaron Grantham, Adam C. Salisbury
Summary: Although older adults are less likely to receive CTO percutaneous coronary intervention for angina relief compared to younger adults, this study found that adults aged >= 75 years experienced similar angina-related health status benefits after the procedure compared to adults aged <75 years.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Padma Kaul, Sarah Rathwell, Carolyn S. P. Lam, Cynthia M. Westerhout, John A. Spertus, Kevin J. Anstrom, Robert O. Blaustein, Justin A. Ezekowitz, Burkert Pieske, Lothar Roessig, Javed Butler, Paul W. Armstrong
Summary: This study investigated the association between frailty and health status in patients with heart failure with preserved ejection fraction (HFpEF). The results showed that patient-reported frailty was modestly correlated with the KCCQ-PLS and 6MWD, and could offer prognostic insight into 6MWD at 24 weeks.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Brett W. W. Sperry, Mazen Hanna, Mathew S. S. Maurer, Jose Nativi-Nicolau, Lysbeth Floden, Michelle Stewart, Kathleen W. W. Wyrwich, Alexandra I. I. Barsdorf, Heli Kapadia, John A. A. Spertus
Summary: In patients with transthyretin (ATTR) amyloidosis, tafamidis reduced mortality and hospitalizations related to cardiovascular events, and improved patient-reported health status over a 30-month period. The clinical significance of health status changes, especially in patients with NYHA class III symptoms, remains uncertain.
Article
Cardiac & Cardiovascular Systems
Islam Shatla, Rayan S. El-Zein, Aamer Ubaid, Ahmed ElBallat, Yasser Sammour, Kevin F. Kennedy, Kayla Barta, Tara Brand-Moody, Faith Cordle, LeAndrea Williams, Michael Giocondo, Sanjaya Gupta, Brian Ramza, Daniel Steinhaus, Omair Yousuf, John A. Spertus, Alan P. Wimmer
Summary: The COVID-19 pandemic sped up the adoption of telehealth in healthcare. A study was conducted to analyze the impact of telehealth on atrial fibrillation (AF) management. The study compared clinical outcomes, quality metrics, and clinical activity indicators of AF patients during a 10-week period in 2020 with a corresponding period in 2019. The results showed similar clinical outcomes and quality metrics, but differences in clinical activity. The importance rating for this report is: 8/10.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Kashvi Gupta, John A. Spertus, Mary Birmingham, Kensey L. Gosch, Mansoor Husain, Dalane W. Kitzman, Bertram Pitt, Sanjiv J. Shah, James L. Januzzi, Ildiko Lingvay, Javed Butler, Mikhail Kosiborod, David E. Lanfear
Summary: The health status of Black patients with heart failure is worse compared to White patients. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) can reduce cardiovascular mortality and improve health status in heart failure patients, but it is unclear if the effect is similar across races. The study found that SGLT2i improves health status equally for Black and White patients.
Article
Cardiac & Cardiovascular Systems
Sarah Chuzi, Jane E. Wilcox, Andrew Kao, John A. Spertus, Eileen Hsich, Mary Amanda Dew, Clyde W. Yancy, Duc T. Pham, Justin Hartupee, Michael Petty, William Cotts, Salpy V. Pamboukian, Francis D. Pagani, Brent Lampert, Maryl Johnson, Margaret Murray, Koji Takeda, Melana Yuzefpolskaya, Scott Silvestry, James K. Kirklin, Tingqing Wu, Adin-Cristian Andrei, Abigail Baldridge, Kathleen L. Grady
Summary: This study aimed to explore changes in health-related quality of life (HRQOL) among caregivers of older heart failure patients undergoing heart transplantation and mechanical circulatory support surgeries. The results showed that caregivers reported high HRQOL before and early post-surgery. Factors such as patient pulmonary hypertension and arrhythmia were associated with decreased caregiver HRQOL, while patient marital/partner status and presurgery coronary disease were associated with improved caregiver HRQOL.
CIRCULATION-HEART FAILURE
(2023)
Letter
Cardiac & Cardiovascular Systems
Stephen J. Greene, John A. Spertus, Wenxi Tang, Amiee Kang, Yue Zhong, Michael C. Myers, Sophie Shen, Jenny Jiang, Xuejun Liu, David R. Steffen, Marta G. Viola, G. Michael Felker
CIRCULATION-HEART FAILURE
(2023)
Article
Medicine, General & Internal
Chinenye M. Okafor, Cenjing Zhu, Valeria Raparelli, Terrence E. Murphy, Andrew Arakaki, Gail D'Onofrio, Sui W. Tsang, Marcella Nunez Smith, Judith H. Lichtman, John A. Spertus, Louise Pilote, Rachel P. Dreyer
Summary: Among younger adults hospitalized for acute myocardial infarction (AMI), there is a higher rate of all-cause readmission for Black individuals compared to White individuals, even after adjustment for cardiac factors and social determinants of health (SDOHs).
Article
Cardiac & Cardiovascular Systems
Mariane Cecilia dos Reis, Juliana Araujo Nascimento, Geisa Nascimento de Andrade, Ana Claudia de Souza Costa, Julio Yoshio Takada, Antonio de Padua Mansur, Edimar Alcides Bocchi, Gianni Mara Silva dos Santos, John A. Spertus, Naomi Kondo Nakagawa
Summary: The Portuguese version of the KCCQ-12 questionnaire has high internal consistency and construct validity in assessing the health status of patients with chronic heart failure. It can be confidently used in Brazil for research and clinical care.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Letter
Medicine, General & Internal
Han S. Lim, Omar Farouque, Prashanthan Sanders
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
