Article
Multidisciplinary Sciences
Randall J. Eck, Rebecca L. Kow, Aristide H. Black, Nicole F. Liachko, Brian C. Kraemer
Summary: The pathological accumulation of the microtubule binding protein tau is the main cause of age-related neurodegenerative diseases known as tauopathies. A study using a Caenorhabditis elegans model found that the toxicity of tau depends on the nuclear E3 ubiquitin ligase adaptor protein SPOP. Loss of function mutations in the spop-1 gene improved behavioral deficits in tau transgenic animals, while overexpression of SPOP-1 worsened these deficits. Furthermore, loss of spop-1 rescued various tau-related phenotypes, including tau protein accumulation, neurodegeneration, and shortened lifespan.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biotechnology & Applied Microbiology
Sai Sreenivasamurthy, Mahek Laul, Nan Zhao, Tiffany Kim, Donghui Zhu
Summary: Alzheimer's disease is a progressive neurodegenerative disease associated with aging. Two-dimensional cell culture and animal models have contributed to our understanding of the disease mechanism, but they cannot fully capture the complexity of human brain tissue. The emergence of three-dimensional cerebral organoid models offers a more accurate representation of human brain tissue.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Neurosciences
Devargya Ganguly, Joshua Abby Thomas, Abid Ali, Rahul Kumar
Summary: EphA-4 plays a significant role in the onset and progression of Alzheimer's disease. Inhibition of EphA-4 can alleviate symptoms and affect the development of the disease. Further research on the regulation pathways of EphA-4 and the development of therapeutic methods targeting its enzymatic activity are important.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Alexandra J. Malbon, Lorena Sordo, Liam A. Wilson, Danielle Gunn-Moore, Georgios Paraschou, Neil Macintyre, Tobias Schwarz, Bruce McGorum, Caroline Hahn
Summary: Neurodegenerative disorders are becoming increasingly important in ageing populations of animals and people. This study identified the characteristic lesions of Alzheimer's disease (AD) in the brains of donkeys, which may prompt further research on their metabolic status.
NEUROBIOLOGY OF AGING
(2022)
Review
Neurosciences
Preetpal Kaur, Alisha Khera, Hema K. Alajangi, Akanksha Sharma, Pradeep K. Jaiswal, Gurpal Singh, Ravi P. Barnwal
Summary: Several protein kinases and phosphatases regulate tau protein phosphorylation, and an imbalance in their activity leads to tau hyper-phosphorylation. Aberrant tau phosphorylation causes it to dissociate from microtubules and form neurofibrillary tangles, contributing to neurodegenerative disorders. Restorative approaches targeting hyperphosphorylated tau protein are being explored, and drug delivery systems based on nanocarriers provide a potential solution for the limited transport of drugs to the central nervous system. This review discusses tau protein, regulation of its phosphorylation, drugs in use or under clinical trials, and treatment strategies for tauopathies based on the role of tau hyperphosphorylation in disease pathogenesis.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sarah Holper, Rosie Watson, Nawaf Yassi
Summary: The advances in tau detection have revolutionized the diagnosis of neurodegenerative diseases, offering improved diagnostic accuracy and potential as a predictor of clinical progression and drug therapy response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Paul A. Yushkevich, Monica Munoz Lopez, Maria Mercedes Iniguez de Onzono Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L. Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M. Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R. Das, Emilio Artacho-Perula, Mari'a Del Mar Arroyo Jimenez, Mari'a Pilar Marcos Raba, Francisco Javier Molina Romero, Sandra Cebada Sanchez, Jose Carlos Delgado Gonzalez, Carlos De la Rosa-Prieto, Marta Corcoles Parada, Edward B. Lee, John Q. Trojanowski, Daniel T. Ohm, Laura E. M. Wisse, David A. Wolk, David J. Irwin, Ricardo Insausti
Summary: This study utilized ex vivo MRI and dense serial histological imaging to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe, revealing significant variation along different anatomical regions. The findings provide valuable insights into the distribution of this neurodegenerative pathology and may support the development and validation of neuroimaging biomarkers.
Review
Neurosciences
Kesevan Rajah Kumaran, Suleiman Yunusa, Enoch Perimal, Habibah Wahab, Christian P. Mueller, Zurina Hassan
Summary: The aging population is increasing steadily due to a healthy lifestyle and medical advancements. However, Alzheimer's disease (AD) is becoming more common and problematic among older adults, with an increasing trend in AD-related cases each year. AD is an irreversible and progressive brain disorder that damages cognitive functions and daily tasks ability. Currently, the cause of AD is poorly understood, and there is no safe and effective therapeutic agent to cure or slow down its progression. Understanding the pathophysiology of AD can help develop therapeutic strategies for its treatment.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Aiko Robert, Michael Scholl, Thomas Vogels
Summary: Recent research has shown that injecting purified tau aggregates from human tauopathy patients can replicate the structural features and cell type specificity of the original tau pathology. These models may have unique translational value in studying the functional consequences of tau pathology, tau-based diagnostics, and tau-targeting therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Jamie M. Walker, William Goette, Kurt Farrell, Megan A. Iida, Esma Karlovich, Charles F. White III, John E. Crary, Timothy Richardson
Summary: The distribution and spread of neurofibrillary degeneration in Alzheimer's disease (AD) and primary age-related tauopathy (PART) are influenced by the presence and extent of amyloid beta (Aβ) burden in the entorhinal cortex and CA1 subregion of the hippocampus. However, there is an early selective vulnerability of the CA2 subregion in PART, which is not correlated with Aβ burden.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cell Biology
Michael Fassler, Clara Benaim, Jacob George
Summary: This study investigated the effects of the TREM2 monoclonal antibody Ab-T1 on Tau protein in neurodegenerative diseases. The results showed that Ab-T1 enhanced the uptake of Tau protein by microglia, reduced Tau propagation and phosphorylation, and improved cognitive decline and neuroinflammation. These findings indicate that TREM2 activation has beneficial effects in reducing Tau-driven neurodegeneration.
Article
Clinical Neurology
Shama D. Karanth, Yuriko Katsumata, Peter T. Nelson, David W. Fardo, Jaclyn K. McDowell, Frederick A. Schmitt, Richard J. Kryscio, Steven R. Browning, Dejana Braithwaite, Susanne M. Arnold, Erin L. Abner
Summary: This study investigated the association between cancer diagnosis and neuropathological and cognitive features of dementia. The findings showed that cancer diagnosis was associated with a lower burden of Alzheimer's disease pathology and less cognitive impairment.
Review
Cell Biology
Scott Ayton, Ashley Bush
Summary: Alzheimer's disease is a major disease without preventative or disease modifying therapy, and current drugs targeting amyloid beta have been unsuccessful in slowing cognitive decline. Debate is ongoing about whether to continue anti-A beta therapy or pursue alternative targets. The need for disease modifying AD therapies has become one of the highest priorities in all of medicine due to the growing burden of the disease on patients, families, and healthcare budgets.
AGEING RESEARCH REVIEWS
(2021)
Review
Medicine, Research & Experimental
Shreya Asher, Ronny Priefer
Summary: This article reviews the history of clinical trials for Alzheimer's disease and analyzes the reasons for their failures.
Review
Biochemistry & Molecular Biology
Lucia Gallego Villarejo, Lisa Bachmann, David Marks, Maite Brachthaeuser, Alexander Geidies, Thorsten Mueller
Summary: Intracellular amyloid beta (iAβ) plays a crucial role in neurodegeneration and serves as a pathological marker. Modulating iAβ through pharmacological treatment has shown beneficial effects on cognitive properties. Future research should focus on the impact of viral infections on iAβ generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ruizhi Wang, Hongjie Wang, Ivan Carrera, Shaohua Xu, Madepalli K. Lakshmana
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Neurosciences
Juan Pablo Palavicini, Hongjie Wang, Dmitriy Minond, Elisabetta Bianchi, Shaohua Xu, Madepalli K. Lakshmana
JOURNAL OF ALZHEIMERS DISEASE
(2014)
Article
Biochemistry & Molecular Biology
Hongjie Wang, Debleena Dey, Ivan Carrera, Dmitriy Minond, Elisabetta Bianchi, Shaohua Xu, Madepalli K. Lakshmana
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Engineering, Chemical
Berrin Tansel, John Sager, Jay Garland, Shaohua Xu
JOURNAL OF MEMBRANE SCIENCE
(2009)
Article
Microscopy
Y. Lin, S. Xu
JOURNAL OF MICROSCOPY
(2011)
Article
Chemistry, Physical
Shaohua Xu
JOURNAL OF PHYSICAL CHEMISTRY B
(2009)
Article
Neurosciences
Ruizhi Wang, Juan Pablo Palavicini, Hongjie Wang, Panchanan Maiti, Elisabetta Bianchi, Shaohua Xu, B. N. Lloyd, Ken Dawson-Scully, David E. Kang, Madepalli K. Lakshmana
NEUROBIOLOGY OF DISEASE
(2014)
Article
Neurosciences
H. Wang, M. Lewsadder, E. Dorn, S. Xu, M. K. Lakshmana
Article
Multidisciplinary Sciences
Hongjie Wang, Ruizhi Wang, Shaohua Xu, Madepalli K. Lakshmana
Article
Multidisciplinary Sciences
Hongxuan Wang, Yamei Tang, Xiaoming Rong, Hui Li, Rui Pan, Yidong Wang, Ying Peng
Article
Multidisciplinary Sciences
Daniel Woodard, Dylan Bell, David Tipton, Samuel Durrance, Lisa Cole, Bin Li, Shaohua Xu
Article
Cell Biology
J. P. Palavicini, H. Wang, E. Bianchi, S. Xu, J. S. Rao, D. E. Kang, M. K. Lakshmana
CELL DEATH & DISEASE
(2013)
Article
Neurosciences
Hongjie Wang, Ruizhi Wang, Ivan Carrera, Shaohua Xu, Madepalli K. Lakshmana
Meeting Abstract
Biophysics
Shaohua Xu
BIOPHYSICAL JOURNAL
(2011)