Article
Geriatrics & Gerontology
Emerald Jenkins, Binu Koirala, Tamar Rodney, Ji Won Lee, Valerie T. Cotter, Sarah L. Szanton, Janiece L. Taylor
Summary: This review examined home/community-based interventions for individuals with mild cognitive impairment/early dementia and found that interventions incorporating visual/written elements, technology-based training, and caregiver support were effective in improving function. Participants simulated Instrumental Activities of Daily Living and cognitive function was assessed using both objective and subjective measures. However, gaps were identified in the literature regarding the inclusion of race/ethnicity and appropriate socioeconomic status measures.
Article
Multidisciplinary Sciences
Hiroyuki Umegaki, Yusuke Suzuki, Hitoshi Komiya, Kazuhisa Watanabe, Masaaki Nagae, Yosuke Yamada, Masafumi Kuzuya
Summary: This study investigated the association between gait speed and qualitative errors on the Clock Drawing Test (CDT) in individuals with mild cognitive impairment (MCI). The results showed that conceptual deficit (CD) type errors were negatively associated with maximum gait speed. This study further supports the clinical importance of qualitative assessments of the CDT.
SCIENTIFIC REPORTS
(2022)
Article
Nursing
Qiao-hong Yang, Xia Lyu, Qing-ran Lin, Zi-wen Wang, Li Tang, Yu Zhao, Qi-yuan Lyu
Summary: The study evaluated the effects of a multicomponent intervention on Chinese patients with mild cognitive impairment. The results showed that the intervention had beneficial effects on cognitive function, physical function, depression symptoms, and quality of life, slowing the progression of the disease.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Article
Neurosciences
Liang Cui, Keliang Chen, Lin Huang, Jiawei Sun, Yating Lv, Xize Jia, Qihao Guo
Summary: The study revealed significant decline in semantic performance in patients with mild cognitive impairment due to semantic dementia, but no decline in other cognitive domains. Resting-state functional MRI showed local functional changes in multiple brain regions, with some located outside the atrophic areas. Functional connectivity changes in the left precuneus might play a crucial role in preclinical semantic dementia.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neuroimaging
Yu-Ling Chang, Ruei-Yi Chao, Yung-Chin Hsu, Ta-Fu Chen, Wen-Yih Isaac Tseng
Summary: This study investigated white matter microstructural integrity and cognitive correlates of memory awareness in older adults with or without mild cognitive impairment (MCI). While patients with MCI and poor awareness of memory deficits showed lower integrity in certain white matter fibers, the memory awareness deficits in MCI patients could not be solely explained by mnemonic anosognosia.
NEUROIMAGE-CLINICAL
(2021)
Review
Geriatrics & Gerontology
Rwei-Ling Yu, Ruey-Meei Wu
Summary: Mild cognitive impairment (MCI) is a common non-motor symptom in patients with Parkinson's disease (PD), but lacks consistent diagnostic criteria. Different types of cognitive impairments have different progression rates. This review provides an overview of the diagnostic criteria for PD-MCI and the heterogeneity of patients' cognitive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychiatry
Jin-Hyuck Park
Summary: This study investigates the effects of virtual shopping training on executive function and instrumental activities of daily living (IADL) in patients with mild cognitive impairment (MCI). The results suggest that virtual shopping training may be clinically beneficial in enhancing executive function and IADL in patients with MCI.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Aline de Moura Brasil Matos, Flavia Esper Dahy, Joao Victor Luisi de Moura, Rosa Maria Nascimento Marcusso, Andre Borges Ferreira Gomes, Fernanda Martins Maia Carvalho, Gustavo Bruniera Peres Fernandes, Alvina Clara Felix, Jerusa Smid, Jose Ernesto Vidal, Norberto Anizio Ferreira Frota, Jorge Casseb, Ava Easton, Tom Solomon, Steven S. Witkin, Camila Malta Romano, Augusto Cesar Penalva de Oliveira
Summary: This study described seven cases from Brazil of outpatients with mild or moderate COVID-19 who developed subacute cognitive disturbances after recovery. The results suggest that these cognitive symptoms might be related to SARS-CoV-2-induced damage to cortico-subcortical associative pathways, rather than solely due to inflammation and hypoxia.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Erik Kaestner, Anny Reyes, Austin Chen, Jun Rao, Anna Christina Macari, Joon Yul Choi, Deqiang Qiu, Kelsey Hewitt, Zhong Irene Wang, Daniel L. Drane, Bruce Hermann, Robyn M. Busch, Vineet Punia, Carrie R. McDonald
Summary: Older adults with temporal lobe epilepsy show patterns of cortical atrophy and cognitive impairment similar to those with amnestic mild cognitive impairment, with both groups exhibiting memory and language impairments. Late-onset temporal lobe epilepsy patients have more consistent cortical thinning compared to early-onset patients.
Article
Neurosciences
Chengping Hu, Ling Wang, Xudong Zhao, Binggen Zhu, Ming Tian, Hongyun Qin
Summary: Age and worsening attention, but not depression, in MCI patients were independently associated with the progression to dementia in a 6-year follow-up period. Age was identified as an independent risk factor for MCI aggravation, while attention (MoCA) was an independent protective factor for MCI progression.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Sung Hoon Kang, Jinhee Kim, Jungyeun Lee, Seong-Beom Koh
Summary: Cognitive impairment is often accompanied by gait disturbance in patients with Parkinson's disease (PD). This study aimed to investigate the association between gait parameters and mild cognitive impairment (MCI), as well as the correlation between performance on comprehensive neuropsychological tests and gait parameters in PD patients. The results showed that gait velocity and stride length were associated with MCI in PD patients, and these gait parameters were primarily influenced by attention and frontal-executive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Lars Michels, Florian Riese, Rafael Meyer, Andrea M. Kaelin, Sandra E. Leh, Paul G. Unschuld, Roger Luechinger, Christoph Hock, Ruth O'Gorman, Spyros Kollias, Anton Gietl
Summary: The study used EEG-fMRI to evaluate brain activity in patients with mild cognitive impairment (MCI) and found abnormal coupling in multiple networks in MCI patients. Amyloid deposition was associated with abnormal signal coupling in visual, fronto-parietal regions, and some core memory regions.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
Lei Zhuang, Yan Yang, Jianqun Gao
Summary: Mild cognitive impairment (MCI) is a clinical condition with a high risk of progressing to dementia. Early diagnosis and intervention at the MCI stage are considered critical strategies in disease management. Lack of consensus on guidelines for routine screening of MCI leads to a considerable number of undiagnosed patients in the community.
JOURNAL OF NEUROLOGY
(2021)
Review
Geriatrics & Gerontology
Dan Yu, Xun Li, Frank Ho-yin Lai
Summary: This review suggests that virtual reality (VR) may contribute to improving executive function in older adults with mild cognitive impairment (MCI), particularly semi-immersive VR. However, further well-designed studies are needed to investigate the most beneficial level of immersive VR on executive function.
AGING & MENTAL HEALTH
(2023)
Article
Neurosciences
Rachel Fremont, Masood Manoochehri, Nicole M. Armstrong, Venkata S. Mattay, Jose A. Apud, Mary C. Tierney, D. P. Devanand, Yunglin Gazes, Christian Habeck, Eric M. Wassermann, Jordan Grafman, Edward D. Huey
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Neurosciences
Clara Dominguez-Vivero, Liwen Wu, Seonjoo Lee, Masood Manoochehri, Sarah Cines, Adam M. Brickman, Batool Rizvi, Anthony Chesebro, Yunglin Gazes, Emer Fallon, Timothy Lynch, Judith L. Heidebrink, Henry Paulson, Jill S. Goldman, Edward Huey, Stephanie Cosentino
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Clinical Neurology
Edward D. Huey, Rachel Fremont, Masood Manoochehri, Yunglin Gazes, Seonjoo Lee, Stephanie Cosentino, Michael Tierney, Eric M. Wassermann, Parastoo Momeni, Jordan Grafman
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
(2020)
Article
Clinical Neurology
Melanie T. Gentry, Maria Lapid, Jeremy Syrjanen, Kendrick Calvert, Samantha Hughes, Danielle Brushaber, Walter Kremers, Jessica Bove, Patrick Brannelly, Giovanni Coppola, Christina Dheel, Bradley Dickerson, Susan Dickinson, Kelley Faber, Julie Fields, Jamie Fong, Tatiana Foroud, Leah Forsberg, Ralitza Gavrilova, Deb Gearhart, Nupur Ghoshal, Jill Goldman, Jonathan Graff-Radford, Neill Graff-Radford, Murray Grossman, Dana Haley, Hilary Heuer, Ging-Yuek Hsiung, Edward Huey, David Irwin, David Jones, Lynne Jones, Kejal Kantarci, Anna Karydas, David Knopman, John Kornak, Joel Kramer, Walter Kukull, Diane Lucente, Codrin Lungu, Ian Mackenzie, Masood Manoochehri, Scott McGinnis, Bruce Miller, Rodney Pearlman, Len Petrucelli, Madeline Potter, Rosa Rademakers, Eliana Marisa Ramos, Katherine Rankin, Katya Rascovsky, Pheth Sengdy, Leslie Shaw, Nadine Tatton, Joanne Taylor, Arthur Toga, John Trojanowski, Sandra Weintraub, Bonnie Wong, Zbigniew Wszolek, Bradley F. Boeve, Adam Boxer, Howard Rosen
ALZHEIMERS & DEMENTIA
(2020)
Editorial Material
Behavioral Sciences
Megan S. Barker, Hannah E. Silverman, Rachel Fremont, Masood Manoochehri, Stephanie Cosentino, Edward D. Huey
Article
Neurosciences
Hannah E. Silverman, Yunglin Gazes, Megan S. Barker, Masood Manoochehri, Jill S. Goldman, Eric M. Wassermann, Michael C. Tierney, Stephanie Cosentino, Jordan Grafman, Edward D. Huey
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Behavioral Sciences
Megan S. Barker, Masood Manoochehri, Sandra J. Rizer, Brian S. Appleby, Danielle Brushaber, Sheena Dev, Katrina L. Devick, Bradford C. Dickerson, Julie A. Fields, Tatiana M. Foroud, Leah K. Forsberg, Douglas R. Galasko, Nupur Ghoshal, Neill R. Graff-Radford, Murray Grossman, Hilary W. Heuer, Ging-Yuek Hsiung, John Kornak, Irene Litvan, Ian R. Mackenzie, Mario F. Mendez, Belen Pascual, Katherine P. Rankin, Katya Rascovsky, Adam M. Staffaroni, Maria Carmela Tartaglia, Sandra Weintraub, Bonnie Wong, Bradley F. Boeve, Adam L. Boxer, Howard J. Rosen, Jill Goldman, Edward D. Huey, Stephanie Cosentino
Summary: This study aimed to investigate the performance patterns on an abbreviated list learning task in mutation carriers with mild behavioral and/or cognitive symptoms consistent with prodromal bvFTD, with a focus on recognition memory. Results showed that MAPT mutation carriers performed worse in list recall and had difficulty discriminating targets from distractors on the recognition memory task. Identification of the earliest cognitive indicators of bvFTD is of critical importance, and distinct cognitive profiles may be evident in carriers of the three disease causing genes during the prodromal stage.
Article
Clinical Neurology
Hannah E. Silverman, Jeannie M. Ake, Masood Manoochehri, Brian S. Appleby, Danielle Brushaber, Katrina L. Devick, Bradford C. Dickerson, Julie A. Fields, Leah K. Forsberg, Nupur Ghoshal, Neill R. Graff-Radford, Murray Grossman, Hilary W. Heuer, John Kornak, Maria Lapid, Irene Litvan, Ian R. Mackenzie, Mario F. Mendez, Chiadi U. Onyike, Belen Pascual, Maria Carmela Tartaglia, Bradley F. Boeve, Adam L. Boxer, Howard J. Rosen, Stephanie Cosentino, Edward D. Huey, Megan S. Barker, Jill S. Goldman
Summary: This study identified apathy, disinhibition, and psychosis as the behavioral features most strongly associated with caregiver burden in patients with frontotemporal lobar degeneration spectrum disorders. These findings highlight the importance of early education for caregivers on managing the behavioral symptoms of these disorders. Interventions targeting these specific behaviors may be most effective in reducing caregiver burden.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Megan S. Barker, Reena T. Gottesman, Masood Manoochehri, Silvia Chapman, Brian S. Appleby, Danielle Brushaber, Katrina L. Devick, Bradford C. Dickerson, Kimiko Domoto-Reilly, Julie A. Fields, Leah K. Forsberg, Douglas R. Galasko, Nupur Ghoshal, Jill Goldman, Neill R. Graff-Radford, Murray Grossman, Hilary W. Heuer, Ging-Yuek Hsiung, David S. Knopman, John Kornak, Irene Litvan, Ian R. Mackenzie, Joseph C. Masdeu, Mario F. Mendez, Belen Pascual, Adam M. Staffaroni, Maria Carmela Tartaglia, Bradley F. Boeve, Adam L. Boxer, Howard J. Rosen, Katherine P. Rankin, Stephanie Cosentino, Katya Rascovsky, Edward D. Huey
Summary: Currently, there are no research criteria for diagnosing prodromal behavioural variant frontotemporal dementia (bvFTD), but early detection is highly important for research purposes. This study aimed to develop and validate a proposed set of research criteria for prodromal bvFTD called 'mild behavioural and/or cognitive impairment in bvFTD' (MBCI-FTD). The criteria included seven core features and supportive features, and showed high accuracy in classifying prodromal bvFTD.
Article
Health Care Sciences & Services
Jing Yuan, Rhoda Au, Cody Karjadi, Ting Fang Ang, Sherral Devine, Sanford Auerbach, Charles DeCarli, David J. Libon, Jesse Mez, Honghuang Lin
Summary: This study investigated the association between digital Clock Drawing Test (dCDT) features and brain volume in a large population-based cohort. The findings showed that dCDT composite scores were significantly associated with multiple brain MRI measures. The results suggest that dCDT has the potential to be used as a cognitive assessment tool in the clinical diagnosis of mild cognitive impairment (MCI).
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Geriatrics & Gerontology
Corinne Sejourne, Jordan D. Dworkin, Megan S. Barker, Masood Manoochehri, Reena T. Gottesman, Eric M. Wassermann, Michael C. Tierney, Edward D. Huey, Jordan Grafman
Summary: This study examines the frequency and correlates of initial idiopathic psychiatric diagnosis in patients with Frontotemporal Dementia (FTD). The study finds that 25% of the patients reviewed were initially misdiagnosed, with depression being the most common misdiagnosis. It also suggests that family history of dementia, family history of mental illness, and the type of first symptoms may be associated with a higher likelihood of initial idiopathic psychiatric diagnosis in FTD patients.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Review
Clinical Neurology
Christiane Reitz, Margaret A. Pericak-Vance, Tatiana Foroud, Richard Mayeux
Summary: The lack of ancestral diversity in study cohorts limits progress in Alzheimer disease genetics. This article summarizes the current knowledge of Alzheimer disease genetics globally and highlights efforts to increase cohort diversity. Identifying genetic causes of Alzheimer disease can lead to potential treatments by uncovering underlying pathological mechanisms. Large-scale genome-wide analyses suggest that multiple genes or loci contribute to the disease. However, most genetic data have been obtained from non-Hispanic white individuals in Europe and North America, hindering the development of personalized approaches for individuals of other ethnicities.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Clinical Neurology
Rachel Fremont, Jordan Dworkin, Masood Manoochehri, Frank Krueger, Edward Huey, Jordan Grafman
Summary: This study examines the effect of damage to different elements of the cortico-striato-thalamo-cortical (CSTC) circuits on the development of compulsive behaviors and tics. The findings indicate that damage to specific CSTC elements can be associated with the development of compulsive behaviors and tics that are not necessarily accompanied by obsessions.
BMJ NEUROLOGY OPEN
(2022)
Meeting Abstract
Neurosciences
Rachel Fremont, Jordan Dworkin, Masood Manoochehri, Frank Krueger, Edward Huey, Jordan Grafman
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Clinical Neurology
Bradley Boeve, Adam Boxer, Howard Rosen, Leah Forsberg, Hilary Heuer, Danielle Brushaber, Brian Appleby, Joanna Biernacka, Yvette Bordelon, Hugo Botha, Patrick Brannelly, Bradford Dickerson, Susan Dickinson, Dennis Dickson, Kimiko Domoto-Reilly, Kelley Faber, Anne Fagan, Julie Fields, Ann Fishman, Tatiana Foroud, Douglas Galasko, Ralitza Gavrilova, Tania Gendron, Daniel Geschwind, Nupur Ghoshal, Jill Goldman, Jonathan Graff-Radford, Neill Graff-Radford, Ian Grant, Murray Grossman, Ging-Yuek Hsiung, Eric Huang, Edward Huey, David Irwin, David Jones, Kejal Kantarci, Anna Karydas, Daniel Kaufer, David Knopman, Joel Kramer, Walter Kremers, John Kornak, Walter Kukull, Emma Lagone, Irene Litvan, Peter Ljubenkov, Diane Lucente, Ian R. A. Mackenzie, Masood Manoochehri, Joseph Masdeu, Scott McGinnis, Mario Mendez, Bruce Miller, Toji Miyagawa, Kevin Nelson, Chiadi Onyike, Alexander Pantelyat, Belen Pascual, Rodney Pearlman, Leonard Petrucelli, Rosa Rademakers, Eliana Marisa Ramos, Katherine Rankin, Katya Rascovsky, Jessica Rexach, Aaron Ritter, Erik Roberson, Julio Rojas-Martinez, Marwan Sabbagh, David Salmon, Rodolfo Savica, William Seeley, Adam Staffaroni, Jeremy Syrjanen, Carmela Tartaglia, Nadine Tatton, Joanne Taylor, Arthur Toga, Sandra Weintraub, Diana Wheaton, Bonnie Wong, Zbigniew Wszolek