Article
Clinical Neurology
Eva C. Alden, Shehroo B. Pudumjee, Emily S. Lundt, Sabrina M. Albertson, Mary M. Machulda, Walter K. Kremers, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, Michelle M. Mielke, Nikki H. Stricker
Summary: The study evaluated the diagnostic accuracy of the Cogstate Brief Battery for MCI and prodromal AD in a population-based sample. The results showed that the diagnostic accuracy of CBB improved when discriminating between CU A-T- and MCI A+T+ as well as differentiating MCI participants without AD biomarkers from those with prodromal AD. However, the clinical utility of CBB for detecting MCI in a population-based sample was found to be lower than expected.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Brandy L. Callahan, Michael McLaren-Gradinaru, Ford Burles, Giuseppe Iaria
Summary: In individuals with bipolar disorder, indicators of early dementia can be detected through declining trajectories in memory, language, and speeded attention. Cognitive performance in the natural course of BD is generally stable, but impairment on specific cognitive tests may indicate an early neurodegenerative process.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Maryam Ghahremani, Meng Wang, Hung-Yu Chen, Henrik Zetterberg, Eric Smith, Zahinoor Ismail
Summary: This study investigated the association between mild behavioral impairment (MBI) and plasma p-tau181 levels, cognitive function changes, and the risk of developing Alzheimer's disease (AD). The findings showed that compared to individuals with no behavioral symptoms, those with MBI had higher levels of p-tau181, which was associated with declined memory and executive function, and an increased risk of developing AD.
Article
Neuroimaging
Kejal Kantarci, Bradley F. Boeve, Scott A. Przybelski, Timothy G. Lesnick, Qin Chen, Julie Fields, Christopher G. Schwarz, Matthew L. Senjem, Jeffrey L. Gunte, Clifford R. Jack, Paul Min, Manoj Jain, Toji Migayawa, Rodolfo Savica, Jonathan Graff-Radford, Hugo Botha, David T. Jones, David S. Knopman, Neill Graff-Radford, Tanis J. Ferman, Ronald C. Petersen, Val J. Lowe
Summary: Patients with mild cognitive impairment (MCI) who progressed to probable dementia with Lewy bodies (DLB) show hypometabolism in the parieto-occipital cortex extending into temporal lobes, substantia nigra, and thalamus. In comparison to those who progressed to Alzheimer's disease (AD) dementia, MCI-DLB patients exhibit preserved medial temporal and posterior cingulate metabolism, along with greater hypometabolism in the substantia nigra. The CIS ratio and medial temporal to substantia nigra ratio are identified as useful in distinguishing prodromal DLB from AD.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Joseph Mole, Simon Mead, Peter Rudge, Akin Nihat, Tzehow Mok, John Collinge, Diana Caine
Summary: This study focuses on whether cognitive features anticipate the onset of symptoms in inherited prion disease, revealing the significant value of cognitive tests in predicting disease onset before symptoms occur.
Article
Clinical Neurology
Alberto Benussi, Antonella Alberici, Kiran Samra, Lucy L. Russell, Caroline Greaves, Martina Bocchetta, Simon Ducharme, Elizabeth Finger, Giorgio Fumagalli, Daniela Galimberti, Lize C. Jiskoot, Isabelle Le Ber, Mario Masellis, Benedetta Nacmias, James B. Rowe, Raquel Sanchez-Valle, Harro Seelaar, Matthis Synofzik, Jonathan D. Rohrer, Barbara Borroni
Summary: The presymptomatic stages of frontotemporal dementia (FTD) have not been clearly defined, indicating a need for a consensus lexicon to comprehensively describe the stages that anticipate dementia and to formulate a better strategy for characterizing these disease stages.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Zhenrong Fu, Mingyan Zhao, Yuxia Li, Yirong He, Xuetong Wang, Zongkui Zhou, Ying Han, Shuyu Li
Summary: This study evaluated SCD subtypes in a Chinese cohort and examined associated neuroimaging markers, biomarkers, and clinical outcomes. Four subtypes were identified: dysexecutive/mixed SCD, neuropsychiatric SCD, amnestic SCD, and cluster-derived normal. Each subtype showed distinct patterns in gray matter volume and amplitude of low-frequency fluctuations.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Geriatrics & Gerontology
Feifei Jia, Yanyan Li, Min Li, Fenglin Cao
Summary: The study found that cognitive reserve can attenuate the association between subjective cognitive decline and the risk of developing dementia. Particularly in the low cognitive reserve group, the association between subjective cognitive decline and dementia was more significant.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Psychology, Multidisciplinary
Marina Maffoni, Antonia Pierobon, Cira Fundaro
Summary: This paper proposes a new screening tool called MASCoD, with English and Italian versions, and explores its preliminary adoption on a pilot sample. The tool shows promise in helping professionals make differential diagnosis and predict the risk of developing severe cognitive impairment over time, allowing for personalized care. It is brief, easily embeddable in usual clinical assessment, and can be administered by different professionals.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Valerie Turcotte, Carol Hudon, Olivier Potvin, Mahsa Dadar, Simon Duchesne
Summary: This study aimed to predict cognitive decline in older adults using birth cohorts and cognitive reserve (CR). The findings showed that CR was only associated with slower decline in verbal episodic memory, while more recent birth cohorts predicted slower decline in all cognitive domains except for executive functions. This suggests that both CR and birth cohorts have significant implications for future cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Mario H. Flores-Torres, Kjetil Bjornevik, Albert Y. Hung, Brian C. Healy, Michael A. Schwarzschild, Deborah Blacker, Alberto Ascherio
Summary: This study found that subjective cognitive decline (SCD) is more likely to be present in women with features suggestive of prodromal Parkinson's disease (PD). Women experiencing hyposmia, constipation, and probable rapid eye movement sleep behavior disorder, three major features of prodromal PD, had the worst SCD score and the highest odds of poor subjective cognition. SCD was also more common in women with a high probability of prodromal PD.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Jacob D. Jones, Carmen Uribe, Joseph Bunch, Kelsey R. Thomas
Summary: For individuals with PD, the Obj-SCD criteria can predict future cognitive decline and difficulties with ADLs, serving as a useful tool for identification. Obj-SCD represents an intermediate level of impairment in cognition and ADL, between CN and PD-MCI.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Laura Zamarian, Elfriede Karner, Thomas Bodner, Atbin Djamshidian, Margarete Delazer
Summary: This study reveals the differential effects of education on cognitive performance in older patients with cognitive decline. Higher education is advantageous for verbal memory, executive functions, object naming, and constructional praxis tests, but less beneficial at lower global mental status levels.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
V. Bessi, G. Giacomucci, S. Mazzeo, S. Bagnoli, S. Padiglioni, J. Balestrini, G. Tomaiuolo, I. Piaceri, M. Carraro, L. Bracco, S. Sorbi, B. Nacmias
Summary: The study found that the variant of PER2 could affect cognitive reserve and cognition, with PER2 G carriers showing lower premorbid intelligence, fewer years of education, and a lower frequency of family history of AD. In addition, PER2 G carriers performed worse in baseline tests for MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Andrea Horta-Barba, Saul Martinez-Horta, Jesus Perez-Perez, Arnau Puig-Davi, Natascia de Lucia, Giuseppe de Michele, Elena Salvatore, Stefanie Kehrer, Josef Priller, Simone Migliore, Ferdinando Squitieri, Anna Castaldo, Caterina Mariotti, Veronica Mananes, Jose Luis Lopez-Sendon, Noelia Rodriguez, Asuncion Martinez-Descals, Filipa Julio, Cristina Januario, Marianna Delussi, Marina de Tommaso, Sandra Noguera, Jesus J. Ruiz-Idiago, Emilia Sitek, Renata Wallner, Angela Nuzzi, Javier Pagonabarraga, Jaime Kulisevsky
Summary: This study developed a specific assessment tool, the Parkinson's Disease-Cognitive Rating Scale (PD-CRS), to evaluate the cognitive status of Huntington's disease patients and monitor the progression of cognitive impairment. Through evaluating 180 gene-positive patients, criteria for classifying normal cognition, mild cognitive impairment, and dementia were established, and the PD-CRS demonstrated good sensitivity and specificity. Additionally, the PD-CRS captured cognitive progression in different cognitive groups and showed sensitivity to change in mild cognitive impairment and dementia.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Pratishtha Chatterjee, Steve Pedrini, James D. Doecke, Rohith Thota, Victor L. Villemagne, Vincent Dore, Abhay K. Singh, Penghao Wang, Stephanie Rainey-Smith, Christopher Fowler, Kevin Taddei, Hamid R. Sohrabi, Mark P. Molloy, David Ames, Paul Maruff, Christopher C. Rowe, Colin L. Masters, Ralph N. Martins
Summary: This study investigated the changes in several blood biomarkers across the AD continuum and their associations with cognitive decline and brain Aβ-PET load. The results showed that plasma Aβ1-42/Aβ1-40 ratio decreased, p-tau181 and GFAP increased in predicting the β-amyloid positive/negative status across the AD continuum.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Pratishtha Chatterjee, Lisa Vermunt, Brian A. Gordon, Steve Pedrini, Lynn Boonkamp, Nicola J. Armstrong, Chengjie Xiong, Abhay K. Singh, Yan Li, Hamid R. Sohrabi, Kevin Taddei, Mark Molloy, Tammie L. S. Benzinger, John C. Morris, Celeste Karch, Sarah Berman, Jasmeer Chhatwal, Carlos Cruchaga, Neill R. Graff-Radford, Gregory S. Day, Martin Farlow, Nick Fox, Alison Goate, Jason Hassenstab, Jae-Hong Lee, Johannes Levin, Eric McDade, Hiroshi Mori, Richard Perrin, Raquel Sanchez-Valle, Peter R. Schofield, Allan Levey, Mathias Jucker, Colin L. Masters, Anne M. Fagan, Randall J. Bateman, Ralph N. Martins, Charlotte Teunissen
Summary: This study found that plasma GFAP levels increase a decade before symptom onset in AD and are associated with Aβ load, neurodegeneration, and cognitive decline.
ALZHEIMERS & DEMENTIA
(2023)
Review
Nutrition & Dietetics
Carolina B. Castro, Cintia B. Dias, Heidi Hillebrandt, Hamid R. Sohrabi, Pratishtha Chatterjee, Tejal M. Shah, Stephanie J. Fuller, Manohar L. Garg, Ralph N. Martins
Summary: This systematic review and meta-analysis examined the effects of medium-chain fatty acid (MCFA) supplementation on circulating ketone bodies and cognition in individuals with cognitive decline and Alzheimer's disease. The results showed that MCFA supplementation increases blood ketone levels and enhances brain energy metabolism. However, the effects on cognition varied and further research is needed to determine if MCFA-mediated increase in brain energy metabolism can improve cognition.
Article
Multidisciplinary Sciences
Nicholas W. G. Murray, Petra L. L. Graham, Paul F. F. Sowman, Greg Savage
Summary: Episodic memory deficits are common in aging and neurodegenerative disorders. Transcranial electrical stimulation (TES) is a promising tool for memory enhancement, but the optimal stimulation parameters are not yet determined. In a double-blind, randomized, sham-controlled study, applying TES over the left temporal lobe resulted in a decrease in word recall and an increase in memory errors compared to sham stimulation.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Educational
Thomas B. McGuckian, Peter H. Wilson, Rich D. Johnston, Shahin Rahimi-Golkhandan, Jan Piek, Dido Green, Jeffrey M. Rogers, Paul Maruff, Bert Steenbergen, Scott Ruddock
Summary: This longitudinal study examined the development of children's complex executive function (EF) using the Groton Maze Learning Task (GMLT). A total of 147 children (61 males, ages 5.5-11 years) were recruited from six multicultural primary schools in Melbourne and Perth, Australia. The study spanned from 2010 to 2012, with assessments on the GMLT conducted every 6 months. Growth curve models indicated a quadratic growth trajectory in each measure of error, reflecting visuospatial memory, executive control, and complex EF. The ability to apply rules for action, a key aspect of complex EF, developed rapidly during early-to-mid childhood.
Article
Neurosciences
Eleanor Curran, Victoria J. Palmer, Kathryn A. Ellis, Terence W. H. Chong, Thomas Rego, Kay L. Cox, Kaarin J. Anstey, Alissa Westphal, Rebecca Moorhead, Jenny Southam, Rhoda Lai, Emily You, Nicola T. Lautenschlager
Summary: This study aimed to develop a specified model to guide interventions for people experiencing depressive or anxiety symptoms and cognitive concerns in order to optimize physical activity engagement and reduce dementia risk. The findings suggest that individuals in this population require tailored interventions to improve their participation in physical activities.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Pratishtha Chatterjee, Vincent Dore, Steve Pedrini, Natasha Krishnadas, Rohith Thota, Pierrick Bourgeat, Milos D. Ikonomovic, Stephanie R. Rainey-Smith, Samantha C. Burnham, Christopher Fowler, Kevin Taddei, Rachel Mulligan, David Ames, Colin L. Masters, Jurgen Fripp, Christopher C. Rowe, Ralph N. Martins, Victor L. Villemagne
Summary: Astrocyte reactivity is associated with the elevation of plasma glial fibrillary acidic protein (GFAP) and monoamine oxidase-B (MAO-B) in Alzheimer's disease. The association between plasma GFAP and regional F-18-SMBT-1 PET is dependent on brain β-amyloid (Aβ) load.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Health Care Sciences & Services
Kerryn Pike, Carl Moller, Christina Bryant, Maree Farrow, Duy P. Dao, Kathryn A. Ellis
Summary: This study evaluated the feasibility, acceptability, and efficacy of the Online Personalised Training in Memory Strategies for Everyday (OPTIMiSE) program, a web-based intervention for older adults with cognitive decline. The results showed that OPTIMiSE was feasible, acceptable, and efficacious, with improvements in memory, strategy knowledge and use, and mood. The participants reported significant changes in strategy use, daily life improvements, reduced concern about memory, and increased confidence and self-efficacy, which were consistent with previous in-person interventions. This web-based program has the potential to provide evidence-based memory interventions for older adults worldwide.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Psychology, Clinical
Laura A. Rabin, Sietske A. M. Sikkes, Douglas Tommet, Richard N. Jones, Paul K. Crane, Milushka M. Elbulok-Charcape, Mark A. Dubbelman, Rebecca Koscik, Rebecca E. Amariglio, Rachel F. Buckley, Merce Boada, Gael Chetelat, Bruno Dubois, Kathryn A. Ellis, Katherine A. Gifford, Angela L. Jefferson, Frank Jessen, Sterling Johnson, Mindy J. Katz, Richard B. Lipton, Tobias Luck, Eleni Margioti, Paul Maruff, Jose Luis Molinuevo, Audrey Perrotin, Ronald C. Petersen, Lorena Rami, Barry Reisberg, Dorene M. Rentz, Steffi G. Riedel-Heller, Shannon L. Risacher, Octavio Rodriguez-Gomez, Perminder S. Sachdev, Andrew J. Saykin, Nikolaos Scarmeas, Colette Smart, Beth E. Snitz, Reisa A. Sperling, Vanessa Taler, Wiesje M. van der Flier, Argonde C. van Harten, Michael Wagner, Steffen Wolfsgruber
Summary: This study aimed to link self-perceived cognitive functioning data from international aging studies using item response theory. The results demonstrated that a single-factor structure was reasonable for the latent trait, and identified top items that made the greatest contribution to measurement precision. This allows for joint or pooled analyses across international studies and may lead to the development of new self-perceived cognitive functioning questionnaires.
Article
Psychology, Clinical
Lisa Bransby, Emily Rosenich, Rachel F. Buckley, Nawaf Yassi, Matthew P. Pase, Paul Maruff, Yen Ying Lim
Summary: This study aimed to determine the frequency and co-occurrence of modifiable dementia risk factors (MDRFs) in a large sample of middle-aged adults. The results showed that most individuals reported MDRFs in two or more domains, and these multidomain MDRFs were related to poorer cognition.
Review
Behavioral Sciences
Andrea Brown, Sarah K. Salo, Greg Savage
Summary: This narrative synthesis summarizes the cognitive profiles of frontal variant Alzheimer's disease (fvAD) and highlights the need for further investigation into differential diagnostic markers, such as executive dysfunction and behavioral symptoms. It also reveals some similarities between fvAD and typical AD, which may guide future research in disease diagnosis.
Article
Clinical Neurology
John J. Alam, Paul Maruff, Susan R. Doctrow, Hui-May Chu, Jennifer Conway, Stephen N. Gomperts, Charlotte Teunissen
Summary: This study evaluates the relationship between plasma tau phosphorylated at residue 181 (ptau181), a biomarker of Alzheimer disease (AD) copathology, and the treatment effects of the p38 alpha kinase inhibitor neflamapimod in patients with dementia with Lewy bodies (DLB). The results suggest that DLB patients with lower pretreatment ptau181 levels may show better treatment response to neflamapimod, with improvement in attention, cognitive assessment, and daily functioning. Plasma biomarkers of AD copathology should be considered as stratification variables in DLB clinical trials.
Article
Geriatrics & Gerontology
M. B. Formica, J. Gianoudis, C. A. Nowson, S. L. O'Connell, C. Milte, K. A. Ellis, Robin M. Daly
Summary: This study found that consuming lean red meat on three exercise training days per week did not promote greater improvements in health-related quality of life compared to exercise alone in community-dwelling older adults.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Review
Neurosciences
Matin Ramezani, Malika Fernando, Shaun Eslick, Prita R. Asih, Sina Shadfar, Ekanayaka M. S. Bandara, Heidi Hillebrandt, Silochna Meghwar, Maryam Shahriari, Pratishtha Chatterjee, Rohith Thota, Cintia B. Dias, Manohar L. Garg, Ralph N. Martins
Summary: Alzheimer's disease is the most common form of dementia, characterized by cognitive dysfunction and behavioral changes. Pathological markers and neural damage in AD are associated with altered brain energy metabolism. The ketogenic diet has been shown to increase ketone body production, improving brain energy metabolism and potentially affecting AD biomarkers and neuroinflammation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Jun Yuan, Steve Pedrini, Rohith Thota, James Doecke, Pratishtha Chatterjee, Hamid R. Sohrabi, Charlotte E. Teunissen, Inge M. W. Verberk, Erik Stoops, Hugo Vanderstichele, Bruno P. Meloni, Christopher Mitchell, Stephanie Rainey-Smith, Kathryn Goozee, Andrew Chi Pang Tai, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Junjie Gao, Delin Liu, Frank Mastaglia, Charles Inderjeeth, Minghao Zheng, Ralph N. Martins
Summary: This study investigated the association between plasma SOST levels and brain amyloid-beta load in older individuals. The results showed that plasma SOST levels were higher in individuals with brain amyloid-beta load, and the combination of plasma SOST and Aβ 42/Aβ40 ratio improved the predictive accuracy for preclinical Alzheimer's disease.
