Article
Clinical Neurology
Asma Khan, Robert Johnson, Carrie Wittmer, Michelle Maile, Keith Tatsukawa, Julian L. Wong, Martin B. Gill, Emily M. Stocking, Srinivasa R. Natala, Amy D. Paulino, Jon K. Bowden-Verhoek, Wolfgang Wrasidlo, Eliezer Masliah, Douglas W. Bonhaus, Diana L. Price
Summary: NPT520-34 has shown beneficial effects on both inflammation and protein-pathology endpoints in animal models, leading to improvements in motor function in a Parkinson's disease model.
Article
Cell Biology
Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B. Williams, Zhen Yan
Summary: Research suggests that targeting EHMT2 can reverse the repressive H3K9me2 histone mark in the brain of P301S Tau mice, improving spatial and recognition memory deficits. In addition, EHMT inhibition can normalize neuronal excitability and glutamatergic synaptic transmission in the PFC of P301S Tau mice. UNC0642 treatment has been shown to regulate dysregulated genes and may be used to treat cognitive and synaptic deficits in neurodegenerative diseases associated with tauopathies.
Article
Behavioral Sciences
Martina Stazi, Oliver Wirths
Summary: The research demonstrates that prolonged physical activity and cognitive stimulation in a mouse model of AD overexpressing only Aβ(4-42) peptides lead to preservation of recognition and spatial memory, rescue of motor deficits, and improvement of phenotypes in the Morris water maze task. These findings support the notion that physical activity and cognitive stimulation could be effective strategies in preventing age-related neurodegenerative disorders like AD.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rongzi Li, Wei Xiong, Boying Li, Yixuan Li, Bing Fang, Xifan Wang, Fazheng Ren
Summary: Adult hippocampal neurogenesis (AHN) is crucial for cognitive function and is dysregulated in Alzheimer's disease (AD). Plasmalogen (PLA), a group of phospholipids, has neuroprotective properties, but its effect on altered AHN in AD has not been studied. In this study, PLA was found to attenuate the decrease in neural stem cell viability and neuronal differentiation induced by β-amyloid (Aβ), partly through regulating the Wnt/β-catenin pathway. In AD mice, PLA supplementation improved impaired AHN and memory function. Therefore, PLA could regulate NSC differentiation and ameliorate AD-related memory impairment by up-regulating AHN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Shokufeh Bagheri, Masome Rashno, Iraj Salehi, Seyed Asaad Karimi, Safoura Raoufi, Alireza Komaki
Summary: This study aimed to evaluate the effects of geraniol (GR) on an AD rat model induced by A beta 1-40 ICV microinjection. The results showed that GR could improve memory deficits, enhance hippocampal synaptic plasticity, and reduce A beta plaque accumulation in the A beta-infused rats. The study indicates that GR alleviates A beta-induced memory impairment possibly by improving hippocampal synaptic dysfunction and inhibiting A beta plaque formation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Ze Li, Zhenyan Song, Chunxiang He, Jialong Fan, Wenjing Yu, Miao Yang, Ping Li, Rongsiqing Luo, Jinyong Zhou, Sijie Xu, Bin Liu, Shaowu Cheng
Summary: This study developed a nano delivery system that can reverse microglia polarization, improve learning and memory, alleviate glial cell activation, and enhance cognitive function in Alzheimer's disease treatment, indicating its promising therapeutic potential.
MATERIALS TODAY ADVANCES
(2022)
Article
Biochemistry & Molecular Biology
Bisan Saleh, Kolluru D. Srikanth, Tal Sneh, Lambert Yue, Steven Pelech, Evan Elliott, Hava Gil-Henn
Summary: This study reveals the in vivo role of focal adhesion kinase (FAK) in Alzheimer's disease (AD) pathology. The overexpression of FAK leads to a decrease in learning and memory capabilities and an increase in amyloid beta (Aβ) load. In addition, the overexpression of FAK alters neuronal morphology. Proteomics analysis shows that FAK controls AD-like phenotypes by inhibiting cytoskeletal remodeling, increasing Tau hyperphosphorylation, and blocking astrocyte differentiation. FAK also activates cell cycle re-entry, cell death, and downregulates insulin signaling, leading to insulin resistance and oxidative stress. This study highlights FAK as a novel therapeutic target for treating AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Martina Stazi, Sandra Lehmann, M. Sadman Sakib, Tonatiuh Pena-Centeno, Luca Buschgens, Andre Fischer, Sascha Weggen, Oliver Wirths
Summary: Research suggests that moderate caffeine consumption reduces the risk of Alzheimer's disease and can improve neuronal loss, behavioral deficits, and neurogenesis in mouse models of the disease. The study challenges the belief that caffeine is anti-amyloidogenic and highlights the potential role of promoting neurogenesis in its beneficial effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marta Zamarbide, Eva Martinez-Pinilla, Francisco Gil-Bea, Masashi Yanagisawa, Rafael Franco, Alberto Perez-Mediavilla
Summary: The study demonstrates the presence of the FFA3 receptor in the human brain and its involvement in cognitive processes. Inactivating the FFA3 gene can prevent AD-like cognitive decline and pathological hallmarks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Amandine Jullienne, Ryan Quan, Jenny Szu, Michelle Trinh, Erik J. Behringer, Andre Obenaus
Summary: This study utilized the 3xTg-AD mouse model to examine the role of vascular dysfunction and structural abnormalities in the progression of Alzheimer's disease. The findings demonstrate progressive alterations in individual cortical vessels and the cortical vascular network, potentially identifying unique diagnostic signatures of AD progression.
Article
Immunology
Tahir Ali, Antonia N. Klein, Keegan McDonald, Lovisa Johansson, Priyanka Ganguli Mukherjee, Martin Hallbeck, Katsumi Doh-ura, Hermann M. Schatzl, Sabine Gilch
Summary: Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disease associated with the accumulation of amyloid beta (Aβ) and neuroinflammation. Cellulose ether compounds (CEs) have been found to inhibit protein misfolding and replication and have shown therapeutic effects against AD. In vitro and in vivo studies demonstrated that a representative CE, TC-5RW, inhibited Aβ aggregation, neurotoxicity, and immunoreactivity and improved memory functions in transgenic AD mice. TC-5RW also reduced Aβ oligomer and plaque burden, as well as associated neuroinflammation, by regulating glial activation and proinflammatory mediator GMFβ. These findings suggest that FDA-approved CEs are potential therapeutics for AD and other protein misfolding-related neurodegenerative diseases.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Stefanie Grabrucker, Moira Marizzoni, Edina Silajdzic, Nicola Lopizzo, Elisa Mombelli, Sarah Nicolas, Sebastian Dohm-Hansen, Catia Scassellati, Davide Vito Moretti, Melissa Rosa, Karina Hoffmann, John F. Cryan, Olivia F. O'Leary, Jane A. English, Aonghus Lavelle, Cora O'Neill, Sandrine Thuret, Annamaria Cattaneo, Yvonne M. Nolan
Summary: Recent research suggests that alterations in the gut microbiota are associated with Alzheimer's disease. Through transplantation of microbiota from Alzheimer's patients and healthy controls into rats, the study found that the microbiota from Alzheimer's patients affected memory and mood. Changes in hippocampal neurogenesis and metabolome were also observed in the rats.
Article
Pharmacology & Pharmacy
Lin Zhu, Fangjin Lu, Xiaoran Zhang, Siyuan Liu, Ping Mu
Summary: The study found that Pterostilbene (PTE) in blueberries has neuroprotective properties in the treatment of Alzheimer's disease, improving cognitive dysfunction and neuronal plasticity. Its mechanism may be related to inhibiting mitochondria-dependent apoptosis through the antioxidant effect regulated by SIRT1/Nrf2.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Yifan Xiao, Xiaokang Gong, Ronghua Deng, Wei Liu, Youhua Yang, Xiaochuan Wang, Jianzhi Wang, Jian Bao, Xiji Shu
Summary: The study found that a high-fat diet led to nonheme iron overload in the brains of AD mice, but iron chelation treatment could alleviate memory deficits caused by HFD and effectively reduce synaptic impairment in the hippocampus and neuronal degeneration in the cortex.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Neurosciences
Gregory Hook, Mark Kindy, Vivian Hook
Summary: The lysosomal cysteine protease cathepsin B (CTSB) is a potential biomarker for Alzheimer's disease (AD) as elevated levels of serum CTSB have been correlated with cognitive dysfunction in AD patients. Knocking out the CTSB gene has been shown to improve memory deficits in AD animal models, but the effects on amyloid-beta (Aβ) pathology depend on the specific hAβPP transgenes used in the models.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
