Article
Cardiac & Cardiovascular Systems
Asthildur Arnadottir, Sune Pedersen, Rasmus Bo Hasselbalch, Jens P. Goetze, Lennart J. Friis-Hansen, Anna-Marie Bloch-Munster, Jan Skov Jensen, Henning Bundgaard, Kasper Iversen
Summary: This study is the first to report the early-release kinetics of cTn concentrations after different durations of experimental coronary balloon occlusion in humans. All assays detected a cTn increase after only 30 s of ischemia. hs-cTnI (Siemens) rose faster and reached a higher peak. Copeptin levels did not change significantly.
Article
Cardiac & Cardiovascular Systems
Masaomi Gohbara, Noriaki Iwahashi, Kozo Okada, Yutaka Ogino, Yohei Hanajima, Jin Kirigaya, Yugo Minamimoto, Yasushi Matsuzawa, Manabu Nitta, Masaaki Konishi, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Teruyasu Sugano, Toshiyuki Ishikawa, Kouichi Tamura, Kazuo Kimura
Summary: The aim of this study was to create a risk scoring model to differentiate obstructive coronary artery from coronary artery spasm in the etiology of acute coronary syndrome. The study found that a total score of <20 could potentially indicate coronary artery spasm-induced ACS.
CIRCULATION JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Yuriko Yoshida, Koki Nakanishi, Masao Daimon, Jumpei Ishiwata, Naoko Sawada, Megumi Hirokawa, Hidehiro Kaneko, Tomoko Nakao, Yoshiko Mizuno, Hiroyuki Morita, Marco R. Di Tullio, Shunichi Homma, Issei Komuro
Summary: The study showed that subclinical left ventricular dysfunction can have negative effects on the geometry and function of the left atrium and right ventricle. Impaired left ventricular global longitudinal strain was associated with decreased left atrial and right ventricular function, highlighting the interdependence between atrioventricular and ventricular function, which could contribute to heart failure development.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Laurie W. Geenen, Vivan J. M. Baggen, Annemien E. van den Bosch, Jannet A. Eindhoven, Robert M. Kauling, Judith A. A. E. Cuypers, Jolien W. Roos-Hesselink, Eric Boersma
Summary: This study investigated the temporal evolution of hs-CRP in patients with adult congenital heart disease (ACHD), finding that higher baseline hs-CRP was independently associated with increased risk of death or heart failure. Repeated measurements of hs-CRP were also found to be predictive of adverse outcomes, beyond NT-proBNP and hs-troponin T.
Article
Cardiac & Cardiovascular Systems
Arjun Sinha, Yinan Zheng, Drew Nannini, Yishu Qu, Lifang Hou, Sanjiv J. Shah, Clyde W. Yancy, Elizabeth M. McNally, Myriam Fornage, Joao Lima, Donald M. Lloyd-Jones, Laura J. Rasmussen-Torvik, Sadiya S. Khan
Summary: This study focused on 875 Black participants from the Coronary Artery Risk Development in Young Adults cohort to investigate the association between the V122I TTR genetic variant and cardiac structure and function in middle age individuals without heart failure. The findings revealed a significant link between the TTR V122I variant and worse left ventricular structure and cardiac mechanics at an average age of 54 years, suggesting that early screening with echocardiography in Black middle-aged adults carrying the TTR V122I variant can help guide the use of novel therapies and risk factor modification to prevent or delay heart failure.
Article
Cardiac & Cardiovascular Systems
Srisakul Chaichuum, Shuo-Ju Chiang, Masao Daimon, Su-Chen Chang, Chih-Lin Chan, Chu-Ying Hsu, Hsiang-Ho Chen, Ching-Li Tseng
Summary: Two-dimensional speckle tracking echocardiography (2D-STE) has been used as a diagnostic tool for coronary artery disease (CAD). This study found a correlation between myocardial strain and strain rate with the severity of coronary artery stenosis in CAD patients. The application of 2D-STE may offer a non-invasive method to simplify the diagnosis of CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Karam R. Motawea, Rowan H. Elhalag, Samah S. Rouzan, Nesreen Elsayed Talat, Sarraa M. Reyad, Pensee Chebl, Mai Saad Mohamed, Jaffer Shah
Summary: We conducted a meta-analysis to investigate the diagnostic and prognostic value of Cyclophilin C in Coronary Artery Disease. Four studies with a total of 454 individuals were included. The analysis showed a significant association between CAD and increased levels of Cyclophilin C. Subgroup analysis further demonstrated the association in acute and chronic CAD. The results suggest that Cyclophilin C could be a promising diagnostic and prognostic biomarker for CAD.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yumin Li, Jia Liu, Yukun Cao, Xiaoyu Han, Guozhu Shao, Xiaoyue Zhou, Jin Gu, Tong Liu, Yue Cui, Heshui Shi
Summary: This study found that in HCM patients, serum Nt-proBNP levels were associated with the presence of LGE. Combining Nt-proBNP and MWT has good diagnostic performance for detecting LGE. LV GCS may be a more sensitive indicator for reflecting myocardial fibrosis than GLS.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Jolanda Sabatino, Salvatore De Rosa, Isabella Leo, Antonio Strangio, Carmen Spaccarotella, Alberto Polimeni, Sabato Sorrentino, Giovanni Di Salvo, Ciro Indolfi
Summary: This study demonstrated that non-invasive estimation of myocardial work indices can predict the risk area of ischemia in patients with critical coronary artery stenosis with a higher diagnostic performance.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yi-Ping Gao, Wei Zhou, Pei-Na Huang, Hong-Yun Liu, Xiao-Jun Bi, Ying Zhu, Jie Sun, Qiao-Ying Tang, Li Li, Jun Zhang, Rui-Ying Sun, Xue-Qing Cheng, Ya-Ni Liu, You-Bin Deng
Summary: This study found no significant cardiac structural and functional abnormalities in COVID-19 survivors 327 days after recovery, including patients with myocardial injury at admission.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Concetta Pastore, Giulia Elena Mandoli, Andrea Stefanini, Nicolo Ghionzoli, Chiara Carrucola, Giuseppe De Carli, Matteo Lisi, Luna Cavigli, Flavio D'Ascenzi, Marta Focardi, Serafina Valente, Giuseppe Patti, Sergio Mondillo, Matteo Cameli
Summary: This study aimed to determine the association between NT-proBNP and PALS and its prognostic implications in patients with HF. Global PALS showed a significant inverse correlation with NT-proBNP in acute and chronic HF. Global PALS was the only independent predictor of the combined endpoint. Optimal risk stratification for the composite endpoint was provided combining PALS <= 15% and NTproBNP >= 874.5 ng/l.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Pascal B. Meyre, Stefanie Aeschbacher, Steffen Blum, Gian Voellmin, Peter M. Kastner, Elisa Hennings, Beat A. Kaufmann, Michael Kuehne, Stefan Osswald, David Conen
Summary: This study investigated the changes in biomarkers and clinical measures in patients with and without atrial fibrillation (AF) recurrence after electrical cardioversion. The results showed significant differences in bone morphogenetic protein 10 (BMP10), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and total bilirubin levels between patients with and without AF recurrence. The reductions in BMP10 and NT-proBNP levels were independently associated with the follow-up rhythm status.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Jingru Lin, Weichun Wu, Lijian Gao, Jia He, Zhenhui Zhu, Kunjing Pang, Jiangtao Wang, Mengyi Liu, Hao Wang
Summary: The study investigates the use of global myocardial work (MW) combined with treadmill exercise stress to detect significant coronary artery disease (CAD) in patients with angina pectoris. The results show that peak global work efficiency (GWE) and recovery global wasted work (GWW) can predict significant CAD. A model combining peak GWE and recovery GWW performs better in identifying significant CAD compared to peak GWE alone. Overall, global MW parameters combined with exercise stress serve as an accurate noninvasive screening method before invasive diagnostic techniques.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Veterinary Sciences
Domingo Casamian-Sorrosal, Rafael Barrera-Chacon, Sonja Fonfara, Silvia Belinchon-Lorenzo, Luis Gomez-Gordo, Javier Galapero-Arroyo, Javier Fernandez-Cotrina, Jose Ignacio Cristobal-Verdejo, Francisco Javier Duque
Summary: This study found that MPL levels in dogs with advanced CanL are variable but generally high. A strong association between MPL and cTnI was observed, which suggests further exploration of cTnI as a biomarker in CanL.
Article
Medicine, General & Internal
Anna Gudmundsdottir, Marco Bartocci, Oda Picard, Joanna Ekstrom, Alexander Chakhunashvili, Kajsa Bohlin, Caroline Attner, Gordana Printz, Mathias Karlsson, Lilly-Ann Mohlkert, Jonna Karlen, Cecilia Pegelow Halvorsen, Anna-Karin Edstedt Bonamy
Summary: This study aimed to investigate the association between gestational age (GA), echocardiographic markers, and plasma N-terminal pro-B-type natriuretic peptide (NTproBNP) levels with the closure rate of a clinically significant patent ductus arteriosus (hsPDA). The results showed that the spontaneous closure rate of PDA is relatively high in extremely preterm infants. Early NTproBNP levels can be used in conjunction with GA to guide management decisions for hsPDA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shruti S. Joshi, Ivan Stankovic, Ahmet Demirkiran, Kristina Haugaa, Pal Maurovich-Horvat, Bogdan A. Popescu, Bernard Cosyns, Thor Edvardsen, Steffen E. Petersen, Ricardo Fontes Carvalho, Matteo Cameli, Marc R. Dweck
Summary: The European Association of Cardiovascular Imaging Scientific Initiatives Committee conducted a global survey to evaluate the impact of the COVID-19 pandemic on the mental well-being of cardiac imaging specialists. The survey results showed that more than half of the specialists experienced anxiety, one-third felt melancholic, and a quarter increased their alcohol intake. More than half reported difficulties in sleeping and 44% considered quitting their job.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas H. Marwick, Alessia Gimelli, Sven Plein, Jeroen J. Bax, Phillippe Charron, Victoria Delgado, Erwan Donal, Patrizio Lancellotti, Eylem Levelt, Pal Maurovich-Horvat, Stefan Neubauer, Gianluca Pontone, Antti Saraste, Bernard Cosyns, Thor Edvardsen, Bogdan A. Popescu, Maurizio Galderisi, Genevieve Derumeaux
Summary: Heart failure is a significant complication of diabetes mellitus, and detecting subclinical dysfunction may help reduce its incidence. However, there is insufficient evidence for heart failure screening in diabetes patients, and further research is needed to establish the relationship between detection, treatment, and improved outcomes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Otto A. Smiseth, Daniel A. Morris, Nuno Cardim, Maja Cikes, Victoria Delgado, Erwan Donal, Frank A. Flachskampf, Maurizio Galderisi, Bernhard L. Gerber, Alessia Gimelli, Allan L. Klein, Juhani Knuuti, Patrizio Lancellotti, Julia Mascherbauer, Davor Milicic, Petar Seferovic, Scott Solomon, Thor Edvardsen, Bogdan A. Popescu
Summary: Heart failure with preserved ejection fraction (HFpEF) has a prognosis similar to heart failure with reduced EF (HFrEF), but treatment options are limited. HFpEF may involve a wide range of pathological processes, which can be differentiated using multimodality imaging.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Monica Chivulescu, Eivind W. Aabel, Erik Gjertsen, Einar Hopp, Esther Scheirlynck, Bernard Cosyns, Erik Lyseggen, Thor Edvardsen, Oyvind H. Lie, Lars A. Dejgaard, Kristina H. Haugaa
Summary: This study aimed to characterize the substrate of T-wave inversion (TWI) and investigate the association between diffuse fibrosis and ventricular arrhythmias (VA) in patients with mitral valve prolapse (MVP). The results showed that an increasing number of ECG leads with TWI reflected a higher risk of severe VA and a higher degree of lateral diffuse fibrosis. Furthermore, lateral diffuse fibrosis was associated with VA even in the absence of late gadolinium enhancement (LGE).
Article
Cardiac & Cardiovascular Systems
Anette B. Kvaslerud, Sara Bardan, Kristoffer Andresen, Sophie F. Klove, Morten W. Fagerland, Thor Edvardsen, Lars Gullestad, Kaspar Broch
Summary: The aim of this trial was to evaluate whether intravenous iron could provide benefit beyond transcatheter aortic valve implantation (TAVI) in iron-deficient patients with severe aortic stenosis. The study found that treatment with intravenous iron did not provide clinical benefit beyond TAVI in this patient population.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Eivind W. Aabel, Monica Chivulescu, Oyvind H. Lie, Einar Hopp, Erik Gjertsen, Margareth Ribe, Thomas M. Helle-Valle, Thor Edvardsen, Finn Hegbom, Lars A. Dejgaard, Kristina H. Haugaa
Summary: This prospective study aimed to describe the incidence and morphology of ventricular arrhythmia in patients with arrhythmic mitral valve syndrome and propose risk stratification. The yearly incidence of ventricular arrhythmia was high in these patients, especially in those with secondary preventive implantable cardioverter-defibrillators (ICD). Predictors of first severe arrhythmic event included frequent premature ventricular complexes, non-sustained ventricular tachycardias, greater left ventricular diameter, and greater posterolateral mitral annular disjunction distance.
Article
Cardiac & Cardiovascular Systems
Theo Pezel, Augustin Coisne, Blazej Michalski, Hatem Soliman, Nina Ajmone, Robin Nijveldt, Ivan Stankovic, Erwan Donal, Joost van der Maaten, Constantinos Papadopoulos, Thor Edvardsen, Denisa Muraru, Steffen E. Petersen, Bernard Cosyns
Summary: The study aimed to assess the level of transesophageal echocardiography (TOE) knowledge and skills among young cardiologists. Results from an online evaluation showed a relatively low level of TOE skills and knowledge among young cardiologists worldwide. Prior participation in TOE simulation-based training, a higher number of TOE exams performed per week, and EACVI certification for TOE were independently associated with higher scores.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Letter
Cardiac & Cardiovascular Systems
Eivind W. Aabel, Lars A. Dejgaard, Monica Chivulescu, Thomas M. Helle-Valle, Thor Edvardsen, Nina E. Hasselberg, Finn Hegbom, oyvind H. Lie, Kristina H. Haugaa
Article
Cardiac & Cardiovascular Systems
Bernard Cosyns, Leyla Elif Sade, Bernhard L. Gerber, Alessia Gimelli, Denisa Muraru, Gerald Maurer, Thor Edvardsen
Summary: The European Heart Journal-Cardiovascular Imaging, launched in 2012, has become one of the leading multimodality cardiovascular imaging journals over the years. It currently ranks 19th among all cardiovascular journals, with an impressive impact factor of 9.130. The most important studies published in the journal in 2021 will be highlighted in two reports, with Part II focusing on valvular heart disease, heart failure, cardiomyopathies, and congenital heart disease, while Part I has focused on studies related to myocardial function, risk prediction, myocardial ischemia, and emerging techniques in cardiovascular imaging.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Christine Bjorkvik Erevik, Oyunn Kleiven, Vidar Froysa, Magnus Bjorkavoll-Bergseth, Monica Chivulescu, Lars Gunnar Klaeboe, Lars Dejgaard, Bjorn Auestad, Oyvind Skadberg, Tor Melberg, Stig Urheim, Kristina Haugaa, Thor Edvardsen, Stein Orn
Summary: This study aimed to determine the effect of prolonged, high-intensity endurance exercise on myocardial function. The results showed that increased exercise duration and intensity resulted in increased myocardial wasted work without alterations in left ventricular ejection fraction and global longitudinal strain. These findings suggest that markers of myocardial inefficiency may precede reduction in global left ventricular function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Marianne Inngjerdingen Forsa, Anders W. Bjerring, Kristina H. Haugaa, Marit Kristine Smedsrud, Sebastian Sarvari, Hege W. Landgraff, Jostein Hallen, Thor Edvardsen
Summary: This study aimed to investigate the effect of sex on cardiac remodelling during adolescence in athletes. The results showed that male adolescent athletes displayed greater cardiac remodelling compared to females, and this difference increased throughout adolescence. The left ventricular end-diastolic volumes and left ventricular mass index of males showed a progressive increase from age 12 to 18.
Article
Medicine, General & Internal
Thuy Mi Nguyen, Daniela Melichova, Eivind W. Aabel, Oyvind H. Lie, Lars Gunnar Klaeboe, Bjornar Grenne, Benthe Sjoli, Harald Brunvand, Kristina Haugaa, Thor Edvardsen
Summary: This study aimed to compare long-term outcomes between NSTEMI and STEMI patients in Southern Norway. The results showed that mortality remained high and unchanged in NSTEMI patients, while mortality decreased in STEMI patients over a decade of treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Marianne Forsa, Marit K. Smedsrud, Kristina H. Haugaa, Anders W. Bjerring, Andreas Fruh, Sebastian Sarvari, Hege W. Landgraff, Jostein Hallen, Thor Edvardsen
Summary: This study compared left ventricular (LV) hypertrophy in early adolescent athletes and hypertrophic cardiomyopathy (HCM) genotype positive patients. The results showed that LV hypertrophy was found in a similar proportion in both groups, but only HCM genotype positive patients showed progression of hypertrophy. The study also identified a potential grey zone of LV hypertrophy with septum thickness Z-scores ranging from 2.0 to 3.3. LV volumes remained larger in athletes. These findings can help clinicians distinguish physiological LV hypertrophy from early HCM.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Esra Kaya, Kristoffer Andresen, oyvind H. Lie, Lars Aaberge, Kristina H. Haugaa, Thor Edvardsen, Helge Skulstad
Summary: Left ventricular mechanical dispersion (MeDi) can be used as a predictor of the need for permanent pacemaker (PM) implantation after transcatheter aortic valve implantation (TAVI), independent of other factors.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kristine Andreassen, Chloe Rixon, Marie Haugsten Hansen, Ida Marie Hauge-Iversen, Ivar Sjaastad, Geir Christensen, Kristina H. Haugaa, Thor Edvardsen, Ida G. Lunde, Mathis K. Stokke
CIRCULATION RESEARCH
(2022)