Article
Immunology
Magdalena Maj, Gina M. Fake, John H. Walker, Ryan Saltzman, John A. Howard
Summary: Oral administration of maize-produced S antigen to pregnant sows can protect nursing piglets against porcine epidemic diarrhea virus (PEDV), as shown by reduced disease severity and increased survival rates in piglets from sows fed with S antigen compared to controls. Higher levels of neutralizing antibodies and lower levels of certain cytokines in sows' milk were associated with higher piglet survivability.
Article
Food Science & Technology
Zulkiflee Kuedo, Lalita Chotphruethipong, Navaneethan Raju, Ratchaneekorn Reudhabibadh, Soottawat Benjakul, Pennapa Chonpathompikunlert, Wanwimol Klaypradit, Pilaiwanwadee Hutamekalin
Summary: This study found that the ethanolic extract-loaded liposome from white shrimp shells had neuroprotective effects on Aβ-induced memory impairment in rats. It improved memory ability through the regulation of memory-related proteins and activation of signaling pathways.
Article
Dentistry, Oral Surgery & Medicine
Peiyang Yuan, Xuemei Qiu, Lu Ye, Feifei Hou, Yuye Liang, Han Jiang, Yuting Zhang, Yiming Xu, Yutong Sun, Xiaoting Deng, Hao Xu, Lu Jiang
Summary: The relative ranking of topical administration varies depending on different indicators. Dexamethasone, triamcinolone, and betamethasone are recommended for better efficacy and safety based on joint consideration of clinical response rate and adverse event occurrence. The optimal treatment for oral lichen planus patients varies under different conditions.
Article
Medicine, Research & Experimental
Oksana Sintsova, Darya Popkova, Aleksandr Kalinovskii, Anton Rasin, Natalya Borozdina, Elvira Shaykhutdinova, Anna Klimovich, Alexander Menshov, Natalia Kim, Stanislav Anastyuk, Mikhail Kusaykin, Igor Dyachenko, Irina Gladkikh, Elena Leychenko
Summary: Diabetes mellitus poses a serious threat to human health worldwide. The current lack of sufficient drugs for diabetes treatment has led to the study of new potent alpha-amylase inhibitors. In this study, we successfully produced the sea anemone derived alpha-amylase inhibitor magnificamide in Escherichia coli. Our results showed that magnificamide effectively inhibits human pancreatic alpha-amylase, and has the potential to control postprandial hyperglycemia.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Microbiology
Martin K. Kankam, Jennifer M. Burns, Marc S. Collett, Michael L. Corrado, Jeffrey R. Hincks
Summary: The study showed that V-7404 was well absorbed after oral administration in healthy adult volunteers, with dose-proportional pharmacokinetic exposure and no significant accumulation. V-7404 demonstrated acceptable safety and pharmacokinetic profile, supporting further clinical investigation for the treatment of serious EV infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Zoe Kane, Roberto Picetti, Alison Wilby, Joseph F. Standing, Stanislas Grassin-Delyle, Ian Roberts, Haleema Shakur-Still
Summary: The study suggests that intramuscular administration of TXA may achieve targeted exposure and capture variability in pharmacokinetics. Well-designed clinical trials are recommended to validate these findings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Bogdan Vlacho, Xavier Mundet-Tuduri, Manel Mata-Cases, Joan Antoni Valles-Callol, Jordi Real, Magi Farre, Francesc Xavier Cos, Kamlesh Khunti, Didac Mauricio, Josep Franch-Nadal
Summary: The study compared the effects of adding DPP-4 inhibitors, SGLT-2 inhibitors, or sulfonylureas to metformin in real-world conditions. The results showed that SGLT-2 inhibitors were associated with greater reductions in weight and the combined target of weight-HbA1c compared to SU and DPP4 inhibitors, although there were no significant differences in hypoglycemic effectiveness among the three drug classes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Nanoscience & Nanotechnology
Changjiang Li, Na Wang, Guodong Zheng, Licong Yang
Summary: A Res-selenium-peptide nanocomposite was developed to improve cognitive dysfunction in AD model mice by reducing Aβ aggregation, inhibiting Aβ deposition, decreasing oxidative stress and inflammation, and alleviating gut microbiota disorder.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Microbiology
Michael R. Hodges, Eric Ople, Pamela Wedel, Karen J. Shaw, Abhijeet Jakate, William G. Kramer, Sjoerd van Marle, Ewoud-Jan van Hoogdalem, Margaret Tawadrous
Summary: Fosmanogepix is a novel antifungal drug candidate being developed for the treatment of invasive fungal infections. It can be administered intravenously or orally and works by interfering with fungal cell wall synthesis. Two clinical studies have shown its safety and pharmacokinetic properties.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Shawn Gulati, Ahmad A. Aref
Summary: This article provides a comprehensive review on the best practices for using acetazolamide in ophthalmic practice, covering its history, mechanism of action, methods of observing efficacy, indications, side effects, allergy information, formulations, dosing, and monitoring. Expert opinion suggests that the benefits of oral carbonic anhydrase inhibitor therapy outweigh the risks in many circumstances, emphasizing the importance of collaboration between eye care practitioners and primary care providers in monitoring and mitigating risks.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Cristina Duran-Rosas, Bryan Adrian Priego-Parra, Eliana Morel-Cerda, Lydia A. Mercado-Jauregui, Carlos Arturo Aquino-Ruiz, Arturo Triana-Romero, Mercedes Amieva-Balmori, Jose Antonio Velarde-Ruiz Velasco, Jose Maria Remes-Troche
Summary: This study found that a short-term 7-day PPI course induced SIBO in 7.8% of healthy subjects, with patients experiencing bloating and flatulence having a higher prevalence of developing SIBO after 7 days of treatment. Although caution against inappropriate PPI use is warranted, the benefits of PPI administration seem to outweigh the disadvantages as more than 90% of subjects did not develop SIBO after a week of treatment.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Pharmacology & Pharmacy
In-hwan Baek, Hyun-moon Back, Jung-woo Chae, Eun-Sol Ha, Heejun Park, Du Hyung Choi, Christine E. Staatz, Min-Soo Kim
Summary: This study characterized the pharmacokinetics of eperisone following oral administration to Korean volunteers, identifying potential covariates and developing a disposition model for eperisone.
BIOPHARMACEUTICS & DRUG DISPOSITION
(2021)
Article
Hematology
Masayuki Aiba, Akio Shigematsu, Toma Suzuki, Takuto Miyagishima
Summary: Venetoclax (VEN) is widely used in the treatment of elderly patients with acute myelogenous leukemia (AML) who are not eligible for intensive remission induction therapy. Shortening the duration of VEN administration during induction therapy may reduce myelosuppression, infection, and hospital stays. A retrospective analysis of 13 newly diagnosed AML patients showed that the VEN14 group had a similar composite complete remission (CRc) rate as the VEN28 group, but a potentially lower risk of febrile neutropenia and shorter hospital stays.
ANNALS OF HEMATOLOGY
(2023)
Article
Toxicology
Benedikt Ringbeck, Daniel Bury, Alexandra Gotthardt, Heiko Hayen, Rainer Otter, Tobias Weiss, Thomas Bruening, Holger M. Koch
Summary: The study provides quantitative data on human DnBA metabolism and excretion, indicating that MnBA and 3OH-MnBA can serve as specific exposure biomarkers for DnBA. Metabolite excretion was faster in the oral study compared to the dermal study, suggesting potential differences in absorption routes.
TOXICOLOGY LETTERS
(2021)
Article
Virology
Larisa N. N. Shishkina, Oleg Yu. Mazurkov, Nikolai I. I. Bormotov, Maksim O. O. Skarnovich, Olga A. A. Serova, Natalia A. A. Mazurkova, Maria A. A. Skarnovich, Alexander A. A. Chernonosov, Boris A. A. Selivanov, Alexey Ya. Tikhonov, Svetlana G. G. Gamaley, Galina G. G. Shimina, Galina M. M. Sysoyeva, Oleg S. S. Taranov, Elena D. D. Danilenko, Alexander P. P. Agafonov, Rinat A. A. Maksyutov
Summary: The study aimed to determine the characteristics, safety, and bioavailability of the chemical substance NIOCH-14 in laboratory animals. Results showed that NIOCH-14 had high bioavailability in mice and rats, with significant levels found in various organs. It was also found to be safe, with no lethal effects observed at appropriate dosages. Therefore, NIOCH-14 shows potential as an effective drug for treating viral infections, including smallpox.