Article
Clinical Neurology
Hatice Eraslan Boz, Koray Kocoglu, Muege Akkoyun, Isil Yagmur Tufekci, Merve Ekin, Guelden Akdal
Summary: The study found that visual search impairment exists in early stages of both AD and aMCI, highlighting the importance of addressing visual processes in the Alzheimer's continuum.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Eun Jin Yoon, Jun-Young Lee, Seyul Kwak, Yu Kyeong Kim
Summary: Mild behavioral impairment (MBI) is a neurobehavioral syndrome associated with a higher risk of progression to Alzheimer's disease (AD) in individuals with amnestic mild cognitive impairment (MCI). The presence of multiple MBI domains is also associated with cortical thinning in specific brain regions.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
S. Fountain-Zaragoza, O. Horn, K. E. Thorn, A. Z. Kraal, Andreana Benitez
Summary: This study aimed to determine whether normative morphometric estimates generated from open-source software replicate established patterns of neurodegeneration in aMCI and whether these metrics correlate with episodic memory performance. The results showed that participants in the aMCI group exhibited poorer memory and smaller volumes in AD-relevant regions compared to the CN group. These findings support the validity and cost-effectiveness of free software as alternatives to proprietary software for research settings.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Marleen Haupt, Steffen Joedecke, Annie Srowig, Natan Napiorkowski, Christoph Preul, Otto W. Witte, Kathrin Finke
Summary: The study found that patients with amnestic mild cognitive impairment (aMCI) have higher visual processing speed with warning signals compared to without, but still lower than cognitively normal older adults. This suggests that while the processing system of aMCI patients shows general declines, they can still integrate auditory warning signals on a perceptual level.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Ping Liu, Xi-Ze Jia, Yi Chen, Yang Yu, Kan Zhang, Ya-Jie Lin, Bao-Hong Wang, Guo-Ping Peng
Summary: The study revealed that alterations in gut microbiota (GM) in patients with amnestic mild cognitive impairment (aMCI) can impact local spontaneous brain activity and subsequently affect cognitive function. Specific correlations were found between different GM compositions and brain activity. Members of Clostridium were positively correlated with brain activity, while Veillonellaceae showed a negative correlation.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Geriatrics & Gerontology
Yanlu Huang, Lin Huang, Yifan Wang, Yuchen Liu, Chun-Yi Zac Lo, Qihao Guo
Summary: This study aimed to examine the relationship between hippocampal subfield volumes and visual memory in SCD and aMCI patients. The results indicate different associations between visual memory and hippocampal subfield volumes in SCD and aMCI patients.
Article
Geriatrics & Gerontology
Joseph M. Gullett, Alejandro Albizu, Ruogu Fang, David A. Loewenstein, Ranjan Duara, Monica Rosselli, Melissa J. Armstrong, Tatjana Rundek, Hanna K. Hausman, Steven T. Dekosky, Adam J. Woods, Ronald A. Cohen
Summary: This study successfully predicted the conversion to dementia in high-risk aMCI patients based on baseline data using multimodal MRI, and identified brain regions associated with long-term decline to dementia. By combining T1 MRI and rsfMRI modalities and using SVM classification, a high prediction accuracy was achieved.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Immunology
Erin E. Sundermann, Mark W. Bondi, Laura M. Campbell, Ben Gouaux, Raeanne C. Moore, Virawudh Soontornniyomkij, David J. Moore
Summary: This study aimed to distinguish aMCI from HAND in PWH using a neuropsychological method, finding a higher prevalence of high aMCI risk in the HAND group, with beta-amyloid pathology being associated with high aMCI risk, while phospho-Tau pathology did not differ by aMCI classification.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Shanshan Chen, Yu Song, Huimin Wu, Honglin Ge, Wenzhang Qi, Yue Xi, Jiayi Wu, Yuxiang Ji, Kexin Chen, Xingjian Lin, Jiu Chen
Summary: In patients with amnestic mild cognitive impairment (aMCI), anosognosia is associated with increased tau accumulation in specific brain regions, disrupted functional connectivity, and accelerates progression to Alzheimer's disease dementia.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Alessandro Galgani, Francesco Lombardo, Nicola Martini, Andrea Vergallo, Luca Bastiani, Harald Hampel, Hana Hlavata, Filippo Baldacci, Gloria Tognoni, Daniele De Marchi, Irene Ghicopulos, Sara De Cori, Francesca Biagioni, Carla Letizia Busceti, Roberto Ceravolo, Ubaldo Bonuccelli, Dante Chiappino, Gabriele Siciliano, Francesco Fornai, Nicola Pavese, Filippo Sean Giorgi
Summary: This study used LC-MRI to investigate the involvement of the pontine nucleus Locus Coeruleus (LC) in Alzheimer's disease progression and its association with prognosis and cognitive performance in amnestic Mild Cognitive Impairment. The findings suggest that reductions in LC-MRI parameters may be predictive of clinical progression in Mild Cognitive Impairment and support the role of LC degeneration in the continuum of Alzheimer's disease.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Nena Lejko, Shankar Tumati, Esther M. Opmeer, Jan-Bernard C. Marsman, Fransje E. Reesink, Peter P. De Deyn, Andre Aleman, Branislava Curcic-Blake
Summary: The impaired planning ability in individuals with amnestic mild cognitive impairment (aMCI) is associated with lower activation in a diffuse cortico-thalamic network. Higher planning-related activity is related to better memory performance.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Geriatrics & Gerontology
Tammy T. Tran, Caroline L. Speck, Michela Gallagher, Arnold Bakker
Summary: The entorhinal cortex is affected by early pathological changes in Alzheimer's disease, resulting in neuronal, synaptic, and volumetric loss. Specifically, the lateral entorhinal cortex accumulates tau neurofibrillary tangles in the amnestic mild cognitive impairment (aMCI) phase. Structural and functional changes in the lateral entorhinal cortex are associated with impaired memory function in aMCI patients, while the medial entorhinal cortex appears to be less affected.
NEUROBIOLOGY OF AGING
(2022)
Article
Geriatrics & Gerontology
Qi Feng, Luoyu Wang, Xue Tang, Xiuhong Ge, Hanjun Hu, Zhengluan Liao, Zhongxiang Ding
Summary: Hippocampal subfield volume can serve as a predictive marker for aMCI, and the findings underscore the sensitivity of hippocampal subfield volume to overall cognitive performance.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Sheng-Lan Gao, Jinhuan Yue, Xiao-Ling Li, Ang Li, Dan-Na Cao, Sheng-Wang Han, Ze-Yi Wei, Guanhu Yang, Qinhong Zhang
Summary: Amnestic mild cognitive impairment (aMCI) is a transitional stage between normal aging and Alzheimer's disease (AD), characterized by noticeable memory decline. Advanced multimodal magnetic resonance imaging techniques have been used to study the brain structure and functional networks of individuals with aMCI. This comprehensive review aims to uncover potential biomarkers and gain insights into the underlying pathogenesis of aMCI.
Article
Clinical Neurology
Jinhuan Yue, Sheng-wang Han, Xiao Liu, Song Wang, Wei-wei Zhao, Li-na Cai, Dan-na Cao, Jeffrey Zhongxue Mah, Yu Hou, Xuan Cui, Yang Wang, Li Chen, Ang Li, Xiao-ling Li, Guanhu Yang, Qinhong Zhang
Summary: This study used resting-state functional magnetic resonance imaging (rs-fMRI) to analyze the brain function of patients with amnestic mild cognitive impairment (aMCI). The results showed functional changes in multiple brain regions in aMCI patients compared to healthy controls. These findings suggest that the abnormal activity in multiple specific brain regions may be an indicator of impaired central function in aMCI patients.
FRONTIERS IN NEUROLOGY
(2023)
